Herpes simplex virus type 1 and Alzheimer’s disease: possible mechanisms and signposts

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

(2017) Haibo Wang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genome instability in Alzheimer disease

(2017) Yujun Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Neuronal Cytoskeletal Dynamic Modification and Neurodegeneration Induced by Infection with Herpes Simplex Virus Type 1

(2017) Ángara Zambrano et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease-Specific Tau Phosphorylation is Induced by Herpes Simplex Virus Type 1

(2017) Matthew A. Wozniak et al.   JOURNAL OF ALZHEIMERS DISEASE

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

(2016) Keith A. Vossel et al.   ANNALS OF NEUROLOGY

High avidity HSV-1 antibodies correlate with absence of amnestic Mild Cognitive Impairment conversion to Alzheimer’s disease

(2016) Simone Agostini et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Epigenetics and Genetics of Viral Latency

(2016) Paul M. Lieberman   Cell Host & Microbe

DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases

(2016) Daniela Merlo et al.   Current Alzheimer Research

Abnormal regulation of the antiviral response in neurological/neurodegenerative diseases

(2016) Mannie Man Wai Lam et al.   CYTOKINE

HSV presence in brains of individuals without dementia: the TASTY brain series

(2016) Jan Olsson et al.   Disease Models & Mechanisms

Elevated Epstein-Barr Virus Antibody Level is Associated with Cognitive Decline in the Korean Elderly

(2016) Sung-Mi Shim et al.   JOURNAL OF ALZHEIMERS DISEASE

Herpes and Alzheimer’s Disease: Subversion in the Central Nervous System and How It Might Be Halted

(2016) Ruth F. Itzhaki   JOURNAL OF ALZHEIMERS DISEASE

Meta-analysis of Telomere Length in Alzheimer’s Disease

(2016) Diego A. Forero et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

(2016) Michael Van Meter et al.   Cell Reports

Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons

(2016) Giovanna De Chiara et al.   Frontiers in Aging Neuroscience

Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

(2016) Meryl S. Lillenes et al.   Molecular Brain

Alzheimer's disease: An acquired neurodegenerative laminopathy

(2016) Bess Frost   Nucleus

Alzheimer's disease: An acquired neurodegenerative laminopathy

(2016) Bess Frost   Nucleus

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation

(2015) Anna R. Cliffe et al.   Cell Host & Microbe

HSV-I and the cellular DNA damage response

(2015) Samantha Smith et al.   Future Virology

Comment on “Cytomegalovirus Infection and Risk of Alzheimer Disease in Older Black and White Individuals,”Journal of Infectious Diseases, 8 August 2014

(2015) Ruth F. Itzhaki et al.   JOURNAL OF INFECTIOUS DISEASES

Reactivation of HSV-1 following explant of tree shrew brain

(2015) Lihong Li et al.   JOURNAL OF NEUROVIROLOGY

Infectious Burden and Cognitive Decline in the Northern Manhattan Study

(2015) Clinton B. Wright et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Herpes simplex virus type 2 infection induces AD-like neurodegeneration markers in human neuroblastoma cells

(2015) Henrike Kristen et al.   NEUROBIOLOGY OF AGING

Apolipoprotein 4 may increase viral load and seizure frequency in mesial temporal lobe epilepsy patients with positive human herpes virus 6B

(2015) Cheng Huang et al.   NEUROSCIENCE LETTERS

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

Establishment of HSV1 Latency in Immunodeficient Mice Facilitates Efficient In Vivo Reactivation

(2015) Chandran Ramakrishna et al.   PLoS Pathogens

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

A study on the association between infectious burden and Alzheimer's disease

(2014) X.-L. Bu et al.   EUROPEAN JOURNAL OF NEUROLOGY

The role of DNA repair in herpesvirus pathogenesis

(2014) Jay C. Brown   GENOMICS

Cytomegalovirus Infection and Risk of Alzheimer Disease in Older Black and White Individuals

(2014) Lisa L. Barnes et al.   JOURNAL OF INFECTIOUS DISEASES

A pilot study on the use of interferon beta-1a in early Alzheimer’s disease subjects

(2014) Luigi Maria Grimaldi et al.   Journal of Neuroinflammation

Structure of the Herpes Simplex Virus 1 Genome: Manipulation of Nicks and Gaps Can Abrogate Infectivity and Alter the Cellular DNA Damage Response

(2014) S. Smith et al.   JOURNAL OF VIROLOGY

In Vivo Reactivation of Latent Herpes Simplex Virus 1 in Mice Can Occur in the Brain before Occurring in the Trigeminal Ganglion

(2014) H.-W. Yao et al.   JOURNAL OF VIROLOGY

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

(2014) Mitchell R. White et al.   PLoS One

HSV-1 Remodels Host Telomeres to Facilitate Viral Replication

(2014) Zhong Deng et al.   Cell Reports

Relationship between herpes simplex virus-1-specific antibody titers and cortical brain damage in Alzheimer’s disease and amnestic mild cognitive impairment

(2014) Roberta Mancuso et al.   Frontiers in Aging Neuroscience

Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus

(2014) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms

(2013) Jeannie Chin et al.   EPILEPSY & BEHAVIOR

Infectious burden and cognitive function: The Northern Manhattan Study

(2013) M. Katan et al.   NEUROLOGY

DNA extraction from fresh-frozen and formalin-fixed, paraffinembedded human brain tissue

(2013) Jian-Hua Wang et al.   Neuroscience Bulletin

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype

(2013) Orwa Aboud et al.   Acta Neuropathologica Communications

Seizures and encephalitis: Clinical features, management, and potential pathophysiologic mechanisms

(2012) Benedict D. Michael et al.   EPILEPSIA

Could antivirals be used to treat Alzheimer’s disease?

(2012) Ruth F Itzhaki et al.   Future Microbiology

Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age

(2012) Raymond P. Stowe et al.   JOURNAL OF MEDICAL VIROLOGY

Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells

(2012) Gema Álvarez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

(2012) Xiao-Xin Yan et al.   PLoS One

Valacyclovir for Herpes Simplex Encephalitis

(2011) Thomas Pouplin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

(2011) Mark A. Lovell et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells

(2011) Soraya Santana et al.   NEUROBIOLOGY OF AGING

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

APOE genetic associations with seizure development after severe traumatic brain injury

(2010) Megan A. Miller et al.   BRAIN INJURY

Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis

(2010) Pitt Niehusmann et al.   EPILEPSIA

HSV-1 promotes Ca2+-mediated APP phosphorylation and Aβ accumulation in rat cortical neurons

(2010) Roberto Piacentini et al.   NEUROBIOLOGY OF AGING

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Seizures in Alzheimer Disease

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Beta interferon plus gamma interferon efficiently reduces acyclovir-resistant herpes simplex virus infection in mice in a T-cell-independent manner

(2009) W.-Y. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Late Relapse of Herpes Simplex Virus Encephalitis in a Child Due to Reactivation of Latent Virus: Clinicopathological Report and Review

(2008) Ronen Spiegel et al.   JOURNAL OF CHILD NEUROLOGY

Delivery of Interferon-γ by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways

(2008) Daniel J.J. Carr et al.   JOURNAL OF NEUROIMMUNOLOGY

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY