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Biochemistry & Molecular Biology
Ming-Zhu Zhu, Yi Li, Jin-Chuan Zhou, Dong-Xue Lv, Xiao-Jie Fu, Zhen Liang, Shuang-Zhi Yuan, Jing-Jing Han, Jiao-Zhen Zhang, Ze-Jun Xu, Wen-Qiang Chang, Hong-Xiang Lou
Summary: Seven new ent-eudesmane sesquiterpenoids (1-7) and seven known analogs (8-14) were isolated from Chiloscyphus polyanthus var. rivularis, a liverwort plant from China. Their structures were determined using spectroscopy analysis, electronic circular dichroism calculations, and biosynthetic considerations. Preliminary tests showed that these isolated compounds did not exhibit significant cytotoxicity against HepG2 cancer cells and antifungal activity against Candida albicans SC5314.
Article
Plant Sciences
Mingzhu Zhu, Yi Li, Jinchuan Zhou, Tian Wang, Xiaobin Li, Jiaozhen Zhang, Yanan Qiao, Jingjing Han, Zejun Xu, Hongxiang Lou
Summary: Nine new pinguisane sesquiterpenoid compounds were isolated from Chinese liverwort, with one compound showing significant inhibitory effects on NO production in macrophages and another compound displaying moderate anti-inflammatory activity in a zebrafish model.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Chun-Yang Zhang, Zhao-Jun Chu, Jin-Chuan Zhou, Shu-Gong Liu, Jiao-Zhen Zhang, Lining Qian, Hong-Xiang Lou
Summary: Ten new triterpenoids were isolated and purified from the Chinese liverwort Lepidozia reptans, with compound 7 showing inhibitory effects on a panel of cancer cell lines and inducing PC-3 cell death through mitochondrial-related apoptosis.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Ryosuke Fukada, Jin Kawano, Tomoki Tsuruta, Takuto Nonaka, Kosuke Sato, Susumu Miyajima, Shinnosuke Ishigami, Takahiro Ishii, Keisuke Nishikawa, Yoshinori Asakawa, Takashi Kamada
Summary: Two new eremophilane-type sesquiterpenoids, fusumaols A and B, were isolated from the stem-leafy liverwort, Bazzania japonica, collected in Mori-Machi, Shizuoka, Japan. The structures of the compounds were determined using extensive spectroscopic techniques, and the absolute configuration of compound 1 was determined by the modified Mosher's method. This is the first report of eremophilanes in the liverwort genus Bazzania. The repellent activities of compounds 1 and 2 against rice weevils were evaluated using the modified filter paper impregnation method, showing moderate repellent activities.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Xue Wang, Lilin Qian, Yanan Qiao, Xueyang Jin, Jinchuan Zhou, Shuangzhi Yuan, Jiaozhen Zhang, Chunyang Zhang, Hongxiang Lou
Summary: A chemical investigation of the Chinese liverwort revealed five undescribed cembrane-type diterpenoids, along with known cembrane diterpenes, a fusicoccane-type diterpenoid, and a dolabellane-type diterpenoid. The structures were determined through comprehensive analysis and their cytotoxicity against cancer cell lines was evaluated.
Article
Biochemistry & Molecular Biology
Yi Li, Xiao-Bin Li, Jin-Chuan Zhou, Ze-Jun Xu, Ming-Zhu Zhu, Yan Zong, Jiao-Zhen Zhang, Jing-Jing Han, Ya-Jie Tang, Hong-Xiang Lou
Summary: Three unprecedented ent-labdane and pallavicinin based dimers, pallamins A-C, and eight biosynthetically related monomers were isolated from Pallavicinia ambigua. Their structures were determined by extensive analysis of HRESIMS and NMR spectra. The absolute configurations of the labdane dimers were determined by single crystal X-ray diffraction, 13C NMR, and ECD calculations. Additionally, the anti-inflammatory activities of the isolated compounds were evaluated using the zebrafish model, with three of the monomers showing significant activity.
Article
Biochemistry & Molecular Biology
Yali Wang, Qinghua Jiang, Dejuan Sun, Na Zhang, Yu Lin, Hua Li, Lixia Chen
Summary: Phytochemical investigation on Euphorbia wallichii led to the discovery of twelve diterpenoids, including nine previously undescribed compounds. These compounds showed potent inhibitory effects on NO production in LPS-induced RAW264.7 cells, with wallkaurane A being the most active (IC50 = 4.21 mu M). Mechanistic studies revealed that wallkaurane A could suppress the generation of pro-inflammatory cytokines, decrease the expression of iNOS and COX-2, and regulate the NF-kappa B and JAK2/STAT3 signaling pathways to suppress inflammation and apoptosis.
Article
Chemistry, Multidisciplinary
Linh Thuy Khanh Nguyen, Phu Quynh Dinh Nguyen, Chau Bao Hoai Nguyen, Hoai Thi Nguyen, Thi Van Anh Tran, Thanh-Tan Mai, Thai-Son Tran, Duc Viet Ho
Summary: This study evaluated the acetylcholinesterase inhibitory activities of sesquiterpenoids from the rhizomes of Homalomena pendula, and found that teucmosin exhibited significant anti-cholinesterase activity, along with good pharmacokinetic properties on common targets in Alzheimer's disease (AD).
Article
Biochemistry & Molecular Biology
Hong-Zhen Shu, Cheng Peng, Lan Bu, Li Guo, Fei Liu, Liang Xiong
Summary: Bisabolane-type sesquiterpenoids are a class of monocyclic sesquiterpenoids widely distributed in nature, with antibacterial, anti-inflammatory, and cytotoxic effects being the most commonly reported pharmacological properties. These compounds have been used in traditional medicines for a long time and show great potential for the development of new drugs.
Article
Agriculture, Multidisciplinary
Ruonan Ning, Hongyan Mu, Li Chen, Tianqi Wang, Xing Xu, Shijun He, Min Jiang, Weimin Zhao
Summary: Dihydro-beta-agarofuran-type sesquiterpenoids are characteristic metabolites of Celastraceae plants, and extracts from these plants have been developed into botanical pesticides. In this study, eight new dihydro-beta-agarofuran-type sesquiterpenoids were identified from the stems of Celastrus monospermus Roxb. Three of these compounds showed inhibitory activities against osteoclastogenesis and affected the expression of genes and proteins related to bone metabolism. This is the first report on the potential medical applications of dihydro-beta-agarofuran-type sesquiterpenoids in bone metabolic diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Jinliang Li, Fengchao Li, Guoxing Wu, Furong Gui, Hongmei Li, Lili Xu, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Xiaoping Qin
Summary: In this study, two new sesquiterpenes were isolated from Laggera pterodonta, along with six known eudesmane-type sesquiterpenes, and their inhibitory effect on acetylcholinesterase (AChE) was characterized. The results showed that these compounds had a dose-dependent inhibitory effect on AChE, with compound 5 exhibiting the highest inhibitory activity. Additionally, all compounds showed certain levels of toxicity on C. elegans and displayed good ADMET properties.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ming-Zhu Zhu, Yi Li, Jin-Chuan Zhou, Tian Wang, Li-Lin Qian, Jiao-Zhen Zhang, Jing-Jing Han, Ze-Jun Xu, Tao Shen, Hong-Xiang Lou
Summary: This study isolated a novel compound and two unknown epimers from the Chinese liverwort, as well as five known compounds. The structures of the new compounds were determined using various methods, and their biological activities in cells were investigated.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Chen Wang, Jiao Tian, Chaoge Liu, Yiming He, Jiahang Li, Qiang Zhang, Ting Xiao, Chunfeng Xie, Cheng Yang
Summary: Nine undescribed labdane diterpenoids (1-9) and one undescribed ent-halimane diterpenoid (10) were isolated from Leonurus sibiricus. Compound 4 possessed a rare 10-epi labdane scaffold. Compound 1 showed the most inhibitory effect against interleukin (IL)-6-stimulated signal transducer and activator of transcription (STAT3) expression and potential for treating nasopharyngeal carcinoma.
Article
Infectious Diseases
Marco Masi, Emanuela Roscetto, Alessio Cimmino, Maria Rosaria Catania, Giuseppe Surico, Antonio Evidente
Summary: Chiliadenus lopadusanus Brullo is a plant species endemic to Lampedusa island in Italy, with its organic extract showing antibiotic activity against Staphylococcus aureus and Acinetobacter baumannii. Three main farnesane-type sesquiterpenoids from the extract were identified, showing antibacterial and antibiofilm activities against methicillin-resistant S. aureus and A. baumannii. This plant could potentially serve as a source for new antibiotics.
Article
Chemistry, Medicinal
Ziang Chen, Chang-Qiang Ke, Shuaizhen Zhou, Lu Feng, Chunping Tang, Yang Ye
Summary: Ten undescribed cadinane-type sesquiterpenes were isolated from the whole plant of Eupatorium chinense. Their planar structures were elucidated mainly through analysis of spectroscopic data and DFT NMR calculations, with the absolute configurations determined by various experimental methods. A possible biosynthetic pathway for these new sesquiterpenes was proposed.
