Review
Immunology
Takanori Teshima, Geoffrey R. R. Hill
Summary: Allogeneic hematopoietic cell transplantation is an effective treatment for hematologic malignancies, but graft-versus-host disease remains a significant complication. Insights from animal models have led to new therapeutic approaches in the clinic, focusing on histocompatibility matching, GVHD prophylaxis, and novel inhibitors for cytokine signaling to improve patient outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Pauline Formaglio, Mohamad Alabdullah, Anastasios Siokis, Juliane Handschuh, Ina Sauerland, Yan Fu, Anna Krone, Patricia Gintschel, Juliane Stettin, Sandrina Heyde, Juliane Mohr, Lars Philipsen, Anja Schroeder, Philippe A. Robert, Gang Zhao, Sahamoddin Khailaie, Anne Dudeck, Jessica Bertrand, Gerald F. Spaeth, Sascha Kahlfuss, Philippe Bousso, Burkhart Schraven, Jochen Huehn, Sebastian Binder, Michael Meyer-Hermann, Andreas J. Mueller
Summary: Nitric oxide plays a dual role in controlling Leishmania major by directly killing the pathogen and restricting the supply of host cells necessary for pathogen proliferation.
Article
Dermatology
Ying GU, Jing SUN, Kun LI, Xia WU, Jianzhong ZHANG
Summary: The study investigated the cutaneous microbiome in relation to the pathogenesis of cutaneous GVHD in patients with haematopoietic stem cell transplantation. Changes in the microbiota in lesions were found to be associated with the development of cutaneous GVHD, suggesting potential therapeutic targets for intervention. Further research is needed to explore the mechanistic relevance of these microbial dynamics for therapeutic interventions.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Surgery
Shih-Heng Chen, Mehmet Emin Cem Yildirim, Seyed Abolghasem Mousavi, Hung-Chi Chen
Summary: The study showed that using STSGs for lower-limb lymphedema in the HCC-modified Charles' procedure can yield satisfactory long-term outcomes without joint contracture. Early physiotherapy and successful take of STSGs are crucial for good functional results.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Biophysics
Gregory Wallace, Pooja Khandelwal, Kasiani C. Myers, Emma M. R. Perentesis, Adam Lane, Ashley Teusink-Cross, Kristi Smiley, Stella M. Davies, Sonata Jodele
Summary: This study demonstrated promising results in using topical Calcipotriene as a novel therapeutic option for acute skin GVHD, especially in patients presenting with pruritus. Further large-scale prospective studies are warranted to validate these findings.
BONE MARROW TRANSPLANTATION
(2021)
Review
Cell & Tissue Engineering
Han Yang, Sousan Cheong, Yunfan He, Feng Lu
Summary: The application of MSCs presents a promising approach for treating autoimmune-related fibrotic skin diseases: SSc and Scl-GVHD. Therapies involving MSCs and MSC extracellular vesicles have been found to operate through three primary mechanisms: rebalancing the immune and inflammatory disorders, resisting oxidant stress, and inhibiting overactivated fibrosis (including fibroblast activation and ECM remodeling). However, the effectiveness of these interventions requires further validation through extensive clinical investigations, particularly randomized control trials and phase III/IV clinical trials. Additionally, the hypothetical mechanism underlying these therapies could be elucidated through further research.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Surgery
David Bastian, Xiaohui Sui, Hung Dang Nguyen, Yongxia Wu, Steven Schutt, Linlu Tian, Mohammed Hanief Sofi, Yuejun Liu, Paul Martin, Eric Bartee, Xue-Zhong Yu
Summary: IL-39 is identified as a pathogenic factor in acute GVHD, potentially promoting the pathological activation of donor T cells in GVHD development. Levels of IL-39 positively correlate with the development of acute GVHD in experimental models and clinical settings. IL-39 represents a novel potential therapeutic target for controlling GVHD and other inflammatory disorders.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Laura Solan, Diego Carbonell, Paula Muniz, Nieves Dorado, Elena Landete, Maria Chicano-Lavilla, Javier Anguita, Jorge Gayoso, Mi Kwon, Jose Luis Diez-Martin, Carolina Martinez-Laperche, Ismael Buno
Summary: This study investigated the significance of elafin plasma levels in haplo-HSCT with PTCy, revealing a correlation between elafin levels and the risk of severe skin aGVHD. Higher elafin levels were associated with a higher incidence of severe skin aGVHD, suggesting that measuring elafin may help in early identification and improve treatment and prognosis for these patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
James Lopez, Vishal Devarkonda, Moe Thuzar, Roberto Silva, Hugo Akabane
Summary: Acute graft vs. host disease (aGVHD) is caused by newly transplanted donor immune cells recognizing recipient tissues as foreign, resulting in organ damage. Diagnosis involves a combination of clinical evaluation, histological examination, laboratory tests, and imaging studies. Solid organ transplant GVHD (SOT-GVHD) associated with kidney-pancreas transplants is extremely rare. Our case highlights the importance of considering a broad range of differential diagnoses when evaluating solid organ transplant patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tong Xing, Xinglian Xu, Lin Zhang, Feng Gao
Summary: The study demonstrated that acute L-glutamine (Gln) supplementation in broilers exposed to pre-slaughter transport can enhance the expression of HSP70 in the pectoralis major (PM) muscles, leading to improvements in meat quality by increasing muscle pH and water-holding capacity, reducing muscle fiber shrinkage, increasing ATP content, decreasing glycolytic enzyme activities, regulating AMP-activated protein kinase phosphorylation levels, and enhancing total superoxide dismutase and total antioxidant capability while decreasing reactive oxygen species, malonaldehyde, and carbonyl levels in the PM of transported broilers.
Article
Medicine, Legal
Mihwa Na, Devin O'Brien, G. Frank Gerberick, Petra S. Kern, Maura Lavelle, Isabelle Lee, Rahul Parakhia, Cindy Ryan, Anne Marie Api
Summary: SENS-IS is an in vitro test based on a reconstructed human skin model, that was developed to predict the hazard and potency of potential skin sensitizers. The performance of SENS-IS in potency prediction for 174 materials was evaluated, showing that SENS-IS provides a good approximation of the skin sensitization potency.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Surgery
Chang-Ju Wu, Jung-Jie Li, Wen-Chieh Liao, Tien-Hsiang Wang, Cherng-Kang Perng, Hsu Ma, Yu-Chung Shih, Mei-Chun Chen, Chih-Hsun Lin
Summary: Meek and ReCell treatments had acceptable success rates, while CEA treatment did not. ReCell and CEA treatments are useful in cases of extremely limited donor sites, but they are fragile, easily infected, and technically challenging. These techniques also require longer hospitalization and tend to be more expensive, factors that should be considered when assessing treatment options.
ANNALS OF PLASTIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Yong Cao, Li Shao, Lianyun Wang, Kai Su, Dong Zhang, Yilin Xie, Qing Zheng, Yanhua Xu, Hui Lu, Mei Xin, Zhongdong Qiao, Yinshi Guo
Summary: This study aimed to investigate the allergenicity of camphor pollen and identified HSC70L2 protein as the major potential allergenic protein. The experiment confirmed that HSC70L2 can cause allergies and predicted its T cell epitope, providing new diagnostic and therapeutic targets for camphor pollen allergies.
MOLECULAR IMMUNOLOGY
(2023)
Article
Environmental Sciences
Sung-Hyun Kim, So-Hye Hong, Jin Hee Lee, Dong Han Lee, Kikyung Jung, Jun-Young Yang, Hyo-Sook Shin, JeongPyo Lee, Jayoung Jeong, Jae-Ho Oh
Summary: The study found that graphene nanoplatelets do not induce skin sensitization and do not cause cytotoxicity or skin toxicity in experiments using alternative test methods.
