Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation

Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD

(2020) Kati Hyvärinen et al.   Frontiers in Immunology

Recipient and donor genetic variants associated with mortality after allogeneic hematopoietic cell transplantation

(2020) Paul J. Martin et al.   Blood Advances

A review of kernel methods for genetic association studies

(2019) Nicholas B. Larson et al.   GENETIC EPIDEMIOLOGY

Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection

(2019) Nicholas J. Steers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT

(2019) Jarmo Ritari et al.   Frontiers in Immunology

Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation

(2018) Ugur Sahin et al.   ANNALS OF HEMATOLOGY

Genetics of Natural Killer Cells in Human Health, Disease, and Survival

(2018) Peter Parham et al.   Annual Review of Immunology

Killer Cell Immunoglobulin-Like Receptor–Ligand Mismatch in Donor versus Recipient Direction Provides Better Graft-versus-Tumor Effect in Patients with Hematologic Malignancies Undergoing Allogeneic T Cell–Replete Haploidentical Transplantation Followed by Post-Transplant Cyclophosphamide

(2018) Anne Wanquet et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Inosine Monophosphate Dehydrogenase Pharmacogenetics in Hematopoietic Cell Transplantation Patients

(2018) Jeannine S. McCune et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation

(2018) Qianqian Zhu et al.   BLOOD

The impact of cytokine gene polymorphisms on the outcome of HLA matched sibling hematopoietic stem cell transplantation

(2018) Azza M. Kamel et al.   CYTOKINE

HLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor

(2018) Jacek Nowak et al.   HUMAN IMMUNOLOGY

Increased levels of circulating (TNF-α) is associated with (-308G/A) promoter polymorphism of TNF-α gene in Diabetic Nephropathy

(2018) Dhamodharan Umapathy et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Relationship between TNF-α −1031T/C gene polymorphism, plasma level of TNF-α, and risk of cachexia in head and neck cancer patients

(2018) Tomasz Powrózek et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Killer cell immunoglobulin-like receptor ligand mismatching and outcome after haploidentical transplantation with post-transplant cyclophosphamide

(2018) Avichai Shimoni et al.   LEUKEMIA

Characterization of monocyte subtypes regarding their phenotype and development in the context of graft-versus-host disease

(2018) Katharina Reinhardt-Heller et al.   TRANSPLANT IMMUNOLOGY

Hidden genomic MHC disparity between HLA-matched sibling pairs in hematopoietic stem cell transplantation

(2018) Satu Koskela et al.   Scientific Reports

Donor Genotype in the Interleukin-7 Receptor α-Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation

(2018) Katrine Kielsen et al.   Frontiers in Immunology

The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation

(2018) Jean Norden et al.   International Journal of Immunogenetics

Genomic prediction of relapse in recipients of allogeneic haematopoietic stem cell transplantation

(2018) J. Ritari et al.   LEUKEMIA

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Who is the best donor for haploidentical stem cell transplantation?

(2018) Piyanuch Kongtim et al.   SEMINARS IN HEMATOLOGY

Donor killer-cell immunoglobulin-like receptor (KIR) genotype does not improve graft-versus-leukemia responses in chronic lymphocytic leukemia (CLL) after unrelated donor transplant: a CIBMTR analysis

(2018) Veronika Bachanova et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Sequences of 95 humanMHChaplotypes reveal extreme coding variation in genes other than highly polymorphicHLA class IandII

(2017) Paul J. Norman et al.   GENOME RESEARCH

Association of cytokine gene polymorphisms with the complications of allogeneic haematopoietic stem cell transplantation

(2017) Anna Dukat-Mazurek et al.   HUMAN IMMUNOLOGY

The impact of KIR2DS4 gene on clinical outcome after hematopoietic stem cell transplantation

(2017) Marija Burek Kamenaric et al.   HUMAN IMMUNOLOGY

Associations of TNF-α -238 A/G and IL-10 -1082 G/A Genetic Polymorphisms With the Risk of NONFH in the Chinese Population

(2017) Biao-Fang Wei et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Posttranscriptional Regulation of HLA-A Protein Expression by Alternative Polyadenylation Signals Involving the RNA-Binding Protein Syncrip

(2017) Smita Kulkarni et al.   JOURNAL OF IMMUNOLOGY

Genetic polymorphism related to monocyte-macrophage function is associated with graft-versus-host disease

(2017) Kati Hyvärinen et al.   Scientific Reports

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype

(2017) Daisuke Koyama et al.   PLoS One

Associations of interactions between NLRP3 SNPs and HLA mismatch with acute and extensive chronic graft-versus-host diseases

(2017) Hidekazu Takahashi et al.   Scientific Reports

Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation

(2016) D. Fuerst et al.   BLOOD

Replication of associations between genetic polymorphisms and chronic graft-versus-host disease

(2016) P. J. Martin et al.   BLOOD

Matching for the nonconventional MHC-IMICAgene significantly reduces the incidence of acute and chronic GVHD

(2016) Raphael Carapito et al.   BLOOD

Genetic risk factors for sclerotic graft-versus-host disease

(2016) Y. Inamoto et al.   BLOOD

Genome-wide minor histocompatibility matching as related to the risk of graft-versus-host disease

(2016) Paul J. Martin et al.   BLOOD

Novel HLA-DP region susceptibility loci associated with severe acute GvHD

(2016) R K Goyal et al.   BONE MARROW TRANSPLANTATION

Association of the −1031T>C polymorphism and soluble TNF-α levels with Acute Coronary Syndrome

(2016) Elena Sandoval-Pinto et al.   CYTOKINE

Donor and recipient sex in allogeneic stem cell transplantation: what really matters

(2016) H. T. Kim et al.   HAEMATOLOGICA

Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers

(2016) D P Granados et al.   LEUKEMIA

The statistical properties of gene-set analysis

(2016) Christiaan A. de Leeuw et al.   NATURE REVIEWS GENETICS

Soluble heat shock protein 70 members in patients undergoing allogeneic hematopoietic cell transplantation

(2016) Nora Mirza et al.   TRANSPLANT IMMUNOLOGY

Exome Sequencing and Prediction of Long-Term Kidney Allograft Function

(2016) Laurent Mesnard et al.   PLoS Computational Biology

Donor and recipient sex in allogeneic stem cell transplantation: what really matters

(2016) H. T. Kim et al.   HAEMATOLOGICA

Impact of the MICA-129Met/Val Dimorphism on NKG2D-Mediated Biological Functions and Disease Risks

(2016) Antje Isernhagen et al.   Frontiers in Immunology

Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation

(2016) Rehan Mujeeb Faridi et al.   PLoS One

Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation

(2015) Ronald M. Sobecks et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Measuring Therapeutic Response in Chronic Graft-versus-Host Disease. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2014 Response Criteria Working Group Report

(2015) Stephanie J. Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation

(2015) A. Sato-Otsubo et al.   BLOOD

The effect of donor characteristics on survival after unrelated donor transplantation for hematologic malignancy

(2015) C. Kollman et al.   BLOOD

Predicting survival using clinical risk scores and non-HLA immunogenetics

(2015) Y Balavarca et al.   BONE MARROW TRANSPLANTATION

Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics of Immunosuppressants in Allogeneic Hematopoietic Cell Transplantation: Part II

(2015) Jeannine S. McCune et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetics, Pharmacodynamics and Pharmacogenomics of Immunosuppressants in Allogeneic Haematopoietic Cell Transplantation: Part I

(2015) Jeannine S. McCune et al.   CLINICAL PHARMACOKINETICS

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation

(2015) Antje Isernhagen et al.   EMBO Molecular Medicine

5′ and 3′ untranslated regions contribute to the differential expression of specific HLA-A alleles

(2015) Céline René et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA

(2015) Antje Isernhagen et al.   IMMUNOGENETICS

Role of Pharmacogenetics in Hematopoietic Stem Cell Transplantation Outcome in Children

(2015) Raffaella Franca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

(2015)   NATURE NEUROSCIENCE

High HLA-DP Expression and Graft-versus-Host Disease

(2015) Effie W. Petersdorf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Elevated level of HSPA1L mRNA correlates with graft-versus-host disease

(2015) Sadaf Atarod et al.   TRANSPLANT IMMUNOLOGY

Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells

(2015) Rafijul Bari et al.   Scientific Reports

One million haemopoietic stem-cell transplants: a retrospective observational study

(2015) Alois Gratwohl et al.   Lancet Haematology

HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation

(2014) E. W. Petersdorf et al.   BLOOD

Biological significance of HLA locus matching in unrelated donor bone marrow transplantation

(2014) Y. Morishima et al.   BLOOD

Risk stratification of organ-specific GVHD can be improved by single-nucleotide polymorphism-based risk models

(2014) D Kim et al.   BONE MARROW TRANSPLANTATION

A Network-Based Kernel Machine Test for the Identification of Risk Pathways in Genome-Wide Association Studies

(2014) Saskia Freytag et al.   HUMAN HEREDITY

IL-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-versus-Host Disease

(2014) Renata Gonçalves Resende et al.   MEDIATORS OF INFLAMMATION

Statistical power and significance testing in large-scale genetic studies

(2014) Pak C. Sham et al.   NATURE REVIEWS GENETICS

A polymorphism in theTYMPgene is associated with the outcome of HLA-identical sibling allogeneic stem cell transplantation

(2013) Vicent Guillem et al.   AMERICAN JOURNAL OF HEMATOLOGY

Major Histocompatibility Complex Genomics and Human Disease

(2013) John Trowsdale et al.   Annual Review of Genomics and Human Genetics

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

Multicenter Analyses Demonstrate Significant Clinical Effects of Minor Histocompatibility Antigens on GvHD and GvL after HLA-Matched Related and Unrelated Hematopoietic Stem Cell Transplantation

