- Home
- Publications
- Publication Search
- Publication Details
Title
Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms
Authors
Keywords
-
Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 64, Issue s1, Pages S379-S395
Publisher
IOS Press
Online
2018-05-29
DOI
10.3233/jad-179944
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases
- (2018) Gerwyn Morris et al. BEHAVIOURAL BRAIN RESEARCH
- Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes
- (2018) Darius J.R. Lane et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis
- (2018) Anja Jelinek et al. FREE RADICAL BIOLOGY AND MEDICINE
- Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer’s Disease Mouse Model
- (2018) Busra Gurel et al. JOURNAL OF ALZHEIMERS DISEASE
- Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice
- (2018) Douglas G. Peters et al. Metallomics
- Neuronal Cell Death
- (2018) Michael Fricker et al. PHYSIOLOGICAL REVIEWS
- Apoptosis and Oxidative Stress in Neurodegenerative Diseases
- (2018) Elena Radi et al. JOURNAL OF ALZHEIMERS DISEASE
- Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models
- (2017) Agnese Gugliandolo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways
- (2017) Tracey A. Rouault et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study
- (2017) Scott Ayton et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells
- (2017) Takayoshi Yamauchi et al. MOLECULAR AND CELLULAR BIOLOGY
- Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
- (2017) Q-z Tuo et al. MOLECULAR PSYCHIATRY
- Ferroptosis and cell death mechanisms in Parkinson's disease
- (2017) Stephanie J. Guiney et al. NEUROCHEMISTRY INTERNATIONAL
- Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)
- (2017) Richard J. Kryscio et al. JAMA Neurology
- Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers
- (2017) Scott Ayton et al. JAMA Neurology
- BID links ferroptosis to mitochondrial cell death pathways
- (2017) Sandra Neitemeier et al. Redox Biology
- Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
- (2017) William Sealy Hambright et al. Redox Biology
- On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death
- (2017) Omkar Zilka et al. ACS Central Science
- Three-Dimensional Tomographic Imaging and Characterization of Iron Compounds within Alzheimer's Plaque Core Material
- (2017) Joanna F. Collingwood et al. JOURNAL OF ALZHEIMERS DISEASE
- Mitochondrial Iron Metabolism and Its Role in Neurodegeneration
- (2017) Maxx P. Horowitz et al. JOURNAL OF ALZHEIMERS DISEASE
- Iron, Copper, and Zinc Concentration in Aβ Plaques in the APP/PS1 Mouse Model of Alzheimer’s Disease Correlates with Metal Levels in the Surrounding Neuropil
- (2016) Simon A. James et al. ACS Chemical Neuroscience
- Ferroptosis: process and function
- (2016) Y Xie et al. CELL DEATH AND DIFFERENTIATION
- Ferroptosis is an autophagic cell death process
- (2016) Minghui Gao et al. CELL RESEARCH
- Mechanisms of ferroptosis
- (2016) Jennifer Yinuo Cao et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The Role of Presenilin in Protein Trafficking and Degradation—Implications for Metal Homeostasis
- (2016) M.A. Greenough JOURNAL OF MOLECULAR NEUROSCIENCE
- Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
- (2016) Abdel A. Belaidi et al. JOURNAL OF NEUROCHEMISTRY
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses
- (2016) Yang Ou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
- (2016) Wan Seok Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferroptosis: Death by Lipid Peroxidation
- (2016) Wan Seok Yang et al. TRENDS IN CELL BIOLOGY
- Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification
- (2016) Jian Yang et al. Scientific Reports
- Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update
- (2015) Melissa A. Bradley-Whitman et al. ARCHIVES OF TOXICOLOGY
- Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease
- (2015) D.J.R. Lane et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability
- (2015) Viktoria Désirée Paul et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- (2015) Liuji Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders
- (2015) Natalia P. Mena et al. MITOCHONDRION
- Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier
- (2015) Annette Burkhart et al. MOLECULAR NEUROBIOLOGY
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Trajectories of memory decline in preclinical Alzheimer's disease: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing
- (2015) Robert H. Pietrzak et al. NEUROBIOLOGY OF AGING
- Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation
- (2015) Jared M. Fine et al. NEUROSCIENCE LETTERS
- Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE
- (2015) Scott Ayton et al. Nature Communications
- Iron entry in neurons and astrocytes: a link with synaptic activity
- (2015) Franca Codazzi et al. Frontiers in Molecular Neuroscience
- Chaperone protein involved in transmembrane transport of iron
- (2014) Izumi Yanatori et al. BIOCHEMICAL JOURNAL
- Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: Maintenance of brain iron homeostasis
- (2014) Sanghamitra Bandyopadhyay et al. BIOCHEMICAL PHARMACOLOGY
- Homeostasis of metals in the progression of Alzheimer’s disease
- (2014) Raúl González-Domínguez et al. BIOMETALS
- sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin
- (2014) R. C. McCarthy et al. EMBO REPORTS
- Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron
- (2014) Scott Ayton et al. FREE RADICAL BIOLOGY AND MEDICINE
- The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!
- (2014) Darius J.R. Lane et al. FREE RADICAL BIOLOGY AND MEDICINE
- Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease
- (2014) Scott Ayton et al. Molecular Neurodegeneration
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
- (2014) Joseph D. Mancias et al. NATURE
- Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease
- (2014) Javier Becerril-Ortega et al. NEUROBIOLOGY OF AGING
- Biometals and Their Therapeutic Implications in Alzheimer’s Disease
- (2014) Scott Ayton et al. Neurotherapeutics
- β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin
- (2014) Bruce X. Wong et al. PLoS One
- Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration
- (2014) Scott Ayton et al. Biomed Research International
- Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease
- (2014) Grazia Isaya Frontiers in Pharmacology
- Special delivery: distributing iron in the cytosol of mammalian cells
- (2014) Caroline C. Philpott et al. Frontiers in Pharmacology
- Iron uptake in quiescent and inflammation-activated astrocytes: A potentially neuroprotective control of iron burden
- (2013) Ilaria Pelizzoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism
- (2013) Darius J.R. Lane et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-κB in aged rat kidney
- (2013) Kyung Jin Jung et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ferroportin and Exocytoplasmic Ferroxidase Activity Are Required for Brain Microvascular Endothelial Cell Iron Efflux
- (2013) Ryan C. McCarthy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin
- (2013) Sebastien Leidgens et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
- (2013) Pamela Urrutia et al. JOURNAL OF NEUROCHEMISTRY
- Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
- (2013) Xinxin Li et al. NEUROSCIENCE LETTERS
- Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders
- (2013) Andrea Steinbicker et al. Nutrients
- A delicate balance: Iron metabolism and diseases of the brain
- (2013) Dominic Hare et al. Frontiers in Aging Neuroscience
- Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action
- (2012) Alfons Lawen et al. ANTIOXIDANTS & REDOX SIGNALING
- Physiologic implications of metal-ion transport by ZIP14 and ZIP8
- (2012) Supak Jenkitkasemwong et al. BIOMETALS
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- The Glutamate Aspartate Transporter (GLAST) Mediates l-Glutamate-Stimulated Ascorbate-Release Via Swelling-Activated Anion Channels in Cultured Neonatal Rodent Astrocytes
- (2012) Darius J. R. Lane et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease
- (2012) T. A. Rouault Disease Models & Mechanisms
- Metallostasis in Alzheimer's disease
- (2012) Scott Ayton et al. FREE RADICAL BIOLOGY AND MEDICINE
- Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1
- (2012) Khizr I. Rathore et al. GLIA
- Coming into View: Eukaryotic Iron Chaperones and Intracellular Iron Delivery: FIGURE 1.
