Association between Alzheimer’s Disease and Oral and Gut Microbiota: Are Pore Forming Proteins the Missing Link?

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Infection and Alzheimer's Disease: A Meta-Analysis

(2018) Priya Maheshwari et al.   JOURNAL OF ALZHEIMERS DISEASE

Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

(2017) James K.Y. Hooi et al.   GASTROENTEROLOGY

Early Adhesion of Candida albicans onto Dental Acrylic Surfaces

(2017) S. Aguayo et al.   JOURNAL OF DENTAL RESEARCH

Late-Onset Alzheimer Disease

(2017) Aimee L. Pierce et al.   NEUROLOGIC CLINICS

Surface characteristics influencing bacterial adhesion to polymeric substrates

(2017) Yue Yuan et al.   RSC Advances

The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases

(2017) Chris J. Carter et al.   Frontiers in Aging Neuroscience

Periodontitis and Alzheimer’s Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation

(2017) Francisco B. Teixeira et al.   Frontiers in Aging Neuroscience

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury

(2017) Martina Bielaszewska et al.   PLoS Pathogens

New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs

(2017) Geyu Zhou et al.   Frontiers in Microbiology

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(2017) Martin H. Thornhill et al.   Current Infectious Disease Reports

Leaky Gut As a Danger Signal for Autoimmune Diseases

(2017) Qinghui Mu et al.   Frontiers in Immunology

Treatment of biofilms in bacterial vaginosis by an amphoteric tenside pessary-clinical study and microbiota analysis

(2017) Cornelia Gottschick et al.   Microbiome

Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease -- Role of Spirochetes1

(2017) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and Peripheral Infections: The Possible Contribution from Periodontal Infections, Model and Hypothesis

(2017) Angela R. Kamer et al.   JOURNAL OF ALZHEIMERS DISEASE

Cryptococcal Meningitis Misdiagnosed as Alzheimer's Disease: Complete Neurological and Cognitive Recovery with Treatment

(2017) Michael Hoffmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease-Specific Tau Phosphorylation is Induced by Herpes Simplex Virus Type 1

(2017) Matthew A. Wozniak et al.   JOURNAL OF ALZHEIMERS DISEASE

Association between tooth loss and cognitive decline: A 13-year longitudinal study of Chinese older adults

(2017) Juan Li et al.   PLoS One

Polymicrobial Infections In Brain Tissue From Alzheimer’s Disease Patients

(2017) Diana Pisa et al.   Scientific Reports

The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible

(2017) Felice Contaldi et al.   Scientific Reports

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

A gut (microbiome) feeling about the brain

(2016) Eoin Sherwin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Membrane Damage Induced by Amyloid Beta and a Potential Link with Neuroinflammation

(2016) Eduardo J. Fernandez-Perez et al.   CURRENT PHARMACEUTICAL DESIGN

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques

(2016) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Periodontal disease and inflammatory blood cytokines in patients with stable coronary artery disease

(2016) Cassio KAMPITS et al.   Journal of Applied Oral Science

Amyloid Structures as Biofilm Matrix Scaffolds

(2016) Agustina Taglialegna et al.   JOURNAL OF BACTERIOLOGY

Innate Immunity and Saliva in Candida albicans–mediated Oral Diseases

(2016) O. Salvatori et al.   JOURNAL OF DENTAL RESEARCH

High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis

(2016) Bradley Field Bale et al.   POSTGRADUATE MEDICAL JOURNAL

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

(2016) A P Allen et al.   Translational Psychiatry

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Population prevalence of edentulism and its association with depression and self-rated health

(2016) Stefanos Tyrovolas et al.   Scientific Reports

Bifidobacteria modulate cognitive processes in an anxious mouse strain

(2015) H.M. Savignac et al.   BEHAVIOURAL BRAIN RESEARCH

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(2015) Shohreh Majd et al.   BMC NEUROSCIENCE

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting

(2015) L. Genton et al.   CLINICAL NUTRITION

Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome

(2015) Rachel D. Moloney et al.   CNS Neuroscience & Therapeutics

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(2015) Takahiro Shimizu et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

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(2015) Arvind Anand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Java project on periodontal diseases: causes of tooth loss in a cohort of untreated individuals

(2015) Ubele van der Velden et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Porphyromonas gingivalisPeriodontal Infection and Its Putative Links with Alzheimer’s Disease

(2015) Sim K. Singhrao et al.   MEDIATORS OF INFLAMMATION

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress

(2015) S. Liang et al.   NEUROSCIENCE

Flagellar motility of the pathogenic spirochetes

(2015) Charles W. Wolgemuth   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dentures are a Reservoir for Respiratory Pathogens

(2015) Lindsay E. O'Donnell et al.   Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry

Lactobacillus fermentumNS9 restores the antibiotic induced physiological and psychological abnormalities in rats

(2015) T. Wang et al.   Beneficial Microbes

Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease

(2015) Judith Miklossy   Frontiers in Aging Neuroscience

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(2015) Shahryar Khaleghi et al.   Therapeutic Advances in Gastroenterology

The Antimicrobial Activity of Gramicidin A Is Associated with Hydroxyl Radical Formation

(2015) Je-Wen Liou et al.   PLoS One

Different Brain Regions are Infected with Fungi in Alzheimer’s Disease

(2015) Diana Pisa et al.   Scientific Reports

Establishment of Intestinal Microbiota during Early Life: a Longitudinal, Explorative Study of a Large Cohort of Danish Infants

(2014) A. Bergstrom et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Alzheimer’s disease and disseminated mycoses

(2014) R. Alonso et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Early-onset Alzheimer's disease: a global cross-sectional analysis

(2014) P. K. Panegyres et al.   EUROPEAN JOURNAL OF NEUROLOGY

Contribution of the Interaction of Streptococcus mutans SerotypekStrains with Fibrinogen to the Pathogenicity of Infective Endocarditis

(2014) Ryota Nomura et al.   INFECTION AND IMMUNITY

Denture Wearing during Sleep Doubles the Risk of Pneumonia in the Very Elderly

(2014) T. Iinuma et al.   JOURNAL OF DENTAL RESEARCH

Porphyromonas gingivalis Outer Membrane Vesicles Exclusively Contain Outer Membrane and Periplasmic Proteins and Carry a Cargo Enriched with Virulence Factors

(2014) Paul D. Veith et al.   JOURNAL OF PROTEOME RESEARCH

Lactobacillus helveticus–fermented milk improves learning and memory in mice

(2014) Kazuhito Ohsawa et al.   NUTRITIONAL NEUROSCIENCE

Serum IgG Antibody Levels to Periodontal Microbiota Are Associated with Incident Alzheimer Disease

(2014) James M. Noble et al.   PLoS One

Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat

(2014) Jia Luo et al.   Science China-Life Sciences

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms

(2014) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Staphylococcus aureus Extracellular Vesicles Carry Biologically Active β-Lactamase

(2013) Jaewook Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Neisseria meningitidis PorA and PorB Expression in Antimicrobial Susceptibility

(2013) Ian R. Peak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

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(2013) Fei Wang et al.   CANCER LETTERS

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(2013) Kelly Schwartz et al.   CURRENT OPINION IN MICROBIOLOGY

The intricate association between gut microbiota and development of Type 1, Type 2 and Type 3 diabetes

(2013) Pjotr Bekkering et al.   Expert Review of Clinical Immunology

Structure-Function Studies of the Neisseria gonorrhoeae Major Outer Membrane Porin

(2013) Adrienne Chen et al.   INFECTION AND IMMUNITY

Periodontal disease and diabetes mellitus

(2013) Carlos Antonio NEGRATO et al.   Journal of Applied Oral Science

Adverse Oral Health and Cognitive Decline: The Health, Aging and Body Composition Study

(2013) Robert Stewart et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide

(2013) Christian Peters et al.   NEUROBIOLOGY OF AGING

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease

(2013) Fernando J. Sepúlveda et al.   NEUROBIOLOGY OF AGING

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Disease to Dirt: The Biology of Microbial Amyloids

(2013) David A. Hufnagel et al.   PLoS Pathogens

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease

(2012) Pamela Sparks Stein et al.   Alzheimers & Dementia

Brain Abscess Caused by Enterococcus faecalis following a Dental Procedure in a Patient with Hereditary Hemorrhagic Telangiectasia

(2012) E. Mylona et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Longitudinal plasma amyloid beta as a biomarker of Alzheimer’s disease

(2012) Robert A. Rissman et al.   JOURNAL OF NEURAL TRANSMISSION

Therapeutic strategies for tau mediated neurodegeneration

(2012) Y. Yoshiyama et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

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(2012) Arthur J. Kim et al.   JOURNAL OF PERIODONTOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

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(2012)   NATURE

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Moraxella catarrhalisOuter Membrane Vesicles Carry β-Lactamase and Promote Survival ofStreptococcus pneumoniaeandHaemophilus influenzaeby Inactivating Amoxicillin

(2011) Viveka Schaar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

(2011) Jianhong Wang et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

(2011) G.-D. Batty et al.   EUROPEAN PSYCHIATRY

Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics

(2011) T A Ajslev et al.   INTERNATIONAL JOURNAL OF OBESITY

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

(2011) Judith Miklossy   Journal of Neuroinflammation

The microbiome-gut-brain axis: from bowel to behavior

(2011) J. F. Cryan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Diversity, biogenesis and function of microbial amyloids

(2011) Luz P. Blanco et al.   TRENDS IN MICROBIOLOGY

Lipid raft disruption protects mature neurons against amyloid oligomer toxicity

(2010) Fiorella Malchiodi-Albedi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

(2010) L. E. Wroblewski et al.   CLINICAL MICROBIOLOGY REVIEWS

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

The Human Oral Microbiome

(2010) F. E. Dewhirst et al.   JOURNAL OF BACTERIOLOGY

Role of Excitatory Amino Acid Transporter-2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics

(2010) Keetae Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses

(2010) J.B. Kaplan   JOURNAL OF DENTAL RESEARCH

Effect of alkaline growth pH on the expression of cell envelope proteins in Fusobacterium nucleatum

(2010) P. S. Zilm et al.   MICROBIOLOGY-SGM

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

(2010) Fernando J. Sepulveda et al.   PLoS One

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

Microbiology of Odontogenic Bacteremia: beyond Endocarditis

(2009) N. B. Parahitiyawa et al.   CLINICAL MICROBIOLOGY REVIEWS

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(2009) Tania Beatriz Romero-Adrián et al.   CURRENT MICROBIOLOGY

Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-κB dependent pathway in human astrocytes

(2009) Sung Mi Ju et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

(2009) Angela R. Kamer et al.   JOURNAL OF NEUROIMMUNOLOGY

Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease

(2009) Jannis Kountouras et al.   JOURNAL OF NEUROLOGY

Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III

(2009) J M Noble et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Verification of a topology model of PorT as an integral outer-membrane protein in Porphyromonas gingivalis

(2009) K.-A. Nguyen et al.   MICROBIOLOGY-SGM

Periodontitis in systemic rheumatic diseases

(2009) Paola de Pablo et al.   Nature Reviews Rheumatology

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

(2009) Jennifer M. Bomberger et al.   PLoS Pathogens

Lack of Evidence for Borrelia burgdorferi Seropositivity in Alzheimer Disease

(2008) Alessio Galbussera et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Interaction of the Lyme Disease Spirochete Borrelia burgdorferi with Brain Parenchyma Elicits Inflammatory Mediators from Glial Cells as Well as Glial and Neuronal Apoptosis

(2008) Geeta Ramesh et al.   AMERICAN JOURNAL OF PATHOLOGY

Clathrin-dependent entry of a gingipain adhesin peptide andPorphyromonas gingivalisinto host cells

(2008) Heike Boisvert et al.   CELLULAR MICROBIOLOGY

Bacteremia Associated With Toothbrushing and Dental Extraction

(2008) Peter B. Lockhart et al.   CIRCULATION

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Tau-based treatment strategies in neurodegenerative diseases

(2008) Anja Schneider et al.   Neurotherapeutics

Periodontal Infection Is Associated With Endothelial Dysfunction in Healthy Subjects and Hypertensive Patients

(2007) Yukihito Higashi et al.   HYPERTENSION