Article
Oncology
Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Areeb Rizwan, Fatima Faraz, Syeda Alveena Shah, Mahrukh Farooqi, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Suhail Razak
Summary: This study identified a positive association of IL-4 -590C/T and CTLA-4 + 49A/G gene polymorphisms with HCV-induced HCC in Pakistan. The findings may serve as genetic markers for HCC.
Article
Cell & Tissue Engineering
Mahdiyar Iravani Saadi, Mingjun Jiang, Morteza Banakar, Fatemeh Mardani Valandani, Maryam Ahmadyan, Hossain Ali Rostamipour, Nadiya Kheradmand, Nasrin Noshadi, Zahed Karimi, Ehsan Nabi Abdolyousefi, Mani Ramzi, Hourvash Haghighinejad, Ramin Yaghobi, Fakhroddin Hosseini
Summary: Studies have shown a significant correlation between CTLA-4 gene polymorphisms and infection in organ transplantation. However, other CTLA-4 gene polymorphisms are not significantly associated with infection in organ transplantation. Further research is needed to explore the interactions between genes and gene-diet interactions in relation to this association.
CELL TRANSPLANTATION
(2023)
Article
Cell Biology
Chuankun Zhou, Shutao Gao, Xi Yuan, Zixing Shu, Song Li, Xuying Sun, Jun Xiao, Hui Liu
Summary: CTLA-4 gene polymorphisms may be associated with the risk of Rheumatoid arthritis (RA), with rs3087243 and rs231775 polymorphisms showing significant associations, while rs5742909 polymorphism is not associated with RA risk. Meta-analysis confirms the relationship between CTLA-4 gene polymorphisms and RA risk in different populations.
Article
Immunology
Lingxiang Yu, Ming Shao, Tingting Zhou, Huimin Xie, Feier Wang, Jiangping Kong, Shenqian Xu, Zongwen Shuai, Faming Pan
Summary: Based on the results of meta-analysis, the CTLA-4 (+49 A/G) gene rs231775 G allele increases the risk of autoimmune diseases in Caucasian populations, particularly in relation to both RA in Caucasian and Mongolian populations. Larger sample sizes and more elaborately designed studies are needed to further clarify the relationship between the CTLA-4 (+49 A/G) gene rs231775 G allele and autoimmune diseases, especially AS and SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Hematology
Zhuo Wang, Yunwei Zhang, Yazhe Du, Fei Song, Sujun Gao
Summary: This meta-analysis indicates that donors with the +49 GG genotype may have an increased risk of chronic GVHD, while donors with the CT60 G allele may be associated with worse overall survival and lower susceptibility to severe acute GVHD.
Article
Immunology
Chunxu Gao, Debra Gardner, Marie-Clare Theobalds, Shannon Hitchcock, Heather Deutsch, Chidozie Amuzie, Matteo Cesaroni, Davit Sargsyan, Tadimeti S. Rao, Ravi Malaviya
Summary: The study demonstrated the preventive effect of targeting CTLA-4 pathway in xeno-GvHD, while anti-CTLA-4 antibody treatment exacerbated the lethality and morbidity associated with GvHD. Further insights were gained into the gene pathways impacted by these treatments, highlighting the potential therapeutic utility of co-inhibitory pathways in immune-mediated diseases driven by hyperactive T cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Surgery
Ahmad Najafi, Reza Alizadeh-Navaei, Siavash Rahimi, Reza Valadan, Mohsen Tehrani
Summary: This study suggests that the CT60 CTLA-4 polymorphism could be a significant risk factor for chronic GVHD.
CLINICAL TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Jakub Rosik, Bartosz Szostak, Filip Machaj, Andrzej Pawlik
Summary: HLA matching, transplantation technique, or underlying disease greatly influences the probability of long-term transplantation success. Genetic variations affecting antigen presentation also contribute to solid organ transplantation and allogeneic haematopoietic stem cell transplantation outcomes. Studies suggest that some CTLA4 gene polymorphisms may impact acute graft rejection and transplantation outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Haipeng Pang, Shuoming Luo, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: The study aimed to quantitatively assess the relationship between polymorphisms rs231775 and rs3087243 of CTLA-4 gene and LADA through meta-analysis, revealing significant associations between these polymorphisms and the risk of LADA. Subgroup analyses also indicated positive associations between rs231775 and LADA in different ethnic groups, suggesting potential risk factors and genetic biomarkers for LADA.
BIOCHEMICAL GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Liping Sun, Tianfeng Niu, Yi Zhang
Summary: The study aimed to investigate the relationship between CTLA-4 gene polymorphisms and the onset of thyroid cancer. The results revealed significant differences in the polymorphic regions at CTLA-4 gene loci between the disease group and the control group. Moreover, the expression level of the CTLA-4 gene was found to be associated with certain clinical indices. Therefore, CTLA-4 gene polymorphisms may serve as a susceptible factor for the progression of thyroid cancer.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Letter
Medicine, General & Internal
Alexander M. Menzies, Ines Pires da Silva, Claudia Trojaniello
Summary: The study suggests that tumors that become resistant to PD-1 and LAG-3 therapy may also develop cross-resistance to ipilimumab.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Rheumatology
Worawit Louthrenoo, Nuntana Kasitanon, Antika Wongthanee, Shoji Kuwata, Fujio Takeuchi
Summary: The A allele at the +49A/G locus of the CTLA-4 gene was associated with RA in Thai patients, and was significantly higher in the subgroup of RA patients with positive RF and anti-CCP. No polymorphisms at these 4 loci were observed in SLE or SSc patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Immunology
Qi Ji, Yongping Zhang, Yixin Hu, Lixia Liu, Shanbo Cao, Li Gao, Bohan Li, Yuanyuan Tian, Lingjun Kong, Shuiyan Wu, Jing Ling, Peifang Xiao, Jun Lu, Jie Li, Yanhua Yao, Jiayue Qin, Shaoyan Hu
Summary: This study retrospectively assessed the relationship between MTX-related transporter and metabolizing enzyme gene polymorphisms, clinical characteristics, and outcomes in 57 pediatric patients who received haplo-HSCT with malignant tumors at a single center.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
RuiHao Huang, XiaoQi Wang, Xi Zhang
Summary: With the rapid development of therapies, hemopoietic stem cell transplantation (HSCT) and chimeric antigen receptor T (CAR-T) cell therapy have emerged as promising treatments for hematological malignancies. However, disease relapse, complications, and side effects continue to pose challenges. This review aims to explore ways to maximize the benefits of each therapy and improve patient prognosis.
Article
Multidisciplinary Sciences
Brianna M. Lax, Joseph R. Palmeri, Emi A. Lutz, Allison Sheen, Jordan A. Stinson, Lauren Duhamel, Luciano Santollani, Alan Kennedy, Adrienne M. Rothschilds, Stefani Spranger, David M. Sansom, K. Dane Wittrup
Summary: Anti-CTLA-4 antibodies have limited long-term benefit in tumor regression. We engineered a nonantagonistic CTLA-4 binding domain and found that both CTLA-4 antagonism and intratumoral Treg depletion are needed for maximum efficacy in anti-CTLA-4 therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Anthropology
M. H. Sellami, H. Kaabi, B. Midouni, A. Dridi, N. Mojaat, M. K. Boukef, S. Hmida
ANNALS OF HUMAN BIOLOGY
(2008)
Article
Anthropology
A. Hajjej, M. H. Sellami, H. Kaabi, G. Hajjej, A. El-Gaaied, K. Boukef, W. Y. Almawi, S. Hmida
ANNALS OF HUMAN BIOLOGY
(2011)
Article
Anthropology
Khalid R. Albalushi, Mohamed H. Sellami, Hamad AlRiyami, Mathew Varghese, Mohamed K. Boukef, Slama Hmida
Article
Biochemistry & Molecular Biology
Meriem Bani, Houda Kaabi, Mohamed Hichem Sellami, Manel Chaabane, Ghaya Cherif, Hedi Bellali, Brahim Midouni, Nejia Chalfouh, Amel Dridi, Afef Jeridi, Slama Hmida
BIOCHEMICAL GENETICS
(2011)
Article
Cell Biology
Mohamed Hichem Sellami, Saloua Ladeb, Houda Kaabi, Ghaya Cherif, Lamia Torjemane, Tarek Ben Othman, Slama Hmida
CELLULAR IMMUNOLOGY
(2010)
Article
Medical Laboratory Technology
Mohamed Hichem Sellami, Lamia Torjemane, Saloua Ladeb, Houda Kaabi, Amira Ben Ahmed, Ghaya Cherif, Brahim Midouni, Tarek Ben Othmane, Slama Hmida
CLINICAL BIOCHEMISTRY
(2011)
Article
Medicine, General & Internal
Mohamed Hichem Sellami, Lamia Torjemane, Alejandro Espadas de Arias, Houda Kaabi, Saloua Ladeb, Francesca Poli, Tarek Ben Othmane, Slama Hmida
Article
Biochemistry & Molecular Biology
Mohamed Hichem Sellami, Manel Chaabane, Houda Kaabi, Lamia Torjemane, Saloua Ladeb, Tarek Ben Othmane, Slama Hmida
DNA AND CELL BIOLOGY
(2012)
Article
Immunology
Mohamed Hichem Sellami, Lamia Torjemane, Alejandro Espadas de Arias, Houda Kaabi, Saloua Ladeb, Tarek Ben Othman, Francesca Poli, Slama Hmida
IMMUNOLOGICAL INVESTIGATIONS
(2010)
Article
Cell Biology
M. H. Sellami, H. Kaabi, A. Bibi, C. Sahli, M. Bani, A. Ben Ahmed, T. Massoud, S. Hmida
Article
Cell Biology
M. H. Sellami, A. Ben Ahmed, H. Kaabi, A. Jridi, A. Dridi, S. Hmida
Article
Hematology
M. Oueslati Belhaj Hassine, H. Ennafaa, S. Kalai, R. Kibech, M. H. Sellami, L. Bouzid, S. Kaabi, S. Abid
TRANSFUSION CLINIQUE ET BIOLOGIQUE
(2012)
Article
Immunology
Mohamed Hichem Sellami, Manel Chaabane, Houda Kaabi, Lamia Torjemane, Saloua Ladeb, Tarek Ben Othmane, Slama Hmida
TRANSPLANT IMMUNOLOGY
(2011)
Article
Cell Biology
A. Hajjej, H. Kaabi, M. H. Sellami, A. Dridi, A. Jeridi, W. El borgi, G. Cherif, A. Elgaaied, W. Y. Almawi, K. Boukef, S. Hmida