Iron Homeostasis in Health and Disease

The Pathophysiology of Heme in the Brain

(2016) Raffaella Gozzelino   Current Alzheimer Research

Iron deficiency anaemia

(2016) Anthony Lopez et al.   LANCET

The importance of eukaryotic ferritins in iron handling and cytoprotection

(2015) P. Arosio et al.   BIOCHEMICAL JOURNAL

Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability

(2015) Viktoria Désirée Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

New insights into iron regulation and erythropoiesis

(2015) Airie Kim et al.   CURRENT OPINION IN HEMATOLOGY

The Iron age of host-microbe interactions

(2015) M. P. Soares et al.   EMBO REPORTS

Anemia: progress in molecular mechanisms and therapies

(2015) Vijay G Sankaran et al.   NATURE MEDICINE

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

The importance of iron in pathophysiologic conditions

(2015) Raffaella Gozzelino et al.   Frontiers in Pharmacology

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload

(2014) Sandro Altamura et al.   Cell Metabolism

Anemia of Inflammation

(2014) Elizabeta Nemeth et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Regulation of cellular iron metabolism and its implications in lung cancer progression

(2014) Wei Xiong et al.   MEDICAL ONCOLOGY

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

Perioperative anemia management in colorectal cancer patients: A pragmatic approach

(2014) Manuel Muñoz   WORLD JOURNAL OF GASTROENTEROLOGY

Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control

(2014) Caiguo Zhang   Protein & Cell

Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

(2014) Caiguo Zhang et al.   Protein & Cell

HFE gene variants, iron, and lipids: a novel connection in Alzheimer’s disease

(2014) Fatima Ali-Rahmani et al.   Frontiers in Pharmacology

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

(2014) Gregory M. Vercellotti et al.   Frontiers in Pharmacology

The extrahepatic role of TFR2 in iron homeostasis

(2014) Laura Silvestri et al.   Frontiers in Pharmacology

Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major

(2014) A. John Baksi et al.   Frontiers in Pharmacology

Atherogenesis and iron: from epidemiology to cellular level

(2014) Francesca Vinchi et al.   Frontiers in Pharmacology

The physiological functions of iron regulatory proteins in iron homeostasis - an update

(2014) De-Liang Zhang et al.   Frontiers in Pharmacology

The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders

(2014) Bruce X. Wong et al.   Frontiers in Pharmacology

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia

(2014) Stylianos Kosmidis et al.   Frontiers in Pharmacology

Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms

(2014) Sonia Levi et al.   Frontiers in Pharmacology

Ferritin polarization and iron transport across monolayer epithelial barriers in mammals

(2014) Esther G. Meyron-Holtz et al.   Frontiers in Pharmacology

Expression of ABCG2 (BCRP) in mouse models with enhanced erythropoiesis

(2014) Gladys O. Latunde-Dada et al.   Frontiers in Pharmacology

Pathophysiology of the Belgrade rat

(2014) Tania Veuthey et al.   Frontiers in Pharmacology

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

(2014) Christal A. Worthen et al.   Frontiers in Pharmacology

Iron at the interface of immunity and infection

(2014) Manfred Nairz et al.   Frontiers in Pharmacology

Mechanisms of iron metabolism in Caenorhabditis elegans

(2014) Cole P. Anderson et al.   Frontiers in Pharmacology

The role of iron metabolism as a mediator of macrophage inflammation and lipid handling in atherosclerosis

(2014) Anwer Habib et al.   Frontiers in Pharmacology

Physiological implications of NTBI uptake by T lymphocytes

(2014) Jorge P. Pinto et al.   Frontiers in Pharmacology

Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases

(2014) Guofen Gao et al.   Frontiers in Pharmacology

Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation

(2014) Alain Martelli et al.   Frontiers in Pharmacology

Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis

(2014) Amanda B. Core et al.   Frontiers in Pharmacology

Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease

(2014) Grazia Isaya   Frontiers in Pharmacology

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders

(2014) Pamela J. Urrutia et al.   Frontiers in Pharmacology

The role of iron in anthracycline cardiotoxicity

(2014) Elena Gammella et al.   Frontiers in Pharmacology

Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism

(2014) Tamara Korolnek et al.   Frontiers in Pharmacology

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

Iron deficiency in the elderly population, revisited in the hepcidin era

(2014) Fabiana Busti et al.   Frontiers in Pharmacology

Influence of host iron status on Plasmodium falciparum infection

(2014) Martha A. Clark et al.   Frontiers in Pharmacology

Iron, anemia and hepcidin in malaria

(2014) Natasha Spottiswoode et al.   Frontiers in Pharmacology

Special delivery: distributing iron in the cytosol of mammalian cells

(2014) Caroline C. Philpott et al.   Frontiers in Pharmacology

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

The role of TMPRSS6/matriptase-2 in iron regulation and anemia

(2014) Chia-Yu Wang et al.   Frontiers in Pharmacology

The role of iron in the skin and cutaneous wound healing

(2014) Josephine A. Wright et al.   Frontiers in Pharmacology

Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism

(2014) Lu Zhao et al.   Frontiers in Pharmacology

The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light

(2014) Joanna F. Collingwood et al.   Frontiers in Pharmacology

Hepcidin antagonists for potential treatments of disorders with hepcidin excess

(2014) Maura Poli et al.   Frontiers in Pharmacology

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Hepcidin and ferritin blood level as noninvasive tools for predicting breast cancer

(2013) R. Orlandi et al.   ANNALS OF ONCOLOGY

Coupling Heme and Iron Metabolism via Ferritin H Chain

(2013) Raffaella Gozzelino et al.   ANTIOXIDANTS & REDOX SIGNALING

Dietary Iron Concentration May Influence Aging Process by Altering Oxidative Stress in Tissues of Adult Rats

(2013) Lorena Fernandes Arruda et al.   PLoS One

Regional siderosis: a new challenge for iron chelation therapy

(2013) Zvi Ioav Cabantchik et al.   Frontiers in Pharmacology

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanisms of free radical-induced damage to DNA

(2012) Miral Dizdaroglu et al.   FREE RADICAL RESEARCH

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

(2012) Deborah Chiabrando et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

(2012) Rasmus Larsen et al.   Frontiers in Pharmacology

Ironing Out Cancer

(2011) S. V. Torti et al.   CANCER RESEARCH

Host-mediated regulation of superinfection in malaria

(2011) Silvia Portugal et al.   NATURE MEDICINE

Anemia in cancer

(2010) M. Dicato et al.   ANNALS OF ONCOLOGY

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY

Iron and Colorectal Cancer Risk: Human Studies

(2010) Richard L. Nelson   NUTRITION REVIEWS

The molecular basis of hepcidin-resistant hereditary hemochromatosis

(2009) A. Fernandes et al.   BLOOD

The association of biomarkers of iron status with peripheral arterial disease in US adults

(2009) Andy Menke et al.   BMC Cardiovascular Disorders

Altered iron metabolism, inflammation, transferrin receptors, and ferritin expression in non-small-cell lung cancer

(2009) Suzana Kukulj et al.   MEDICAL ONCOLOGY

FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

(2009) Andrew J. Deans et al.   MOLECULAR CELL

Molecular mechanisms of oxidative stress-induced carcinogenesis: From epidemiology to oxygenomics

(2008) Shinya Toyokuni   IUBMB LIFE

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle

(2008) A. K. Sendamarai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE