Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia

Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

(2016) Jerzy Leszek et al.   CNS & Neurological Disorders-Drug Targets

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner

(2015) Jun Taneo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amyloid β25–35 induced ROS-burst through NADPH oxidase is sensitive to iron chelation in microglial Bv2 cells

(2015) Kristin Part et al.   BRAIN RESEARCH

Cerebral nitric oxide represses choroid plexus NF B-dependent gateway activity for leukocyte trafficking

(2015) K. Baruch et al.   EMBO JOURNAL

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

(2015) Elena Rodriguez-Vieitez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Iron entry in neurons and astrocytes: a link with synaptic activity

(2015) Franca Codazzi et al.   Frontiers in Molecular Neuroscience

Microglial Aβ Receptors in Alzheimer’s Disease

(2014) Yang Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

3-N-Butylphthalide (NBP) Attenuates the Amyloid-�-Induced Inflammatory Responses in Cultured Astrocytes via the Nuclear Factor-κB Signaling Pathway

(2013) Hong-Mei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

(2013) Willem Kamphuis et al.   NEUROBIOLOGY OF AGING

Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation

(2013) Ângela C. Crespo et al.   NEUROBIOLOGY OF AGING

Cellular Catabolism of the Iron-Regulatory Peptide Hormone Hepcidin

(2013) Gloria Cuevas Preza et al.   PLoS One

A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease

(2013) Gaëlle Naert et al.   Journal of Molecular Cell Biology

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice

(2012) Ying-Hsien Huang et al.   PEPTIDES

Hepcidin Treatment Modulates the Expression of Divalent Metal Transporter-1, Ceruloplasmin, and Ferroportin-1 in the Rat Cerebral Cortex and Hippocampus

(2011) Lin Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

(2011) A. Pagani et al.   BLOOD

Soybean isoflavone alleviates β-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-κB activity in rats

(2011) B.J. Ding et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia

(2011) Tom Schilling et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cognitive and histological disturbances after chlorpyrifos exposure and chronic Aβ(1–42) infusions in Wistar rats

(2011) Ana M. Ruiz-Muñoz et al.   NEUROTOXICOLOGY

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

(2010) Ivana De Domenico et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of water-soluble functionalized multi-walled carbon nanotubes examined by different cytotoxicity methods in human astrocyte D384 and lung A549 cells

(2010) T. Coccini et al.   TOXICOLOGY

Role of hepcidin in murine brain iron metabolism

(2009) S.-M. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Altered Iron Metabolism Is Part of the Choroid Plexus Response to Peripheral Inflammation

(2009) F. Marques et al.   ENDOCRINOLOGY

Activated macrophages induce hepcidin expression in HuH7 hepatoma cells

(2009) P. Matak et al.   HAEMATOLOGICA

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2

(2009) I. De Domenico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease

(2008) C. Balistreri et al.   CURRENT PHARMACEUTICAL DESIGN

Lipopolysaccharide Induces a Significant Increase in Expression of Iron Regulatory Hormone Hepcidin in the Cortex and Substantia Nigra in Rat Brain

(2008) Qin Wang et al.   ENDOCRINOLOGY

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA