Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities

Oxidative and Nitrosative Modifications of Biliverdin Reductase-A in the Brain of Subjects with Alzheimer's Disease and Amnestic Mild Cognitive Impairment

(2018) Eugenio Barone et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Overexpression of Heme Oxygenase 1 Promotes Tau Aggregation in Mouse Brain by Inducing Tau Phosphorylation

(2018) Yang Hui et al.   JOURNAL OF ALZHEIMERS DISEASE

HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease

(2018) Fabio Di Domenico et al.   JOURNAL OF ALZHEIMERS DISEASE

Clioquinol Reduces Zinc Accumulation in Neuritic Plaques and Inhibits the Amyloidogenic Pathway in AβPP/PS1 Transgenic Mouse Brain

(2018) Tao Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Deferiprone Reduces Amyloid-β and Tau Phosphorylation Levels but not Reactive Oxygen Species Generation in Hippocampus of Rabbits Fed a Cholesterol-Enriched Diet

(2018) Jaya R.P. Prasanthi et al.   JOURNAL OF ALZHEIMERS DISEASE

Prion Protein Regulates Iron Transport by Functioning as a Ferrireductase

(2018) Ajay Singh et al.   JOURNAL OF ALZHEIMERS DISEASE

Liver Fatty Acid-Binding Protein Gene-Ablated Female Mice Exhibit Increased Age-Dependent Obesity

(2018) Gregory G. Martin et al.   JOURNAL OF NUTRITION

Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

(2017) Sandro Altamura et al.   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

A Low-Molecular-Weight Ferroxidase Is Increased in the CSF of sCJD Cases: CSF Ferroxidase and Transferrin as Diagnostic Biomarkers for sCJD

(2013) Swati Haldar et al.   ANTIOXIDANTS & REDOX SIGNALING

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Role of Reactive Oxygen Species-Mediated Signaling in Aging

(2012) Vyacheslav M. Labunskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

(2012) Pabla Aguirre et al.   BIOMETALS

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action

(2012) Eliška Macková et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Heme Oxygenase/Biliverdin Reductase Pathway in Drug Research and Development

(2012) C. Mancuso et al.   CURRENT DRUG METABOLISM

Neurodegeneration with brain iron accumulation

(2012) Petr Dusek et al.   CURRENT OPINION IN NEUROLOGY

Design of iron chelators with therapeutic application

(2012) Tao Zhou et al.   DALTON TRANSACTIONS

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

(2012) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage

(2012) Martin A. Baraibar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

(2012) Daniela M. Arduíno et al.   HUMAN MOLECULAR GENETICS

Reduction of protein kinase MARK4 in the brains of experimental scrapie rodents and human prion disease correlates with deposits of PrPSc

(2012) HAN-SHI GONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Human Anti-prion Antibodies Block Prion Peptide Fibril Formation and Neurotoxicity

(2012) Xing Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-linked Sideroblastic Anemia Due to Carboxyl-terminal ALAS2 Mutations That Cause Loss of Binding to the β-Subunit of Succinyl-CoA Synthetase (SUCLA2)

(2012) David F. Bishop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism

(2012) Yulia Pollak et al.   JOURNAL OF NEURAL TRANSMISSION

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

(2012) I. Ahmed et al.   JOURNAL OF NEUROSCIENCE

Absorption of Iron from Ferritin Is Independent of Heme Iron and Ferrous Salts in Women and Rat Intestinal Segments

(2012) Elizabeth C. Theil et al.   JOURNAL OF NUTRITION

Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation

(2012) Filip Kielar et al.   Metallomics

PANK2andC19orf12mutations are common causes of neurodegeneration with brain iron accumulation

(2012) Mitra Ansari Dezfouli et al.   MOVEMENT DISORDERS

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Prion propagation, toxicity and degradation

(2012) Adriano Aguzzi et al.   NATURE NEUROSCIENCE

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

(2012) David N. Hauser et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein expression is modulated at the translational level by iron

(2012) Fabia Febbraro et al.   NEUROREPORT

Analysis of ATP13A2 in large neurodegeneration with brain iron accumulation (NBIA) and dystonia-parkinsonism cohorts

(2012) Michael C. Kruer et al.   NEUROSCIENCE LETTERS

Copper Chelator Induced Efficient Episodic Memory Recovery in a Non-Transgenic Alzheimer’s Mouse Model

(2012) Johnatan Ceccom et al.   PLoS One

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia

(2012) M. Whitnall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndromes of Neurodegeneration With Brain Iron Accumulation

(2012) Susanne A. Schneider et al.   Seminars in Pediatric Neurology

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity

(2012) Erin K. Butler et al.   PLoS Genetics

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

Absence of an Orphan Mitochondrial Protein, C19orf12, Causes a Distinct Clinical Subtype of Neurodegeneration with Brain Iron Accumulation

(2011) Monika B. Hartig et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Neuroimaging Features of Neurodegeneration with Brain Iron Accumulation

(2011) M.C. Kruer et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Knockout Mouse Models of Iron Homeostasis

(2011) Robert E. Fleming et al.   Annual Review of Nutrition

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

(2011) Rommy von Bernhardi et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease

(2011) Alzbeta Trancikova et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of mitochondrial complex I inhibition on Fe–S cluster protein activity

(2011) Natalia P. Mena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

(2011) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Structure–Function Analysis of Friedreich’s Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe–S Assembly Complex

(2011) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

(2011) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transition metal homeostasis: from yeast to human disease

(2011) Mark R. Bleackley et al.   BIOMETALS

Iron chaperones for mitochondrial Fe–S cluster biosynthesis and ferritin iron storage

(2011) Poorna Subramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Childhood disorders of neurodegeneration with brain iron accumulation (NBIA)

(2011) MANJU A KURIAN et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

The molecular basis of iron overload disorders and iron-linked anemias

(2011) Jerry Kaplan et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Isd11p Protein Activates the Mitochondrial Cysteine Desulfurase Nfs1p Protein

(2011) Alok Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms

(2011) Daniel F. Tardiff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

(2011) Cesare Mancuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

(2011) Katherine C. M. Chew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Ceruloplasmin Oxidation, a Feature of Parkinson's Disease CSF, Inhibits Ferroxidase Activity and Promotes Cellular Iron Retention

(2011) S. Olivieri et al.   JOURNAL OF NEUROSCIENCE

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Change in the characteristics of ferritin induces iron imbalance in prion disease affected brains

(2011) Ajay Singh et al.   NEUROBIOLOGY OF DISEASE

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

(2011) M. Decressac et al.   NEUROBIOLOGY OF DISEASE

A novel deletion–insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype

(2011) Marguerite V. Evans-Galea et al.   NEUROGENETICS

MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

(2011) Berkin Bilgic et al.   NEUROIMAGE

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Decreased CSF Transferrin in sCJD: A Potential Pre-Mortem Diagnostic Test for Prion Disorders

(2011) Ajay Singh et al.   PLoS One

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex

(2011) Stéphane Schmucker et al.   PLoS One

Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity

(2011) Alberto Granzotto et al.   PLoS One

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

(2011) Suh Young Jeong et al.   PLoS One

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA)

(2010) Michael C. Kruer et al.   ANNALS OF NEUROLOGY

Iron Homeostasis and the Inflammatory Response

(2010) Marianne Wessling-Resnick   Annual Review of Nutrition

Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities

(2010) Orly Weinreb et al.   ANTIOXIDANTS & REDOX SIGNALING

Friedreich Ataxia: Molecular Mechanisms, Redox Considerations, and Therapeutic Opportunities

(2010) Renata Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

(2010) Darius J.R. Lane et al.   BIOCHEMICAL JOURNAL

The crystal structure of human GLRX5: iron–sulfur cluster co-ordination, tetrameric assembly and monomer activity

(2010) Catrine Johansson et al.   BIOCHEMICAL JOURNAL

Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease

(2010) Hong Ye et al.   BIOCHEMISTRY

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration

(2010) Barry B. Muhoberac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis

(2010) W. Chen et al.   BLOOD

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia

(2010) Daniel Velasco-Sánchez et al.   CEREBELLUM

Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30

(2010) Y. Avramovich-Tirosh et al.   Current Alzheimer Research

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

(2010) Karen Nuytemans et al.   HUMAN MUTATION

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genoprotective Effects of the Green Tea-Derived Polyphenol/Epicatechin Gallate in C6 Astroglial Cells

(2010) Renata T. Abib et al.   JOURNAL OF MEDICINAL FOOD

Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson’s disease

(2010) Zhanyun Lv et al.   JOURNAL OF NEURAL TRANSMISSION

Brain iron metabolism and its perturbation in neurological diseases

(2010) Robert R. Crichton et al.   JOURNAL OF NEURAL TRANSMISSION

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

(2010) Marcus W. Brazier et al.   JOURNAL OF NEUROCHEMISTRY

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

(2010) Drew S. Folk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aceruloplasminemia in a Japanese woman with a novel mutation of CP gene: Clinical presentations and analysis of genetic and molecular pathogenesis

(2010) Ayumi Hida et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy

(2010) Ana G Barbeito et al.   Molecular Neurodegeneration

Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations

(2010) Coro Paisán-Ruiz et al.   NEUROBIOLOGY OF AGING

Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation

(2010) Maura Poli et al.   NEUROBIOLOGY OF DISEASE

Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy

(2010) Xiaoling Deng et al.   NEUROSCIENCE LETTERS

Mechanisms of rotenone-induced proteasome inhibition

(2010) Arthur P. Chou et al.   NEUROTOXICOLOGY

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Mitophagy: the latest problem for Parkinson's disease

(2010) Cristofol Vives-Bauza et al.   TRENDS IN MOLECULAR MEDICINE

Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

(2010) Filippo Prischi et al.   Nature Communications

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

(2010) Rong Shi et al.   PLOS BIOLOGY

Identification of a Novel Mutation in the L Ferritin Iron-Responsive Element Causing Hereditary Hyperferritinemia-Cataract Syndrome

(2009) E. Messa et al.   ACTA HAEMATOLOGICA

Mitochondrial Iron Metabolism and Sideroblastic Anemia

(2009) Alex D. Sheftel et al.   ACTA HAEMATOLOGICA

The dorsal root ganglion in Friedreich’s ataxia

(2009) Arnulf H. Koeppen et al.   ACTA NEUROPATHOLOGICA

Redox Control of Prion and Disease Pathogenesis

(2009) Neena Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane

(2009) Elisabeth M. Froschauer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Specific iron chelators determine the route of ferritin degradation

(2009) I. De Domenico et al.   BLOOD

A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats

(2009) RVM Krishnamurthi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

An extended-release formulation of desferrioxamine for subcutaneous administration

(2009) Tayebeh Toliyat et al.   DRUG DELIVERY

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

(2009) Orly Weinreb et al.   Genes and Nutrition

A new missense mutation in the L ferritin coding sequence associated with elevated levels of glycosylated ferritin in serum and absence of iron overload

(2009) C. Kannengiesser et al.   HAEMATOLOGICA

Frataxin interacts with Isu1 through a conserved tryptophan in its β-sheet

(2009) Sébastien Leidgens et al.   HUMAN MOLECULAR GENETICS

Unraveling of the E-helices and Disruption of 4-Fold Pores Are Associated with Iron Mishandling in a Mutant Ferritin Causing Neurodegeneration

(2009) Martin A. Baraibar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene

(2009) Ana G. Barbeito et al.   JOURNAL OF NEUROCHEMISTRY

Friedreich ataxia: The clinical picture

(2009) Massimo Pandolfo   JOURNAL OF NEUROLOGY

Mitochondrial Ferritin in the Substantia Nigra in Restless Legs Syndrome

(2009) Amanda M. Snyder et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins

(2009) Tracey A. Rouault et al.   METABOLIC BRAIN DISEASE

Overexpression of the yeast frataxin homolog (Yfh1): Contrasting effects on iron–sulfur cluster assembly, heme synthesis and resistance to oxidative stress

(2009) Alexandra Seguin et al.   MITOCHONDRION

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology

A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: Description of clinical features and implications for genotype-phenotype correlations

(2009) Akatsuki Kubota et al.   MOVEMENT DISORDERS

Journal club

(2009) Douglas Kell   NATURE

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

(2009) Pier Giorgio Mastroberardino et al.   NEUROBIOLOGY OF DISEASE

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE

Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis

(2009) Ajay Singh et al.   PLoS One

Prion Protein (PrP) Knock-Out Mice Show Altered Iron Metabolism: A Functional Role for PrP in Iron Uptake and Transport

(2009) Ajay Singh et al.   PLoS One

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

(2009) M. L.-H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

(2009) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

(2009) A. A. Salahudeen et al.   SCIENCE

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

(2009) A. A. Vashisht et al.   SCIENCE

Curcumin in clinical practice: myth or reality?

(2009) Cesare Mancuso et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders

(2009) Ajay Singh et al.   PLoS Pathogens

Disrupted Membrane Homeostasis and Accumulation of Ubiquitinated Proteins in a Mouse Model of Infantile Neuroaxonal Dystrophy Caused by PLA2G6 Mutations

(2008) Ibrahim Malik et al.   AMERICAN JOURNAL OF PATHOLOGY

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

(2008) Elizabeth L. Mackenzie et al.   ANTIOXIDANTS & REDOX SIGNALING

Green Tea Epigallocatechin 3-Gallate Accumulates in Mitochondria and Displays a Selective Antiapoptotic Effect Against Inducers of Mitochondrial Oxidative Stress in Neurons

(2008) Emily K. Schroeder et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

(2008) Jack T. Rogers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Iron metabolism in the anemia of chronic disease

(2008) Günter Weiss   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of iron in mitochondrial function

(2008) Sonia Levi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferritins: A family of molecules for iron storage, antioxidation and more

(2008) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Yeast as a model for studying human neurodegenerative disorders

(2008) Leonor Miller-Fleming et al.   Biotechnology Journal

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator

(2008) Y. Jiao et al.   BLOOD

Clinical features and natural history of neuroferritinopathy caused by the 458dupA FTL mutation

(2008) D. Devos et al.   BRAIN

Fine Tuning of Hepcidin Expression by Positive and Negative Regulators

(2008) Martina U. Muckenthaler   Cell Metabolism

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

(2008) K. Li et al.   HUMAN MOLECULAR GENETICS

Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia

(2008) A. Campanella et al.   HUMAN MOLECULAR GENETICS

Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration

(2008) Martin A. Baraibar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species Regulate Ceruloplasmin by a Novel mRNA Decay Mechanism Involving Its 3′-Untranslated Region

(2008) Nisha Tapryal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide

(2008) Louise K. Charkoudian et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Tim-2 is the receptor for H-ferritin on oligodendrocytes

(2008) Bozho Todorich et al.   JOURNAL OF NEUROCHEMISTRY

Expression of a Mutant Form of the Ferritin Light Chain Gene Induces Neurodegeneration and Iron Overload in Transgenic Mice

(2008) R. Vidal et al.   JOURNAL OF NEUROSCIENCE

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Elevated manganese levels in blood and CNS in human prion disease

(2008) Shirley Hesketh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Protection against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts Using Novel Iron Chelators of the 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone Class

(2008) C. K. Lim et al.   MOLECULAR PHARMACOLOGY

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

(2008) Shuzhen Zhang et al.   NEUROBIOLOGY OF AGING

Genetics of iron regulation and the possible role of iron in Parkinson's disease

(2008) Shannon L. Rhodes et al.   NEUROBIOLOGY OF DISEASE

NEUROFERRITINOPATHY IN A JAPANESE FAMILY WITH A DUPLICATION IN THE FERRITIN LIGHT CHAIN GENE

(2008) E. Ohta et al.   NEUROLOGY

Neurodegeneration associated with genetic defects in phospholipase A2

(2008) A. Gregory et al.   NEUROLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation

(2008) M. Whitnall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cytosolic Iron Chaperone That Delivers Iron to Ferritin

(2008) H. Shi et al.   SCIENCE

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Mechanisms of heme iron absorption: Current questions and controversies

(2008) Adrian R West et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

(2007) Tamar Amit et al.   FASEB JOURNAL

Gated pores in the ferritin protein nanocage

(2007) Elizabeth C. Theil et al.   INORGANICA CHIMICA ACTA

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

(2005) Alessandra Gaeta et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exacerbation of Copper Toxicity in Primary Neuronal Cultures Depleted of Cellular Glutathione

(2003) Anthony R. White et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities

(2003) Boon-Seng Wong et al.   JOURNAL OF NEUROCHEMISTRY