Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

Mitochondrial Iron Metabolism and Its Role in Neurodegeneration

(2017) Maxx P. Horowitz et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model

(2013) Fabia Febbraro et al.   EXPERIMENTAL NEUROLOGY

Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial

(2013) Anthony HV Schapira et al.   LANCET NEUROLOGY

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Targeting Mitochondria for Neuroprotection in Parkinson's Disease

(2012) Anthony Henry Vernon Schapira   ANTIOXIDANTS & REDOX SIGNALING

Chelating Agents for the Treatment of Systemic Iron Overload

(2012) Y. Ma et al.   CURRENT MEDICINAL CHEMISTRY

Does structural neuroimaging reveal a disturbance of iron metabolism in Parkinson’s disease? Implications from MRI and TCS studies

(2012) Adriane Gröger et al.   JOURNAL OF NEURAL TRANSMISSION

X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons

(2012) Tanja Dučić et al.   JOURNAL OF NEUROCHEMISTRY

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease

(2012) C. Laloux et al.   PHARMACOLOGICAL RESEARCH

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia

(2012) M. Whitnall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease

(2011) Michael Li-Hsuan Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Profile of altered brain iron acquisition in restless legs syndrome

(2011) J. R. Connor et al.   BRAIN

Oxidation Chemistry of Catecholamines and Neuronal Degeneration: An Update

(2011) A. Napolitano et al.   CURRENT MEDICINAL CHEMISTRY

The Mitochondrial Dynamics of Alzheimers Disease and Parkinsons Disease Offer Important Opportunities for Therapeutic Intervention

(2011) David J. Bonda et al.   CURRENT PHARMACEUTICAL DESIGN

H-ferritin is the major source of iron for oligodendrocytes

(2011) Bozho Todorich et al.   GLIA

A pilot trial of deferiprone for neurodegeneration with brain iron accumulation

(2011) G. Abbruzzese et al.   HAEMATOLOGICA

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes

(2011) Olivier Rascol et al.   LANCET NEUROLOGY

The potential application of iron chelators for the treatment of neurodegenerative diseases

(2011) Robert C. Hider et al.   Metallomics

Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

(2011) Guangwei Du et al.   MOVEMENT DISORDERS

NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis

(2011) Paolo Montuschi et al.   THORAX

Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities

(2010) Orly Weinreb et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development

(2010) Stefania Recalcati et al.   ANTIOXIDANTS & REDOX SIGNALING

Magnetic resonance imaging markers of Parkinson’s disease nigrostriatal signature

(2010) Patrice Péran et al.   BRAIN

Rescuing iron-overloaded macrophages by conservative relocation of the accumulated metal

(2010) Yang-Sung Sohn et al.   BRITISH JOURNAL OF PHARMACOLOGY

Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulationThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Or Kakhlon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia

(2010) Daniel Velasco-Sánchez et al.   CEREBELLUM

Iron chelation and neuroprotection in neurodegenerative diseases

(2010) Xuping Li et al.   JOURNAL OF NEURAL TRANSMISSION

Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson’s disease after peripheral administration

(2010) David T. Dexter et al.   JOURNAL OF NEURAL TRANSMISSION

Study of brain anatomy with high-field MRI: recent progress

(2010) Jozef H. Duyn   MAGNETIC RESONANCE IMAGING

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Deferiprone Chelation Therapy for Thalassemia Major

(2009) R. Galanello et al.   ACTA HAEMATOLOGICA

Glutathione—a review on its role and significance in Parkinson’s disease

(2009) Heather L. Martin et al.   FASEB JOURNAL

Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity

(2009) Donna W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anemia or low hemoglobin levels preceding Parkinson disease: A case-control study

(2009) R. Savica et al.   NEUROLOGY

A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease

(2009) C. Warren Olanow et al.   NEW ENGLAND JOURNAL OF MEDICINE

MRI assessment of basal ganglia iron deposition in Parkinson's disease

(2008) Lauren I. Wallis et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

(2008) Francisco Molina-Holgado et al.   JOURNAL OF NEUROCHEMISTRY

Increased oxidative damage in peripheral blood correlates with severity of Parkinson's disease

(2008) Chiung-Mei Chen et al.   NEUROBIOLOGY OF DISEASE

Intracellular labile iron

(2007) William Breuer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of iron acquisition and storage: consequences for iron-linked disorders

(2007) Ivana De Domenico et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY