Generation of Soluble NKG2D Ligands: Proteolytic Cleavage, Exosome Secretion and Functional Implications

Valproic Acid Upregulates NKG2D Ligand Expression through an ERK-dependent Mechanism and Potentially Enhances NK Cell-mediated Lysis of Myeloma

(2015) Xiaosong Wu et al.   NEOPLASIA

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA

(2014) M. Kloss et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Down-Regulation of MHC Class I-Related Chain A on Tumor Cells by IFN- -Induced MicroRNA

(2014) D. Yadav et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Metalloproteinase ADAM17/TNF- -Converting Enzyme Regulates Proteolytic Shedding of the MHC Class I-Related Chain B Protein

(2014) P. Boutet et al.   JOURNAL OF IMMUNOLOGY

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

(2013) Theresa L. Whiteside   BIOCHEMICAL SOCIETY TRANSACTIONS

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17

(2013) Guranda Chitadze et al.   INTERNATIONAL JOURNAL OF CANCER

Epithelial-Mesenchymal Transition Induces an Antitumor Immune Response Mediated by NKG2D Receptor

(2013) A. Lopez-Soto et al.   JOURNAL OF IMMUNOLOGY

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

(2013) Kelly Hudspeth et al.   Frontiers in Immunology

Metastamir-mediated immune evasion

(2013) Pinchas Tsukerman et al.   OncoImmunology

Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

(2012) Keisuke Kohga et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

MiR-10b Downregulates the Stress-Induced Cell Surface Molecule MICB, a Critical Ligand for Cancer Cell Recognition by Natural Killer Cells

(2012) P. Tsukerman et al.   CANCER RESEARCH

Diagnostic and prognostic impact of serum-soluble UL16-binding protein 2 in lung cancer patients

(2012) Kosuke Yamaguchi et al.   CANCER SCIENCE

Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells

(2012) Camilla H. F. Hansen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HER2/HER3 Signaling Regulates NK Cell-Mediated Cytotoxicity via MHC Class I Chain-Related Molecule A and B Expression in Human Breast Cancer Cell Lines

(2012) R. Okita et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Analysis of NKG2D Ligand Expression and Release in Leukemia: Implications for NKG2D-Mediated NK Cell Responses

(2012) J. Hilpert et al.   JOURNAL OF IMMUNOLOGY

Regulation of NKG2D-ligand cell surface expression by intracellular calcium after HDAC-inhibitor treatment

(2012) Helle Jensen et al.   MOLECULAR IMMUNOLOGY

Human NKG2D-ligands: cell biology strategies to ensure immune recognition

(2012) Lola Fernández-Messina et al.   Frontiers in Immunology

Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the  c cytokines and TGF- 1

(2011) Y. P. Park et al.   BLOOD

Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

(2011) A. Heinemann et al.   CANCER RESEARCH

MMP9 mediates MICA shedding in human osteosarcomas

(2011) Dahui Sun et al.   CELL BIOLOGY INTERNATIONAL

Regulation of immune cell function and differentiation by the NKG2D receptor

(2011) Biljana Zafirova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding

(2011) Sonia Agüera-González et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NKG2D performs two functions in invariant NKT cells: Direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d

(2011) Carlotta Kuylenstierna et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of the Receptor NKG2D Leads to Production of Th17 Cytokines in CD4+ T Cells of Patients With Crohn's Disease

(2011) Benjamin Pariente et al.   GASTROENTEROLOGY

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

(2011) Kerry S. Campbell et al.   IMMUNOLOGY

The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells

(2011) L. Fernandez-Messina et al.   JOURNAL OF CELL SCIENCE

CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells

(2011) Zhangguo Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of NKG2D-ligand Cell Surface Expression Enhances Immune Cell Therapy of Cancer

(2011) Baocheng Huang et al.   JOURNAL OF IMMUNOTHERAPY

Vis-à-Vis in the NKC: Genetically Linked Natural Killer Cell Receptor/Ligand Pairs in the Natural Killer Gene Complex (NKC)

(2011) Isabel Vogler et al.   Journal of Innate Immunity

Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells

(2011) Malin Hedlund et al.   PLoS One

Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection

(2011) Ya-Ting Chang et al.   PLoS One

Vesicular Stomatitis Virus Infection Promotes Immune Evasion by Preventing NKG2D-Ligand Surface Expression

(2011) Helle Jensen et al.   PLoS One

Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

(2011) A. C. Benitez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

ADAM-Mediated Shedding, A New Flavor in Angiogenesis Regulation

(2010) Lena Claesson-Welsh   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

Control of death receptor ligand activity by posttranslational modifications

(2010) R. Weinlich et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands

(2010) Lola Fernández-Messina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Sequestration of the NKG2D Ligand ULBP3 by Human Cytomegalovirus

(2010) N. J. Bennett et al.   JOURNAL OF IMMUNOLOGY

NKG2D Initiates Caspase-Mediated CD3  Degradation and Lymphocyte Receptor Impairments Associated with Human Cancer and Autoimmune Disease

(2010) N. Hanaoka et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases

(2010) G. Liu et al.   JOURNAL OF IMMUNOLOGY

The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia

(2010) H Nückel et al.   LEUKEMIA

Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity

(2010) Yamanegi   ONCOLOGY REPORTS

Functional Dichotomy between NKG2D and CD28-Mediated Co-Stimulation in Human CD8+ T Cells

(2010) Kamalakannan Rajasekaran et al.   PLoS One

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors

(2009) Y. T. Bryceson et al.   BLOOD

Anticancer Chemotherapy Inhibits MHC Class I-Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma

(2009) K. Kohga et al.   CANCER RESEARCH

Differential Clinical Significance of Individual NKG2D Ligands in Melanoma: Soluble ULBP2 as an Indicator of Poor Prognosis Superior to S100B

(2009) A. Paschen et al.   CLINICAL CANCER RESEARCH

NKG2D Ligand Expression in Human Colorectal Cancer Reveals Associations with Prognosis and Evidence for Immunoediting

(2009) R. W. McGilvray et al.   CLINICAL CANCER RESEARCH

Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9

(2009) Keisuke Kohga et al.   HEPATOLOGY

Normally occurring NKG2D+CD4+T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

(2009) Zhenpeng Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brief Residence at the Plasma Membrane of the MHC Class I-Related Chain B Is Due to Clathrin-Mediated Cholesterol-Dependent Endocytosis and Shedding

(2009) S. Aguera-Gonzalez et al.   JOURNAL OF IMMUNOLOGY

NKG2D-Dependent IL-17 Production by Human T Cells in Response to an Intracellular Pathogen

(2009) P. Paidipally et al.   JOURNAL OF IMMUNOLOGY

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

(2009) M. Hedlund et al.   JOURNAL OF IMMUNOLOGY

NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142

(2009) O. Ashiru et al.   JOURNAL OF VIROLOGY

Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate

(2009) A Poggi et al.   LEUKEMIA

Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα

(2009) Sophie Viaud et al.   PLoS One

Cellular Expression, Trafficking, and Function of Two Isoforms of Human ULBP5/RAET1G

(2009) Robert A. Eagle et al.   PLoS One

Induction of MHC class I-related chain B (MICB) by 5-aza-2′-deoxycytidine

(2008) Kai-Fu Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis

(2008) Kui Li et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Synergistic Inhibition with a Dual Epidermal Growth Factor Receptor/HER-2/neu Tyrosine Kinase Inhibitor and a Disintegrin and Metalloprotease Inhibitor

(2008) L. Witters et al.   CANCER RESEARCH

Tumor-Associated MICA Is Shed by ADAM Proteases

(2008) I. Waldhauer et al.   CANCER RESEARCH

Line of attack: NK cell specificity and integration of signals

(2008) Yenan T Bryceson et al.   CURRENT OPINION IN IMMUNOLOGY

Soluble NKG2D ligands: prevalence, release, and functional impact

(2008) Helmut Rainer Salih   Frontiers in Bioscience-Landmark

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY

IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells

(2008) H SONG et al.   IMMUNOLOGY LETTERS

Tumor-derived soluble MICs impair CD3+CD56+ NKT-like cell cytotoxicity in cancer patients

(2008) H WANG et al.   IMMUNOLOGY LETTERS

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY