Hepcidin and the Iron-Infection Axis

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children

(2012) A. M. Prentice et al.   BLOOD

Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children

(2012) M. Gwamaka et al.   CLINICAL INFECTIOUS DISEASES

Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C

(2012) John D. Ryan et al.   HEPATOLOGY

Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis

(2012) Meghan A. Baker et al.   JOURNAL OF INFECTIOUS DISEASES

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Hepcidin regulation by innate immune and infectious stimuli

(2011) A. E. Armitage et al.   BLOOD

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Host-mediated regulation of superinfection in malaria

(2011) Silvia Portugal et al.   NATURE MEDICINE

Malaria impairs resistance to Salmonella through heme- and heme oxygenase–dependent dysfunctional granulocyte mobilization

(2011) Aubrey J Cunnington et al.   NATURE MEDICINE

Investigation of a Researcher's Death Due to Septicemic Plague

(2011) Karen M. Frank et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

(2010) B. J. Sasu et al.   BLOOD

Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

(2010) John D. Ryan et al.   HEPATOLOGY

Role of Ferroportin in Macrophage-Mediated Immunity

(2010) E. E. Johnson et al.   INFECTION AND IMMUNITY

Both Hemolytic Anemia and Malaria Parasite-Specific Factors Increase Susceptibility to Nontyphoidal Salmonella enterica Serovar Typhimurium Infection in Mice

(2010) C. M. Roux et al.   INFECTION AND IMMUNITY

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin induces HIV-1 transcription inhibited by ferroportin

(2010) Min Xu et al.   Retrovirology

Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction

(2009) Joann M McDermid et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

(2009) T. Tanno et al.   BLOOD

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

Reduced serum hepcidin levels in patients with chronic hepatitis C

(2009) Domenico Girelli et al.   JOURNAL OF HEPATOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity

(2009) Susana J. Oliveira et al.   PLoS One

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

Assessment of Urinary Concentrations of Hepcidin Provides Novel Insight into Disturbances in Iron Homeostasis during Malarial Infection

(2008) Quirijn de Mast et al.   JOURNAL OF INFECTIOUS DISEASES

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE