Article
Cell Biology
Loic Louvet, Gaelle Lenglet, A. Michaela Krautzberger, Romuald Mentaverri, Frederic Hague, Clara Kowalewski, Nassim Mahtal, Julie Lesieur, Anne-Laure Bonnet, Caroline Andrique, Celine Gaucher, Cathy Gomila, Heinrich Schrewe, Pierre-Louis Tharaux, Said Kamel, Catherine Chaussain, Isabelle Six
Summary: In this study, we investigated the role of Vasn expression in vascular function. Vasn knockout mice showed decreases in blood pressure, angiotensin II levels, and vessel contractibility. In vitro experiments revealed that Vasn deficiency resulted in SMC contractile phenotype switching, changes in intracellular calcium levels, and impaired NO signaling. These findings highlight the importance of Vasn SMC expression in maintaining vascular functions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Kristen J. Bubb, Owen Tang, Carmine Gentile, Seyed M. Moosavi, Thomas Hansen, Chia-Chi Liu, Belinda A. Di Bartolo, Gemma A. Figtree
Summary: FXYD1 plays a crucial role in protecting eNOS from oxidative stress and contributes to cardiovascular health; FXYD1 regulates oxidative dysregulation within caveolae where it is colocalized; In addition to impacting eNOS function, FXYD1 is closely associated with hypertension and diabetic vascular oxidative stress.
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joel D. Trinity, Oh Sung Kwon, Ryan M. Broxterman, Jayson R. Gifford, Andrew C. Kithas, Jay R. Hydren, Catherine L. Jarrett, Katherine L. Shields, Angela Bisconti, Soung Hun Park, Jesse C. Craig, Ashley D. Nelson, David E. Morgan, Jacob E. Jessop, Amber D. Bledsoe, Russell S. Richardson
Summary: Passive Leg Movement (PLM) induces a nitric oxide (NO)-mediated increase in blood flow that is not fully inhibited by NOS inhibition. The combination of prostaglandin (PG) and endothelium-derived hyperpolarizing factor (EDHF) does not collectively contribute to this non-NOS-derived NO-mediated, endothelium-dependent hyperemic response.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Yuji Takaeko, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yiming Han, Yoshiki Aibara, Farina Mohamad Yusoff, Yukiko Nakano, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, Kenichi Yoshimura, Yukihito Higashi
Summary: The study showed a significant positive correlation between serum potassium levels and vascular function, with maintaining serum potassium levels of 4.5-<5.0 mmol/L associated with better vascular function.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Review
Biochemistry & Molecular Biology
Oguzhan Yildiz, Kemal Gokhan Ulusoy
Summary: This review summarizes the role of taurine in vascular tone and blood pressure modulation. Taurine supplementation prevents hypertension and reduces blood pressure in hypertensive patients. The mechanisms underlying taurine's vascular effects are still largely unknown.
Article
Nutrition & Dietetics
Ellen T. H. C. Smeets, Ronald P. Mensink, Peter J. Joris
Summary: In a study involving 18 apparently healthy overweight and slightly obese men, it was found that macronutrients did not differently affect postprandial endothelial function.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Andrology
Monica G. Ferrini, Andrea Abraham, Leslie Graciano, Sabine Nguyen, Jesse N. Mills, Jacob Rajfer
Summary: Revactin (R) can up-regulate nitrite formation and cGMP expression in human CSMC by activating the iNOS-NO-cGMP pathway, without affecting the expression of eNOS or nNOS.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jing Wu, Larry N. Agbor, Shi Fang, Masashi Mukohda, Anand R. Nair, Pablo Nakagawa, Avika Sharma, Donald A. Morgan, Justin L. Grobe, Kamal Rahmouni, Robert M. Weiss, James A. McCormick, Curt D. Sigmund
Summary: Our study found that mice expressing a dominant-negative mutation of peroxisome proliferator-activated receptor gamma in vascular smooth muscle developed salt-sensitive hypertension during a high salt diet, with impaired vasodilation in systemic and renal vessels occurring before hypertension onset. The impairment of vasodilation after salt loading led to increased peripheral vascular resistance.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Justine Bonetti, Alessandro Corti, Lucie Lerouge, Alfonso Pompella, Caroline Gaucher
Summary: Monocytes/macrophages and vascular smooth muscle cells (vSMCs) play key roles in atherosclerosis development and exhibit plasticity in response to environmental changes; vSMCs can switch from a contractile to a secretory phenotype and display macrophage characteristics, contributing to foam cell formation in atherosclerotic plaques. Nitric oxide levels impact molecular pathways involved in these processes, suggesting potential therapeutic targets for further exploration.
Article
Biochemistry & Molecular Biology
Anastasia A. Shvetsova, Anna A. Borzykh, Ekaterina K. Selivanova, Oxana O. Kiryukhina, Dina K. Gaynullina, Olga S. Tarasova
Summary: Nitric oxide (NO) deficiency during pregnancy is a key factor in the development of preeclampsia, affecting the expression of specific genes in arterial smooth muscle of newborn offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Michael J. Davis, Scott Earley, Yi-Shuan Li, Shu Chien
Summary: This review provides an overview of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), discussing their sensing of mechanical stimuli and transduction of mechanical signals. It covers various mechanosensors and mechanosignaling pathways involved, as well as the mechanical regulation of transcriptome and epigenetics. The relevance of mechanotransduction to health and disease, as well as the interactions between VSMCs and ECs, are also examined. The review emphasizes the need to understand the vasculature as a whole system for a comprehensive understanding and effective management of vascular diseases.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Brittany G. Durgin, Katherine C. Wood, Scott A. Hahn, Brenda McMahon, Jeffrey J. Baust, Adam C. Straub
Summary: The study demonstrates that under chronic hypoxia conditions, SMC CYB5R3 deficiency exacerbates bilateral ventricular hypertrophy and impairs NO-dependent vasodilation, suggesting potential early cardiac remodeling and functional changes in response to hypoxic stress.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Peripheral Vascular Disease
Amy C. Keller, Ji H. Chun, L. A. Knaub, M. M. Henckel, S. E. Hull, R. L. Scalzo, G. B. Pott, L. A. Walker, J. E. B. Reusch
Summary: This study found that housing rats in thermoneutral conditions leads to dysfunctional vasoreactivity, decreased lipid mitochondrial metabolism, and modified cellular signaling.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Mamta P. Sumi, Blair Tupta, Sanjoy Roychowdhury, Suzy Comhair, Kewal Asosingh, Dennis J. Stuehr, Serpil C. Erzurum, Arnab Ghosh
Summary: This study discovered that hemoglobin in lung epithelial cells can protect soluble guanylyl cyclase in smooth muscles from excessive nitric oxide. However, in patients with asthma or chronic obstructive pulmonary disease, lung epithelial hemoglobin may be unable to scavenge nitric oxide due to a lack of heme.
Article
Cell Biology
Bruno Matheus de Campos Facchin, Julia Salvan da Rosa, Ana Beatriz Gobbo Luz, Yeo Jim Kinoshita Moon, Tamires Cardoso de Lima, Rosana Casoti, Maique Weber Biavatti, Eduardo Monguilhott Dalmarco, Tania Silvia Froede
MEDIATORS OF INFLAMMATION
(2020)
Article
Cell Biology
Geison Vicente, Yeo Jim Kinoshita Moon, Daniela Weingartner Rosa, Luise Azevedo Lima, Najla Adel Saleh, Julia Salvan da Rosa, Tania Beatriz Creczynski-Pasa, Maique Weber Biavatti, Eduardo Monguilhott Dalmarco, Tania Silvia Frode
MEDIATORS OF INFLAMMATION
(2020)
Article
Chemistry, Applied
Vanessa Rocha Machado, Amanda Virtuoso Jacques, Natalia Stefanes Marceli, Maique Weber Biavatti, Maria Claudia Santos-Silva
Summary: The study found that lupeol and some of its derivatives have cytotoxic effects on acute myeloid leukemia cells and acute lymphoid leukemia cells, with strong selectivity for leukemia cells over healthy cells. These compounds showed high blood compatibility, making them potential candidates for the development of anti-leukemic drugs that can be administered intravenously.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Luis Eduardo Silva Nascimento, Nathalia Darminia Aceval Arriola, Layzon Antonio Lemos da Silva, Larissa Gabriela Faqueti, Louis Pergaud Sandjo, Carlos Eduardo Salles de Araujo, Maique Weber Biavatti, Jorge Luiz Barcelos-Oliveira, Renata Dias de Mello Castanho Amboni
Article
Plant Sciences
Amanda Ellen de Athayde, Carlos Eduardo Salles de Araujo, Louis Pergaud Sandjo, Maique Weber Biavatti
Summary: This study aimed to compare the main plants recognized as arnica in Brazil using metabolomic analysis. The research utilized UPLC-ESI-QTof-MS2 data and multivariate statistical analysis to identify chemical similarities and differences among these plants. The results showed that some species have similar chemical features to Arnica montana, while others are chemically diverse. The study concluded that mass spectrometry combined with multivariate statistical analysis is a valuable tool for identifying correlated compounds and verifying chemical similarity among different plant species.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Bruna de Siqueira Nunes, Rosana Araujo Rosendo, Abrahao Alves de Oliveira Filho, Marcus Vinicius Lia Fook, Wladymyr Jefferson Bacalhau de Sousa, Rossemberg Cardoso Barbosa, Hermano de Vasconcelos Pina, Joao Emidio da Silva Neto, Solomon Kweku Sagoe Amoah, Carlos Eduardo Fontana, Carlos Eduardo da Silveira Bueno, Alexandre Sigrist De Martin
Summary: This study aimed to develop a chitosan-based biomaterial with calcium hydroxide and 2% chlorhexidine for intracanal treatment to reduce microorganisms in the root canal system. The formulated biomaterial showed promising antimicrobial properties, with larger inhibition zones observed in samples containing chlorhexidine.
