Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus

Gene Signature in Alzheimer's Disease and Environmental Factors: The Virus Chronicle

(2018) Federico Licastro et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Cleavage at D421 by Caspase-3 is Induced in Neurons and Astrocytes Infected with Herpes Simplex Virus Type 1

(2018) Rodrigo Lerchundi et al.   JOURNAL OF ALZHEIMERS DISEASE

Aging-Related Neurostructural, Neuropathological, and Behavioral Changes Associated with Herpes Simplex Virus Type 1 Brain Infection in Mice

(2018) Fernando Guzman-Sanchez et al.   JOURNAL OF ALZHEIMERS DISEASE

Titers of Herpes Simplex Virus Type 1 Antibodies Positively Correlate with Grey Matter Volumes in Alzheimer's Disease

(2018) Roberta Mancuso et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory and Neurodegeneration Markers during Asymptomatic HSV-1 Reactivation

(2018) Carolina Martin et al.   JOURNAL OF ALZHEIMERS DISEASE

Reactivated herpes simplex infection increases the risk of Alzheimer's disease

(2015) Hugo Lövheim et al.   Alzheimers & Dementia

Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer’s Disease

(2014) Gabriel Westman et al.   PLoS One

The helicase-primase inhibitor BAY 57–1293 reduces the Alzheimer’s disease-related molecules induced by herpes simplex virus type 1

(2013) M.A. Wozniak et al.   ANTIVIRAL RESEARCH

Central Nervous System Herpes Simplex and Varicella Zoster Virus Infections in Natalizumab-Treated Patients

(2013) A. J. Fine et al.   CLINICAL INFECTIOUS DISEASES

Synthesis and Comparison of the Meta-Analyses Evaluating the Efficacy of Memantine in Moderate to Severe Stages of Alzheimer’s Disease

(2013) Benoît Rive et al.   CNS DRUGS

Cytomegalovirus: An Improbable Cause of Alzheimer Disease

(2013) R. F. Itzhaki et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent Viral Pathogens and Cognitive Impairment Across the Life Course in the Third National Health and Nutrition Examination Survey

(2013) Kara D. Tarter et al.   JOURNAL OF INFECTIOUS DISEASES

Virological and Immunological Characteristics of Human Cytomegalovirus Infection Associated With Alzheimer Disease

(2013) Nell S. Lurain et al.   JOURNAL OF INFECTIOUS DISEASES

Intravenous immunoglobulin reduces beta amyloid and abnormal tau formation caused by herpes simplex virus type 1

(2013) Matthew A. Wozniak et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Treatment with Neuroprotective and Antiviral Properties against a Neuroinvasive Human Respiratory Virus

(2013) E. Brison et al.   JOURNAL OF VIROLOGY

Infectious burden and cognitive function: The Northern Manhattan Study

(2013) M. Katan et al.   NEUROLOGY

Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders

(2013) Chris J. Carter   Pathogens and Disease

Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer’s disease

(2012) Nobuyuki Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Could antivirals be used to treat Alzheimer’s disease?

(2012) Ruth F Itzhaki et al.   Future Microbiology

HSV, axonal transport and Alzheimer’s disease:in vitroandin vivoevidence for causal relationships

(2012) Elaine L Bearer   Future Virology

Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age

(2012) Raymond P. Stowe et al.   JOURNAL OF MEDICAL VIROLOGY

Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections

(2012) Jan Jessen Krut et al.   JOURNAL OF NEUROLOGY

Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ligand serum amyloid A in astrocytes

(2012) Melina Villalba et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Exposure to Herpes Simplex Virus Type 1 and Cognitive Impairments in Individuals With Schizophrenia

(2012) K. M. Prasad et al.   SCHIZOPHRENIA BULLETIN

Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice

(2011) Michael Sy et al.   AMERICAN JOURNAL OF PATHOLOGY

Herpes Simplex Virus Dances with Amyloid Precursor Protein while Exiting the Cell

(2011) Shi-Bin Cheng et al.   PLoS One

Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

(2011) Gerard ILL-Raga et al.   PLoS One

Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels

(2011) Catherine Féart et al.   PLoS One

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

Alzheimer's disease gene signature says: beware of brain viral infections

(2011) Elisa Porcellini et al.   Immunity & Ageing

First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia

(2010) Li Zhou et al.   Molecular Neurodegeneration

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding

(2010) D. M. Koelle et al.   SEXUALLY TRANSMITTED INFECTIONS

Antiviral agents in Alzheimer’s disease: hope for the future?

(2010) Matthew A. Wozniak et al.   Therapeutic Advances in Neurological Disorders

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

(2008) Luc Letenneur et al.   PLoS One

Apolipoprotein E- 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV

(2008) A N Jayasuriya et al.   SEXUALLY TRANSMITTED INFECTIONS