Article
Transplantation
Yasar Caliskan, Gonca Karahan, Sebahat Usta Akgul, Safak Mirioglu, Yasemin Ozluk, Halil Yazici, Erol Demir, Ahmet B. Dirim, Aydin Turkmen, John Edwards, Fatma Oguz Savran, Mehmet S. Sever, Krzysztof Kiryluk, Ali Gharavi, Krista L. Lentine
Summary: The study revealed that recipients with the GG genotype of LIMS1 have a higher risk of TCMR after kidney transplantation, suggesting the importance of LIMS1 in allograft rejection. However, the GG genotype was not significantly associated with allograft loss.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Immunology
Qinfan Yao, Cuili Wang, Yucheng Wang, Wenyu Xiang, Yin Chen, Qin Zhou, Jianghua Chen, Hong Jiang, Dajin Chen
Summary: This study identified key differentially expressed genes (DEGs) in acute allograft rejection (AR) and found that they have the potential to be used as biomarkers for early-stage AR diagnosis. The expression of these genes can reflect the immune status of patients with AR.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Priyanka Jethwani, Arundati Rao, Laurine Bow, Madhav C. Menon
Summary: Although there have been significant improvements in the rates of acute allograft rejection, kidney allograft longevity has not seen proportional improvements. Recent research suggests that anti-donor immune mechanisms play a role in cases of allograft loss, even without overt evidence of acute rejection. In addition to evaluating highly polymorphic HLA genes, specific variants in donor and recipient genes outside of the HLA loci have been shown to impact transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Garrett S. Dunlap, Daniel DiToro, Joel Henderson, Sujal I. Shah, Mike Manos, Mariano Severgnini, Astrid Weins, Indira Guleria, Patrick A. Ott, Naoka Murakami, Deepak A. Rao
Summary: Kidney transplant recipients are at risk for tumors and are often treated with immune checkpoint inhibitors (ICIs), but this therapy can lead to transplant rejection. In this study, TCR sequencing was used to track and identify alloreactive T cells in a melanoma patient who experienced kidney transplant rejection after PD-1 inhibition. The patient showed an increase in alloreactive CD8(+) T cell clones in the blood, which had a unique transcriptomic signature and were also found in the rejected kidney but not in tumor sites. Longitudinal and cross-tissue TCR analyses revealed unintended expansion of alloreactive CD8(+) T cells induced by ICI therapy, coinciding with organ rejection.
NATURE COMMUNICATIONS
(2023)
Article
Medical Laboratory Technology
Hyun Ji Lee, Kyung-Hwa Shin, Il Young Kim, Byung Hyun Choi, Hyung-Hoi Kim
Summary: This study found that anti-ETAR antibodies are associated with AMR, and patients with both anti-ETAR antibodies and de novo HLA DSAs were at a high risk of AMR.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Urology & Nephrology
Greg Knoll, Patricia Campbell, Michael Chasse, Dean Fergusson, Tim Ramsay, Priscilla Karnabi, Jeffrey Perl, Andrew A. House, Joseph Kim, Olwyn Johnston, Rahul Mainra, Isabelle Houde, Dana Baran, Darin J. Treleaven, Lynne Senecal, Lee Anne Tibbles, Marie-Josee Hebert, Christine White, Martin Karpinski, John S. Gill
Summary: This study investigated the use of immunosuppressants in patients with kidney transplant failure and found that prolonged use of immunosuppressants for more than 2 years was not associated with an increased risk of death or hospitalized infection. However, continued use of immunosuppressants did not prevent rejection of the failed allograft or an increase in anti-HLA antibodies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Biochemistry & Molecular Biology
Karsten Suhre, Darshana M. Dadhania, John Richard Lee, Thangamani Muthukumar, Qiuying Chen, Steven S. Gross, Manikkam Suthanthiran
Summary: Noninvasive biomarkers of kidney allograft status, measured through urine metabolites, can serve as indicators of rejection events; while metabolite profiles are effective for discriminating rejection biopsies, estimated Glomerular Filtration Rate (eGFR) also plays a significant role in the metabolite signal.
Article
Medicine, General & Internal
Luc Colas, Linh Bui, Clarisse Kerleau, Mohamed Lemdani, Karine Autain-Renaudin, Antoine Magnan, Magali Giral, Sophie Brouard
Summary: This study found that blood count eosinophils (BCEo) greater than 0.3 G/L may increase the risk of organ rejection in kidney transplant recipients, independent of donor specific antibodies or graft survival. Further mechanistic research is needed to understand the role of eosinophils in allo-immunity.
