Article
Immunology
Paul J. Martin, David M. Levine, Barry E. Storer, Xiuwen Zheng, Deepti Jain, Ben Heavner, Brandon M. Norris, Daniel E. Geraghty, Stephen R. Spellman, Cassie L. Sather, Feinan Wu, John A. Hansen
Summary: In allogeneic hematopoietic cell transplantation between HLA-identical siblings, minor histocompatibility antigens manifest as a set of peptides originating from annotated proteins and non-annotated open reading frames, which can evoke a donor immune response. The attribution of the immune response and consequent clinical outcomes to individual peptide components within this set may vary from patient to patient.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Rahma Said, Mohamed Hichem Sellami, Houda Kaabi, Slama Hmida
Summary: This study investigated the molecular polymorphism of two minor histocompatibility antigens in the Tunisian population. The results showed a high frequency of immunogenic variants and carriers of specific HLA molecules in Tunisians, similar to other populations. These findings have important implications for clinical and anthropological studies.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Oncology
Nicolas Leuthold, Marco Cattaneo, Jorg Halter, Claudia Huegli, Monika Kirsch, Anna Petropoulou, Tobias E. Erlanger, Sabine Gerull, Jakob Passweg, Alix O'Meara Stern
Summary: "The majority of patients deemed a minimal survival benefit of at least 5 or 10 years sufficient to justify allogeneic HCT, with age at transplant playing a significant role in expected minimal survival and cure rates. Patients generally expected higher treatment outcomes, with younger patients willing to accept smaller benefits."
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Article
Hematology
Fateeha Furqan, Kwang W. Ahn, Yue Chen, Manmeet Kaur, Syed A. Abutalib, Nausheen Ahmed, Sairah Ahmed, Mohamed A. Kharfan-Dabaja, Johnathan Friedberg, Tara Gregory, LaQuisa Hill, Cole Sterling, Stephan K. Barta, Mazyar Shadman, Miguel-Angel Perales, Jasmine Zain, Alex F. Herrera, Craig Sauter, Mehdi Hamadani
Summary: This study evaluated the outcomes of allo-HCT in patients with relapsed/refractory ALCL and found that it can result in durable disease control in a significant proportion of patients. However, refractory disease and racial minority status predicted inferior outcomes after allo-HCT.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Oncology
Chiara Visintini, Irene Mansutti, Alvisa Palese
Summary: This review aims to summarize the prevalence of medication adherence (MA) among adult recipients of allogeneic hematopoietic stem cell transplantation (HSCT) and the tools used to measure it. It also examines factors affecting medication non-adherence (MNA), interventions promoting MA, and the clinical outcomes of MNA. The review found that MA is still an issue among these patients, with suboptimal prevalence rates. Subjective measures have been most commonly used to evaluate MA. Younger age, higher psychosocial risk, daily immunosuppressors, decreased concomitant therapies, and experiencing more side effects are among the factors affecting MNA. The review suggests the need for multidisciplinary care models and further research on risk factors and interventions.
Article
Infectious Diseases
Moshe Yeshurun, Oren Pasvolsky, Liat Shargian, Dafna Yahav, Haim Ben-Zvi, Maly Rubinstein, Michal Sela-Navon, Ofir Wolach, Pia Raanani, Uri Rozovski
Summary: This study assessed the humoral immune response to the BNT162b2 vaccine after allogeneic haematopoietic cell transplantation. The results showed that a significant proportion of patients receiving immunosuppression had inadequate humoral response to the vaccine. Patients with acute and chronic graft-versus-host disease were more likely to remain seronegative.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Cell Biology
Cecile Pochon, Anne-Beatrice Notarantonio, Caroline Laroye, Loic Reppel, Daniele Bensoussan, Allan Bertrand, Marie-Therese Rubio, Maud D'Aveni
Summary: Mesenchymal stromal cells (MSCs) have great potential in regenerative medicine, tissue engineering, and immunomodulation. Wharton's jelly MSCs (WJ-MSCs) derived from the umbilical cord are a promising candidate for cellular therapy in hematology, with the ability to sustain hematopoietic stem cell engraftment and modulate transplant immune reactions.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Amandine Pradier, Samuel Cordey, Marie-Celine Zanella, Astrid Melotti, Sisi Wang, Anne-Claire Mamez, Yves Chalandon, Stavroula Masouridi-Levrat, Laurent Kaiser, Federico Simonetta, Diem-Lan Vu
Summary: This study reveals a potential association between the non-pathogenic HPgV-1 virus and immunomodulation after allo-HSCT, suggesting that HPgV-1 may impair NK cell immune-reconstitution. This provides initial evidence for the potential impact of HPgV-1 infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ana Claudia Scaraficci, Patricia Maria Fernandes, Fabio Abreu Alves, Jayr Schmidt Filho, Graziella Chagas Jaguar