- (2012) Caroline C. Philpott JOURNAL OF BIOLOGICAL CHEMISTRY
- Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
- (2012) Peng Lei et al. NATURE MEDICINE
- Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease
- (2012) Chuang Guo et al. NEUROBIOLOGY OF AGING
- Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
- (2012) Chuang Guo et al. NEUROCHEMISTRY INTERNATIONAL
- Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events
- (2011) Nigel Francis et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Effects of essential fatty acids in iron deficient and sleep-disturbed attention deficit hyperactivity disorder (ADHD) children
- (2011) S Yehuda et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity
- (2011) Pablo Muñoz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx
- (2011) Ilaria Pelizzoni et al. JOURNAL OF NEUROCHEMISTRY
- Linking lipids to Alzheimer's disease: cholesterol and beyond
- (2011) Gilbert Di Paolo et al. NATURE REVIEWS NEUROSCIENCE
- Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron
- (2010) Darius J.R. Lane et al. BIOCHEMICAL JOURNAL
- Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage
- (2010) Paolo Arosio et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
- (2010) James A. Duce et al. CELL
- Two to Tango: Regulation of Mammalian Iron Metabolism
- (2010) Matthias W. Hentze et al. CELL
- Hepatic iron loading in mice increases cholesterol biosynthesis
- (2010) Ross M. Graham et al. HEPATOLOGY
- Cytochrome P450 7A1 Cholesterol 7α-Hydroxylation
- (2010) Raku Shinkyo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1
- (2010) Hyun-Hee Cho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation
- (2010) Beinan Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxidative stress in Alzheimer disease: A possibility for prevention
- (2010) David J. Bonda et al. NEUROPHARMACOLOGY
- Accumulation of Non-Transferrin-Bound Iron by Neurons, Astrocytes, and Microglia
- (2010) Glenda M. Bishop et al. NEUROTOXICITY RESEARCH
- Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
- (2010) D. R. Richardson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger
- (2009) Jaya P. Gnana-Prakasam et al. BIOCHEMICAL JOURNAL
- Specific iron chelators determine the route of ferritin degradation
- (2009) I. De Domenico et al. BLOOD
- Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease
- (2009) Thomas Rival et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Ascorbate and plasma membrane electron transport—Enzymes vs efflux
- (2009) Darius J.R. Lane et al. FREE RADICAL BIOLOGY AND MEDICINE
- MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
- (2009) Mark D. Meadowcroft et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Phosphorylation of soluble tau differs in Pick’s disease and Alzheimer’s disease brains
- (2009) Janet van Eersel et al. JOURNAL OF NEURAL TRANSMISSION
- Maternal Iron Deficiency Alters Essential Fatty Acid and Eicosanoid Metabolism and Increases Locomotion in Adult Guinea Pig Offspring
- (2009) Caroline P. LeBlanc et al. JOURNAL OF NUTRITION
- Function and biogenesis of iron–sulphur proteins
- (2009) Roland Lill NATURE
- HFE polymorphisms affect cellular glutamate regulation
- (2009) Ryan M. Mitchell et al. NEUROBIOLOGY OF AGING
- Brain iron homeostasis and neurodegenerative disease
- (2009) E. E. Benarroch NEUROLOGY
- Activated Src kinases interact with theN-methyl-D-aspartate receptor after neonatal brain ischemia
- (2008) Xiangning Jiang et al. ANNALS OF NEUROLOGY
- Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network
- (2008) Martina U. Muckenthaler et al. Annual Review of Nutrition
- Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease
- (2008) Jack T. Rogers et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
- (2008) Leah R Hanson et al. BMC NEUROSCIENCE
- Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons
- (2008) Jixu Yu et al. BRAIN RESEARCH
- Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
- (2008) Wan Seok Yang et al. CHEMISTRY & BIOLOGY
- Non-transferrin Iron Reduction and Uptake Are Regulated by Transmembrane Ascorbate Cycling in K562 Cells
- (2008) Darius J. R. Lane et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal
- (2008) Domenico Praticò TRENDS IN PHARMACOLOGICAL SCIENCES
- Characterization of Copper Interactions with Alzheimer Amyloid β Peptides
- (2003) Craig S. Atwood et al. JOURNAL OF NEUROCHEMISTRY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started