Article
Medicine, Research & Experimental
Jeannine S. Mccune, Sandi L. Navarro, Linda J. Risler, Brian R. Phillips, Suping Ren, H. Gary Schoch, K. Scott Baker
Summary: Busulfan metabolites are present in patients' plasma before allograft infusion, but are not associated with clinical outcomes. However, pre-graft endogenous metabolomic compounds (EMCs) are statistically significantly associated with neutrophil nadir.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Microbiology
Philip R. R. Selby, Aaron J. J. Heffernan, David Yeung, Morgyn S. S. Warner, Sandra L. L. Peake, Uwe Hahn, Steven C. C. Wallis, Brett Mcwhinney, Jacobus P. J. Ungerer, Sepehr Shakib, Jason A. A. Roberts
Summary: This study aimed to develop a population pharmacokinetic model for ganciclovir in alloHCT patients and determine dosing regimens to achieve therapeutic exposure targets.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
A. Laura Nijstad, Stefan Nierkens, Caroline A. Lindemans, Jaap Jan Boelens, Marc Bierings, A. Birgitta Versluys, Kim C. M. van der Elst, Alwin D. R. Huitema
Summary: Clofarabine has been evaluated for conditioning in pediatric hematopoietic stem cell transplantation, with its population PK studied in 80 pediatric patients and one adult. A two-compartment model described its pharmacokinetics, with body weight and eGFR impacting clearance. Interestingly, variability in exposure was observed, indicating a need for personalized dosing strategies beyond BSA-based dosing.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Dong, Chie Emoto, Tsuyoshi Fukuda, Danielle E. Arnold, Parinda A. Mehta, Rebecca A. Marsh, Alexander A. Vinks
Summary: This study characterized the population pharmacokinetic/pharmacodynamic of alemtuzumab and proposed individualized subcutaneous dosing schemes for pediatric patients undergoing allogeneic hematopoietic cell transplantation. By utilizing allometric or body surface area-based dosing regimens and Bayesian PK estimation, optimal therapeutic outcomes were achieved for this patient population.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Banaz Abbas, Nagwa A. Sabri, Amal A. El-Khouly
Summary: The study aimed to investigate the effects of food and selected single nucleotide polymorphisms in the UGT2B7 gene on the pharmacokinetics and pharmacodynamics behavior of indapamide. The results showed that food had a modest impact on the maximum concentration and absorption time of indapamide, while genetic variations in the UGT2B7 gene had no significant impact on the pharmacokinetic parameters. It was concluded that food had a moderate effect on the pharmacokinetics, but there were no significant differences in safety and efficacy.
Article
Immunology
Vera Portillo, Stavroula Masouridi-Levrat, Lena Royston, Sabine Yerly, Manuel Schibler, Maria Mappoura, Sarah Morin, Federica Giannotti, Anne-Claire Mamez, Christian van Delden, Yves Chalandon, Dionysios Neofytos
Summary: Positive CMV serology in allogeneic hematopoietic cell transplant recipients (allo-HCTRs) may be false-positive due to transfusion-associated passive immunity. Reclassifying CMV status can help accurately assess the risk of CMV infection in these patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, Silvia Turroni, Patrizia Brigidi, Andrea Pession
Summary: The gut microbiome plays a significant role in hematopoietic stem cell transplantation, with its metabolites mediating interactions between intestinal microbial communities and the host. New data offer a fresh perspective on the role of microbiome-derived metabolites in transplant settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Kalpna Jakhar, Swetha Vaishnavi, Prabhsimran Kaur, Paramdeep Singh, Anjana Munshi
Summary: This review discusses the role and influencing factors of GLP-1RA drugs in the treatment of type 2 diabetes, as well as information on their pharmacokinetics and pharmacodynamics.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Immunology
Sikemi Ibikunle, Dolores Grosso, Usama Gergis
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for multiple hematological conditions. The two-step approach to HSCT, described here, aims to achieve an optimal balance in immune recovery, graft-versus-host disease control, and disease control. This review highlights key results from studies over the past two decades and discusses current strategies to optimize graft-versus-tumor effect and limit transplant-related toxicities.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Linlu Tian, Besim Ogretmen, Brian Y. Chung, Xue-Zhong Yu
Summary: Allogeneic hematopoietic cell transplantation is an effective immunotherapy against hematopoietic malignancies, but GVHD and tumor relapse are major concerns. Sphingolipid metabolism plays a crucial role in immune responses, highlighting the need to explore therapeutic strategies targeting sphingolipid metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jonathan Bordat, Sebastien Maury, Mathieu Leclerc
Summary: Allo-HSCT recipients are highly vulnerable to COVID-19 due to immunodeficiency, and changes in clinical practice have been implemented to reduce the risk. mRNA vaccines have shown effectiveness in preventing severe forms of the disease, but Allo-HSCT recipients may have a poor response to vaccination. Challenges include adapting vaccine protection to emerging variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yosuke Okada, Hideki Nakasone, Yuhei Nakamura, Masakatsu Kawamura, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Yukiko Misaki, Kazuki Yoshimura, Shimpei Matsumi, Ayumi Gomyo, Aki Tanihara, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Shun-Ichi Kimura, Shinichi Kako, Noriko Oyama-Manabe, Yoshinobu Kanda
Summary: Pancreatic atrophy is associated with chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation. The recovery of pancreatic thickness plays a crucial role in body weight recovery, but pancreatic atrophy may have a negative impact on prognosis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Medicine, General & Internal
Nishka Bhalla, Anjali Bhargav, Sandeep Kumar Yadav, Aloukick Kumar Singh
Summary: Sickle cell disease (SCD) has been mentioned in the literature for a century, and advancements in understanding its molecular basis have provided various treatment options. Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only available option, although limitations such as donor availability and risks of complications exist. This review discusses different approaches to allogeneic HSCT for curing SCD, and highlights the potential of using megadose T-cell-depleted bone marrow in combination with donor-derived CD8 veto T cells under reduced intensity conditioning (RIC).
FRONTIERS IN MEDICINE
(2023)
Article
Pediatrics
Beth Apsel Winger, Susie E. Long, Jordan Brooks, Ashish O. Gupta, Christopher C. Dvorak, Janel Renee Long-Boyle
Summary: This article discusses a systematic process for reviewing concomitant medications to avoid drug-drug interactions with conditioning agents in pediatric patients undergoing alloHCT. It provides detailed timelines for discontinuation or modification of common concomitant medications, and addresses scenarios where discontinuation is not an option. The article also includes a table of alternative psychiatric medications to address problematic DDIs.
FRONTIERS IN PEDIATRICS
(2021)
Review
Clinical Neurology
Zhuo Wang, Munan Zhao, Sujun Gao
Summary: The incidence of epileptic seizures after allogeneic hematopoietic stem cell transplantation has raised concerns among clinicians for its impact on patient survival and quality of life. This review aims to elucidate the incidence, etiologies, mechanisms, clinical manifestations, therapeutic schedule, and prognosis of post-transplantation seizures to improve doctors' understanding and management of this complication for better patient outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Letter
Biophysics
Kai Littlejohn, Kelly Tomlinson, Saro H. Armenian, Ryotaro Nakamura, Mohamed L. Sorror, Jeannine S. McCune
BONE MARROW TRANSPLANTATION
(2021)
Article
Biochemical Research Methods
Jeannine S. McCune, Jozefa S. McKiernan, Erik van Maarseveen, Alwin D. R. Huitema, Timothy W. Randolph, H. Joachim Deeg, Ryotaro Nakamura, K. Scott Baker
Summary: Busulfan-based conditioning is commonly used in allogeneic hematopoietic cell transplant. A study identified potential biomarkers for relapse and acute GVHD in HCT patients receiving targeted busulfan. Pathways involving cysteine/methionine, glycine/serine/threonine, arginine/proline, and D-arginine/D-ornithine metabolism were associated with relapse and acute GVHD in this cohort. Larger studies are needed to validate these findings.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Oncology
Aminah Jatoi, Fang-Shu Ou, Daniel H. Ahn, Tyler J. Zemla, Jennifer G. Le-Rademacher, Patrick Boland, Kristen K. Ciombor, Nisha L. Jacobs, Boris Pasche, James M. Cleary, Jeannine S. McCune, Katrina S. Pedersen, Afsaneh Barzi, E. Gabriela Chiorean, Erica N. Heying, Heinz-Josef Lenz, Jeff A. Sloan, Axel Grothey, Mario E. Lacouture, Tanios Bekaii-Saab
Summary: A study shows that preemptive use of clobetasol can reduce the incidence and severity of hand-foot skin reactions caused by regorafenib, which has a positive impact on patients' quality of life.
Review
Pharmacology & Pharmacy
Emily J. Cox, Dan-Dan Tian, John D. Clarke, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine
Summary: The article discusses the potential risks of botanical drugs on drug metabolism and provides a method for developing and applying models for pharmacokinetic interactions.
PHARMACOLOGICAL REVIEWS
(2021)
Article
Medical Laboratory Technology
Jeannine S. McCune, Arjen M. Punt, Rosa F. Yeh, L. Lee Dupuis, Dina M. Kweekel, Eric J. F. Franssen, James C. Ritchie, Erik van Maarseveen, Alwin D. R. Huitema
Summary: A novel interlaboratory proficiency program was developed to evaluate busulfan quantitation, pharmacokinetic modeling, and dosing, aiming to improve accuracy in laboratories. The results suggest that additional educational efforts and proficiency rounds are needed to ensure appropriate busulfan dosing.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Biophysics
Albert C. Yeh, Paul O'Donnell, Gary Schoch, Paul J. Martin, Chris McFarland, Jeannine S. McCune, Jason P. Cooper, Kris Doney, Mary E. D. Flowers, Mohamed L. Sorror, Frederick R. Appelbaum, Barry E. Storer, Ted Gooley, H. Joachim Deeg
Summary: In this study, long-term outcomes in MDS and AML patients receiving different conditioning regimens were evaluated, with BuFluTHY conditioning associated with lower rates of chronic GVHD and long-term mixed T-cell chimerism, but potentially higher risks of relapse and non-relapse mortality.
BONE MARROW TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Jeannine S. McCune, Ryotaro Nakamura, Denis O'Meally, Timothy W. Randolph, Brenda M. Sandmaier, Aleksandra Karolak, David Hockenbery, Sandi L. Navarro
Summary: This study used global metabolomics to identify endogenous metabolomic compounds associated with the clearance of 4-hydroxycyclophosphamide (4HCY), a cytotoxic metabolite of cyclophosphamide (CY). The results showed that certain metabolites were associated with 4HCY clearance at different time points, suggesting the potential of pharmacometabolomics in optimizing the use of CY.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Review
Medicine, Research & Experimental
Emily J. Cox, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine
Summary: Pharmacokinetic drug interactions caused by botanical and natural products are not well studied, due to the challenges associated with their complex chemistries and variability. This Recommended Approach aims to provide guidance for designing clinical pharmacokinetic studies of natural products and their interactions with drugs, in order to bridge the gap between regulatory agencies' guidance and current research efforts.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Engineering, Biomedical
Minqiang Wang, Yiran Yang, Jihong Min, Yu Song, Jiaobing Tu, Daniel Mukasa, Cui Ye, Changhao Xu, Nicole Heflin, Jeannine S. McCune, Tzung K. Hsiai, Zhaoping Li, Wei Gao
Summary: A wearable electrochemical biosensor has been developed to continuously detect trace levels of multiple metabolites and nutrients in sweat during physical exercise and at rest, providing real-time monitoring and assessment of health risks and nutritional status.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Medicine, Research & Experimental
Sandi L. Navarro, Zihan Zheng, Timothy W. Randolph, Ryotaro Nakamura, Brenda M. Sandmaier, David Hockenbery, Jeannine S. McCune
Summary: Biomarker-guided dosing could potentially improve the effectiveness and safety of cyclophosphamide (CY), but evaluating its association with CY plasma concentration-time curve (AUC) is time-consuming. This study aimed to identify lipidomic biomarkers associated with 4-hydroxycyclophosphamide (4HCY) formation clearance in hematopoietic cell transplant patients receiving CY. The results showed the feasibility of lipidomics but further studies are needed to optimize CY dosing in larger samples.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jeannine S. McCune, Sandi L. Navarro, K. Scott Baker, Linda J. Risler, Brian R. Phillips, Timothy W. Randolph, Laura Shireman, H. Gary Schoch, H. Joachim Deeg, Yuzheng Zhang, Alex Men, Loes Maton, Alwin D. R. Huitema
Summary: A linear regression model of 13 endogenous metabolomic compounds (EMCs) can be used to predict an individual's busulfan clearance (BuCL) before administration. This pharmacometabolomics method is more effective than using a busulfan test dose or pharmacogenomics to guide dosing.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Guofang Shen, Kao Tang Ying Moua, Kathryn Perkins, Deron Johnson, Arthur Li, Peter Curtin, Wei Gao, Jeannine S. McCune
Summary: Sirolimus, a mTOR inhibitor, is prescribed to treat various diseases in children. Precision dosing through therapeutic drug monitoring is the current standard of care, but variability in pharmacokinetics, toxicity, and effectiveness still exists. Model-informed precision dosing and pharmacogenomic tools should be further explored. Point-of-care quantitation of sirolimus using dried blood spots is not recommended.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Jeannine S. McCune, Saro H. Armenian, Ryotaro Nakamura, Haoyue Shan, Christopher G. Kanakry, Marco Mielcarek, Wei Gao, Donald E. Mager
Summary: This study assessed the feasibility of using the Medication Event Monitoring (MEMS (R)) Cap to improve immunosuppressant adherence and treatment outcomes in allogeneic hematopoietic cell transplant (HCT) recipients. The results showed that only 25.9% of the participants used the MEMS (R) Cap, indicating a need for further investigation on its feasibility in HCT recipients.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Medicine, Research & Experimental
Jeannine S. Mccune, Sandi L. Navarro, Linda J. Risler, Brian R. Phillips, Suping Ren, H. Gary Schoch, K. Scott Baker
Summary: Busulfan metabolites are present in patients' plasma before allograft infusion, but are not associated with clinical outcomes. However, pre-graft endogenous metabolomic compounds (EMCs) are statistically significantly associated with neutrophil nadir.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
John D. Clarke, Sabrina M. Judson, Dan-Dan Tian, Trevor O. Kirby, Rakshit S. Tanna, Adrienn Matula-Pentek, Miklos Horvath, Matthew E. Layton, John R. White, Nadja B. Cech, Kenneth E. Thummel, Jeannine S. Mccune, Danny D. Shen, Mary F. Paine
Summary: This study found that green tea had a pharmacokinetic interaction with raloxifene that was opposite to the predicted effect. The results suggested that one or more processes involved in intestinal absorption were affected. MRP3 was the only identified transporter that may contribute to the interaction. There was no evidence that green tea interrupted raloxifene enterohepatic recycling through inhibition of bacterial beta-glucuronidase activity. The existing gut microbiota may interact with green tea to influence raloxifene stool recovery.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
