Article
Multidisciplinary Sciences
Huiru Wang, Huilan Liu, Li Zhou, Dongyao Wang, Shushu Wang, Qian Liu, Yun Wu, Meijuan Tu, Zimin Sun, Xiaohu Zheng, Binqing Fu, Baolong Wang, Haiming Wei
Summary: This study compared the immune cells of patients with controlled and uncontrolled CMV infection after allo-HSCT. It found that patients with uncontrolled infection had insufficient B-cells due to impaired B-cell reconstitution. In contrast, patients with controlled infection had reconstructed B-cells showing mature B-cell characteristics and enrichment of CMV-associated B-cell receptors. Additionally, the controlled infection group had higher levels of anti-CMV-specific immunoglobulin G (IgG) in their serum, which could effectively inhibit CMV infection. These findings highlight the importance of B-cells and anti-CMV-specific neutralizing IgGs in controlling CMV infection post-allo-HSCT and suggest their potential as a supplementary treatment for improved outcomes.
Article
Oncology
Laura Wetzel, Susan Wittig, Bernd Gruhn
Summary: The study identified the IL6-174 and IL6-597 GG genotypes of pediatric allogeneic HSCT recipients as genetic risk factors for the development of acute GVHD and chronic GVHD. These findings suggest potential adjustments to prophylactic measures in order to reduce the occurrence of acute and chronic GVHD.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Virology
Matthias J. Reddehase, Rafaela Holtappels, Niels A. W. Lemmermann
Summary: Hematopoietic cell transplantation is a last resort for treating hematopoietic malignancies that are refractory to standard therapies, aiming to reconstitute hematopoiesis and immune function. Mismatches in HLA and minor histocompatibility antigens may increase the risk of complications from cytomegalovirus infection.
Review
Immunology
Richard J. Lin, Harold K. Elias, Marcel R. M. van den Brink
Summary: Older patients with hematologic malignancies are increasingly undergoing allogeneic hematopoietic cell transplantation, with aging-related thymic dysfunction and other aging hallmarks potentially impacting immune reconstitution post-transplantation. Mechanism-based therapeutic interventions are being discussed to address these issues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Paul J. Martin, David M. Levine, Barry E. Storer, Xiuwen Zheng, Deepti Jain, Ben Heavner, Brandon M. Norris, Daniel E. Geraghty, Stephen R. Spellman, Cassie L. Sather, Feinan Wu, John A. Hansen
Summary: In allogeneic hematopoietic cell transplantation between HLA-identical siblings, minor histocompatibility antigens manifest as a set of peptides originating from annotated proteins and non-annotated open reading frames, which can evoke a donor immune response. The attribution of the immune response and consequent clinical outcomes to individual peptide components within this set may vary from patient to patient.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Vera Portillo, Stavroula Masouridi-Levrat, Lena Royston, Sabine Yerly, Manuel Schibler, Maria Mappoura, Sarah Morin, Federica Giannotti, Anne-Claire Mamez, Christian van Delden, Yves Chalandon, Dionysios Neofytos
Summary: Positive CMV serology in allogeneic hematopoietic cell transplant recipients (allo-HCTRs) may be false-positive due to transfusion-associated passive immunity. Reclassifying CMV status can help accurately assess the risk of CMV infection in these patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Asim Saha, Bruce R. Blazar
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment option for hematological malignancies. However, conventional allo-HSCT methods have adverse effects and can lead to graft-versus-host-disease. Recent developments in targeted radiotherapy and antibody-based conditioning show promise in improving the outcomes of allo-HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Jun Hong Park, Je Hwan Lee, Jung Hee Lee, Han Seung Park, Eun Ji Choi, Young Ah Kang, Hyeran Kang, Ji Min Woo, Young Shin Lee, Mijin Jeon, Kyoo Hyung Lee
Summary: Primary graft failure (GF) has a high mortality rate, while the 10-year cumulative incidence of secondary GF is 4.5%, with a median onset of 3 months post-transplant and a 5-year Kaplan-Meier survival of 28.8%. The diagnosis of severe aplastic anemia and use of reduced intensity conditioning were both associated with higher incidence and better survival rates in the secondary GF group.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Immunology
Linlu Tian, Besim Ogretmen, Brian Y. Chung, Xue-Zhong Yu
Summary: Allogeneic hematopoietic cell transplantation is an effective immunotherapy against hematopoietic malignancies, but GVHD and tumor relapse are major concerns. Sphingolipid metabolism plays a crucial role in immune responses, highlighting the need to explore therapeutic strategies targeting sphingolipid metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Infectious Diseases
Fatima Allaw, Sara F. Haddad, Johnny Zakhour, Souha S. Kanj
Summary: Cytomegalovirus (CMV) is a common infection in immunocompromised patients, especially those undergoing allo-HSCT. Recent management strategies include pre-emptive treatment with frequent CMV PCR monitoring and the use of new drugs like letermovir. Treatment of CMV disease is challenging due to drug resistance, but promising results have been seen with maribavir and other alternative treatments such as immunotherapy, artesunate, and leflunomide.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Hematology
Amanda M. Casto, Sachiko Seo, David M. Levine, Barry E. Storer, Xinyuan Dong, John A. Hansen, Michael Boeckh, Paul J. Martin
Summary: This study found that only the donor ABCB1 gene variant was associated with CMV reactivation after allogeneic hematopoietic cell transplantation. Other genetic variants previously linked to CMV phenotypes did not significantly alter the risk for CMV reactivation or disease post-transplant.
Review
Immunology
Muhammad Umair Mushtaq, Moazzam Shahzad, Amna Y. Shah, Sibgha Gull Chaudhary, Muhammad U. Zafar, Iqra Anwar, Karun Neupane, Ayesha Khalid, Nausheen Ahmed, Rajat Bansal, Ramesh Balusu, Anurag K. Singh, Sunil H. Abhyankar, Natalie S. Callander, Peiman Hematti, Joseph P. McGuirk
Summary: NK cells play a vital role in immune reconstitution after allogeneic hematopoietic stem cell transplantation. Higher NK cell reconstitution and graft NK cell content are associated with better overall survival, lower relapse rate, and lower acute GVHD incidence. Pre-emptive NK cell infusions may prevent disease relapse post-HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Feiyan Mo, Norihiro Watanabe, Kayleigh I. Omdahl, Phillip M. Burkhardt, Xiaoyun Ding, Eiko Hayase, Angela Panoskaltsis-Mortari, Robert R. Jenq, Helen E. Heslop, Leslie S. Kean, Malcolm K. Brenner, Victor Tkachev, Maksim Mamonkin
Summary: OX40 plays a central role in aGVHD by regulating activation and expansion of T cells. Researchers have developed a specific OX40 cytotoxic receptor that selectively eliminates OX40-positive T cells, reducing the occurrence of aGVHD. Furthermore, combining OX40 targeting with leukemia-specific chimeric antigen receptor provides simultaneous protection against leukemia and aGVHD in post-transplant residual disease.
Article
Hematology
Danniel Zamora, Elizabeth R. Duke, Hu Xie, Bradley C. Edmison, Brenda Akoto, Richard Kiener, Terry Stevens-Ayers, Ralf Wagner, Marco Mielcarek, Wendy M. Leisenring, Keith R. Jerome, Joshua T. Schiffer, Greg Finak, Stephen C. De Rosa, Michael Boeckh
Summary: The study suggests that letermovir may delay CMV-specific cellular reconstitution, possibly due to decreased CMV antigen exposure. Evaluating T-cell polyfunctionality can help identify patients at risk for late CMV infection after HCT.
Article
Multidisciplinary Sciences
Chloe Pasin, Ryan H. Moy, Ran Reshef, Andrew J. Yates
Summary: Allogeneic hematopoietic cell transplantation is a potential curative treatment for many diseases, but the main barriers to success are relapse and graft-versus-host disease. Studies have shown that variable selection methods can help in exploring rich clinical data and identifying cell subsets associated with clinical outcomes.
SCIENTIFIC REPORTS
(2021)
Review
Hematology
Anna Karen Haugaard, Josefine Kofoed, Tania Nicole Masmas, Hans Ole Madsen, Hanne Vibeke Marquart, Carsten Heilmann, Klaus Gottlob Muller, Marianne Ifversen
Article
Biophysics
Helene Jeppesen, Henrik Sengelov, Frank Eriksson, Jens Folke Kiilgaard, Susanne Tvede Andersen, Jens Lindegaard, Hanne Olsen Julian, Steffen Heegaard
Summary: This study found that patients with dry eye disease before HSCT are at higher risk of developing chronic ocular GVHD post-transplantation, recommending a baseline ophthalmological examination before HSCT to assess patients' risk factors.
BONE MARROW TRANSPLANTATION
(2021)
Article
Biophysics
Malene Mejdahl Nielsen, Sidsel Mathiesen, Anu Suominen, Kaspar Sorensen, Marianne Ifversen, Christian Molgaard, Paivi M. Lahteenmaki, Anders Juul, Kirsi Jahnukainen, Klaus Mueller
Summary: Among survivors of paediatric allogeneic hematopoietic stem cell transplantation (HSCT), lower Lean Body Mass Index and Skeletal Muscle Mass Index, as well as higher android/gynoid (AG) fat ratio, were observed. Low lean mass was associated with chronic graft-versus-host disease, while high AG ratio was related to lower testosterone levels. The combination of low lean mass and high AG ratio increases the risk of cardio-metabolic disease, emphasizing the importance of long-term monitoring in these patients.
