Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

(2016) Mitsuru Shinohara et al.   ACTA NEUROPATHOLOGICA

APOE2eases cognitive decline during Aging: Clinical and preclinical evaluations

(2016) Mitsuru Shinohara et al.   ANNALS OF NEUROLOGY

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

(2016) Masaya Tachibana et al.   EXPERIMENTAL NEUROLOGY

Meta-analysis of apolipoprotein E levels in the cerebrospinal fluid of patients with Alzheimer's disease

(2016) Puneet Talwar et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Microglia-specific targeting by novel capsid-modified AAV6 vectors

(2016) Awilda M Rosario et al.   Molecular Therapy-Methods & Clinical Development

Cerebrovascular disease in ageing and Alzheimer’s disease

(2015) Seth Love et al.   ACTA NEUROPATHOLOGICA

Thyroid hormones upregulate apolipoprotein E gene expression in astrocytes

(2015) Corina Roman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice

(2015) Rebecca Skerrett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway

(2015) Caroline S. Casey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease

(2015) B. T. Casali et al.   JOURNAL OF NEUROSCIENCE

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

(2015) Wendy E. Heywood et al.   Molecular Neurodegeneration

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice

(2015) De-shan Liu et al.   Molecular Neurodegeneration

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

(2015) Mikael Marttinen et al.   Molecular Neurodegeneration

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

(2015) Manasi Malik et al.   Molecular Neurodegeneration

Inducible in vivo genome editing with CRISPR-Cas9

(2015) Lukas E Dow et al.   NATURE BIOTECHNOLOGY

Re-evaluation of the Blood-Brain Barrier in the Presence of Alzheimer’s Disease Pathology

(2015) Jason D. Ulrich et al.   NEURON

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Brave New Genome

(2015) Eric S. Lander   NEW ENGLAND JOURNAL OF MEDICINE

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy

(2015) C. Long et al.   SCIENCE

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

(2015) M. Tabebordbar et al.   SCIENCE

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

(2015) C. E. Nelson et al.   SCIENCE

Treatment of Mycosis Fungoides with Bexarotene Results in Remission of Diffuse Plane Xanthomas

(2015) Stamatis Gregoriou et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

(2015) Catherine Marquer et al.   Molecular Neurodegeneration

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer’s disease patients and controls

(2014) Eduardo Martínez-Morillo et al.   ACTA NEUROPATHOLOGICA

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

(2014) Daniel M. Michaelson   Alzheimers & Dementia

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo

(2014) Moran Gilat-Frenkel et al.   Current Alzheimer Research

The APOE Genotype: Modification of Therapeutic Responses in Alzheimer's Disease

(2014) Angela Hanson et al.   CURRENT PHARMACEUTICAL DESIGN

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

(2014) Jing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

(2014) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

Anti-ApoE Antibody Given after Plaque Onset Decreases A  Accumulation and Improves Brain Function in a Mouse Model of A  Amyloidosis

(2014) F. Liao et al.   JOURNAL OF NEUROSCIENCE

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance

(2014) Y. Shibuya et al.   JOURNAL OF NEUROSCIENCE

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

(2014) Ann Brinkmalm et al.   Molecular Neurodegeneration

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

(2014) Leon M Tai et al.   Molecular Neurodegeneration

Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

(2014) Katherine A Price et al.   Molecular Neurodegeneration

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration

(2014) Courtney Lane-Donovan et al.   NEURON

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise, APOE genotype, and the evolution of the human lifespan

(2014) David A. Raichlen et al.   TRENDS IN NEUROSCIENCES

Associations Between Cerebral Small-Vessel Disease and Alzheimer Disease Pathology as Measured by Cerebrospinal Fluid Biomarkers

(2014) Maartje I. Kester et al.   JAMA Neurology

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

(2014) Angel C. Y. Mak et al.   JAMA Neurology

Ten-year Experience of Bexarotene Therapy for Cutaneous T-cell Lymphoma in Finland

(2013) L Väkevä et al.   ACTA DERMATO-VENEREOLOGICA

Effect of APOE genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from Alzheimer's disease

(2013) Richard E. Kennedy et al.   Alzheimers & Dementia

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

(2013) Magdalena A. Kuszczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

SnapShot: Genetics of Alzheimer’s Disease

(2013) Rita Guerreiro et al.   CELL

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

(2013) Shan Liu et al.   JOURNAL OF NEUROCHEMISTRY

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD Mice

(2013) Rachel E. Bennett et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

(2013) Katherine D LaClair et al.   Molecular Neurodegeneration

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

(2013) E. Hudry et al.   Science Translational Medicine

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

(2013) Angela J. Hanson et al.   JAMA Neurology

Plasma Signaling Proteins in Persons at Genetic Risk for Alzheimer Disease

(2012) John M. Ringman et al.   ARCHIVES OF NEUROLOGY

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma

(2012) J.J. Scarisbrick et al.   BRITISH JOURNAL OF DERMATOLOGY

APOE genotype alters glial activation and loss of synaptic markers in mice

(2012) Yuangui Zhu et al.   GLIA

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

(2012) Jungsu Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology

(2012) Robert W. Mahley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent A  Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

(2012) N. Bien-Ly et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

Total ApoE and ApoE4 Isoform Assays in an Alzheimer's Disease Case-control Study by Targeted Mass Spectrometry (n= 669): A Pilot Assay for Methionine-containing Proteotypic Peptides

(2012) Romain Simon et al.   MOLECULAR & CELLULAR PROTEOMICS

APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer’s Disease Transgenics

(2012) M.P. Vitek et al.   Neurodegenerative Diseases

The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features

(2012) Kaushik Ghosal et al.   Neurodegenerative Diseases

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

The role of inflammatory processes in Alzheimer’s disease

(2012) G. Joseph Broussard et al.   INFLAMMOPHARMACOLOGY

Bexarotene Is Active Against Subcutaneous Panniculitis-Like T-Cell Lymphoma in Adult and Pediatric Populations

(2011) Neha Mehta et al.   Clinical Lymphoma Myeloma & Leukemia

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

(2011) Jens Brodbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-  Amyloidosis

(2011) J. Kim et al.   JOURNAL OF NEUROSCIENCE

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population

(2011) Afef Achouri Rassas et al.   NEUROLOGICAL SCIENCES

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-  (A ) and acts in concert with A  to elicit neuronal and behavioral deficits in mice

(2011) N. Bien-Ly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

(2010) Ditte Z. Christensen et al.   ACTA NEUROPATHOLOGICA

Variants at APOE influence risk of deep and lobar intracerebral hemorrhage

(2010) Alessandro Biffi et al.   ANNALS OF NEUROLOGY

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

(2010) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein (CETP) Gene With Memory Decline and Incidence of Dementia

(2010) Amy E. Sanders   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

ApoE mimetic peptide decreases Aβ production in vitro and in vivo

(2010) S Sakura Minami et al.   Molecular Neurodegeneration

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline

(2010) Jae H. Kang et al.   NEUROBIOLOGY OF AGING

Aβ20–29 peptide blocking apoE/Aβ interaction reduces full-length Aβ42/40 fibril formation and cytotoxicity in vitro

(2010) Jian Hao et al.   NEUROPEPTIDES

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Apolipoprotein mimetic peptides: Mechanisms of action as anti-atherogenic agents

(2010) David O. Osei-Hwedieh et al.   PHARMACOLOGY & THERAPEUTICS

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E: From lipid transport to neurobiology

(2010) Paul S. Hauser et al.   PROGRESS IN LIPID RESEARCH

Polymorphisms of APOE and LRP Genes in Brazilian Individuals With Alzheimer Disease

(2009) Valéria Santoro Bahia et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Acyl-coenzyme A:cholesterol acyltransferases

(2009) Ta-Yuan Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

Apolipoprotein E protects cultured pericytes and astrocytes from D-Aβ1–40-mediated cell death

(2009) Ilona B. Bruinsma et al.   BRAIN RESEARCH

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

(2009) S. B. Dumanis et al.   JOURNAL OF NEUROSCIENCE

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

Isoform-specific proteolysis of apolipoprotein-E in the brain

(2009) David A. Elliott et al.   NEUROBIOLOGY OF AGING

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

Apolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice

(2008) Ning Zhong et al.   Alzheimers & Dementia

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

(2008) Sigrid B Sando et al.   BMC Neurology

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING