Natural products as a source of Alzheimer's drug leads

The Arsenic Exposure Hypothesis for Alzheimer Disease

(2010) Gordon Gong et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-β25-35 Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice

(2010) Li Li et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: Implications for subcellular traffic and neurodegenerative disorders

(2010) Rituraj Pal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus

(2010) Torsten Geissler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

(2010) Hyun Ah Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities

(2010) Zha-Jun Zhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice

(2010) Xiao-Li He et al.   BRAIN RESEARCH

BACE1 (Beta-Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid fromHomalomena occulta

(2010) Xiao-Yan Tian et al.   CHEMISTRY & BIODIVERSITY

Medicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging?

(2010) Elaine Perry et al.   CNS Neuroscience & Therapeutics

New Methods to Explore Marine Resources for Alzheimers Therapeutics

(2010) P. Williams et al.   Current Alzheimer Research

Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors

(2010) Bin Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bapineuzumab

(2010) Geoffrey A Kerchner et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents

(2010) Altaf S Darvesh et al.   Expert Review of Neurotherapeutics

Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice

(2010) Chun Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetylcholinesterase Inhibitory Activity of Volatile Oil from Peltophorum dasyrachis Kurz ex Bakar (Yellow Batai) and Bisabolane-Type Sesquiterpenoids

(2010) Mai Fujiwara et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Blueberry Supplementation Improves Memory in Older Adults†

(2010) Robert Krikorian et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vitro biological activities of niloticane, a new bioactive cassane diterpene from the bark of Acacia nilotica subsp. kraussiana

(2010) I.M.S. Eldeen et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Bastadin with Potent and Selective δ-Opioid Receptor Binding Affinity from the Australian SpongeIanthella flabelliformis

(2010) Anthony R. Carroll et al.   JOURNAL OF NATURAL PRODUCTS

Xestosaprols from the Indonesian Marine SpongeXestospongiasp.

(2010) Jingqiu Dai et al.   JOURNAL OF NATURAL PRODUCTS

Withanolide A and Asiatic Acid Modulate Multiple Targets Associated with Amyloid-β Precursor Protein Processing and Amyloid-β Protein Clearance

(2010) Sachin P. Patil et al.   JOURNAL OF NATURAL PRODUCTS

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

Dictazoles: Potential Vinyl Cyclobutane Biosynthetic Precursors to the Dictazolines

(2010) Jingqiu Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals

(2010) Isabelle Bonnard et al.   Marine Drugs

Biological Activities of Aqueous and Organic Extracts from Tropical Marine Sponges

(2010) Kristina Sepčić et al.   Marine Drugs

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats

(2010) Fei Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sebestenoids A–D, BACE1 inhibitors from Cordia sebestena

(2010) Jingqiu Dai et al.   PHYTOCHEMISTRY

Bioactive Alkaloids from the Plant Endophytic FungusAspergillus terreus

(2010) Hui Ge et al.   PLANTA MEDICA

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

(2010) J. M. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protective Effects of Red Wine Flavonols on 4-Hydroxynonenal-Induced Apoptosis in PC12 Cells

(2009) Young Jin Jang et al.   Annals of the New York Academy of Sciences

Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay

(2009) Xi-yuan Zheng et al.   ARCHIVES OF PHARMACAL RESEARCH

Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity

(2009) Chang-Yul Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata

(2009) Hyun Ah Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats

(2009) Anil Kumar et al.   BEHAVIOURAL BRAIN RESEARCH

Ready for a comeback of natural products in oncology

(2009) Christian Bailly   BIOCHEMICAL PHARMACOLOGY

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

(2009) Hyun Ah Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors

(2009) Rong Sheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors

(2009) Ling Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases

(2009) Taufiq Rahman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aβ Oligomers and Fibrillar Aggregates Induce Different Apoptotic Pathways in LAN5 Neuroblastoma Cell Cultures

(2009) Pasquale Picone et al.   BIOPHYSICAL JOURNAL

Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential

(2009) Jun Wang et al.   BMC NEUROSCIENCE

Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

(2009) P Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Natural Products Beauveriolide I and III: a New Class of β-Amyloid-Lowering Compounds

(2009) Daniel P. Witter et al.   CHEMBIOCHEM

Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies

(2009) Mahmud Tareq Hassan Khan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Searching for Disease Modifiers-PKC Activation and HDAC Inhibition-A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress

(2009) Alan P. Kozikowski et al.   ChemMedChem

Alternative Aβ Immunotherapy Approaches for Alzheimers Disease

(2009) Terrence Town   CNS & Neurological Disorders-Drug Targets

Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection

(2009) Merce Pallas et al.   CURRENT NEUROVASCULAR RESEARCH

Protective effect of hopeahainol A, a novel acetylcholinesterase inhibitor, on hydrogen peroxide-induced injury in PC12 cells

(2009) Da Hua Shi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

New potential AChE inhibitor candidates

(2009) A.A.N. de Paula et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells

(2009) Teresa Valero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antioxidant effects of Epicatechin on the hippocampal toxicity caused by Amyloid-beta 25-35 in rats

(2009) Elvis Cuevas et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae)

(2009) Federica Menichini et al.   FITOTERAPIA

Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider

(2009) I. Orhan et al.   FOOD AND CHEMICAL TOXICOLOGY

Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease

(2009) Pennapa Chonpathompikunlert et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by d-galactose in mice

(2009) Anil Kumar et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia

(2009) İbrahim Kivrak et al.   FOOD CHEMISTRY

Chemical analysis, antioxidant, antiinflammatory and anticholinesterase activities of Origanum ehrenbergii Boiss and Origanum syriacum L. essential oils

(2009) Monica R. Loizzo et al.   FOOD CHEMISTRY

Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin

(2009) Pamela Maher   Genes and Nutrition

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

(2009) Orly Weinreb et al.   Genes and Nutrition

Acetylcholinesterase Inhibitory Activity and Chemical Composition of Commercial Essential Oils

(2009) Satomi Dohi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reduction of β-Amyloid Levels by Novel Protein Kinase Cϵ Activators

(2009) Thomas J. Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper in the brain and Alzheimer’s disease

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metabolite profile andin vitroactivities ofPhagnalon saxatile(L.) Cass. relevant to treatment of Alzheimer’s disease

(2009) Filomena Conforti et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, Synthesis, and Examination of Neuron Protective Properties of Alkenylated and Amidated Dehydro-Silybin Derivatives†

(2009) Lei Xiang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zeatin Prevents Amyloid β-Induced Neurotoxicity and Scopolamine-Induced Cognitive Deficits

(2009) Soo Jung Choi et al.   JOURNAL OF MEDICINAL FOOD

Memogain is a Galantamine Pro-drug having Dramatically Reduced Adverse Effects and Enhanced Efficacy

(2009) Alfred Maelicke et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity

(2009) Yong Kyung Lee et al.   Journal of Natural Medicines

Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: an updated meta-analysis

(2009) Bai-song Wang et al.   JOURNAL OF NEURAL TRANSMISSION

A traditional medicinal herbPaeonia suffruticosaand its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid β proteinsin vitroandin vivo

(2009) Hironori Fujiwara et al.   JOURNAL OF NEUROCHEMISTRY

Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

(2009) Jiyoung Kim et al.   JOURNAL OF NEUROCHEMISTRY

A Simple Analogue of Tumor-Promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible Protein Kinase C Activator with Bryostatin-like Activity

(2009) Yu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protective effects of flavonoids and two metabolites against oxidative stress in neuronal PC12 cells

(2009) Sanja Pavlica et al.   LIFE SCIENCES

Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow

(2009) Himani Awasthi et al.   LIFE SCIENCES

Alpha7 neuronal nicotinic receptors: The missing link to understanding Alzheimer’s etiopathology?

(2009) Merouane Bencherif et al.   MEDICAL HYPOTHESES

Muscarine, imidazole, oxazole and thiazole alkaloids

(2009) Zhong Jin   NATURAL PRODUCT REPORTS

Cholinesterase inhibitors fromSargassumandGracilaria gracilis: Seaweeds inhabiting South Indian coastal areas (Hare Island, Gulf of Mannar)

(2009) Suganthy Natarajan et al.   NATURAL PRODUCT RESEARCH

Targeting protein kinases in central nervous system disorders

(2009) Laura K. Chico et al.   NATURE REVIEWS DRUG DISCOVERY

Natural Antioxidants Protect Neurons in Alzheimer’s Disease and Parkinson’s Disease

(2009) Baolu Zhao   NEUROCHEMICAL RESEARCH

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

The anti-amnesic effects of luteolin against amyloid β25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit

(2009) R. Liu et al.   NEUROSCIENCE

Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression

(2009) Ji Hoon Oh et al.   NEUROSCIENCE LETTERS

Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata

(2009) N. Suganthy et al.   NEUROSCIENCE LETTERS

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

(2009) Ying Feng et al.   NEUROTOXICOLOGY

Components of lemon essential oil attenuate dementia induced by scopolamine

(2009) Wenjun Zhou et al.   NUTRITIONAL NEUROSCIENCE

Lycojapodine A, a Novel Alkaloid fromLycopodium japonicum

(2009) Juan He et al.   ORGANIC LETTERS

Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood

(2009) Ibrahim Jantan et al.   PHARMACEUTICAL BIOLOGY

Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

(2009) Rahul Agrawal et al.   PHARMACOLOGICAL RESEARCH

Geissospermum vellosii stembark

(2009) Josélia A. Lima et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice

(2009) Bomi Lee et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Conjugates of auxin and cytokinin

(2009) Andrzej Bajguz et al.   PHYTOCHEMISTRY

Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre

(2009) Elsa Steinunn Halldorsdottir et al.   PHYTOCHEMISTRY

Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents

(2009) N. SatheeshKumar et al.   PHYTOMEDICINE

Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission

(2009) David M. Pereira et al.   PHYTOMEDICINE

Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice

(2009) Jiqu Xu et al.   PHYTOTHERAPY RESEARCH

Cryptotanshinone, an Acetylcholinesterase Inhibitor fromSalvia miltiorrhiza, Ameliorates Scopolamine-Induced Amnesia in Morris Water Maze Task

(2009) Kelvin Wong et al.   PLANTA MEDICA

Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities

(2009) Jin-Tai Yu et al.   PROGRESS IN NEUROBIOLOGY

Xestosaprol D and E from the Indonesian marine sponge Xestospongia sp.

(2009) Natalie Millán-Aguiñaga et al.   TETRAHEDRON LETTERS

Alcohol in Moderation, Cardioprotection, and Neuroprotection: Epidemiological Considerations and Mechanistic Studies

(2008) Michael A. Collins et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Disease-modifying therapies in Alzheimer’s disease

(2008) Stephen Salloway et al.   Alzheimers & Dementia

Alzheimer's and Non-Alzheimer's Dementia: A Critical Review of Pharmacological and Nonpharmacological Strategies

(2008) Sahoo Saddichha et al.   American Journal of Alzheimers Disease and Other Dementias

Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease

(2008) Ahmadul Kadir et al.   ANNALS OF NEUROLOGY

In-vitro antiproliferative activities and kinase inhibitory potencies of meridianin derivatives

(2008) Emilie Rossignol et al.   ANTI-CANCER DRUGS

Structure-Activity Relationships Study of Bastadin 6, an Anti-Angiogenic Brominated-Tyrosine Derived Metabolite from Marine Sponge

(2008) Naoyuki Kotoku et al.   ARCHIV DER PHARMAZIE

Resveratrol protects against oxidative injury induced by H2O2 in acute hippocampal slice preparations from Wistar rats

(2008) Lúcia Maria Vieira de Almeida et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

β-secretase (BACE1) inhibitors from Perilla frutescens var. acuta

(2008) Sun-Ha Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: Brain ACh increasing and memory improving properties

(2008) Ariane Hornick et al.   BIOCHEMICAL PHARMACOLOGY

Rifampicin Does Not Prevent Amyloid Fibril Formation by Human Islet Amyloid Polypeptide but Does Inhibit Fibril Thioflavin-T Interactions: Implications for Mechanistic Studies of β-Cell Death†

(2008) Fanling Meng et al.   BIOCHEMISTRY

Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

(2008) Yoshiari Shimmyo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Anti-amnestic Activity of Pseudocoptisine from Corydalis Tuber

(2008) Tran Manh Hung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp

(2008) Veena S. Nukoolkarn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens

(2008) Eun Mi Hwang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lycoparins A–C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase

(2008) Yusuke Hirasawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons

(2008) Elzbieta Zieminska et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

(2008) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Therapeutic potential of resveratrol in Alzheimer's disease

(2008) Valérie Vingtdeux et al.   BMC NEUROSCIENCE

Puerarin protects PC12 cells against β-amyloid-induced cell injury

(2008) H ZHANG et al.   CELL BIOLOGY INTERNATIONAL

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resveratrol: A Natural Compound with Pharmacological Potential in Neurodegenerative Diseases

(2008) Héctor I. Rocha-González et al.   CNS Neuroscience & Therapeutics

Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases

(2008) Silvia A. Mandel et al.   CNS Neuroscience & Therapeutics

Natural Products and their Derivatives as Cholinesterase Inhibitors in the Treatment of Neurodegenerative Disorders: An Update

(2008) Monica Loizzo et al.   CURRENT MEDICINAL CHEMISTRY

The Role of Natural Products in the Ligand Deorphanization of TRP Channels

(2008) G. Appendino et al.   CURRENT PHARMACEUTICAL DESIGN

Non-cholinergic drug development for Alzheimer's disease

(2008) Roy Yaari et al.   Expert Opinion on Drug Discovery

Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update

(2008) Vincenzo Tumiatti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Minocycline reduces the development of abnormal tau species in models of Alzheimer’s disease

(2008) Wendy Noble et al.   FASEB JOURNAL

Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera

(2008) Na Y YOON et al.   FISHERIES SCIENCE

Anticholinesterase and pediculicidal activities of monoterpenoids

(2008) M.I. Picollo et al.   FITOTERAPIA

Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation

(2008) So-Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant and antiacetylcholinesterase activities of essential oils from Cymbopogon schoenanthus L. Spreng. Determination of chemical composition by GC–mass spectrometry and 13C NMR

(2008) Ayda Khadri et al.   FOOD CHEMISTRY

Effects of Anthocyanins on Psychological Stress-Induced Oxidative Stress and Neurotransmitter Status

(2008) M. Mamunur Rahman et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Crystal and Molecular Structure of Piceatannol; Scavenging Features of Resveratrol and Piceatannol on Hydroxyl and Peroxyl Radicals and Docking with Transthyretin

(2008) Miriam Rossi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Berry Fruit Supplementation and the Aging Brain

(2008) Barbara Shukitt-Hale et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tau Mutations in Neurodegenerative Diseases

(2008) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

A potential role of alkaloid extracts fromSalsolaspecies (Chenopodiaceae) in the treatment of Alzheimer's disease

(2008) Rosa Tundis et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii

(2008) Tran Manh Hung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants

(2008) Ilkay Orhan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic Bastadin 24 from the Australian SpongeIanthella quadrangulata⊥

(2008) Hendrik Greve et al.   JOURNAL OF NATURAL PRODUCTS

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

(2008) Mubeen Ahmad Ansari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease

(2008) Cynthia Boudrault et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization Strategy

(2008) Paul A. Wender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biological performance of Eucalyptus camaldulensis leaf oils from Thailand against the subterranean termite Coptotermes formosanus Shiraki

(2008) Pornpun Siramon et al.   JOURNAL OF WOOD SCIENCE

Antioxidant Therapy in Alzheimers Disease: Theory and Practice

(2008) Gjumrakch Aliev et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Terpenoid alkaloids of the Buxaceae family with potential biological importance

(2008) Krishna P. Devkota et al.   NATURAL PRODUCT REPORTS

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

Antiacetylcholinesterase and antioxidantent-Kaurene diterpenoid, melissoidesin fromIsodon wightii(Bentham) H. Hara

(2008) R. Thirugnanasampandan et al.   NATURAL PRODUCT RESEARCH

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

Botanical Phenolics and Brain Health

(2008) Albert Y. Sun et al.   NEUROMOLECULAR MEDICINE

Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons

(2008) M.-K. Song et al.   NEUROSCIENCE

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein

(2008) Tatsuhiro Akaishi et al.   NEUROSCIENCE LETTERS

Measuring target effect of proposed disease-modifying therapies in Alzheimer’s disease

(2008) Randall J. Bateman et al.   Neurotherapeutics

Inhibition of β-amyloid peptide aggregation and neurotoxicity by α-d-mannosylglycerate, a natural extremolyte

(2008) Jungki Ryu et al.   PEPTIDES

Acetylcholinesterase-Inhibitory Activity of Linarin from Buddleja davidii, Structure-Activity Relationships of Related Flavonoids, and Chemical Investigation of Buddleja nitida

(2008) Peihong Fan et al.   PHARMACEUTICAL BIOLOGY

Inhibition of acetylcholinesterase by coumarins: The case of coumarin 106

(2008) A FALLARERO et al.   PHARMACOLOGICAL RESEARCH

Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snailLymnaea acuminata

(2008) Pradeep Kumar et al.   PHYTOTHERAPY RESEARCH

In vitroBACE-1 Inhibitory Phenolic Components from the Seeds ofPsoralea corylifolia

(2008) Yeon Choi et al.   PLANTA MEDICA

Effect of Glabridin from Glycyrrhiza glabra on Learning and Memory in Mice

(2008) Yong-Ming Cui et al.   PLANTA MEDICA

Role of curcumin in health and disease

(2008) Leelavinothan Pari et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (−)-spectaline

(2007) Newton G. Castro et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Multifunction of myricetin on Aβ: Neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases

(2007) Yoshiari Shimmyo et al.   JOURNAL OF NEUROSCIENCE RESEARCH