Review
Urology & Nephrology
Alexandre Loupy, Michael Mengel, Mark Haas
Summary: The Banff classification has become the main reference for the scoring of kidney allograft biopsies, gaining overwhelming international acceptance. Since its establishment in 1991, Banff conferences have been held every two years, resulting in continuous revisions and expansions of the classification, forming a multidisciplinary and international community.
KIDNEY INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Jinwen Lin, Junhao Lv, Xianping Yu, Xing Xue, Shiping Yu, Huiping Wang, Jianghua Chen
Summary: A genetic engineered membrane-coated nanoparticle called DSA trapper, inspired by the affinity of bacterial proteins for antibodies, is able to efficiently adsorb and clear alloreactive antibodies, restoring single-cell transcriptional heterogeneity. DSA trappers absorbed antibodies through heterophagic clearance, reducing IgG deposition and complement activation, providing an immune tolerant niche for restoration of single-cell genetic architecture. In allogeneic transplantation mice, DSA trapper improved glomerular filtration rate and prolonged survival. Overall, DSA trapper offers a promising approach for treating alloantibody-mediated immune injury.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Urology & Nephrology
Christina Lai, Steven J. Chadban, Yik Wen Loh, Tony King-Tak Kwan, Chuanmin Wang, Julian Singer, Paula Niewold, Zheng Ling, Alanna Spiteri, Daniel Getts, Nicholas Jonathan Cole King, Huiling Wu
Summary: Inflammatory monocytes are a major component of acute kidney transplant rejection. This study investigates the therapeutic potential of immune-modifying nanoparticles (IMPs) in preventing kidney allograft rejection. The results show that IMPs significantly reduce acute rejection, improve kidney function, and inhibit inflammatory cell density and cytokine expression. However, IMPs do not offer protection against chronic rejection.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Anil Dangi, Irma Husain, Collin Z. Jordan, Shuangjin Yu, Naveen Natesh, Xiling Shen, Jean Kwun, Xunrong Luo
Summary: This study found that resident macrophages in the donor kidney rapidly expanded during the early stages of kidney transplantation and were induced to express high levels of Ccl8. This led to the infiltration of recipient monocytes, their differentiation into resident macrophages, and subsequent expression of Ccl8. Enhanced infiltration of recipient T cells followed. Targeting the CCL8-CCR8 axis shows promise for reducing early kidney allograft inflammation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Immunology
Randi Lassiter, Todd D. Merchen, Xuexiu Fang, Youli Wang
Summary: Renal tubular epithelial cells (TECs) are the primary targets in kidney transplantation, with rejection and ischemia-reperfusion injury affecting them. Alterations in Bcl2 family proteins, reduction of TJP1, and TEC-specific KMO contribute to TEC injury in rejection allografts. Cytokines IFN gamma, TNF alpha, and IL1 beta are triggers of TEC injury by affecting the expression of Bcl2, BID, and TJP1. The reduction of KMO is associated with allograft rejection and TEC injury, while 3HK and 3HAA protect TEC from injury and prevent rejection by increasing the expression of Bcl-xL and TJP1. Administration of DNA nanoparticles inducing expression of IDO and KMO can improve allograft outcome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Transplantation
Marco van Londen, Jessica van der Weijden, Robert S. Niznik, Aidan F. Mullan, Stephan J. L. Bakker, Stefan P. Berger, Ilja M. Nolte, Jan-Stephan F. Sanders, Gerjan Navis, Andrew D. Rule, Martin H. de Borst
Summary: A new model was developed to predict post-donation measured glomerular filtration rate (mGFR) based on pre-donation serum creatinine, age, and sex. The model showed good accuracy and precision in predicting mGFR, and performed well in high-risk subgroups.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Medicine, General & Internal
Amarens van der Vaart, Martin H. de Borst, Stephan J. L. Bakker, Margery A. Connelly, Peter R. van Dijk, Robin P. F. Dullaart
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Urology & Nephrology
Xiujie Liang, Tamas Aranyi, Jianfu Zhou, Yuting Guan, Hailong Hu, Hongbo Liu, Katalin Susztak
Summary: This study shows that Tet2 and Tet3 play key roles in kidney development and nephron endowment. These proteins regulate gene expression by catalyzing active DNA hydroxymethylation and also have important functions in signaling pathways. The loss of Tet2 and Tet3 leads to defective nephron formation, resulting in kidney failure and perinatal death.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Laura J. Smyth, Katie R. Kerr, Jill Kilner, Aine E. McGill, Alexander P. Maxwell, Amy Jayne McKnight
Summary: This study analyzed the DNA methylation of kidney transplant recipients and identified markers associated with the risk of transplant complications. The findings provide an important reference for future epigenetic studies on posttransplant complications.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Surgery
Tristan McIntosh, Payton Puerzer, Miah T. T. Li, Gregory Malat, Chelsea Sammons, Maxwell Norris, Tara Fallah, Jennifer Trofe-Clark, James M. M. DuBois, Ana Iltis, Sumit Mohan, Deirdre Sawinski
Summary: This study aimed to understand the attitudes and concerns of female solid organ transplant recipients regarding contraception and pregnancy after transplantation. The results showed that the most common concerns among transplant recipients were fetal and maternal health complications, and there was overall support for shared decision-making regarding pregnancy after transplantation.
