Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Innate Immunity and Neurodegeneration

(2018) Larisa I. Labzin et al.   Annual Review of Medicine

Apolipoprotein E, Receptors, and Modulation of Alzheimer’s Disease

(2018) Na Zhao et al.   BIOLOGICAL PSYCHIATRY

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

(2018) Sarah L DeVos et al.   BRAIN

Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections

(2018) Heiko Braak et al.   CEREBRAL CORTEX

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila

(2018) Yasmina Talmat-Amar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Past and the Future of Alzheimer’s Disease Fluid Biomarkers

(2018) Kaj Blennow et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Association between Alzheimer’s Disease and Oral and Gut Microbiota: Are Pore Forming Proteins the Missing Link?

(2018) Sebastian Aguayo et al.   JOURNAL OF ALZHEIMERS DISEASE

The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review

(2018) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

(2018) Sirui Jiang et al.   Molecular Neurodegeneration

Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ?

(2018) Maud Gratuze et al.   NEUROENDOCRINOLOGY

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis

(2018) George S. Bloom et al.   NEUROPHARMACOLOGY

Evidence for altered insulin receptor signaling in Alzheimer's disease

(2018) Chelsea M. Griffith et al.   NEUROPHARMACOLOGY

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

(2018) Nian-Sheng Tzeng et al.   Neurotherapeutics

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease

(2018) Steven A. Harris et al.   Frontiers in Aging Neuroscience

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

(2018) Yan Zhou et al.   Frontiers in Aging Neuroscience

Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

(2018) Christian Benedict et al.   Frontiers in Neuroscience

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Ying Cheng et al.   Frontiers in Neuroscience

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease

(2018) Maria Paraskevaidi et al.   ANALYST

Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease

(2018) Ineke A. van Rossum et al.   JOURNAL OF ALZHEIMERS DISEASE

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer's Disease

(2018) Sim K. Singhrao et al.   JOURNAL OF ALZHEIMERS DISEASE

Biomarkers for Alzheimer's disease: current status and prospects for the future

(2018) K. Blennow et al.   JOURNAL OF INTERNAL MEDICINE

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

(2018) Tamas Fulop et al.   Frontiers in Aging Neuroscience

Role of Microbes in the Development of Alzheimer’s Disease: State of the Art – An International Symposium Presented at the 2017 IAGG Congress in San Francisco

(2018) Tamàs Fülöp et al.   Frontiers in Genetics

RNA binding proteins co-localize with small tau inclusions in tauopathy

(2018) Brandon F. Maziuk et al.   Acta Neuropathologica Communications

Pathological Changes of Tau Related to Alzheimer’s Disease

(2018) Dandan Chu et al.   ACS Chemical Neuroscience

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

(2018) Gary P. Morris et al.   ACTA NEUROPATHOLOGICA

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

(2018) Dallas P. Veitch et al.   Alzheimers & Dementia

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

(2018) Ming-Hsiang Lee et al.   NATURE

APOE ε2 is associated with increased tau pathology in primary tauopathy

(2018) Na Zhao et al.   Nature Communications

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Herpes simplex virus type 1 and Alzheimer’s disease: possible mechanisms and signposts

(2017) Ruth F. Itzhaki   FASEB JOURNAL

Alzheimer’s Disease: It’s More Than Aβ

(2017) Joel N. Buxbaum   FASEB JOURNAL

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

(2017) Michael Doulberis et al.   HELICOBACTER

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

(2017) Christina Ising et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo PET imaging of neuroinflammation in Alzheimer’s disease

(2017) Julien Lagarde et al.   JOURNAL OF NEURAL TRANSMISSION

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study

(2017) Clifford R Jack et al.   LANCET NEUROLOGY

Absence of CX3CR1 impairs the internalization of Tau by microglia

(2017) Marta Bolós et al.   Molecular Neurodegeneration

Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

(2017) Heesun Choi et al.   Molecular Neurodegeneration

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

(2017) Michael G. Agadjanyan et al.   Molecular Neurodegeneration

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

(2017) Harutsugu Tatebe et al.   Molecular Neurodegeneration

Anti-aggregant tau mutant promotes neurogenesis

(2017) Maria Joseph et al.   Molecular Neurodegeneration

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

(2017) Takashi Miyamoto et al.   Molecular Neurodegeneration

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

(2017) Yang Bai et al.   Molecular Neurodegeneration

Targeting psychologic stress signaling pathways in Alzheimer’s disease

(2017) Hunter S. Futch et al.   Molecular Neurodegeneration

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

(2017) Katarina Willén et al.   Molecular Neurodegeneration

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

(2017) Michal Arbel-Ornath et al.   Molecular Neurodegeneration

Tau-dependent suppression of adult neurogenesis in the stressed hippocampus

(2017) C Dioli et al.   MOLECULAR PSYCHIATRY

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

(2017) K E Hopperton et al.   MOLECULAR PSYCHIATRY

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer's disease and its prodromal stages

(2017) Saima Rathore et al.   NEUROIMAGE

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

Harnessing innate immunity to fight neurodegeneration

(2017) Alexandra A. Mushegian   Science Signaling

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

(2017) Kiran Yanamandra et al.   Science Translational Medicine

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

(2017) Stefania Forner et al.   TRENDS IN NEUROSCIENCES

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

(2017) Chang-Kai Chen et al.   Alzheimers Research & Therapy

Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition

(2017) Alice Harding et al.   Frontiers in Aging Neuroscience

Periodontitis, Microbiomes and their Role in Alzheimer’s Disease

(2017) Anna B. Pritchard et al.   Frontiers in Aging Neuroscience

Harnessing innate immunity to fight neurodegeneration

(2017) Alexandra A. Mushegian   Science Signaling

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

(2017) Kevin H. Strang et al.   Acta Neuropathologica Communications

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease

(2017) Myles R. Minter et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Get It through Your Thick Head: Emerging Principles in Neuroimmunology and Neurovirology Redefine Central Nervous System “Immune Privilege”

(2016) Andreas C. Solomos et al.   ACS Chemical Neuroscience

Untangling the Web: Toxic and Protective Effects of Neuroinflammation and PGE2 Signaling in Alzheimer’s Disease

(2016) Nathaniel S. Woodling et al.   ACS Chemical Neuroscience

Host–pathogen interactions in bacterial meningitis

(2016) Kelly S. Doran et al.   ACTA NEUROPATHOLOGICA

Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology

(2016) Christoph Köhler   ACTA NEUROPATHOLOGICA

Neuroimaging biomarkers in Alzheimer’s disease and other dementias

(2016) Victor L. Villemagne et al.   AGEING RESEARCH REVIEWS

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

Tau: From research to clinical development

(2016) David M. Holtzman et al.   Alzheimers & Dementia

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

(2016) Thomas J. Montine et al.   Alzheimers & Dementia

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

(2016) Cheng-Xin Gong et al.   Alzheimers & Dementia

Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

(2016) Rong Xu et al.   BMC Systems Biology

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

(2016) Cyril Laurent et al.   BRAIN

Monitoring the progression of Alzheimer’s disease with τ-PET: Table 1

(2016) Dietmar Rudolf Thal et al.   BRAIN

Distinct tau PET imaging patterns in typical and atypical Alzheimer’s disease

(2016) Marie Sarazin et al.   BRAIN

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Alzheimer's disease: The amyloid hypothesis on trial

(2016) Judith R. Harrison et al.   BRITISH JOURNAL OF PSYCHIATRY

The Prevalence and Incidence of Dementia Due to Alzheimer’s Disease: a Systematic Review and Meta-Analysis

(2016) Kirsten M. Fiest et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier

(2016) Jonathan J Miner et al.   CURRENT OPINION IN IMMUNOLOGY

The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease

(2016) Cristiano Köhler et al.   CURRENT PHARMACEUTICAL DESIGN

Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis

(2016) Noemí Pallas‐Bazarra et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: A View of the Regulatory Science Qualification Landscape from the Coalition Against Major Diseases CSF Biomarker Team

(2016) Stephen P. Arnerić et al.   JOURNAL OF ALZHEIMERS DISEASE

Herpes and Alzheimer’s Disease: Subversion in the Central Nervous System and How It Might Be Halted

(2016) Ruth F. Itzhaki   JOURNAL OF ALZHEIMERS DISEASE

Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly

(2016) Michael Malek-Ahmadi et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modification of Tau by 8-Nitroguanosine 3′,5′-Cyclic Monophosphate (8-Nitro-cGMP)

(2016) Jun Yoshitake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease

(2016) Niklas Mattsson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum

(2016) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons

(2016) Valentina Lacovich et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Neuroinvasion and Inflammation in Viral Central Nervous System Infections

(2016) Tobias Dahm et al.   MEDIATORS OF INFLAMMATION

Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain

(2016) Philipp A. Jaeger et al.   Molecular Neurodegeneration

A seeding based cellular assay of tauopathy

(2016) Yin Xu et al.   Molecular Neurodegeneration

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy

(2016) Erin E. Congdon et al.   Molecular Neurodegeneration

Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy

(2016) Juan Yang et al.   Molecular Neurodegeneration

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

(2016) Peter Dongmin Sohn et al.   Molecular Neurodegeneration

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

(2016) Sofia Söllvander et al.   Molecular Neurodegeneration

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

(2016) Ghulam Jeelani Pir et al.   Molecular Neurodegeneration

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

(2016) Mickael Audrain et al.   Molecular Neurodegeneration

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition

(2016) Kristine Cox et al.   NEUROBIOLOGY OF AGING

Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer’s disease

(2016) Bo-Wen Zheng et al.   NEUROLOGICAL RESEARCH

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules

(2016) Cecilia A. Brunello et al.   Scientific Reports

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Jada Lewis et al.   ACTA NEUROPATHOLOGICA

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

(2015) Sid E. O'Bryant et al.   Alzheimers & Dementia

Dysfunction of Endoplasmic Reticulum (ER) and Mitochondria (MT) in Alzheimer's Disease: The Role of the ER-MT Cross-Talk

(2015) Katalin Volgyi et al.   Current Alzheimer Research

Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions

(2015) Joel Raskin et al.   Current Alzheimer Research

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

(2015) Elena Rodriguez-Vieitez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

(2015) Melissa C. Wren et al.   Molecular Neurodegeneration

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Human tau expression reduces adult neurogenesis in a mouse model of tauopathy

(2015) Yutaro Komuro et al.   NEUROBIOLOGY OF AGING

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

(2015) Marie Violet et al.   NEUROBIOLOGY OF DISEASE

Golgi fragmentation in Alzheimer's disease

(2015) Gunjan Joshi et al.   Frontiers in Neuroscience

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

(2014) Samantha J. Dando et al.   CLINICAL MICROBIOLOGY REVIEWS

Tau acts as a mediator for Alzheimer's disease-related synaptic deficits

(2014) Dezhi Liao et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

(2014) Mitchell R. White et al.   PLoS One

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production

(2014) Gunjan Joshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease and periodontitis - an elusive link

(2014) Abhijit N. Gurav   Revista da Associacao Medica Brasileira

Is pathological aging a successful resistance against amyloid-beta or preclinical Alzheimer’s disease?

(2014) Melissa E Murray et al.   Alzheimers Research & Therapy

Acetylation: a new key to unlock tau’s role in neurodegeneration

(2014) Casey Cook et al.   Alzheimers Research & Therapy

Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus

(2014) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

The therapeutics of Alzheimer's disease: Where we stand and where we are heading

(2013) Dennis J. Selkoe   ANNALS OF NEUROLOGY

A ‘danse macabre’: tau and Fyn in STEP with amyloid beta to facilitate induction of synaptic depression and excitotoxicity

(2013) Jannic Boehm   EUROPEAN JOURNAL OF NEUROSCIENCE

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Increased Expression of Reticulon 3 in Neurons Leads to Reduced Axonal Transport of β Site Amyloid Precursor Protein-cleaving Enzyme 1

(2013) Minzi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

(2013) Stephanie JB Vos et al.   LANCET NEUROLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Tau phosphorylation affects its axonal transport and degradation

(2013) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF AGING

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Intracerebral propagation of Alzheimer’s disease: Strengthening evidence of a herpes simplex virus etiology

(2012) Melvyn J. Ball et al.   Alzheimers & Dementia

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic insights in Alzheimer's disease

(2012) Karolien Bettens et al.   LANCET NEUROLOGY

Injury markers predict time to dementia in subjects with MCI and amyloid pathology

(2012) I. A. van Rossum et al.   NEUROLOGY

 -Amyloid burden in healthy aging: Regional distribution and cognitive consequences

(2012) K. M. Rodrigue et al.   NEUROLOGY

Selective tau tyrosine nitration in non-AD tauopathies

(2011) Juan F. Reyes et al.   ACTA NEUROPATHOLOGICA

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer's Disease

(2011) Juan F. Reyes et al.   AMERICAN JOURNAL OF PATHOLOGY

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

APP physiological and pathophysiological functions: insights from animal models

(2011) Qinxi Guo et al.   CELL RESEARCH

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

(2011) Randall J Bateman et al.   Alzheimers Research & Therapy

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Proteolytic processing of tau

(2010) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease

(2010) Simonetta Camandola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Membrane Localization of β-Amyloid 1–42 in Lysosomes

(2010) Rui-Qin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment

(2009) Niklas Mattsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

(2009) Joseph L. Price et al.   NEUROBIOLOGY OF AGING

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Oskar Fischer and the study of dementia

(2008) M. Goedert   BRAIN

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

The High Prevalence of Herpes Simplex Virus Type 1 DNA in Human Trigeminal Ganglia Is Not a Function of Age or Gender

(2008) J. M. Hill et al.   JOURNAL OF VIROLOGY

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES

β-amyloid burden is not associated with rates of brain atrophy

(2007) Keith A. Josephs et al.   ANNALS OF NEUROLOGY