Review
Biochemistry & Molecular Biology
Ying Fang, Yichen Zhu, Adam Kramer, Yuning Chen, Yan-Ruide Li, Lili Yang
Summary: Allogeneic cell therapies have the potential to be a cost-effective solution for cancer immunotherapy, but the development of graft-versus-host disease (GvHD) remains a challenge. Innate T cells such as MAIT cells, iNKT cells, and gamma delta T cells offer a promising solution as they express MHC-independent T-cell receptors (TCRs) and can avoid MHC recognition and GvHD. This review examines their biology, roles in GvHD modulation and allo HSCT, and explores their potential futures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Juncheng Dai, Mingtao Huang, Christopher I. Amos, Rayjean J. Hung, Adonina Tardon, Angeline Andrew, Chu Chen, David C. Christiani, Demetrius Albanes, Gadi Rennert, Jingyi Fan, Gary Goodman, Geoffrey Liu, John K. Field, Kjell Grankvist, Lambertus A. Kiemeney, Loic Le Marchand, Matthew B. Schabath, Mattias Johansson, Melinda C. Aldrich, Mikael Johansson, Neil Caporaso, Philip Lazarus, Stephan Lam, Stig E. Bojesen, Susanne Arnold, Maria Teresa Landi, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Paul Brennan, Sanjay Shete, Olle Melander, Hans Brunnstrom, Shan Zienolddiny, Penella Woll, Victoria Stevens, Zhibin Hu, Hongbing Shen
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Yuzhuo Wang, Olga Y. Gorlova, Ivan P. Gorlov, Meng Zhu, Juncheng Dai, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary E. Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, Heunz-Erich Wichmann, Heike Bickeboller, David C. Christiani, Gad Rennert, Susanne M. Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline S. Andrew, Lambertus A. Kiemeney, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil E. Caporaso, Penella J. Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Hongxia Ma, Guangfu Jin, Zhibin Hu, Christopher I. Amos, Hongbing Shen
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Multidisciplinary Sciences
Xuemei Ji, Semanti Mukherjee, Maria Teresa Landi, Yohan Bosse, Philippe Joubert, Dakai Zhu, Ivan Gorlov, Xiangjun Xiao, Younghun Han, Olga Gorlova, Rayjean J. Hung, Yonathan Brhane, Robert Carreras-Torres, David C. Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeboeller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, Chu Chen, Jinyoung Byun, Konstantin H. Dragnev, John K. Field, Lambertus F. A. Kiemeney, Philip Lazarus, Shan Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Pier A. Bertazzi, Angela C. Pesatori, Nancy Diao, Li Su, Lei Song, Ruyang Zhang, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H. F. M. van der Heijden, Jin Hee Kim, Michael P. A. Davies, Michael W. Marcus, Hans Brunnstrom, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Erich Wichmann, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Lesley M. Butler, Kenneth Offit, Preethi Srinivasan, Chaitanya Bandlamudi, Matthew D. Hellmann, David B. Solit, Mark E. Robson, Charles M. Rudin, Zsofia K. Stadler, Barry S. Taylor, Michael F. Berger, Richard Houlston, John McLaughlin, Victoria Stevens, David C. Nickle, 'en Obeidat, Wim Timens, Maria Soler Artigas, Sanjay Shete, Hermann Brenner, Stephen Chanock, Paul Brennan, James D. McKay, Christopher Amos
NATURE COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Ryan Sun, Miao Xu, Xihao Li, Sheila Gaynor, Hufeng Zhou, Zilin Li, Yohan Bosse, Stephen Lam, Ming-Sound Tsao, Adonina Tardon, Chu Chen, Jennifer Doherty, Gary Goodman, Stig E. Bojesen, Maria T. Landi, Mattias Johansson, John K. Field, Heike Bickeboeller, H-Erich Wichmann, Angela Risch, Gadi Rennert, Suzanne Arnold, Xifeng Wu, Olle Melander, Hans Brunnstrom, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Eric Duell, Lambertus A. Kiemeney, Hongbing Shen, Aage Haugen, Mikael Johansson, Kjell Grankvist, Neil Caporaso, Penella Woll, M. Dawn Teare, Ghislaine Scelo, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Demetrios Albanes, Raymond Mak, David Barbie, Paul Brennan, Rayjean J. Hung, Christopher I. Amos, David C. Christiani, Xihong Lin
Summary: This study prioritizes and characterizes single nucleotide polymorphisms (SNPs) that increase the risk of squamous cell lung cancer by utilizing extensive multiomics data sources and genome-wide functional annotations. The reanalysis of data highlights the impact of SNPs from nuclear factor-kappa B signaling pathway genes and major histocompatibility complex-mediated immune responses on lung cancer. The strategies introduced in this study provide informative and systematic approaches for incorporating genome-wide annotation data in genetic association studies.
GENETIC EPIDEMIOLOGY
(2021)
Article
Oncology
Wen Zhou, Geoffrey Liu, Rayjean J. Hung, Philip C. Haycock, Melinda C. Aldrich, Angeline S. Andrew, Susanne M. Arnold, Heike Bickeboeller, Stig E. Bojesen, Paul Brennan, Hans Brunnstrom, Olle Melander, Neil E. Caporaso, Maria Teresa Landi, Chu Chen, Gary E. Goodman, David C. Christiani, Angela Cox, John K. Field, Mikael Johansson, Lambertus A. Kiemeney, Stephen Lam, Philip Lazarus, Loic Le Marchand, Gad Rennert, Angela Risch, Matthew B. Schabath, Sanjay S. Shete, Adonina Tardon, Shanbeh Zienolddiny, Hongbing Shen, Christopher I. Amos
Summary: The study found a positive causal effect of high BMI on small cell lung cancer risk, but a negative effect on lung adenocarcinoma. Smoking behaviors play a mediator role in the association between BMI and lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Immunology
Jukka Partanen, Kati Hyvarinen, Heike Bickeboller, Katarzyna Bogunia-Kubik, Rachel E. Crossland, Milena Ivanova, Francesca Perutelli, Ralf Dressel
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
Summary: This study integrated genotype data of lung adenocarcinoma and squamous cell carcinoma cases to analyze susceptibility variants for non-small cell lung cancer, revealing differences between AD and SqCC genes in pathways and functions. The results shed light on the genetic heterogeneity between AD and SqCC in NSCLC.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Rayjean J. Hung, Matthew T. Warkentin, Yonathan Brhane, Nilanjan Chatterjee, David C. Christiani, Maria Teresa Landi, Neil E. Caporaso, Geoffrey Liu, Mattias Johansson, Demetrius Albanes, Loic Le Marchand, Adonina Tardon, Gad Rennert, Stig E. Bojesen, Chu Chen, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Shanbeth Zienolddiny, Stephen Lam, Angeline S. Andrew, Susanne M. Arnold, Melinda C. Aldrich, Heike Bickeboeller, Angela Risch, Matthew B. Schabath, James D. McKay, Paul Brennan, Christopher Amos
Summary: Research suggests that an individual's genetic background may play a role in risk stratification for lung cancer and optimizing LDCT screening.
Article
Cell Biology
Mark Jakob, Mario Hambrecht, Jennifer L. Spiegel, Julia Kitz, Martin Canis, Ralf Dressel, Katrin Streckfuss-Bomeke
Summary: A multimodal therapeutic approach involving radiotherapy is essential for treating head and neck squamous cell carcinoma, but its use is limited due to the risk of damaging surrounding healthy tissue. Mesenchymal stem cells show promising therapeutic potential in cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties. Generating induced pluripotent stem cell-derived mesenchymal stem cells in an autologous manner could be a novel personalized treatment option in regenerative medicine.
