Systemic Iron Homeostasis

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats

(2013) Chia Chi Sun et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

(2012) Paul J. Schmidt et al.   AMERICAN JOURNAL OF HEMATOLOGY

Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice

(2012) Qi Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Known and potential roles of transferrin in iron biology

(2012) Thomas Benedict Bartnikas   BIOMETALS

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

(2012) E. Ramos et al.   BLOOD

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice

(2012) Deborah Chiabrando et al.   BLOOD CELLS MOLECULES AND DISEASES

Iron overload in non-transfusion-dependent thalassemia: a clinical perspective

(2012) Khaled M. Musallam et al.   BLOOD REVIEWS

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

(2012) Sandra L. Ross et al.   Cell Metabolism

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

(2012) Bo Qiao et al.   Cell Metabolism

Binding of Hepcidin to Plasma Proteins

(2012) O. Itkonen et al.   CLINICAL CHEMISTRY

Regulation of iron metabolism in Hamp −/− mice in response to iron-deficient diet

(2012) Patarabutr Masaratana et al.   EUROPEAN JOURNAL OF NUTRITION

Inhibition of hepcidin transcription by growth factors

(2012) Julia B. Goodnough et al.   HEPATOLOGY

A Case of Congenital Dyserythropoietic Anemia Type 1 in a Japanese Adult with a CDAN1 Gene Mutation and an Inappropriately Low Serum Hepcidin-25 Level

(2012) Hiroshi Kawabata et al.   INTERNAL MEDICINE

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

(2012) Deborah Chiabrando et al.   JOURNAL OF CLINICAL INVESTIGATION

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions

(2012) Jeehyea Choi et al.   JOURNAL OF NUTRITION

Absorption of Iron from Ferritin Is Independent of Heme Iron and Ferrous Salts in Women and Rat Intestinal Segments

(2012) Elizabeth C. Theil et al.   JOURNAL OF NUTRITION

Serum levels of the hepcidin-20 isoform in a large general population: The Val Borbera study

(2012) Natascia Campostrini et al.   Journal of Proteomics

The Hypoxia-Inducible Factor-C/EBP  Axis Controls Ethanol-Mediated Hepcidin Repression

(2012) E. R. Anderson et al.   MOLECULAR AND CELLULAR BIOLOGY

Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)

(2012) Qifang Wu et al.   PLoS One

Subcellular Localization of Iron and Heme Metabolism Related Proteins at Early Stages of Erythrophagocytosis

(2012) Constance Delaby et al.   PLoS One

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron

(2011) Jorge J. Pinilla-Tenas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

(2011) W. Chen et al.   BLOOD

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

(2011) K. E. Finberg et al.   BLOOD

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

(2011) A. Pagani et al.   BLOOD

Hepcidin regulation by innate immune and infectious stimuli

(2011) A. E. Armitage et al.   BLOOD

Understanding the Structure/Activity Relationships of the Iron Regulatory Peptide Hepcidin

(2011) Richard J. Clark et al.   CHEMISTRY & BIOLOGY

Antimicrobial peptides important in innate immunity

(2011) Andreas Cederlund et al.   FEBS Journal

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

(2011) M. Mastrogiannaki et al.   HAEMATOLOGICA

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II

(2011) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A possible role for secreted ferritin in tissue iron distribution

(2011) Esther G. Meyron-Holtz et al.   JOURNAL OF NEURAL TRANSMISSION

Host-mediated regulation of superinfection in malaria

(2011) Silvia Portugal et al.   NATURE MEDICINE

Non-HFEHepatic Iron Overload

(2011) Antonello Pietrangelo et al.   SEMINARS IN LIVER DISEASE

Natural History and Management ofHFE-Hemochromatosis

(2011) Eng Gan et al.   SEMINARS IN LIVER DISEASE

Iron disorders of genetic origin: a changing world

(2011) Pierre Brissot et al.   TRENDS IN MOLECULAR MEDICINE

Iron, Meat and Health

(2011) Catherine Geissler et al.   Nutrients

Iron bioavailability and dietary reference values

(2010) Richard Hurrell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

(2010) K. E. Finberg et al.   BLOOD

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

(2010) B. J. Sasu et al.   BLOOD

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2

(2010) K. Maes et al.   BLOOD

Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo

(2010) M. Poli et al.   BLOOD

Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice

(2010) T. B. Bartnikas et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

(2010) D. H. Lee et al.   BLOOD

Detection, evaluation, and management of iron-restricted erythropoiesis

(2010) L. T. Goodnough et al.   BLOOD

Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease

(2010) S.-N. J. Song et al.   BLOOD

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

(2010) L. A. Cohen et al.   BLOOD

Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI)

(2010) Barbra J. Sasu et al.   BLOOD CELLS MOLECULES AND DISEASES

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

(2010) Liviu Vanoaica et al.   Cell Metabolism

Reduction of Serum Hepcidin by Hemodialysis in Pediatric and Adult Patients

(2010) J. Zaritsky et al.   Clinical Journal of the American Society of Nephrology

Inherited disorders of iron metabolism

(2010) Clara Camaschella et al.   CURRENT OPINION IN PEDIATRICS

Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling

(2010) Shan Soe-Lin et al.   EXPERIMENTAL HEMATOLOGY

BMP6 Treatment Compensates for the Molecular Defect and Ameliorates Hemochromatosis in Hfe Knockout Mice

(2010) Elena Corradini et al.   GASTROENTEROLOGY

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

(2010) D. Girelli et al.   HAEMATOLOGICA

Lipid raft-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages

(2010) A. Auriac et al.   HAEMATOLOGICA

Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

(2010) Q. de Mast et al.   HAEMATOLOGICA

The Role of Hepatocyte Hemojuvelin in the Regulation of Bone Morphogenic Protein-6 and Hepcidin Expressionin Vivo

(2010) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Cycling in Iron Uptake, Efflux, and Trafficking

(2010) Daniel J. Kosman   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

(2010) Ivana De Domenico et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferroportin disease: A systematic meta-analysis of clinical and molecular findings

(2010) Roman Mayr et al.   JOURNAL OF HEPATOLOGY

Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation

(2010) Toshihiko Tanno et al.   TRANSFUSION

Mining ferritin iron: 2 pathways

(2009) E. C. Theil   BLOOD

Hepcidin, the hormone of iron metabolism, is bound specifically to  -2-macroglobulin in blood

(2009) G. Peslova et al.   BLOOD

Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation

(2009) R. L. Sham et al.   BLOOD

The molecular basis of hepcidin-resistant hereditary hemochromatosis

(2009) A. Fernandes et al.   BLOOD

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications

(2009) I. Theurl et al.   BLOOD

Not all DMT1 mutations lead to iron overload

(2009) Esther Blanco et al.   BLOOD CELLS MOLECULES AND DISEASES

A novel association between a SNP inCYBRD1and serum ferritin levels in a cohort study ofHFEhereditary haemochromatosis

(2009) Clare C. Constantine et al.   BRITISH JOURNAL OF HAEMATOLOGY

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression

(2009) De-Liang Zhang et al.   Cell Metabolism

Hepcidin--A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease

(2009) J. Zaritsky et al.   Clinical Journal of the American Society of Nephrology

Hepcidin targets ferroportin for degradation in hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

Impaired regulation of serum hepcidin during phlebotomy in patients with chronic hepatitis C

(2009) Ryosuke Sugimoto et al.   HEPATOLOGY RESEARCH

Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression

(2009) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure

(2009) John B. Jordan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemochromatosis and Vibrio vulnificus Wound Infections

(2009) James C. Barton et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Reduced serum hepcidin levels in patients with chronic hepatitis C

(2009) Domenico Girelli et al.   JOURNAL OF HEPATOLOGY

Investigation of the Biophysical and Cell Biological Properties of Ferroportin, a Multipass Integral Membrane Protein Iron Exporter

(2009) Adrian E. Rice et al.   JOURNAL OF MOLECULAR BIOLOGY

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

(2009) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity

(2009) Susana J. Oliveira et al.   PLoS One

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

(2009) S. Soe-Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production

(2009) Misato Hashizume et al.   RHEUMATOLOGY INTERNATIONAL

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

Iron-Refractory Iron Deficiency Anemia

(2009) Karin E. Finberg   SEMINARS IN HEMATOLOGY

Mutations in the Gene Encoding DMT1: Clinical Presentation and Treatment

(2009) Achille Iolascon et al.   SEMINARS IN HEMATOLOGY

Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?

(2009) Duygu-Dee Harrison-Findik   WORLD JOURNAL OF GASTROENTEROLOGY

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

The role of Dcytb in iron metabolism: an update

(2008) Andrew T. McKie   BIOCHEMICAL SOCIETY TRANSACTIONS

Transcripts of ceruloplasmin but not hepcidin, both major iron metabolism genes, exhibit a decreasing pattern along the portocentral axis of mouse liver

(2008) Marie-Bérengère Troadec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I

(2008) H. Tamary et al.   BLOOD

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Immunoassay for human serum hepcidin

(2008) T. Ganz et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

(2008) J. Truksa et al.   BLOOD

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP 

(2008) J. P. Pinto et al.   BLOOD

Current approach to hemochromatosis

(2008) Pierre Brissot et al.   BLOOD REVIEWS

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Involvement of Hepcidin in the Anemia of Multiple Myeloma

(2008) S. Sharma et al.   CLINICAL CANCER RESEARCH

Nramp1 equips macrophages for efficient iron recycling

(2008) Shan Soe-Lin et al.   EXPERIMENTAL HEMATOLOGY

Molecular evolution and characterization of hepcidin gene products in vertebrates

(2008) Kalley B. Hilton et al.   GENE

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

(2008) M. A. Melis et al.   HAEMATOLOGICA

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

(2008) Maria Vittoria Verga Falzacappa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

A Cytosolic Iron Chaperone That Delivers Iron to Ferritin

(2008) H. Shi et al.   SCIENCE

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD

Ferroportin: Lack of evidence for multimers

(2007) Lisa M. Schimanski et al.   BLOOD CELLS MOLECULES AND DISEASES

Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site

(2007) Lan Lin et al.   BLOOD CELLS MOLECULES AND DISEASES

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

(2007) Erika V. Valore et al.   BLOOD CELLS MOLECULES AND DISEASES

Hepatitis C Virus–Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription

(2007) Sohji Nishina et al.   GASTROENTEROLOGY