Role of Microbes in the Development of Alzheimer’s Disease: State of the Art – An International Symposium Presented at the 2017 IAGG Congress in San Francisco

The Past and the Future of Alzheimer’s Disease Fluid Biomarkers

(2018) Kaj Blennow et al.   JOURNAL OF ALZHEIMERS DISEASE

Innovative Biomarkers for Alzheimer’s Disease: Focus on the Hidden Disease Biomarkers

(2018) Roberta Ghidoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

A Lack of Correlation between the Incidence of Lyme Disease and Deaths due to Alzheimer's Disease

(2018) Danton H. O'Day et al.   JOURNAL OF ALZHEIMERS DISEASE

Intracellular and Extracellular Roles for Tau in Neurodegenerative Disease

(2018) Diane P. Hanger et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence that the Human Innate Immune Peptide LL-37 may be a Binding Partner of Amyloid-β and Inhibitor of Fibril Assembly

(2017) Ersilia De Lorenzi et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing

(2017) Ruth Alonso et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of neuroinflammation in neurodegeneration: new insights

(2017) Róisín M. McManus et al.   Alzheimers Research & Therapy

Neuronal Cytoskeletal Dynamic Modification and Neurodegeneration Induced by Infection with Herpes Simplex Virus Type 1

(2017) Ángara Zambrano et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloids: Friend or Foe?

(2017) Neal D. Hammer et al.   JOURNAL OF ALZHEIMERS DISEASE

Chlamydophila Pneumoniae and the Etiology of Late-Onset Alzheimer's Disease

(2017) Brian J. Balin et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

(2017) M. M. Mariani et al.   Scientific Reports

Polymicrobial Infections In Brain Tissue From Alzheimer’s Disease Patients

(2017) Diana Pisa et al.   Scientific Reports

Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation

(2016) Judith Miklossy et al.   Aging-US

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Viral Properties of Amyloid-β Peptides

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques

(2016) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Fungal Enolase, β-Tubulin, and Chitin Are Detected in Brain Tissue from Alzheimer’s Disease Patients

(2016) Diana Pisa et al.   Frontiers in Microbiology

Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation

(2015) Moonhee Lee et al.   BIOCHEMICAL PHARMACOLOGY

Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis

(2015) Simone Filardo et al.   MEDIATORS OF INFLAMMATION

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation

(2015) Roberto Piacentini et al.   Scientific Reports

Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease

(2015) Judith Miklossy   Frontiers in Aging Neuroscience

Establishment of HSV1 Latency in Immunodeficient Mice Facilitates Efficient In Vivo Reactivation

(2015) Chandran Ramakrishna et al.   PLoS Pathogens

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease

(2015) Xiaojuan Sun et al.   Frontiers in Pharmacology

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Chlamydia pneumoniae infection of monocytes in vitro stimulates innate and adaptive immune responses relevant to those in Alzheimer’s disease

(2014) Charles Lim et al.   Journal of Neuroinflammation

1 ,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-  Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

(2014) M. R. Durk et al.   JOURNAL OF NEUROSCIENCE

In Vivo Reactivation of Latent Herpes Simplex Virus 1 in Mice Can Occur in the Brain before Occurring in the Trigeminal Ganglion

(2014) H.-W. Yao et al.   JOURNAL OF VIROLOGY

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

(2014) Mitchell R. White et al.   PLoS One

Detection of bacterial antigens and Alzheimer’s disease-like pathology in the central nervous system of BALB/c mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae

(2014) Christopher S. Little et al.   Frontiers in Aging Neuroscience

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Phenylbutyrate is a Multifaceted Drug that Exerts Neuroprotective Effects and Reverses the Alzheimer´s Disease-like Phenotype of a Commonly Used Mouse Model

(2013) Mar Cuadrado-Tejedor et al.   CURRENT PHARMACEUTICAL DESIGN

Label-Free Quantitative Mass Spectrometry Reveals Novel Pathways Involved in LL-37 Expression

(2013) Andreas Cederlund et al.   Journal of Innate Immunity

HSV, axonal transport and Alzheimer’s disease:in vitroandin vivoevidence for causal relationships

(2012) Elaine L Bearer   Future Virology

Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro

(2012) Eva Sapi et al.   PLoS One

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Emerging roles of pathogens in Alzheimer disease

(2011) Judith Miklossy   EXPERT REVIEWS IN MOLECULAR MEDICINE

Alzheimer’s Disease: Implications of the Updated Diagnostic and Research Criteria

(2011) Eric M. Reiman et al.   JOURNAL OF CLINICAL PSYCHIATRY

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

(2011) Judith Miklossy   Journal of Neuroinflammation

Herpes Simplex Virus Dances with Amyloid Precursor Protein while Exiting the Cell

(2011) Shi-Bin Cheng et al.   PLoS One

Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

(2011) Gerard ILL-Raga et al.   PLoS One

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding

(2010) D. M. Koelle et al.   SEXUALLY TRANSMITTED INFECTIONS

Antiviral agents in Alzheimer’s disease: hope for the future?

(2010) Matthew A. Wozniak et al.   Therapeutic Advances in Neurological Disorders

Phenylbutyrate Induces Antimicrobial Peptide Expression

(2009) J. Steinmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

The chemistry and biology of LL-37

(2009) Matthew F. Burton et al.   NATURAL PRODUCT REPORTS

Lack of Evidence for Borrelia burgdorferi Seropositivity in Alzheimer Disease

(2008) Alessio Galbussera et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae

(2008) Denah M Appelt et al.   BMC NEUROSCIENCE

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Apolipoprotein E4 enhances attachment of Chlamydophila (Chlamydia) pneumoniae elementary bodies to host cells

(2007) Hervé C. Gérard et al.   MICROBIAL PATHOGENESIS

Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: Relevance to pathological-signalling cascades

(2007) C.J. Carter   NEUROCHEMISTRY INTERNATIONAL