Article
Multidisciplinary Sciences
Ignacio Rodriguez-Polo, Sophie Missbach, Stoyan Petkov, Felix Mattern, Anna Maierhofer, Iga Grzadzielewska, Yuliia Tereshchenko, Daniel Urrutia-Cabrera, Thomas Haaf, Ralf Dressel, Iris Bartels, Ruediger Behr
Summary: NHPs are valuable animal models for studying clinically relevant mutations due to their close relationship to humans, but the toolbox for genetic modification of NHPs is less developed compared to other species. PSCs share key molecular signatures with the early embryo and are important for validating genome editing approaches. The piggyBac transposon system has been utilized for various purposes in NHP stem cell technology and genome editing, showing advancements in reprogramming, culture, CRISPR/Cas-based genome editing, and establishment of gene-edited monoclonal NHP-iPSC lines.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Luis Peter Haupt, Sabine Rebs, Wiebke Maurer, Daniela Huebscher, Malte Tiburcy, Steffen Pabel, Andreas Maus, Steffen Koehne, Rewati Tappu, Jan Haas, Yun Li, Andre Sasse, Celio C. X. Santos, Ralf Dressel, Leszek Wojnowski, Gertrude Bunt, Wiebke Moebius, Ajay M. Shah, Benjamin Meder, Bernd Wollnik, Samuel Sossalla, Gerd Hasenfuss, Katrin Streckfuss-Boemeke
Summary: This study developed a patient-specific stem cell model to investigate DOX-induced cardiac dysfunction. The results showed that DOX-induced stress led to arrhythmogenic events and contractile dysfunction, ultimately resulting in heart failure.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hannes Steinkellner, Prakasha Kempaiah, Alexander Beribisky, Sandra Pferschy, Julia Etzler, Anna Huber, Victoria Sarne, Winfried Neuhaus, Mario Kuttke, Jan Bauer, Jayamuruga P. Arunachalam, John Christodoulou, Ralf Dressel, Alexander Mildner, Marco Prinz, Franco Laccone
Summary: This study demonstrates the therapeutic potential of recombinant TAT-MeCP2 in treating Rett syndrome. The findings show that TAT-MeCP2 can reverse the pathological changes of the disease and extend the lifespan of mice. This research lays the foundation for the development of a new therapy for Rett syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemical Research Methods
Kolja A. Thormann, Viola Tozzi, Paula Starke, Heike Bickeboeller, Marcus Baum, Albert Rosenberger
Summary: ImputAccur is a software tool that measures genotype-imputation accuracy. It provides accuracy measures from standard output files of imputation software and supports sample and marker filtering.
BMC BIOINFORMATICS
(2022)
Article
Immunology
Carina Matos, Andreas Mamilos, Pranali N. Shah, Elisabeth Meedt, Daniela Weber, Saroj Ghimire, Andreas Hiergeist, Andre Gessner, Anne Dickinson, Ralf Dressel, Lutz Walter, Klaus Stark, Iris M. Heid, Hendrik Poeck, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Ernst Holler, Marina Kreutz, Sakhila Ghimire
Summary: This study demonstrates the downregulation of vitamin D receptor (VDR) gene expression in patients with severe acute gastrointestinal graft versus host disease (GI-GvHD) after allogeneic haematopoietic stem cell transplantation (HSCT). The reduced VDR expression is associated with higher treatment-related mortality and may play an essential role in the pathogenesis of gut GvHD and the prognosis of patients undergoing HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mohammad Zahidul Hasan, Charlotte Hoeltermann, Beatrix Petersen, Annette Schrod, Kerstin Maetz-Rensing, Artur Kaul, Gabriela Salinas, Ralf Dressel, Lutz Walter
Summary: This study used newly established monoclonal antibodies to detect the expression of NKG2C receptors on primary NK cells in rhesus macaques. The results showed that NKG2C receptor expression was higher in CMV-positive macaques. Furthermore, these NKG2C-positive NK cells had specific molecular features and exhibited high expression of IFNG, indicating their association with CMV.
FRONTIERS IN IMMUNOLOGY
(2022)
