Iron and dopamine: a toxic couple

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

The protective effect of growth hormone on Cu/Zn superoxide dismutase-mutant motor neurons

(2015) Jin-Young Chung et al.   BMC NEUROSCIENCE

Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution

(2015) Dominic J. Hare et al.   CHEMICAL SOCIETY REVIEWS

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

Quantifying brain iron deposition in patients with Parkinson's disease using quantitative susceptibility mapping, R2 and R2*

(2015) Jeam Haroldo Oliveira Barbosa et al.   MAGNETIC RESONANCE IMAGING

Synchrotron radiation based X-ray fluorescence shows changes in the elemental composition of the human substantia nigra in aged brains

(2015) Artur Dawid Surowka et al.   Metallomics

Selenium, selenoproteins and neurodegenerative diseases

(2015) Bárbara Rita Cardoso et al.   Metallomics

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

(2015) Richard Ortega et al.   MOLECULAR NEUROBIOLOGY

Neuropathology of α-synuclein propagation and braak hypothesis

(2015) Heather McCann et al.   MOVEMENT DISORDERS

Is early-life iron exposure critical in neurodegeneration?

(2015) Dominic J. Hare et al.   Nature Reviews Neurology

Ndfip1 attenuated 6-OHDA–induced iron accumulation via regulating the degradation of DMT1

(2015) Wenting Jia et al.   NEUROBIOLOGY OF AGING

Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons

(2015) Maj Schneider Thomsen et al.   NEUROBIOLOGY OF DISEASE

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

(2015) Simon A. James et al.   Chemical Science

Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier

(2015) Ryan C. McCarthy et al.   Frontiers in Molecular Neuroscience

Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease?

(2014) Marco Bisaglia et al.   AGEING RESEARCH REVIEWS

Unity in the Biochemistry of the Iron-Storage Proteins Ferritin and Bacterioferritin

(2014) Kourosh Honarmand Ebrahimi et al.   CHEMICAL REVIEWS

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Nigrosome imaging with T2*-weighted 3T MRI as a diagnostic marker of Parkinson's disease: a case-control and cross-sectional study of diagnostic accuracy

(2014) Stefan T Schwarz et al.   LANCET

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Glial Cell Ceruloplasmin and Hepcidin Differentially Regulate Iron Efflux from Brain Microvascular Endothelial Cells

(2014) Ryan C. McCarthy et al.   PLoS One

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

(2014) Jason Howitt et al.   PLoS One

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis

(2014) Virginie Licker et al.   PROTEOMICS

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

(2014) Dominic J. Hare et al.   Chemical Science

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

(2013) David N. Hauser et al.   FREE RADICAL BIOLOGY AND MEDICINE

Risk factors and prodromal markers and the development of Parkinson’s disease

(2013) Stefanie Lerche et al.   JOURNAL OF NEUROLOGY

Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

(2013) Dominic J. Hare et al.   Metallomics

Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy

(2013) Raymond T Bartus et al.   MOLECULAR THERAPY

Copper pathology in vulnerable brain regions in Parkinson's disease

(2013) Katherine M. Davies et al.   NEUROBIOLOGY OF AGING

Pooled analysis of iron-related genes in Parkinson's disease: Association with transferrin

(2013) Shannon L. Rhodes et al.   NEUROBIOLOGY OF DISEASE

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

(2013) Lars Brichta et al.   TRENDS IN NEUROSCIENCES

A delicate balance: Iron metabolism and diseases of the brain

(2013) Dominic Hare et al.   Frontiers in Aging Neuroscience

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Tools to study distinct metal pools in biology

(2012) Elizabeth J. New   DALTON TRANSACTIONS

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies

(2012) Kostas Vekrellis et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Separation of intermediates of iron-catalyzed dopamine oxidation reactions using reversed-phase ion-pairing chromatography coupled in tandem with UV–visible and ESI-MS detections

(2012) Lin Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

(2012) David N. Hauser et al.   NEUROBIOLOGY OF DISEASE

Preclinical Biomarkers of Parkinson Disease

(2011) Yuncheng Wu et al.   ARCHIVES OF NEUROLOGY

Oxidation Chemistry of Catecholamines and Neuronal Degeneration: An Update

(2011) A. Napolitano et al.   CURRENT MEDICINAL CHEMISTRY

High resolution magnetic susceptibility mapping of the substantia nigra in Parkinson's disease

(2011) Ashley K. Lotfipour et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

(2011) Berkin Bilgic et al.   NEUROIMAGE

Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration

(2010) Zhi Dong Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson’s disease

(2010) Zhanyun Lv et al.   JOURNAL OF NEURAL TRANSMISSION

Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?

(2010) K.L. Double et al.   PROGRESS IN NEUROBIOLOGY

Frequency-specific modulation of population-level frequency tuning in human auditory cortex

(2009) Hidehiko Okamoto et al.   BMC NEUROSCIENCE

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide

(2009) Diego Albani et al.   JOURNAL OF NEUROCHEMISTRY

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

(2009) Pier Giorgio Mastroberardino et al.   NEUROBIOLOGY OF DISEASE

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

(2009) J. Howitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Chemical Imaging of the Developmental Phases of Human Neuromelanin Using Synchrotron X-ray Microspectroscopy

(2008) Sylvain Bohic et al.   ANALYTICAL CHEMISTRY

The comparative biology of neuromelanin and lipofuscin in the human brain

(2008) K. L. Double et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipopolysaccharide Induces a Significant Increase in Expression of Iron Regulatory Hormone Hepcidin in the Cortex and Substantia Nigra in Rat Brain

(2008) Qin Wang et al.   ENDOCRINOLOGY

The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study

(2008) Alexandra Gaenslen et al.   LANCET NEUROLOGY

Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models

(2008) Dominic Hare et al.   Metallomics