Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

A pilot study on the use of interferon beta-1a in early Alzheimer’s disease subjects

(2014) Luigi Maria Grimaldi et al.   Journal of Neuroinflammation

Resveratrol Exacerbates Both Autoimmune and Viral Models of Multiple Sclerosis

(2013) Fumitaka Sato et al.   AMERICAN JOURNAL OF PATHOLOGY

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Molecular Network Analysis of T-Cell Transcriptome Suggests Aberrant Regulation of Gene Expression by NF-κB As a Biomarker for Relapse of Multiple Sclerosis

(2013) Jun-ichi Satoh et al.   DISEASE MARKERS

The increasing burden of mental and neurological disorders

(2013) Ferrán Catalá-López et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis

(2013) Elisa Ridolfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF- B Signaling

(2013) Q.-Q. Yin et al.   JOURNAL OF IMMUNOLOGY

Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation

(2013) Celina Wu et al.   Journal of Neuroinflammation

Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

(2013) Pengwen Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ25–35/IFN-γ–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways

(2013) Yue Qi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Regulation of Neurotropic Signaling by the Inducible, NF-kB-Sensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells

(2013) Yuhai Zhao et al.   MOLECULAR NEUROBIOLOGY

Minimal NF-κB activity in neurons

(2013) S.J. Listwak et al.   NEUROSCIENCE

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

(2013) Conor Mc Guire et al.   TRENDS IN MOLECULAR MEDICINE

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

(2012) Kwok Kin Cheng et al.   AAPS Journal

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

(2012) Wolfgang Brück et al.   ACTA NEUROPATHOLOGICA

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Effects of Resveratrol and trans-3,5,4'-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells

(2012) Dae-Won Kim et al.   Biomolecules & Therapeutics

Diammonium Glycyrrhizinate Attenuates Aβ1-42-Induced Neuroinflammation and Regulates MAPK and NF-κB PathwaysIn VitroandIn Vivo

(2012) Hui Zhao et al.   CNS Neuroscience & Therapeutics

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

(2012) Linda Chami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

(2012) Zoe Fonseca-Kelly et al.   Frontiers in Neurology

A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease

(2011) Touqeer Ahmed et al.   BRAIN RESEARCH

TH17 cytokines in autoimmune neuro-inflammation

(2011) Burkhard Becher et al.   CURRENT OPINION IN IMMUNOLOGY

Novel p65 Binding Glucocorticoid-induced Leucine Zipper Peptide Suppresses Experimental Autoimmune Encephalomyelitis

(2011) Mythily Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice

(2011) T. Clarner et al.   JOURNAL OF NEUROENDOCRINOLOGY

Resveratrol Protects Rats from Aβ-induced Neurotoxicity by the Reduction of iNOS Expression and Lipid Peroxidation

(2011) Tai-Chun Huang et al.   PLoS One

Neuroprotective Effect of Combination Therapy of Glatiramer Acetate and Epigallocatechin-3-Gallate in Neuroinflammation

(2011) Katja Herges et al.   PLoS One

Intrathecal corticosteroids might slow Alzheimer’s disease progression

(2011) Joseph Alisky   Neuropsychiatric Disease and Treatment

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

The influence of donepezil and EGb 761 on the innate immunity of human leukocytes

(2010) Marta Sochocka et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

(2010) Jian Guo Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral Resveratrol Reduces Neuronal Damage in a Model of Multiple Sclerosis

(2010) Kenneth S Shindler et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation

(2010) A.I. Pogue et al.   NEUROSCIENCE LETTERS

Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappaB modulation in MES23.5 cells

(2009) Jun Wang et al.   BIOCHEMICAL PHARMACOLOGY

Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role

(2009) Rubén Martín et al.   BIOCHEMICAL PHARMACOLOGY

Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin

(2009) Balmiki Ray et al.   CURRENT OPINION IN PHARMACOLOGY

Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions

(2009) G. Cuny   CURRENT PHARMACEUTICAL DESIGN

Tripchlorolide protects neuronal cells from microglia-mediated β-amyloid neurotoxicity through inhibiting NF-κB and JNK signaling

(2009) Xiao-Dong Pan et al.   GLIA

Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production

(2009) Lin Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide

(2009) Lijia Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex

(2009) Pablo Kizelsztein et al.   JOURNAL OF NEUROIMMUNOLOGY

Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice

(2009) Jae Woong Lee et al.   JOURNAL OF NUTRITION

Vasoactive intestinal peptide protects against β-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels

(2008) Mario Delgado et al.   GLIA

Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4− IFN-γ+ cells, and decreased macrophage IL-6 expression

(2008) Toby J. Imler et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42

(2008) Virginie Buggia-Prevot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triptolide inhibits amyloid-β1-42-induced TNF-α and IL-1β production in cultured rat microglia

(2008) Jian Jiao et al.   JOURNAL OF NEUROIMMUNOLOGY

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

(2008) Thi A Tran et al.   Journal of Neuroinflammation

Dose-dependent and sequence-sensitive effects of amyloid-β peptide on neurosteroidogenesis in human neuroblastoma cells

(2008) Véronique Schaeffer et al.   NEUROCHEMISTRY INTERNATIONAL

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY