Glial contributions to neurodegeneration in tauopathies

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Interneuronal Transfer of Human Tau Between Lamprey Central Neurons in situ

(2017) WonHee Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2 Function in Alzheimer’s Disease and Neurodegeneration

(2016) Jason D. Ulrich et al.   ACS Chemical Neuroscience

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

(2016) Shuko Takeda et al.   ANNALS OF NEUROLOGY

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

(2016) Kathleen M. Schoch et al.   NEURON

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

(2016) Won-Suk Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

(2016) Seung-Hye Lee et al.   Cell Reports

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

(2016) Astrid Sydow et al.   Acta Neuropathologica Communications

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

(2015) Ann C. McKee et al.   ACTA NEUROPATHOLOGICA

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Current thinking on the mechanistic basis of Alzheimer's and implications for drug development

(2015) C Ising et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

(2015) Marcus Pickhardt et al.   Current Alzheimer Research

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

(2015) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Distinct Therapeutic Mechanisms of Tau Antibodies

(2015) Kristen E. Funk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1 

(2015) S.-H. Cho et al.   JOURNAL OF NEUROSCIENCE

Analysis of in vivo turnover of tau in a mouse model of tauopathy

(2015) Kaoru Yamada et al.   Molecular Neurodegeneration

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

(2015) Manasi Malik et al.   Molecular Neurodegeneration

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Tau Immunotherapy

(2015) Einar M. Sigurdsson   Neurodegenerative Diseases

Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease

(2015) Rommy von Bernhardi et al.   Frontiers in Cellular Neuroscience

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

Loss of tau rescues inflammation-mediated neurodegeneration

(2015) Nicole Maphis et al.   Frontiers in Neuroscience

Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1

(2014) Hirohide Asai et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology

(2014) Claire H. Michel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein Ε e4 Frequency Is Increased among Chinese Patients with Frontotemporal Dementia and Alzheimer's Disease

(2013) Yong Ji et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

In vivo cell tracking via 18F-fluorodeoxyglucose labeling: a review of the preclinical and clinical applications in cell-based diagnosis and therapy

(2012) Chenxi Wu et al.   CLINICAL IMAGING

Extracellular Tau Levels Are Influenced by Variability in Tau That Is Associated with Tauopathies

(2012) Celeste M. Karch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noninvasive Molecular Imaging of Neuroinflammation

(2012) Andreas H Jacobs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prion-like spread of protein aggregates in neurodegeneration: Figure 1.

(2012) Magdalini Polymenidou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies

(2012) Carlo Ballatore et al.   JOURNAL OF MEDICINAL CHEMISTRY

The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention

(2012) Brian Giunta et al.   Journal of Neuroinflammation

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

(2011) Stefani N. Thomas et al.   ACTA NEUROPATHOLOGICA

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

(2011) Sara L. Montgomery et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-β Neurotoxicity

(2011) Tetsuya Mizuno et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-1β potently stabilizes IL-6 mRNA in human astrocytes

(2011) Anneleen Spooren et al.   BIOCHEMICAL PHARMACOLOGY

Pseudohyperphosphorylation Has Differential Effects on Polymerization and Function of Tau Isoforms

(2011) Benjamin Combs et al.   BIOCHEMISTRY

Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury

(2011) Sandra Magnoni et al.   BRAIN

Interleukin-6, a mental cytokine

(2011) Anneleen Spooren et al.   BRAIN RESEARCH REVIEWS

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-  and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

(2011) J. Maeda et al.   JOURNAL OF NEUROSCIENCE

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Cytokine expression and microglial activation in progressive supranuclear palsy

(2011) Rafael Fernández-Botrán et al.   PARKINSONISM & RELATED DISORDERS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

(2011) Jason R. Cannon et al.   TOXICOLOGICAL SCIENCES

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Secretion of human tau fragments resembling CSF-tau in Alzheimer's disease is modulated by the presence of the exon 2 insert

(2010) WonHee Kim et al.   FEBS LETTERS

Immunotherapy for Alzheimer’s disease

(2010) D. Morgan   JOURNAL OF INTERNAL MEDICINE

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Glial Fibrillary Tangles and JAK/STAT-Mediated Glial and Neuronal Cell Death in a Drosophila Model of Glial Tauopathy

(2010) K. J. Colodner et al.   JOURNAL OF NEUROSCIENCE

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study

(2010) Michie Miyoshi et al.   PARKINSONISM & RELATED DISORDERS

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease

(2009) Edward Tobinick   CNS DRUGS

Accumulation of tau induced in neurites by microglial proinflammatory mediators

(2009) Philipp Gorlovoy et al.   FASEB JOURNAL

Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

(2009) Paramita Chakrabarty et al.   FASEB JOURNAL

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Apolipoprotein E ε4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia

(2009) Federica Agosta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau pathophysiology in neurodegeneration: a tangled issue

(2009) Tara L. Spires-Jones et al.   TRENDS IN NEUROSCIENCES

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTauP301L

(2008) Atsushi Sasaki et al.   BRAIN RESEARCH

S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells

(2008) Giuseppe Esposito et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells

(2008) Johanna O. Ojala et al.   JOURNAL OF NEUROIMMUNOLOGY

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY