Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

Case–control association mapping by proxy using family history of disease

(2017) Jimmy Z Liu et al.   NATURE GENETICS

Does Impairment of the Ubiquitin-Proteasome System or the Autophagy-Lysosome Pathway Predispose Individuals to Neurodegenerative Disorders such as Parkinson's Disease?

(2017) Noriyuki Matsuda et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction

(2016) Paul L. Greer et al.   CELL

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

(2016) Li Ma et al.   Molecular Neurodegeneration

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice

(2016) Chao Jiang et al.   NEUROBIOLOGY OF AGING

ABCA7 rare variants and Alzheimer disease risk

(2016) Kilan Le Guennec et al.   NEUROLOGY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

The MS4A family: counting past 1, 2 and 3

(2015) Li Eon Kuek et al.   IMMUNOLOGY AND CELL BIOLOGY

ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing

(2015) Kanayo Satoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study

(2015) Elise Cuyvers et al.   LANCET NEUROLOGY

The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling

(2015) Glenn Cruse et al.   MOLECULAR BIOLOGY OF THE CELL

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

(2015) Stacy Steinberg et al.   NATURE GENETICS

What happens to microglial TREM2 in Alzheimer’s disease: Immunoregulatory turned into immunopathogenic?

(2015) L.-F. Lue et al.   NEUROSCIENCE

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

(2015) Frederik Otzen Bagger et al.   NUCLEIC ACIDS RESEARCH

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

(2015) Maike Gold et al.   Seminars in Immunopathology

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European–Americans

(2015) Jorge L. Del-Aguila et al.   Alzheimers Research & Therapy

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

(2014) Gustavo A Rodriguez et al.   Journal of Neuroinflammation

MS4A Cluster in Alzheimer’s Disease

(2014) Jing Ma et al.   MOLECULAR NEUROBIOLOGY

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Genome-wide Association Studies in Alzheimer’s Disease: A Review

(2013) Giuseppe Tosto et al.   Current Neurology and Neuroscience Reports

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

(2013) Christiane Reitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

CD33 in Alzheimer's Disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Insights into TREM2 biology by network analysis of human brain gene expression data

(2013) Paola Forabosco et al.   NEUROBIOLOGY OF AGING

Blockage of CR1 prevents activation of rodent microglia

(2013) Helen Crehan et al.   NEUROBIOLOGY OF DISEASE

Microglia as Dynamic and Essential Components of the Amyloid Hypothesis

(2013) Sam Gandy et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status

(2013) Jared B. Vasquez et al.   NEUROSCIENCE LETTERS

Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population

(2012) Lan Tan et al.   Alzheimers & Dementia

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer’s disease

(2012) Yu-Lei Deng et al.   HUMAN GENETICS

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Apolipoprotein E isoform-dependent microglia migration

(2011) Eiron Cudaback et al.   FASEB JOURNAL

Complement receptor 1 (CR1) and Alzheimer's disease

(2011) Helen Crehan et al.   IMMUNOBIOLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease

(2011) Carmen Antúnez et al.   Genome Medicine

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

(2010) Rita J. Guerreiro et al.   NEUROBIOLOGY OF AGING

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS