Advances in understanding iron metabolism and its crosstalk with erythropoiesis

Imatinib and spironolactone suppress hepcidin expression

(2017) Katarzyna Mleczko-Sanecka et al.   HAEMATOLOGICA

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency

(2017) Gregory D. Lewis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

(2017) Izumi Yanatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

(2017) Mastura Wahedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling

(2017) Nir Cohen et al.   JOURNAL OF CELL SCIENCE

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

(2017) Xiaoyan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

(2017) Moon-Suhn Ryu et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor

(2017) Shadi Khalil et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

(2017) Anthony S. Grillo et al.   SCIENCE

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

(2017) Sant-Rayn Pasricha et al.   Nature Communications

Imatinib and spironolactone suppress hepcidin expression

(2017) Katarzyna Mleczko-Sanecka et al.   HAEMATOLOGICA

Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials

(2017) Nicole U Stoffel et al.   Lancet Haematology

Erythroid cell mitochondria receive endosomal iron by a “kiss-and-run” mechanism

(2016) Amel Hamdi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hepcidin in the diagnosis of iron disorders

(2016) D. Girelli et al.   BLOOD

A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major

(2016) J. L. Fernandes et al.   BLOOD

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

(2016) A. Nai et al.   BLOOD

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

(2016) Susanna Canali et al.   BLOOD

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

(2016) Philipp-Sebastian Koch et al.   BLOOD

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

(2016) Susanna Canali et al.   ENDOCRINOLOGY

Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD

(2016) Thomas Lee et al.   GUT

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

(2016) Igor Theurl et al.   NATURE MEDICINE

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

(2016) Pavle Matak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

(2016) Samira Lakhal-Littleton et al.   eLife

Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women

(2015) D. Moretti et al.   BLOOD

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

Ineffective erythropoiesis and regulation of iron status in iron loading anaemias

(2015) Clara Camaschella et al.   BRITISH JOURNAL OF HAEMATOLOGY

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

(2015) Chloé Latour et al.   HEPATOLOGY

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

(2015) Haifa H Jabara et al.   NATURE GENETICS

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Iron-Deficiency Anemia

(2015) Clara Camaschella   NEW ENGLAND JOURNAL OF MEDICINE

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis

(2015) Alan C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

(2015) Tomasa Barrientos et al.   EBioMedicine

Bmp6 Expression in Murine Liver Non Parenchymal Cells: A Mechanism to Control their High Iron Exporter Activity and Protect Hepatocytes from Iron Overload?

(2015) Marco Rausa et al.   PLoS One

The second transferrin receptor regulates red blood cell production in mice

(2014) A. Nai et al.   BLOOD

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

(2014) K. Mleczko-Sanecka et al.   BLOOD

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload

(2014) Sandro Altamura et al.   Cell Metabolism

Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency

(2014) P. Ponikowski et al.   EUROPEAN HEART JOURNAL

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

(2014) Thomas Sonnweber et al.   GUT

Hematologic parameters predicting a response to oral iron therapy in chronic inflammation

(2014) S. van Santen et al.   HAEMATOLOGICA

The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice

(2014) A. Nai et al.   HAEMATOLOGICA

Low Intracellular Iron Increases the Stability of Matriptase-2

(2014) Ningning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

(2014) Michael Dussiot et al.   NATURE MEDICINE

FIND-CKD: a randomized trial of intravenous ferric carboxymaltose versus oral iron in patients with chronic kidney disease and iron deficiency anaemia

(2014) I. C. Macdougall et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Expression of the Iron Hormone Hepcidin Distinguishes Different Types of Anemia in African Children

(2014) S.-R. Pasricha et al.   Science Translational Medicine

The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

(2013) M. Mastrogiannaki et al.   BLOOD

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin

(2013) Chloé Latour et al.   HEPATOLOGY

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

(2013) Caroline A. Enns et al.   PLoS One

Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption

(2013) Bruno Galy et al.   Cell Reports

Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia

(2012) David B. Bregman et al.   AMERICAN JOURNAL OF HEMATOLOGY

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children

(2012) A. M. Prentice et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

(2012) Marina Bayeva et al.   Cell Metabolism

Circulating Human Hepcidin-25 Concentrations Display a Diurnal Rhythm, Increase with Prolonged Fasting, and Are Reduced by Growth Hormone Administration

(2012) J. S. Troutt et al.   CLINICAL CHEMISTRY

Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis

(2012) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

(2011) K. E. Finberg et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations

(2011) M. Traglia et al.   JOURNAL OF MEDICAL GENETICS

Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis

(2010) H. Forejtnikova et al.   BLOOD

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

(2010) D. Girelli et al.   HAEMATOLOGICA

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE