Article
Oncology
Rana Yehia, Mona Schaalan, Dalaal M. Abdallah, Amr S. Saad, Neven Sarhan, Samira Saleh
Summary: In both pancreatic and NSCL cancer patients, TNF-alpha gene mutations are associated with cachexia. High levels of miR-155 are positively correlated with cachexia severity. SOCS1 and Foxp3 levels are significantly lower in cachectic patients compared to non-cachectic patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Tomasz Powrozek, Joanna Dziwota, Teresa Malecka-Massalska
Summary: Nutritional deficiencies caused by radiotherapy are important but understudied in cancer patients, especially in head and neck cancer patients where the incidence is high. Malnutrition, sarcopenia, and cachexia are associated with poorer disease prognosis, higher mortality, and reduced quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Ilda Hoxhaj, Vladimir Vukovic, Stefania Boccia, Roberta Pastorino
Summary: Through systematic review and meta-analysis, we identified certain SNPs that may serve as potential markers for identifying HNC survivors at high risk of developing SPC.
Review
Nutrition & Dietetics
Marcin Mazurek, Radoslaw Mlak, Agata Kot, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: The research suggests that HPV infection may increase the risk of malnutrition, significant weight loss, and the need for gastrostomy in head and neck cancer patients. However, the data on the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC patients is still limited and inconclusive.
Review
Cell Biology
Vignesh Vudatha, Teja Devarakonda, Christopher Liu, Devon C. Freudenberger, Andrea N. Riner, Kelly M. Herremans, Jose G. Trevino
Summary: Cancer cachexia is a complex syndrome that affects the quality of life and prognosis of patients, but there is limited research and treatment options for cardiac cachexia. While some potential therapies have been explored, further studies and evaluation are needed.
Article
Nutrition & Dietetics
Liang Fu, Changzhen Lei, Yingxun Chen, Ruiyun Zhu, Minling Zhuang, Liping Dong, Xianghong Ye, Lushan Zheng, Daojun Gong
Summary: This study investigated the TNF-alpha -1,031 T/C gene polymorphism as an unfavorable predictor of malnutrition in gastric cancer patients. Among the 220 patients with gastric cancer, those carrying the C allele had a 2.5 times higher risk of developing malnutrition. Patients with the CC genotype had a significantly higher risk, while those with the CT genotype also had a higher risk of malnutrition.
FRONTIERS IN NUTRITION
(2023)
Article
Oncology
Weihong Xiong, Zhumei Li, Xiangfa Zeng, Jun Cui, Zhiming Cheng, Xiaoying Yang, Yipeng Ding
Summary: This study found that ANXA6 gene variants are associated with susceptibility to head and neck cancer in the Chinese Han population, suggesting that ANXA6 may serve as a potential biomarker for prognosis and diagnosis of head and neck cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Otorhinolaryngology
Anna C. H. Willemsen, Walmari Pilz, Ann Hoeben, Frank J. P. Hoebers, Annemie M. W. J. Schols, Laura W. J. Baijens
Summary: This study investigates the relationship between cancer cachexia and oropharyngeal dysphagia in patients with head and neck cancer. The findings suggest that cachexia independently predicts the presence of patient-reported dysphagia.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Julia Berner, Lea Miebach, Marcel Kordt, Christian Seebauer, Anke Schmidt, Michael Lalk, Brigitte Vollmar, Hans-Robert Metelmann, Sander Bekeschus
Summary: This study explores the effects of medical gas plasma on tumor cells and their adaptation to oxidative stress. The researchers found that gas plasma can induce chronic oxidative stress adaptation in tumor cells, leading to regression of tumor growth. The study also investigated the cellular responses and molecular mechanisms involved in this adaptation process.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Antra, Palak Parashar, Hungharla Hungyo, Anuja Jain, Shandar Ahmad, Vibha Tandon
Summary: Head and neck squamous cell carcinomas (HNSCC) pose major challenges in treatment due to their heterogeneity, late-stage diagnosis, and high recurrence rate. Current biomarkers for diagnosis and prognosis of HNSCC mainly rely on smoking as the major risk factor. This review focuses on the differential environment and gene mutations of HNSCC in Indian patients who consume smokeless tobacco. It reveals frequent mutations in genes involved in DNA repair, cell proliferation, cell death, metastasis, lymphocyte proliferation, cell-cell adhesion, miRNA processing, and inflammatory responses in Indian HNSCC patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Antti A. Makitie, Rasheed Omobolaji Alabi, Helena Orell, Omar Youssef, Alhadi Almangush, Akihiro Homma, Robert P. Takes, Fernando Lopez, Remco de Bree, Juan P. Rodrigo, Alfio Ferlito
Summary: Patients with head and neck cancer often experience functional changes. The treatment of cachexia in these patients includes various interventions such as nutritional, pharmacologic, therapeutic exercise, and multimodal approaches.
ADVANCES IN THERAPY
(2022)
Article
Otorhinolaryngology
Alexander Joseph Jones, Kyle Patrick Davis, Leah J. Novinger, Andrea Bonetto, Avinash Mantravadi, Michael W. Sim, Jessica A. Yesensky, Michael G. Moore
Summary: Cancer cachexia is associated with worse outcomes in head and neck cancer patients undergoing free tissue reconstruction.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Ting Wu, Zhong-ti Zhang, Lin Li, Ru-yue Liu, Bao-ting Bei
Summary: The meta-analysis revealed that both HIF-1 alpha C1772T and G1790A polymorphisms are associated with a higher risk of head and neck cancer, especially in the Caucasian population with the C1772T polymorphism.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Geriatrics & Gerontology
Brennan Olson, Mason A. Norgard, Peter R. Levasseur, Xinxia Zhu, Daniel L. Marks
Summary: Cancer cachexia is a metabolic disorder characterized by progressive loss of fat and lean mass, leading to wasting and increased mortality. Existing pre-clinical models often fail to fully replicate the features of cachexia, but a newly characterized metastatic model of head and neck squamous cell carcinoma shows promising results in mimicking key clinical and molecular features of cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Medicine, General & Internal
Iwona Bojar, Radoslaw Mlak, Iwona Homa-Mlak, Monika Prendecka, Alfred Owoc, Teresa Malecka-Massalska
Summary: This study examined the relationship between body fat level and serum concentration of myostatin protein in peri- and postmenopausal women. The results showed that a decreased level of myostatin is associated with higher body fat in these women.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Marcin Mazurek, Radoslaw Mlak, Iwona Homa-Mlak, Tomasz Powrozek, Anna Brzozowska, Wojciech Kwasniewski, Grzegorz Opielak, Teresa Malecka-Massalska
Summary: A correlation was found between the expression of miR-511-3p and nutritional status in patients with head and neck cancer undergoing radiotherapy. Higher expression of miR-511-3p was observed in well-nourished patients compared to those with malnutrition. This suggests that miR-511-3p could serve as a potential biomarker for nutritional deficiencies in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Powrozek, Dominika Pigon-Zajac, Marcin Mazurek, Michael Ochieng Otieno, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study aimed to evaluate the impact of inflammatory conditions on the expression of long non-coding RNAs (lncRNAs) in a mouse skeletal muscle cell line. Three lncRNAs (Gm4117, Ccdc41os1, and 5830418P13Rik) were found to be significant in inflammatory-related myotube atrophy. The expression of lncRNAs varied depending on the concentration of the inflammatory factor and the treatment time. Bioinformatics analysis identified potential target genes and miRNAs for these lncRNAs, further implicating their involvement in molecular processes related to muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jaromir Jarecki, Teresa Malecka-Masalska, Ewa Kosior-Jarecka, Wojciech Widuchowski, Piotr Krasowski, Martina Gutbier, Maciej Dobrzynski, Tomasz Blicharski
Summary: The aim of this study was to evaluate the levels of MMPs and osteocalcin in the serum and synovial fluid of obese women with osteoarthritis and their correlations with clinical status. The results showed that the levels of MMP3, MMP9, and pro-MMP13 were increased in more advanced stages of osteoarthritis, indicating an underlying inflammatory process.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Katarzyna Geca, Magdalena Skorzewska, Karol Rawicz-Pruszynski, Radoslaw Mlak, Katarzyna Sedlak, Zuzanna Pelc, Wojciech P. Polkowski
Summary: This study evaluated the prognostic value of the One-Step Nucleic Acid Amplification (OSNA) assay in advanced gastric cancer patients. The results showed that a positive OSNA assay result was a significant unfavorable prognostic factor in these patients. The OSNA assay of peritoneal washings could be considered as an adjunct tool to provide precise intraoperative staging and additional prognostic information.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Iwona Homa-Mlak, Marcin Mazurek, Aleksandra Majdan, Radoslaw Mlak, Maria Majdan, Teresa Melecka-Massalska
Summary: This study aimed to evaluate the potential of serum calprotectin as a rapid diagnostic biomarker for systemic lupus erythematosus (SLE). Comparing 59 SLE patients with 52 healthy controls, it was found that the study group had significantly higher levels of calprotectin. Calprotectin showed high sensitivity and specificity in differentiating SLE patients from healthy volunteers, as well as in detecting moderate to severe SLE patients.
MEDICAL SCIENCE MONITOR
(2022)
Article
Oncology
Iwona Homa-Mlak, Radoslaw Mlak, Marcin Mazurek, Anna Brzozowska, Tomasz Powrozek, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study found that the TT genotype of the TNFRSF1A gene (-610 T > G) is independently associated with a higher risk of nutritional disorders in head and neck cancer patients undergoing radiotherapy. This suggests that this genetic polymorphism may be useful in assessing the risk of nutritional deficiencies in these patients.
Review
Nutrition & Dietetics
Marcin Mazurek, Radoslaw Mlak, Agata Kot, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: The research suggests that HPV infection may increase the risk of malnutrition, significant weight loss, and the need for gastrostomy in head and neck cancer patients. However, the data on the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC patients is still limited and inconclusive.
Article
Medicine, Research & Experimental
Iwona Homa-Mlak, Radoslaw Mlak, Anna Brzozowska, Marcin Mazurek, Tomasz Powrozek, Monika Prendecka-Wrobel, Aneta Szudy-Szczyrek, Piotr Dreher, Katarzyna Kaminska, Teresa Malecka-Massalska, Alicja Wojcik-Zaluska
Summary: This study found that there is a correlation between malnutrition and weight loss with the increase in irisin concentration in patients with head and neck cancers. Higher levels of irisin may serve as a useful marker for malnutrition in HNC patients.
MEDICAL SCIENCE MONITOR
(2022)
Article
Cell Biology
Weronika Domerecka, Anna Kowalska-Kepczynska, Iwona Homa-Mlak, Agata Michalak, Radoslaw Mlak, Marcin Mazurek, Halina Cichoz-Lach, Teresa Malecka-Massalska
Summary: This study investigated the role of Extended Inflammation Parameters (EIP) and systemic inflammatory response markers in diagnosing autoimmune hepatitis (AIH). Results showed higher values in AIH patients compared to controls, indicating potential diagnostic value. Additionally, certain markers were also found to be important in detecting liver fibrosis in the course of AIH.
Review
Health Care Sciences & Services
Iwona Homa-Mlak, Dominika Pigon-Zajac, Pawel Wawrejko, Teresa Malecka-Massalska, Radoslaw Mlak
Summary: According to the World Health Organization, cancer remains one of the main causes of mortality globally. Cancer cachexia is a complex disorder characterized by muscle mass loss and inflammation. miRNAs have potential as valuable biomarkers in the diagnosis, treatment, and prognosis of cancer cachexia due to their ability to regulate multiple genes and biological processes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Aneta Szudy-Szczyrek, Radoslaw Mlak, Marcin Mazurek, Tomasz Krajka, Sylwia Chocholska, Paulina Bitkowska, Marta Jutrzenka, Michal Szczyrek, Iwona Homa-Mlak, Andrzej Krajka, Teresa Malecka-Massalska, Marek Hus
Summary: The functional single nucleotide polymorphism (SNP) of the KIAA1524 gene (rs2278911, 686C > T) is associated with disease progression and survival in patients with multiple myeloma (MM). The TT genotype is linked to shorter progression-free survival (PFS) and overall survival (OS). Therefore, evaluating the SNP 686C > T of the KIAA1524 gene could serve as a diagnostic tool for identifying MM patients at risk of early disease progression and death.
Article
Biochemistry & Molecular Biology
Michal Mielnik, Aneta Szudy-Szczyrek, Iwona Homa-Mlak, Radoslaw Mlak, Martyna Podgajna-Mielnik, Aneta Goracy, Teresa Malecka-Massalska, Marek Hus
Summary: This study assessed the correlation between pretreatment serum concentrations of IL-6, IL-8, MCP-1, and VEGF and the clinical outcomes of MM patients. Results showed that IL-8 was significantly correlated with age, staging, performance status, anemia, kidney disease, and VEGF. Chemotherapy responders had lower IL-8, IL-6, and VEGF concentrations compared to non-responders. High levels of IL-6 were associated with a higher risk of disease progression and reduced overall survival.