Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Regulation of Ferroptotic Cancer Cell Death by GPX4

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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

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(2014) Yulia Y. Tyurina et al.   Nature Chemistry

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

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Characterization of cardiolipins and their oxidation products by LC–MS analysis

(2013) Yulia Y. Tyurina et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice

(2013) Markus Wortmann et al.   CIRCULATION RESEARCH

Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury

(2013) Abolfazl Zarjou et al.   JOURNAL OF CLINICAL INVESTIGATION

Unconventional ROR t+ T Cells Drive Hepatic Ischemia Reperfusion Injury

(2013) E. Eggenhofer et al.   JOURNAL OF IMMUNOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: Formation, targets, and inactivation

(2012) Thomas M. McIntyre   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663

(2012) Nathaniel C. Gilbert et al.   FASEB JOURNAL

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

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Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme

(2011) Alexander M. Mannes et al.   FASEB JOURNAL

Monolysocardiolipin: improved preparation with high yield

(2010) Junhwan Kim et al.   JOURNAL OF LIPID RESEARCH

Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects

(2010) Tamas Kriska et al.   JOURNAL OF LIPID RESEARCH

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

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RIPK1 is not essential for TNFR1-induced activation of NF-κB

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Mitochondrial glutathione peroxidase 4 disruption causes male infertility

(2009) Manuela Schneider et al.   FASEB JOURNAL

Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions

(2009) Hanyu Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Oxidative lipidomics of γ-irradiation-induced intestinal injury

(2007) Yulia Y. Tyurina et al.   FREE RADICAL BIOLOGY AND MEDICINE