Liver iron sensing and body iron homeostasis

Hepcidin agonists as therapeutic tools

(2018) Carla Casu et al.   BLOOD

Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.

(2018) Cornel S. G. Mirciov et al.   HAEMATOLOGICA

Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients

(2018) Deborah Stefanova et al.   INFECTION AND IMMUNITY

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk

(2018) De-Liang Zhang et al.   SCIENCE

Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.

(2018) Cornel S. G. Mirciov et al.   HAEMATOLOGICA

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Overview of iron metabolism in health and disease

(2017) Som Dev et al.   Hemodialysis International

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

(2017) Mastura Wahedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B

(2016) Céline Besson-Fournier et al.   BLOOD

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

(2016) A. Nai et al.   BLOOD

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

(2016) Susanna Canali et al.   BLOOD

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

(2016) Philipp-Sebastian Koch et al.   BLOOD

Hepcidin regulation in the anemia of inflammation

(2016) Chia-Yu Wang et al.   CURRENT OPINION IN HEMATOLOGY

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

(2016) Susanna Canali et al.   ENDOCRINOLOGY

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver

(2016) Ningning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

(2015) A. Pagani et al.   HAEMATOLOGICA

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

(2015) Chloé Latour et al.   HEPATOLOGY

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

(2015) Reiya Taniguchi et al.   Nature Communications

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

(2015) A. Pagani et al.   HAEMATOLOGICA

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

(2014) C. Mayeur et al.   BLOOD

The second transferrin receptor regulates red blood cell production in mice

(2014) A. Nai et al.   BLOOD

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

(2014) X.-g. Wu et al.   BLOOD

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

(2014) Daniel F. Wallace et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

(2014) Thomas Sonnweber et al.   GUT

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

(2014) P. Gutschow et al.   HAEMATOLOGICA

Low Intracellular Iron Increases the Stability of Matriptase-2

(2014) Ningning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans

(2013) Chenxi Tian et al.   DEVELOPMENT

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

(2012) Paul J. Schmidt et al.   AMERICAN JOURNAL OF HEMATOLOGY

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6

(2012) Pauline Lee et al.   BLOOD CELLS MOLECULES AND DISEASES

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

(2012) Sandra L. Ross et al.   Cell Metabolism

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

(2012) Bo Qiao et al.   Cell Metabolism

A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum

(2012) W. Chen et al.   HAEMATOLOGICA

Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

(2012) Zhuzhen Zhang et al.   HEPATOLOGY

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)

(2012) Qifang Wu et al.   PLoS One

Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts

(2011) D.-L. Zhang et al.   BLOOD

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

(2011) K. E. Finberg et al.   BLOOD

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

Liver hemojuvelin protein levels in mice deficient in matriptase-2 (Tmprss6)

(2011) Jan Krijt et al.   BLOOD CELLS MOLECULES AND DISEASES

Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

(2011) Elena Corradini et al.   GASTROENTEROLOGY

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

(2010) K. E. Finberg et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

(2010) D. H. Lee et al.   BLOOD

Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice

(2010) Jan Krijt et al.   BLOOD CELLS MOLECULES AND DISEASES

Altered hepatic BMP signaling pathway in human HFE hemochromatosis

(2010) Giuliano Bolondi et al.   BLOOD CELLS MOLECULES AND DISEASES

BMP6 Treatment Compensates for the Molecular Defect and Ameliorates Hemochromatosis in Hfe Knockout Mice

(2010) Elena Corradini et al.   GASTROENTEROLOGY

Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

(2010) John D. Ryan et al.   HEPATOLOGY

Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression

(2010) Julia E. Maxson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neogenin, a Receptor for Bone Morphogenetic Proteins

(2010) Meiko Hagihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone Morphogenetic Protein-2 and -6 Heterodimer Illustrates the Nature of Ligand-Receptor Assembly

(2010) Michael J. Isaacs et al.   MOLECULAR ENDOCRINOLOGY

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression

(2009) L. Kautz et al.   BLOOD

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis

(2009) Elena Corradini et al.   GASTROENTEROLOGY

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Investigation of the Biophysical and Cell Biological Properties of Ferroportin, a Multipass Integral Membrane Protein Iron Exporter

(2009) Adrian E. Rice et al.   JOURNAL OF MOLECULAR BIOLOGY

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

(2009) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

(2009) Beben Benyamin et al.   NATURE GENETICS

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

(2008) J. Truksa et al.   BLOOD

Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin

(2008) David Kuninger et al.   BMC BIOCHEMISTRY

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

(2008) Maria Vittoria Verga Falzacappa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD

Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site

(2007) Lan Lin et al.   BLOOD CELLS MOLECULES AND DISEASES