Summary: The study revealed that the mean time for oral GVHD to develop after AHCT was 229 days, with pain and xerostomia being the main symptoms, and ulcers being the most common oral manifestation. Patients who received myeloablative conditioning regimen had a higher survival rate.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Jochen J. Frietsch, Sarah Flossdorf, James F. Beck, Nicolaus Kroeger, Katharina Fleischhauer, Peter Dreger, Johannes Schetelig, Martin Bornhaeuser, Andreas Hochhaus, Inken Hilgendorf
Summary: This retrospective analysis examined the outcomes of young adults who underwent allogeneic haematopoietic stem cell transplantation (HSCT) in Germany. The study found that the outcomes of young adults after HSCT improved over time and were influenced by factors such as underlying disease, age at disease onset, stem cell source, and donor type. However, the survival rate of HSCT recipients after 10 years was significantly lower compared to the general population of young adults.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Immunology
Xiaoxiao Xu, Xiaoqin Li, Yanmin Zhao, He Huang
Summary: Histone deacetylase inhibitors are the focus of extensive research for their potential in treating immune-mediated diseases like GVHD while preserving beneficial effects on GVL. These drugs may become novel therapies by modifying gene expression and immune cell function to prevent or treat GVHD and other immune conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Elisabeth Meedt, Andreas Hiergeist, Andre Gessner, Katja Dettmer, Gerhard Liebisch, Sakhila Ghimire, Hendrik Poeck, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Ernst Holler, Daniela Weber
Summary: The decrease of butyrogenic commensals after allogeneic stem cell transplantation is associated with increased severity of graft-vs-host disease and increased transplantation-related mortality.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Berenice Manczak, Marie-Clemence Verdier, Joseph P. Dewulf, Florian Lemaitre, Vincent Haufroid, Philippe Hantson
Summary: A 53-year-old woman with a history of acute myeloid leukaemia developed severe lactic acidosis and acute kidney injury after receiving a second allogeneic haematopoietic stem cell transplant. The lactic acidosis was suspected to be caused by mitochondrial toxicity from letermovir treatment. Pharmacokinetic analysis showed a prolonged half-life of letermovir in the patient's plasma, which was not affected by continuous venovenous haemofiltration. Genetic analysis revealed the patient's genetic polymorphisms that could result in nonfunctional organic anion transporting polypeptide 1B1 protein.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jarmo Ritari, Kati Hyvarinen, Jukka Partanen, Satu Koskela
Summary: The KIR gene cluster encodes cell surface glycoproteins that are involved in tumor surveillance, viral infection clearance, and immune-mediated diseases. This study presents a reliable method for inferring KIR gene content with high accuracy.
Article
Cardiac & Cardiovascular Systems
Elisabeth Widen, Nella Junna, Sanni Ruotsalainen, Ida Surakka, Nina Mars, Pietari Ripatti, Juulia J. Partanen, Johanna Aro, Pekka Mustonen, Tiinamaija Tuomi, Aarno Palotie, Veikko Salomaa, Jaakko Kaprio, Jukka Partanen, Kristina Hotakainen, Pasi Pollanen, Samuli Ripatti
Summary: Prediction tools that combine polygenic risk scores with clinical factors can improve the prediction and prevention of atherosclerotic cardiovascular disease. Returning personal risk information via web-based communication motivates positive changes in health behavior and the propensity to seek care.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2022)
Article
Immunology
Jarmo Ritari, Satu Koskela, Kati Hyvarinen, FinnGen, Jukka Partanen
Summary: The human leukocyte antigen (HLA) system is a crucial genetic susceptibility factor for various autoimmune diseases and immunological traits. Through population-level analysis, numerous significant associations between single HLA allele and phenotypes were identified, including some previously poorly established associations. Furthermore, certain HLA alleles were found to be linked to both autoimmune and infectious diseases, suggesting that infections may increase the risk of autoimmune diseases.
Article
Biophysics
Atte K. Lahtinen, Jessica Koski, Jarmo Ritari, Kati Hyvarinen, Satu Koskela, Jukka Partanen, Kim Vettenranta, Minna Koskenvuo, Riitta Niittyvuopio, Urpu Salmenniemi, Maija Itala-Remes, Kirsi Jahnukainen, Outi Kilpivaara, Ulla Wartiovaara-Kautto
Summary: This study found rare harmful germline variants in patients who underwent HSCT, which may impact pre-transplantation care and choice of stem cell donor. The results suggest that clinicians should incorporate germline genetic testing into the HSCT protocol for optimal outcomes.
BONE MARROW TRANSPLANTATION
(2023)
Article
Cell & Tissue Engineering
Jonna Clancy, Kati Hyvarinen, Jarmo Ritari, Tiina Wahlfors, Jukka Partanen, Satu Koskela
Summary: This study demonstrates that HLA imputation in a reasonably sized blood donor biobank can be used to identify suitable HLA-homozygous blood donors for cell therapy, HLA-typed thrombocytes, and research purposes. The homozygotes are HLA-compatible with a large fraction of the Finnish population. Regular blood donors with a positive attitude towards research donation are a good option for these purposes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Rodosthenis S. Rodosthenous, Mari E. K. Niemi, Lila Kallio, Merja Perala, Perttu Terho, Theresa Knopp, Eero Punkka, Enni M. Makkonen, Paula Nurmi, Johanna Makela, Pauli Wihuri, Marco Hautalahti, Corianna Moffatt, Paolo Martini, Laura Germine, Viola A. Makela, Oona A. Karhunen, Jari Lahti, Tero S. Hiekkalinna, Tero Jyrhama, Huei-Yi Shen, Heiko Runz, Aarno Palotie, Markus Perola, Andrea Ganna
Summary: This pilot study aimed to recontact biobank participants and collect cognitive, behavioural and lifestyle information using a secure online platform. The results showed a low participation rate but reliable data.
Review
Immunology
Tiira Johansson, Jukka Partanen, Paeivi Saavalainen
Summary: Varying levels of HLA allele-specific expression are associated with human diseases, and RNA sequencing-based approaches with NGS methodologies have emerged to quantify HLA allele-specific expression and provide important information for predicting immune cell therapy efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Salla Markkinen, Ilkka Helantera, Jouni Lauronen, Marko Lempinen, Jukka Partanen, Kati Hyvarinen
Summary: The genomic mismatch level is associated with acute rejection in deceased-donor kidney transplantation. Mismatches in kidney-related proteins and CFHR gene deletion are associated with acute rejection. Genomic mismatch analysis may be an effective tool for predicting transplantation outcomes.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Mitja Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipila, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Paivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Ramo, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rueger, Susanna Lemmela, Wei Zhou, Sanni Ruotsalainen, Kalle Parn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setala, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Farkkila, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Asa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kahonen, Risto Kajanne, Lila Kallio, Reetta Kalviainen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpelainen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Magi, Johanna Makela, Antti Makitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, George Okafo, Hanna M. Ollila, Antti Palomaki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slave Petrovski, Anne Pitkaranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tonu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. Makela, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie
Summary: Population isolates, like those in Finland, provide valuable insights for genetic research due to the concentration of deleterious alleles in low-frequency variants. FinnGen aims to study the genome and health data of 500,000 Finnish individuals, enabling the identification of new associations and the exploration of their implications for common diseases. The study identified 30 new associations and 2,733 genome-wide significant associations, highlighting the power of bottlenecked populations in uncovering disease biology.
Article
Biochemical Research Methods
Veera A. Timonen, Erja Kerkela, Ulla Impola, Leena Penna, Jukka Partanen, Outi Kilpivaara, Mikko Arvas, Esa Pitkanen
Summary: Imaging flow cytometry (IFC) combines flow cytometry with microscopy to rapidly characterize cellular and molecular properties using high-throughput single-cell fluorescent imaging. DeepIFC, a computational method based on the Inception U-Net neural network architecture, generates fluorescent marker images and learn morphological features from IFC brightfield and darkfield images. It identifies cell types from the generated fluorescent images and visualizes the single-cell features in a 2D space. DeepIFC allows accurate cell reconstruction, typing, and recognition of unseen cell types from brightfield and darkfield images via virtual fluorescent labeling.
Article
Cell Biology
Satu Koskela, Silja Tammi, Jonna Clancy, Jonathan A. M. Lucas, Thomas R. Turner, Kati Hyvarinen, Jarmo Ritari, Jukka Partanen
Summary: Genetic variation in MICA and MICB genes is associated with transplantation outcome, autoimmune diseases, and infections. This study analyzes the polymorphism and allele distribution of these genes in Finland, a population with historical bottleneck and founder effects. The results show population differences and a relatively high level of polymorphism in MICA and MICB genes, including the discovery of novel alleles with amino acid changes.
Meeting Abstract
Cell Biology
Jukka Partanen, Kati Hyvarinen, Satu Koskela, Jarmo Ritari
Meeting Abstract
Cell Biology
Silja Tammi, Satu Koskela, Kati Hyvarinen, Jukka Partanen, Jarmo Ritari
Meeting Abstract
Cell Biology
Jonna Clancy, Kati Hyvarinen, Jarmo Ritari, Jukka Partanen, Satu Koskela
Article
Biochemistry & Molecular Biology
Aleksandra Lukasiewicz, Kari Huhta, Jarmo Ritari, Juha Perasaari, Pia Allinen, Marjo Malinen, Annalaura Jokiniemi, Tanja Turunen, Jukka Partanen, Jukka Kekalainen
Summary: Recent studies have shown that reproductive failure may result from the reproductive incompatibility of partners. Female reproductive secretions, such as follicular fluid, can mediate gamete-level mate choice and determine male-female compatibility. Research found that sperm physiological response to female serum can predict compatibility in 70% of males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