(2013) Eric Spierings et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Mapping MHC haplotype effects in unrelated donor hematopoietic cell transplantation

(2013) E. W. Petersdorf et al.   BLOOD

The major histocompatibility complex: a model for understanding graft-versus-host disease

(2013) E. W. Petersdorf   BLOOD

Biologic markers of chronic GVHD

(2013) J Pidala et al.   BONE MARROW TRANSPLANTATION

Tumor Necrosis Factor gene polymorphism results in high TNF level in sepsis and septic shock

(2013) Nikhil Kothari et al.   CYTOKINE

Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation

(2013) H. Turpeinen et al.   International Journal of Immunogenetics

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Polymorphism in the Interleukin-7 Receptor-alpha and Outcome after Allogeneic Hematopoietic Cell Transplantation with Matched Unrelated Donor

(2013) Z. Shamim et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Generation of Soluble NKG2D Ligands: Proteolytic Cleavage, Exosome Secretion and Functional Implications

(2013) G. Chitadze et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Influence of HLA-C Expression Level on HIV Control

(2013) R. Apps et al.   SCIENCE

The impact of recipient HLA-Cw and donor killer immunoglobulin-like receptor genotyping on the outcome of patients receiving HLA-matched sibling donor hematopoietic stem cell transplantation for myeloid malignancies

(2013) H Wang et al.   SWISS MEDICAL WEEKLY

Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT

(2012) E. H. Warren et al.   BLOOD

Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia

(2012) W. Saber et al.   BLOOD

Production of TNF-α and IL-1β by Peripheral Blood Mononuclear Cells in Carriers of Different Allele Variants of the Gene

(2012) A. N. Silkov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke

(2012) Guanglin Cui et al.   Journal of Neuroinflammation

A Novel Variant Marking HLA-DP Expression Levels Predicts Recovery from Hepatitis B Virus Infection

(2012) R. Thomas et al.   JOURNAL OF VIROLOGY

MHC-Resident Variation Affects Risks After Unrelated Donor Hematopoietic Cell Transplantation

(2012) E. W. Petersdorf et al.   Science Translational Medicine

HLA-E polymorphisms in hematopoietic stem cell transplantation

(2012) D. Fürst et al.   TISSUE ANTIGENS

Clinical Significance of the HLA-E and CD94/NKG2 Interaction

(2011) Milena Iwaszko et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Genetic variation in recipient B-cell activating factor modulates phenotype of GVHD

(2011) W. B. Clark et al.   BLOOD

Differential microRNA regulation of HLA-C expression and its association with HIV control

(2011) Smita Kulkarni et al.   NATURE

An NKG2D-Mediated Human Lymphoid Stress Surveillance Response with High Interindividual Variation

(2011) S. Shafi et al.   Science Translational Medicine

Donor activating KIR3DS1 is associated with decreased acute GVHD in unrelated allogeneic hematopoietic stem cell transplantation

(2010) J. M. Venstrom et al.   BLOOD

Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia

(2010) S. Cooley et al.   BLOOD

Physicians Abstracts

(2010)   BONE MARROW TRANSPLANTATION

A single-nucleotide polymorphism of the Fcγ receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies

(2010) A Takami et al.   BONE MARROW TRANSPLANTATION

TNF-α −308 genotypes are associated with TNF-α and TGF-β1 mRNA expression in blood leucocytes of humans

(2010) Simone Helmig et al.   CYTOKINE

PRE 02 - Immaging Immunity

(2010)   EUROPEAN JOURNAL OF IMMUNOLOGY

Effect of donor CTLA-4 alleles and haplotypes on graft-versus-host disease occurrence in Tunisian patients receiving a human leukocyte antigen–identical sibling hematopoietic stem cell transplant

(2010) Mohamed Hichem Sellami et al.   HUMAN IMMUNOLOGY

Association of HMGB1 Polymorphisms with Outcome after Allogeneic Hematopoietic Cell Transplantation

(2009) Brian Kornblit et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Improved Survival with Inhibitory Killer Immunoglobulin Receptor (KIR) Gene Mismatches and KIR Haplotype B Donors after Nonmyeloablative, HLA-Haploidentical Bone Marrow Transplantation

(2009) Heather J. Symons et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versus-host disease

(2009) W. Boukouaci et al.   BLOOD

KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation

(2009) K Ludajic et al.   BONE MARROW TRANSPLANTATION

Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD

(2009) Y Inamoto et al.   BONE MARROW TRANSPLANTATION

Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus-host disease and affect survival after allogeneic hematopoietic stem cell transplantation

(2009) Sebastian Giebel et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease

(2009) Steven A McCarroll et al.   NATURE GENETICS

Correlation of Hsp70-1 and Hsp70-2 Gene Expression With the Degree of Graft-Versus-Host Reaction in a Rat Skin Explant Model

(2009) Peter Novota et al.   TRANSPLANTATION

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia

(2008) S. Cooley et al.   BLOOD