BONE MARROW TRANSPLANTATION
(2021)
Article
Hematology
Andreas Glenthoj, Lasse H. Jakobsen, Henrik Sengelov, Syed A. Ahmad, Kristian Qvist, Annika Rewes, Christian B. Poulsen, Ulrik M. Overgaard, Ingolf Molle, Marianne T. Severinsen, Casper N. Strandholdt, Jack Maibom, Annette R. Kodahl, Jesper Ryg, Pernille Ravn, Isik S. Johansen, Soren N. Helso, Soren Jensen-Fangel, Jacek Kisielewicz, Lothar Wiese, Marie Helleberg, Ole Kirk, Michael R. Clausen, Henrik Frederiksen
Summary: This prospective study in Danish haematology patients with SARS-CoV-2 infection indicated that older age, severe comorbidities, and critical infection severity were associated with higher mortality rates.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Article
Biophysics
Maria Ebbesen, Sarah Weischendorff, Katrine Kielsen, Marte Kammersgaard, Anders Juul, Klaus Gottlob Mueller
Summary: IGF-I levels are associated with the risk of developing SOS in HSCT patients, with low levels increasing the risk. IGF-I protects against cytotoxic damage and SOS through its trophic effects on endothelial cells and anti-inflammatory properties.
BONE MARROW TRANSPLANTATION
(2021)
Article
Hematology
Lars Klingen Gjaerde, Sisse Rye Ostrowski, Lia Minculescu, Niels Smedegaard Andersen, Lone Smidstrup Friis, Brian Kornblit, Soren Lykke Petersen, Ida Schjodt, Henrik Sengelov
Summary: The study found that higher pre-transplantation vitamin E levels were associated with a lower risk of developing grade II-IV acute GvHD. However, post-transplantation vitamin E levels were not predictive of subsequent acute GvHD.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Emma E. Ilett, Mette Jorgensen, Marc Noguera-Julian, Jens Christian Norgaard, Gedske Daugaard, Marie Helleberg, Roger Paredes, Daniel D. Murray, Jens Lundgren, Cameron MacPherson, Joanne Reekie, Henrik Sengelov
Letter
Oncology
Andreas Glenthoj, Lasse H. Jakobsen, Mads Emil Bjorn, Christian B. Poulsen, Henrik Sengelov, Marianne T. Severinsen, Kristian Qvist, Ulrik M. Overgaard, Syed A. Ahmad, Annika Rewes, Ingolf Molle, Casper N. Strandholdt, Annette R. Kodahl, Jesper Ryg, Christian Brieghel, Isik S. Johansen, Karina Kannik, Soren Jensen-Fangel, Lothar Wiese, Ole Kirk, Michael R. Clausen, Marie Helleberg, Henrik Frederiksen
Article
Biophysics
Helene Jeppesen, Katrine Kielsen, Volkert Siersma, Jens Lindegaard, Hanne Olsen Julian, Steffen Heegaard, Henrik Sengelov, Klaus Muller
Summary: This nationwide single-centre study investigated the incidence and risk factors for ocular graft-versus-host disease (oGVHD) and dry eye disease (DED) in children receiving allogeneic haematopoietic stem cell transplantation (HSCT). The study found a relatively high incidence of oGVHD and DED after HSCT, with the use of Busulfan and malignant disease being identified as risk factors. Younger recipient age was associated with a reduced risk of DED. The study highlights the importance of ophthalmic examinations before and after HSCT to diagnose and treat these complications.
BONE MARROW TRANSPLANTATION
(2022)
Article
Immunology
Dina Leth Moller, Katrine Kielsen, Claus Henrik Nielsen, Henrik Sengelov, Anders Elm Pedersen, Lars Peter Ryder, Klaus Muller
Summary: This study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Hematology
Frederikke Schierbeck, Jann Mortensen, Niels S. Andersen, Lone S. Friis, Brian Kornblit, Soren L. Petersen, Ida Schjodt, Henrik Sengelov
Summary: The study aimed to evaluate the validity of the HCT-CI and pulmonary comorbidity in predicting NRM and OS after HCT. The results showed that both the PCS and HCT-CI had predictive value for OS, while only the PCS was significant for predicting NRM. Pulmonary function was found to be a strong predictor of 2-year OS and NRM after HCT.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Review
Oncology
Peter Schmidt-Andersen, Anna Stage, Anna Pouplier, Louise H. Bastholm, Klaus G. Mueller, Anders Larsen, Kirsten K. Ness, Hanne B. Larsen, Jan Christensen, Martin K. Fridh
Summary: The evidence suggests that children with cancer experience impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the limited number of studies and the clinical heterogeneity of the available evidence reduces its certainty.
PEDIATRIC BLOOD & CANCER
(2023)
Letter
Biophysics
Sidsel Mathiesen, Christian Fuglesang S. Jensen, Anna Byrjalsen, Lise Aksglaede, Niels Jorgensen, Dana Ohl, Jens Sonksen, Klaus Muller
BONE MARROW TRANSPLANTATION
(2023)
Meeting Abstract
Biophysics
F. Schierbeck, N. S. Andersen, L. S. Friis, B. T. Kornblit, S. L. Petersen, I. Schjodt, H. Sengelov
BONE MARROW TRANSPLANTATION
(2022)
Article
Oncology
Silvia De Pietri, Thomas Leth Frandsen, Mette Christensen, Kathrine Grell, Mathias Rathe, Klaus Mueller
Summary: Plasma citrulline levels may help identify patients at increased risk of bacteremia during induction treatment for acute lymphoblastic leukemia (ALL) in children.
PEDIATRIC BLOOD & CANCER
(2021)