The Emerging Roles of Ferroptosis in Huntington’s Disease

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

The role of Nrf2 signaling in counteracting neurodegenerative diseases

(2018) Albena T. Dinkova-Kostova et al.   FEBS Journal

Regulation of lipid peroxidation and ferroptosis in diverse species

(2018) Marcus Conrad et al.   GENES & DEVELOPMENT

Regulatory role of calpain in neuronal death

(2018) Kun Xiong et al.   Neural Regeneration Research

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

(2018) Chuanhong Wu et al.   Scientific Reports

Ferroptosis: bug or feature?

(2017) Scott J. Dixon   IMMUNOLOGICAL REVIEWS

Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease

(2017) Thirunavukkarasu Velusamy et al.   Oxidative Medicine and Cellular Longevity

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

(2017) Luisa Quinti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings

(2017) Morris Gerwyn et al.   Current Rheumatology Reports

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glutathione peroxidase 4: a new player in neurodegeneration?

(2016) B R Cardoso et al.   MOLECULAR PSYCHIATRY

Coenzyme Q and Its Role in the Dietary Therapy against Aging

(2016) Alfonso Varela-López et al.   MOLECULES

A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload

(2016) Jirapas Sripetchwandee et al.   NEUROSCIENCE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies

(2016) Maria Jimenez-Sanchez et al.   Cold Spring Harbor Perspectives in Medicine

Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats

(2016) Suwakon Wongjaikam et al.   PLoS One

Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

(2015) J. M. G. van Bergen et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease

(2015) Guillaume Grolez et al.   BMC Neurology

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases

(2015) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease

(2015) Yash B. Joshi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy

(2014) Daniel A. East et al.   CHEMISTRY & BIOLOGY

A Systematic Review and Meta-Analysis of Deferiprone Monotherapy and in Combination with Deferoxamine for Reduction of Iron Overload in Chronically Transfused Patients with β-Thalassemia

(2014) Kevin H.M. Kuo et al.   HEMOGLOBIN

Iron dysregulation in Huntington's disease

(2014) Michelle Muller et al.   JOURNAL OF NEUROCHEMISTRY

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

(2014) Bindu D. Paul et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

Role of oxidative DNA damage in mitochondrial dysfunction and Huntington’s disease pathogenesis

(2013) Sylvette Ayala-Peña   FREE RADICAL BIOLOGY AND MEDICINE

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

(2013) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

PKA modulates iron trafficking in the striatum via small GTPase, Rhes

(2013) B.-R. Choi et al.   NEUROSCIENCE

Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

(2013) Jianfang Chen et al.   PLoS One

Alterations in Brain Transition Metals in Huntington Disease

(2012) H. Diana Rosas et al.   ARCHIVES OF NEUROLOGY

Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

(2012) Richard Grondin et al.   BRAIN

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mutant huntingtin impairs immune cell migration in Huntington disease

(2012) Wanda Kwan et al.   JOURNAL OF CLINICAL INVESTIGATION

The incidence and prevalence of Huntington's disease: A systematic review and meta-analysis

(2012) Tamara Pringsheim et al.   MOVEMENT DISORDERS

N-Acetylcysteine Reverses Mitochondrial Dysfunctions and Behavioral Abnormalities in 3-Nitropropionic Acid-Induced Huntington’s Disease

(2012) Rajat Sandhir et al.   Neurodegenerative Diseases

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

(2012) William M. Johnson et al.   Nutrients

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

(2011) Jodi L McBride et al.   MOLECULAR THERAPY

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

(2010) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid-induced cognitive deficit, glutathione and mitochondrial alterations in animal model of Huntingtonʼs disease

(2010) Puneet Kumar et al.   BEHAVIOURAL PHARMACOLOGY

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant Huntingtin in Glial Cells Exacerbates Neurological Symptoms of Huntington Disease Mice

(2010) Jennifer Bradford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Pathophysiology of Huntingtonʼs disease: from huntingtin functions to potential treatments

(2009) Emmanuel Roze et al.   CURRENT OPINION IN NEUROLOGY

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE