Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging

(2018) Erika P. Raven et al.   JOURNAL OF ALZHEIMERS DISEASE

Elevation of Zinc Transporter ZnT3 Protein in the Cerebellar Cortex of the AβPP/PS1 Transgenic Mouse

(2017) Wei Zheng et al.   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Free Superoxide is an Intermediate in the Production of H2 O2 by Copper(I)-Aβ Peptide and O2

(2015) Karine Reybier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation

(2015) Ping Hou et al.   NEUROBIOLOGY OF AGING

Metal chaperones prevent zinc-mediated cognitive decline

(2015) Paul A. Adlard et al.   NEUROBIOLOGY OF DISEASE

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

(2015) Polina Egorova et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability

(2015) Sónia S. Leal et al.   Frontiers in Cellular Neuroscience

The complexities of the pathology–pathogenesis relationship in Alzheimer disease

(2014) Rudy J. Castellani et al.   BIOCHEMICAL PHARMACOLOGY

Alzheimer disease therapeutics: Focus on the disease and not just plaques and tangles

(2014) Khalid Iqbal et al.   BIOCHEMICAL PHARMACOLOGY

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Characterization of New Specific Copper Chelators as Potential Drugs for the Treatment of Alzheimer’s Disease

(2014) Michel Nguyen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Amyloid precursor protein and neural development

(2014) M. Nicolas et al.   DEVELOPMENT

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing

(2014) Bong Hwan Park et al.   FEBS LETTERS

Genetic markers for diagnosis and pathogenesis of Alzheimer's disease

(2014) Dong Hee Kim et al.   GENE

Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis

(2014) Diego Sepulveda-Falla et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of biometal profiles in neurological disorders

(2014) Stefanie Pfaender et al.   Metallomics

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease

(2014) Javier Becerril-Ortega et al.   NEUROBIOLOGY OF AGING

Calcium regulates the interaction of amyloid precursor protein with Homer3 protein

(2014) Elli Kyratzi et al.   NEUROBIOLOGY OF AGING

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

S100A9 Knockout Decreases the Memory Impairment and Neuropathology in Crossbreed Mice of Tg2576 and S100A9 Knockout Mice Model

(2014) Hee Jin Kim et al.   PLoS One

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade

(2013) Chao Wang et al.   ACTA NEUROPATHOLOGICA

Familial Alzheimer's disease-linked presenilin-1 mutation M146V affects store-operated calcium entry: Does gain look like loss?

(2013) M. Ryazantseva et al.   BIOCHIMIE

Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

(2013) Stefanie Grabrucker et al.   BRAIN

Review article What causes alzheimer’s disease?

(2013) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease

(2013) Kamran Honarnejad et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Copper enhances APP dimerization and promotes Aβ production

(2013) Yasuha Noda et al.   NEUROSCIENCE LETTERS

Intrinsically Disordered and Aggregation Prone Regions Underlie β-Aggregation in S100 Proteins

(2013) Sofia B. Carvalho et al.   PLoS One

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Rapid Exchange of Metal between Zn7–Metallothionein-3 and Amyloid-β Peptide Promotes Amyloid-Related Structural Changes

(2012) Jeppe T. Pedersen et al.   BIOCHEMISTRY

Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

(2012) Gözde Eskici et al.   BIOCHEMISTRY

Metal ions as modulators of protein conformation and misfolding in neurodegeneration

(2012) Sónia S. Leal et al.   COORDINATION CHEMISTRY REVIEWS

The Role of the Anti-Amyloidogenic Secretase ADAM10 in Shedding the APP-like Proteins

(2012) Kristina Endres et al.   Current Alzheimer Research

Functions of S100 Proteins

(2012) R. Donato et al.   CURRENT MOLECULAR MEDICINE

Pro-Inflammatory S100A8 and S100A9 Proteins: Self-Assembly into Multifunctional Native and Amyloid Complexes

(2012) Thomas Vogl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Amyloid Precursor Protein Copper Binding Domain Histidine Residues 149 and 151 Mediate APP Stability and Metabolism

(2012) Loredana Spoerri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A)

(2012) Xu-Ying Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ1–42 with Cu ions

(2012) Ying Luo et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work

(2012) Jong-Heon Kim et al.   JOURNAL OF NEUROCHEMISTRY

Alteration of the Cerebral Zinc Pool in a Mouse Model of Alzheimer Disease

(2012) Joo-Yong Lee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mammalian metallothioneins: properties and functions

(2012) Petr Babula et al.   Metallomics

The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout

(2012) Keun-A Chang et al.   Neurodegenerative Diseases

MRP14 (S100A9) Protein Interacts with Alzheimer Beta-Amyloid Peptide and Induces Its Fibrillization

(2012) Ce Zhang et al.   PLoS One

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

(2011) Benedikt Bader et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis

(2011) Charlene Supnet et al.   CELL CALCIUM

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ1–42 aggregation and toxicity

(2011) Silvia Bolognin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation

(2011) Wei-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

(2011) Blaine R. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Molecular-Level Examination of Cu2+Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

(2011) Sudhakar Parthasarathy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

(2011) Andreas M Grabrucker et al.   Molecular Neurodegeneration

The Revitalized Tau Hypothesis on Alzheimer's Disease

(2010) Ricardo B. Maccioni et al.   ARCHIVES OF MEDICAL RESEARCH

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity

(2010) Günter Fritz et al.   FEBS Journal

Copper Promotes the Trafficking of the Amyloid Precursor Protein

(2010) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-β aggregates

(2010) Jade Durand et al.   Metallomics

S100a9 Knockdown Decreases the Memory Impairment and the Neuropathology in Tg2576 Mice, AD Animal Model

(2010) Tae-Young Ha et al.   PLoS One

Zinc Overload Enhances APP Cleavage and Aβ Deposition in the Alzheimer Mouse Brain

(2010) Chun-Yan Wang et al.   PLoS One

Calcium and cell death signaling in neurodegeneration and aging

(2009) Soraya Smaili et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Serum zinc is decreased in Alzheimer’s disease and serum arsenic correlates positively with cognitive ability

(2009) Larry Baum et al.   BIOMETALS

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease

(2009) Thomas Rival et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited

(2009) Allana M. Mancino et al.   INORGANIC CHEMISTRY

Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322

(2009) Zhong-Ying Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

(2009) Masashi Kitazawa et al.   JOURNAL OF NEUROCHEMISTRY

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

S100A7, a Novel Alzheimer's Disease Biomarker with Non-Amyloidogenic α-Secretase Activity Acts via Selective Promotion of ADAM-10

(2009) Weiping Qin et al.   PLoS One

Amyloid Formation by the Pro-Inflammatory S100A8/A9 Proteins in the Ageing Prostate

(2009) Kiran Yanamandra et al.   PLoS One

Disassembly of Shank and Homer Synaptic Clusters Is Driven by Soluble β-Amyloid1-40 through Divergent NMDAR-Dependent Signalling Pathways

(2009) Francesco Roselli et al.   PLoS One

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease, metal ions and metal homeostatic therapy

(2009) Paolo Zatta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cu(II) Binding to Monomeric, Oligomeric, and Fibrillar Forms of the Alzheimer’s Disease Amyloid-β Peptide†

(2008) Jesse W. Karr et al.   BIOCHEMISTRY

Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain

(2008) Li-Hong Zhang et al.   BRAIN RESEARCH BULLETIN

Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

(2008) Dror Noy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

(2008) Gabriele Meloni et al.   Nature Chemical Biology

Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain

(2008) Li-Hong Zhang et al.   NEUROBIOLOGY OF AGING

Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production

(2008) Loukia Parisiadou et al.   NEUROBIOLOGY OF DISEASE

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

(2003) Craig S. Atwood et al.   JOURNAL OF NEUROCHEMISTRY