CLINICAL TRANSPLANTATION
(2023)
Editorial Material
Biochemistry & Molecular Biology
Amin Abedini, Konstantin A. Kloetzer, Katalin Susztak
Article
Urology & Nephrology
Miko Yu, Kristen L. King, S. Ali Husain, Anne M. Huml, Rachel E. Patzer, Jesse D. Schold, Sumit Mohan
Summary: This study examined differences in reported deaths among kidney transplant candidates and recipients in three transplant datasets. The results showed large discrepancies in patient outcomes reported across datasets, raising questions about their completeness.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Jesse D. Schold, Anne M. Huml, S. Ali Husain, Sumit Mohan
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Farah Lizotte, Marina Rousseau, Benoit Denhez, Dominique Levesque, Andreanne Guay, Hongbo Liu, Julie Moreau, Sarah Higgins, Robert Sabbagh, Katalin Susztak, Francois-Michel Boisvert, Anne Marie Cote, Pedro Geraldes
Summary: Clinical and experimental data suggest that podocyte injury is involved in the onset and progression of diabetic kidney disease. The protein tyrosine phosphatase SHP-1 plays a major role in the survival and function of podocytes, and its expression is increased in diabetes. The podocyte-specific deletion of SHP-1 can prevent DKD progression and preserve podocyte function.
KIDNEY INTERNATIONAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Tamas Szili-Torok, Yuanxin Xu, Martin H. H. de Borst, Stephan J. L. Bakker, Uwe J. F. Tietge
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Joanna Sophia J. Vinke, Alan R. Gorter, Michele F. Eisenga, Wendy A. Dam, Peter van der Meer, Jacob van den Born, Stephan J. L. Bakker, Martijn F. Hoes, Martin H. de Borst
Summary: Loss of muscle mass is associated with impaired quality of life and increased risk of morbidity and mortality. Iron deficiency has been found to affect muscle mass and function. Studies on a large population-based cohort and cultured skeletal myoblasts and myocytes have shown that iron deficiency contributes to loss of muscle mass and impaired cellular function.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Medicine, General & Internal
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Igor Gouveia Pietrobom, Ana Cristina Carvalho de Matos, Martin H. H. De Borst, Ita Pfeferman Heilberg
Summary: The study investigated the association of urinary calcium with serum sclerostin, bone mineral density, and body composition in stone formers. The results showed that serum sclerostin is associated with urinary calcium levels, suggesting a potential additional role of sclerostin in calcium reabsorption in the kidneys.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Krzysztof Kiryluk, Daniel E. Freedberg, Jai Radhakrishnan, Leslie Segall, Judith S. Jacobson, Mohit Mathur, Sumit Mohan, Alfred I. Neugut
Summary: The reported incidence of IgA nephropathy varies widely across different studies and populations, with higher rates found in Asian populations and among male patients. However, there is no consensus regarding the relationship between race and IgA nephropathy. Future studies should report incidence rates by race/ethnicity and consider the demographic characteristics of the population for accurate comparisons.
Meeting Abstract
Surgery
David Cron, Syed Husain, Kristen King, Sumit Mohan, Joel Adler
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
J. Casper Swarte, Tim J. Knobbe, Johannes R. Bjork, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Summary: This study investigates the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients. The results show that multiple bacterial species are associated with lower HRQoL in this population, and physical and mental HRQoL explain a significant part of the variance in the gut microbiome. Additionally, metabolic and neuroactive pathways are also associated with lower HRQoL, suggesting potential modifiable factors to improve HRQoL.
NATURE COMMUNICATIONS
(2023)