Hepcidin and its therapeutic potential in neurodegenerative disorders

Treating Alzheimer's disease by targeting iron

(2019) Sara Nikseresht et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ferroptosis as a novel therapeutic target for Friedreich's ataxia

(2019) M. Grazia Cotticelli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Emerging Roles of Ferroptosis in Huntington’s Disease

(2019) Yajing Mi et al.   NEUROMOLECULAR MEDICINE

The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls

(2019) Camille Petillon et al.   Frontiers in Neuroscience

A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron metabolism gene

(2019) Shicheng Guo et al.   BLOOD

Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis

(2018) Alessandro Matte et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepcidin agonists as therapeutic tools

(2018) Carla Casu et al.   BLOOD

Phenotyping rare hepcidin deficiency

(2018) Edouard Bardou-Jacquet   BLOOD

Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease

(2018) Kam Sandhu et al.   BLOOD

Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study

(2018) Shu-yang Yu et al.   BMC Neurology

Advances in understanding iron metabolism and its crosstalk with erythropoiesis

(2018) Clara Camaschella et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey

(2018) Andreas M Hohlbaum et al.   BRITISH JOURNAL OF PHARMACOLOGY

CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage

(2018) Jun Zhao et al.   EXPERIMENTAL NEUROLOGY

Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism

(2018) Yashuo Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erythropoietic regulators of iron metabolism

(2018) Tomas Ganz   FREE RADICAL BIOLOGY AND MEDICINE

Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.

(2018) Cornel S. G. Mirciov et al.   HAEMATOLOGICA

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Hepcidin, an emerging and important player in brain iron homeostasis

(2018) Driton Vela   Journal of Translational Medicine

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

(2018) Douglas G. Peters et al.   Metallomics

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

(2018) Mechelle M. Lewis et al.   MOVEMENT DISORDERS

Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6−/− Neurons and Astrocytes Treated with Lipopolysaccharides

(2018) Juan Ma et al.   NEUROCHEMICAL RESEARCH

Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain

(2018) Jin A. Shin et al.   NEUROPHARMACOLOGY

Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology

(2018) Romina María Uranga et al.   Oxidative Medicine and Cellular Longevity

The Aging of Iron Man

(2018) Azhaar Ashraf et al.   Frontiers in Aging Neuroscience

Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.

(2018) Cornel S. G. Mirciov et al.   HAEMATOLOGICA

Hypoxia enhances H 2 O 2 -mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation

(2018) Inês Silva et al.   Redox Biology

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

Target identification of hepcidin production inhibitors by a combination of chemical proteomics and radioactive compound binding assay

(2018) Masato Sasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives

(2018) Takeshi Fukuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling

(2018) Carine Fillebeen et al.   BLOOD

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Metal Theory of Alzheimer's Disease

(2018) Ashley I. Bush   JOURNAL OF ALZHEIMERS DISEASE

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging

(2018) Erika P. Raven et al.   JOURNAL OF ALZHEIMERS DISEASE

Production of bioactive hepcidin by recombinant DNA tagging with an elastin-like recombinamer

(2018) A. da Costa et al.   New Biotechnology

Quantitative Susceptibility MRI to Detect Brain Iron in Amyotrophic Lateral Sclerosis

(2018) Julio Acosta-Cabronero et al.   RADIOLOGY

Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease

(2018) Norishi Ueda et al.   Nutrients

Inflammation, Hemolysis, and Erythropoiesis Lead to Competitive Regulation of Hepcidin and Possibly Systemic Iron Status in Sickle Cell Disease

(2018) Yelena Z. Ginzburg et al.   EBioMedicine

Liver iron sensing and body iron homeostasis

(2018) Chia-Yu Wang et al.   BLOOD

Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load

(2018) Carine Fillebeen et al.   BLOOD

The catalytic, stem, and transmembrane portions of matriptase-2 are required for suppressing the expression of the iron-regulatory hormone hepcidin

(2018) Peizhong Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin and iron regulatory proteins coordinately regulate ferroportin 1 expression in the brain of mice

(2018) Lan Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Dual Role of Hepcidin in Brain Iron Load and Inflammation

(2018) Driton Vela   Frontiers in Neuroscience

Reciprocal regulation between hepcidin and erythropoiesis and its therapeutic application in erythroid disorders

(2017) Caiyi Wang et al.   EXPERIMENTAL HEMATOLOGY

Functional expression and purification of recombinant Hepcidin25 production in Escherichia coli using SUMO fusion technology

(2017) Vahideh Sadr et al.   GENE

Imatinib and spironolactone suppress hepcidin expression

(2017) Katarzyna Mleczko-Sanecka et al.   HAEMATOLOGICA

Cystathionine β-synthase is required for body iron homeostasis

(2017) Yu-Fu Zhou et al.   HEPATOLOGY

Aceruloplasminaemia: a disorder of diabetes and neurodegeneration

(2017) Genevieve L. Calder et al.   INTERNAL MEDICINE JOURNAL

Cortical Iron Reflects Severity of Alzheimer’s Disease

(2017) Sara van Duijn et al.   JOURNAL OF ALZHEIMERS DISEASE

Interleukin-1β (IL-1β) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein δ (C/EBPδ) expression in hepatocytes

(2017) Yohei Kanamori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron transport proteins: Gateways of cellular and systemic iron homeostasis

(2017) Mitchell D. Knutson   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron homeostasis: An anthropocentric perspective

(2017) Richard Coffey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

(2017) Mastura Wahedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain iron accumulation in Wilson's disease: A longitudinal imaging case study during anticopper treatment using 7.0T MRI and transcranial sonography

(2017) Petr Dusek et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia

(2017) Pamela J. Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study

(2017) Scott Ayton et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

CSF ferritin predicts CSF Aβ decline in biomarker-determined Alzheimer’s disease

(2017) James R Connor   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Hepcidin: a real-time biomarker of iron need

(2017) Dominic J. Hare   Metallomics

Non-Anticoagulant Heparins Are Hepcidin Antagonists for the Treatment of Anemia

(2017) Maura Poli et al.   MOLECULES

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models

(2017) Tamar Amit et al.   NEUROPHARMACOLOGY

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

(2017) Sant-Rayn Pasricha et al.   Nature Communications

Imatinib and spironolactone suppress hepcidin expression

(2017) Katarzyna Mleczko-Sanecka et al.   HAEMATOLOGICA

Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease

(2017) Zohara Sternberg et al.   Aging and Disease

Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain

(2017) Fa-Li Zhang et al.   Frontiers in Molecular Neuroscience

Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

(2017) Sandra L. Ross et al.   Frontiers in Pharmacology

Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron

(2017) Yu-Fu Zhou et al.   Frontiers in Physiology

Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

(2017) Ashley I. Bush   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Regulation of Hepcidin by Erythropoiesis: The Story So Far

(2016) Sant-Rayn Pasricha et al.   Annual Review of Nutrition

A diagnostic approach for neurodegeneration with brain iron accumulation: clinical features, genetics and brain imaging

(2016) Rubens Paulo Araújo Salomão et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B

(2016) Céline Besson-Fournier et al.   BLOOD

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Iron and dopamine: a toxic couple

(2016) Dominic J. Hare et al.   BRAIN

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toll-Like Receptor 4/MyD88–Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral HemorrhageClinical Perspective

(2016) Xiao-Yi Xiong et al.   CIRCULATION

Neurodegeneration with Brain Iron Accumulation

(2016) Susanne A. Schneider   Current Neurology and Neuroscience Reports

Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain

(2016) Jing Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron Homeostasis in Health and Disease

(2016) Raffaella Gozzelino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain biometals and Alzheimer's disease – boon or bane?

(2016) Atish Prakash et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes

(2016) Simeng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron metabolism and related genetic diseases: A cleared land, keeping mysteries

(2016) Pierre Brissot et al.   JOURNAL OF HEPATOLOGY

Role of iron in neurodegenerative diseases

(2016) Kai Li et al.   JOURNAL OF NEURAL TRANSMISSION

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells

(2016) Mariia Lunova et al.   JOURNAL OF PATHOLOGY

Iron chelation in the treatment of neurodegenerative diseases

(2016) Petr Dusek et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Nucleic acid oxidative damage in Alzheimer's disease—explained by the hepcidin-ferroportin neuronal iron overload hypothesis?

(2016) Tim Hofer et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Iron and the liver

(2016) Antonello Pietrangelo   LIVER INTERNATIONAL

Brain Iron Metabolism Dysfunction in Parkinson’s Disease

(2016) Hong Jiang et al.   MOLECULAR NEUROBIOLOGY

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

(2016) Li-Na Lu et al.   MOLECULAR NEUROBIOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

(2016) Dominic J. Hare et al.   NEUROIMAGE

Is aceruloplasminemia treatable? Combining iron chelation and fresh-frozen plasma treatment

(2016) L. Poli et al.   NEUROLOGICAL SCIENCES

Brain iron accumulation in Wilson disease: a post mortem 7 Tesla MRI - histopathological study

(2016) P. Dusek et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

(2016) Joana S. Cristóvão et al.   Oxidative Medicine and Cellular Longevity

Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages?

(2016) Lucie Hopes et al.   PLoS One

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

(2016) Pavle Matak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse

(2016) Rosa Maria Pellegrino et al.   Scientific Reports

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

Pharmacological Targeting of the Hepcidin/Ferroportin Axis

(2016) Giada Sebastiani et al.   Frontiers in Pharmacology

Multimodal MRI Evaluation of the MitoPark Mouse Model of Parkinson’s Disease

(2016) Linlin Cong et al.   PLoS One

Neurodegeneration with Brain Iron Accumulation: Genetic Diversity and Pathophysiological Mechanisms

(2015) Esther Meyer et al.   Annual Review of Genomics and Human Genetics

An overview of molecular basis of iron metabolism regulation and the associated pathologies

(2015) Bruno Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Thiol-derivatized minihepcidins retain biological activity

(2015) Eileen Fung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease

(2015) Guillaume Grolez et al.   BMC Neurology

Expression and cellular localization of hepcidin mRNA and protein in normal rat brain

(2015) Ruma Raha-Chowdhury et al.   BMC NEUROSCIENCE

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Hepcidin and iron disorders: new biology and clinical approaches

(2015) J. Arezes et al.   International Journal of Laboratory Hematology

Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation

(2015) Paul J. Schmidt   JOURNAL OF BIOLOGICAL CHEMISTRY

Progesterone receptor membrane component-1 regulates hepcidin biosynthesis

(2015) Xiang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurodegenerative diseases and therapeutic strategies using iron chelators

(2015) Roberta J. Ward et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease

(2015) Eleonora Carboni et al.   Metallomics

Iron and Neurodegeneration: Is Ferritinophagy the Link?

(2015) Giorgio Biasiotto et al.   MOLECULAR NEUROBIOLOGY

Insights into the Antimicrobial Properties of Hepcidins: Advantages and Drawbacks as Potential Therapeutic Agents

(2015) Lisa Lombardi et al.   MOLECULES

Is early-life iron exposure critical in neurodegeneration?

(2015) Dominic J. Hare et al.   Nature Reviews Neurology

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

(2015) Douglas G. Peters et al.   NEUROBIOLOGY OF DISEASE

Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories

(2015) C. E. Arber et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple Sclerosis

(2015) Lukas Haider   Oxidative Medicine and Cellular Longevity

The iron-regulatory hormone hepcidin: A possible therapeutic target?

(2015) Luc Rochette et al.   PHARMACOLOGY & THERAPEUTICS

Modulation of hepcidin to treat iron deregulation: potential clinical applications

(2015) Nicole L. Blanchette et al.   Expert Review of Hematology

Bone Morphogenetic Proteins as Regulators of Iron Metabolism

(2014) Nermi L. Parrow et al.   Annual Review of Nutrition

Activity of Potent and Selective Host Defense Peptide Mimetics in Mouse Models of Oral Candidiasis

(2014) Lisa K. Ryan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: Maintenance of brain iron homeostasis

(2014) Sanghamitra Bandyopadhyay et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Modulation of Hepcidin as Therapy for Primary and Secondary Iron Overload Disorders

(2014) Paul J. Schmidt et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Iron dysregulation in Huntington's disease

(2014) Michelle Muller et al.   JOURNAL OF NEUROCHEMISTRY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Lipopolysaccharides Upregulate Hepcidin in Neuron via Microglia and the IL-6/STAT3 Signaling Pathway

(2014) Zhong-Ming Qian et al.   MOLECULAR NEUROBIOLOGY

Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats

(2014) Fang Du et al.   MOLECULAR NEUROBIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Iron in multiple sclerosis: roles in neurodegeneration and repair

(2014) Erin Stephenson et al.   Nature Reviews Neurology

MRI for Iron Mapping in Alzheimer's Disease

(2014) Christian Langkammer et al.   Neurodegenerative Diseases

Aceruloplasminemia

(2014) Hiroaki Miyajima   NEUROPATHOLOGY

The pathophysiology and pharmacology of hepcidin

(2014) Piotr Ruchala et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Hepcidin antagonists for potential treatments of disorders with hepcidin excess

(2014) Maura Poli et al.   Frontiers in Pharmacology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities

(2013) Neena Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

The liver: conductor of systemic iron balance

(2013) D. Meynard et al.   BLOOD

Regulation of systemic iron homeostasis

(2013) Karin E. Finberg   CURRENT OPINION IN HEMATOLOGY

Huntingtonʼs disease and Huntingtonʼs disease-like syndromes

(2013) Felix Gövert et al.   CURRENT OPINION IN NEUROLOGY

A convenient luminescence assay of ferroportin internalization to study its interaction with hepcidin

(2013) Ge Song et al.   FEBS Journal

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

(2013) Orly Weinreb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manipulation of the hepcidin pathway for therapeutic purposes

(2013) E. Fung et al.   HAEMATOLOGICA

The small molecule, genistein, increases hepcidin expression in human hepatocytes

(2013) Aileen W. Zhen et al.   HEPATOLOGY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Neonatal E. Coli Infection Causes Neuro-Behavioral Deficits Associated with Hypomyelination and Neuronal Sequestration of Iron

(2013) J. C. Lieblein-Boff et al.   JOURNAL OF NEUROSCIENCE

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up

(2013) Miguel Ulla et al.   PLoS One

Abnormal iron homeostasis and neurodegeneration

(2013) Barry B. Muhoberac et al.   Frontiers in Aging Neuroscience

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action

(2012) Alfons Lawen et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

(2012) E. Ramos et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin

(2012) Xiao Luo et al.   FEBS Journal

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alzheimer’s drugs take a new tack

(2012) Ewen Callaway   NATURE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

The pantheon of the fallen: why are there so many forms of cell death?

(2012) Douglas R. Green et al.   TRENDS IN CELL BIOLOGY

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

(2011) K. E. Finberg et al.   BLOOD

Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response

(2011) Ihtzaz Ahmed Malik et al.   CELL AND TISSUE RESEARCH

Hepcidin directly inhibits transferrin receptor 1 expression in astrocytes via a cyclic AMP-protein kinase a pathway

(2011) Fang Du et al.   GLIA

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice

(2011) Giada Sebastiani et al.   Metallomics

Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

(2011) Guangwei Du et al.   MOVEMENT DISORDERS

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Therapeutic Approach for Neurodegenerative Pathologies: Multitarget Iron-Chelating Drugs Regulating Hypoxia-Inducible Factor 1 Signal Transduction Pathway

(2011) Orly Weinreb et al.   Neurodegenerative Diseases

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

(2011) Hui Ding et al.   PLoS One

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin in human iron disorders: Therapeutic implications

(2010) Antonello Pietrangelo   JOURNAL OF HEPATOLOGY

Brain iron metabolism and its perturbation in neurological diseases

(2010) Robert R. Crichton et al.   JOURNAL OF NEURAL TRANSMISSION

Expression of iron-related genes in human brain and brain tumors

(2009) Milla M Hänninen et al.   BMC NEUROSCIENCE

Role of hepcidin in murine brain iron metabolism

(2009) S.-M. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Altered Iron Metabolism Is Part of the Choroid Plexus Response to Peripheral Inflammation

(2009) F. Marques et al.   ENDOCRINOLOGY

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

Unraveling of the E-helices and Disruption of 4-Fold Pores Are Associated with Iron Mishandling in a Mutant Ferritin Causing Neurodegeneration

(2009) Martin A. Baraibar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chelation therapy for neurodegenerative diseases

(2009) Silvia Bolognin et al.   MEDICINAL RESEARCH REVIEWS

Lipopolysaccharide Induces a Significant Increase in Expression of Iron Regulatory Hormone Hepcidin in the Cortex and Substantia Nigra in Rat Brain

(2008) Qin Wang et al.   ENDOCRINOLOGY

Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration

(2008) Martin A. Baraibar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes

(2008) Xiao Hu Ge et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Midbrain iron content in early Parkinson disease: A potential biomarker of disease status

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