Article
Microbiology
Luiz A. E. Pollo, Erlon F. Martin, Vanessa R. Machado, Daire Cantillon, Leticia Muraro Wildner, Maria Luiza Bazzo, Simon J. Waddell, Maique W. Biavatti, Louis P. Sandjo
Summary: The study tested a library of 52 natural and synthetic compounds and identified seven compounds with antimycobacterial activity, suggesting new avenues for drug discovery.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rosine Dushime, Yunhuang Zhu, Hanzhi Wu, Daniel Saez, Kirtikar Shukla, Heather Brown-Harding, Maique W. Biavatti, Kimberly J. Nelson, Leslie B. Poole, William T. Lowther, Paul B. Jones, Cristina M. Furdui, Allen W. Tsang
Review
Peripheral Vascular Disease
Leonardo Gomes-Pereira, Jose Eduardo da Silva-Santos
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Agriculture, Multidisciplinary
Layzon A. Lemos da Silva, Amanda E. de Athayde, Monalisa A. Moreira, Tiago Tizziani, Stephanie Gkionis, Lucas da Silva, Maique W. Biavatti, Ana Carolina R. de Moraes, Marcus V. P. da Santos Nascimento, Eduardo M. Dalmarco, Louis P. Sandjo
Summary: This study investigated the chemical profiles, anti-inflammatory, and antiplatelet activity of young rangpur fruits using UPLC-ESI-MS. The results showed that the extracts obtained from these young fruits exhibited considerable anti-inflammatory and antiplatelet activity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Multidisciplinary
Larissa Gabriela Faqueti, Layzon Antonio Lemos da Silva, Gabriela Salim Gomes Moreira, Scheila Kraus, Gustavo dos Santos Catarina de Jesus, Luciana Aparecida Honorato, Bibiana Verlindo de Araujo, Adair Roberto Soares dos Santos, Teresa Dalla Costa, Maique Weber Biavatti
Summary: This study aimed to investigate the pre-clinical pharmacokinetics behavior and antinociceptive activity of 5'-methoxynobiletin (5'-MeONB). The results showed that 5'-MeONB exhibited one-compartment model in rats and mice plasma, with oral bioavailability ranging from 8 to 11%, and it demonstrated inhibitory effects on acute nocifensive behavior induced by formalin.
PHARMACEUTICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Marcela Guimaraes Landim, Marcella Lemos Brettas Carneiro, Graziella Anselmo Joanitti, Carla Tatiana Mota Anflor, David Dobkowski Marinho, Jose Filipe Bacalhau Rodrigues, Wladymyr Jefferson Bacalhau de Sousa, Daniel de Oliveira Fernandes, Beatriz Ferreira Souza, Alicia Simalie Ombredane, Jessica Catarine Frutuoso do Nascimento, Gisela de Jesus Felice, Aline Midori Adati Kubota, Juliana Simas Coutinho Barbosa, John Hideki Ohno, Solomon Kweku Sagoe Amoah, Lindomar Jose Pena, Glecia Virgolino da Silva Luz, Laise Rodrigues de Andrade, Willie Oliveira Pinheiro, Bergmann Morais Ribeiro, Fabio Rocha Formiga, Marcus Vinicius Lia Fook, Mario Fabricio Fleury Rosa, Henry Maia Peixoto, Rodrigo Luiz Carregaro, Suelia de Siqueira Rodrigues Fleury Rosa
Summary: The novel N95 respirator using chitosan nanoparticles has demonstrated enhanced mechanical, antimicrobial, and antiviral characteristics when compared to traditional N95 respirators. Tests have shown increased resistance to aerosol penetration, improved filtration of microbial and viral particles, and strong antimicrobial activity.
Article
Chemistry, Medicinal
Larissa Frankenberger, Suelin Rover, Thais Labes da Silva, Marcia Regina Faita, Jorge Luiz Barcelos-Oliveira, Alex Sandro Poltronieri, Christiane Meyre-Silva, Maique Weber Biavatti
Summary: The activity and chemical composition of volatile oils and crude extracts from hydrodistillations of Dysphania ambrosioides were investigated. The study found that the volatile oils showed insecticidal and repellent activities against Sitophilus zeamais, with trans-chrysanthenyl acetate and alpha-terpinene being the major compounds. The crude extracts contained rutinoside and its derivatives as major constituents. The research suggests that both the volatile oils and crude extracts from hydroponic and soil-grown D. ambrosioides are potential candidates for the development of bioinsecticides against S. zeamais.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Chemistry, Multidisciplinary
Tamires C. Lima, Rafaela J. Souza, Milene H. Moraes, Saulo S. Matos, Fernando H. O. Almeida, Mario Steindelc, Maique W. Biavatti
Summary: This study isolated and characterized four new germacranolide-type sesquiterpene lactones from Calea uniflora leaves, with compound 4 showing the best leishmanicidal activity among them.
Article
Biochemical Research Methods
Larissa Gabriela Faqueti, Layzon Antonio Lemos da Silva, Gabriela Salim Gomes Moreira, Luciana Aparecida Honorato, Adair Roberto Soares dos Santos, Teresa Dalla Costa, Maique Weber Biavatti
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2020)