Journal
FITOTERAPIA
Volume 139, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2019.104366
Keywords
Lycopodiastrum casuarinoides; Serratene triterpenoids; Abietane diterpenoids; Sesquiterpene; Acetylcholinesterase; Butyrocholinesterase
Categories
Funding
- National Natural Science Foundation of China [31700303]
- China Postdoctoral Science Foundation [2017M622617]
- Natural Science Foundation of Hunnan [2018JJ3839]
- Changsha City Science and Technology Plan [Kq1606003]
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Phytochemical investigation of the ethyl acetate extract of Lycopodiastrum casuarinoides (Spring) Holub (Lycopodiaceae) led to the isolation of nine compounds, including two new serratene triterpenoids, serrat-14-en3 alpha,21 alpha-diol (1), 26-nor-8-oxo-21-one-alpha-onocerin (6), one new abietane diterpenoid, lycocasuarinone A (7), one new sesquiterpene acid, 7, 9-diene-1,4-epoxy-2-hydroxy-10-carboxylic acid (8) and one new chromone derivative, 5,7-dihydroxy-2-methyl esterchromone (9), together with four known serratene triterpenoids (2-5). Abietane diterpenoid (7) and sesquiterpene acid (8) from Lycopodiastrum casuarinoides are reported for the first time. Their structures and stereochemistry were unambiguously elucidated by spectroscopic analysis and comparison with known ones. All the compounds were tested for acetylcholinesterase (AChE) and butyr-ocholinesterase (BuChE) inhibitory activities. Bioactivity assays revealed that compound 6 exhibited the most potent AChE inhibitory effect.
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