Iron and the liver

Pathogens, Metabolic Adaptation, and Human Diseases—An Iron-Thrifty Genetic Model

(2015) Antonello Pietrangelo   GASTROENTEROLOGY

Genetics, Genetic Testing, and Management of Hemochromatosis: 15 Years Since Hepcidin

(2015) Antonello Pietrangelo   GASTROENTEROLOGY

Exome sequencing inHFEC282Y homozygous men with extreme phenotypes identifies aGNPATvariant associated with severe iron overload

(2015) Christine E. McLaren et al.   HEPATOLOGY

Dysregulated iron homeostasis is strongly associated with multiorgan failure and early mortality in acute-on-chronic liver failure

(2015) Jaswinder Singh Maras et al.   HEPATOLOGY

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

(2014) Thomas Sonnweber et al.   GUT

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis

(2014) F. Stickel et al.   HUMAN MOLECULAR GENETICS

MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription

(2014) Kimberly B. Zumbrennen-Bullough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

(2014) Beben Benyamin et al.   Nature Communications

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

(2013) Wen Guo et al.   AGING CELL

Total Mortality by Elevated Transferrin Saturation in Patients With Diabetes

(2013) Christina Ellervik et al.   DIABETES CARE

Gluconeogenic Signals Regulate Iron Homeostasis via Hepcidin in Mice

(2013) Chiara Vecchi et al.   GASTROENTEROLOGY

Testosterone Induces Erythrocytosis via Increased Erythropoietin and Suppressed Hepcidin: Evidence for a New Erythropoietin/Hemoglobin Set Point

(2013) E. Bachman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Iron Metabolism Is Associated With Adipocyte Insulin Resistance and Plasma Adiponectin: The Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study

(2012) N. Wlazlo et al.   DIABETES CARE

Inhibition of hepcidin transcription by growth factors

(2012) Julia B. Goodnough et al.   HEPATOLOGY

Patatin-like phospholipase domain containing-3gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis

(2012) Luca Valenti   WORLD JOURNAL OF GASTROENTEROLOGY

Elevated Transferrin Saturation and Risk of Diabetes: Three population-based studies

(2011) C. Ellervik et al.   DIABETES CARE

Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease

(2011) Kris V. Kowdley et al.   HEPATOLOGY

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

(2011) Mirco Castoldi et al.   JOURNAL OF CLINICAL INVESTIGATION

EASL clinical practice guidelines for HFE hemochromatosis

(2010)   JOURNAL OF HEPATOLOGY

Porphyrias

(2010) Hervé Puy et al.   LANCET

HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2009) Luca Valenti et al.   GASTROENTEROLOGY

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

Marked Iron in Liver Explants in the Absence of Major Hereditary Hemochromatosis Gene Defects: A Risk Factor for Cardiac Failure

(2009) Hubert Fenton et al.   TRANSPLANTATION

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

(2008) Kouichi Miura et al.   HEPATOLOGY

Hepatitis C Virus–Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription

(2007) Sohji Nishina et al.   GASTROENTEROLOGY