In vivo PET imaging of neuroinflammation in Alzheimer’s disease

PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans

(2017) Ansel T. Hillmer et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies

(2017) Daniel García-Lorenzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease

(2017) William C. Kreisl et al.   NEUROBIOLOGY OF AGING

In Vivo Imaging of Human Neuroinflammation

(2016) Daniel S. Albrecht et al.   ACS Chemical Neuroscience

Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study

(2016) Peter S. Bloomfield et al.   AMERICAN JOURNAL OF PSYCHIATRY

Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study

(2016) Tatsuhiro Terada et al.   ANNALS OF NUCLEAR MEDICINE

Preclinical and first-in-man studies of [11C]CB184 for imaging the 18-kDa translocator protein by positron emission tomography

(2016) Jun Toyohara et al.   ANNALS OF NUCLEAR MEDICINE

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Neuroinflammatory and morphological changes in late-life depression: the NIMROD study

(2016) Li Su et al.   BRITISH JOURNAL OF PSYCHIATRY

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders

(2016) Hans O. Kalkman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel MRI and PET markers of neuroinflammation in multiple sclerosis

(2016) Marloes Hagens et al.   CURRENT OPINION IN NEUROLOGY

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

(2016) Rawaha Ahmad et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer’s disease and elderly controls after oral administration of sembragiline

(2016) Stefan Sturm et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer’s Disease and Parkinson’s Disease Dementia?

(2016) Grazia D. Femminella et al.   JOURNAL OF ALZHEIMERS DISEASE

Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195

(2016) Masamichi Yokokura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2

(2016) Roger Slavik et al.   JOURNAL OF NEUROCHEMISTRY

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

(2016) D. Ory et al.   JOURNAL OF NUCLEAR MEDICINE

11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

(2016) Masamichi Ikawa et al.   JOURNAL OF NUCLEAR MEDICINE

Parametric Binding Images of the TSPO Ligand 18F-DPA-714

(2016) S. S. V. Golla et al.   JOURNAL OF NUCLEAR MEDICINE

Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein

(2016) Z. Fan et al.   JOURNAL OF NUCLEAR MEDICINE

Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation

(2016) Paul R. Territo et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of Early-Phase 11C-Deuterium-L-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease

(2016) E. Rodriguez-Vieitez et al.   JOURNAL OF NUCLEAR MEDICINE

Picture imperfect: Going beyond imaging amyloid in Alzheimer's disease

(2016) Ellie Kincaid   NATURE MEDICINE

11 C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease

(2016) William C. Kreisl et al.   NEUROBIOLOGY OF AGING

Exploratory human PET study of the effectiveness of 11 C-ketoprofen methyl ester, a potential biomarker of neuroinflammatory processes in Alzheimer's disease

(2016) Akihito Ohnishi et al.   NUCLEAR MEDICINE AND BIOLOGY

In vivo imaging of neuroinflammation in schizophrenia

(2016) Ofer Pasternak et al.   SCHIZOPHRENIA RESEARCH

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies

(2016) L Su et al.   Translational Psychiatry

Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3

(2016) Muneer Ahamed et al.   Frontiers in Neuroscience

Test-retest analysis of a non-invasive method of quantifying [11C]-PBR28 binding in Alzheimer’s disease

(2016) Akshay Nair et al.   EJNMMI Research

A Novel PET Imaging Probe for the Detection and Monitoring of Translocator Protein 18 kDa Expression in Pathological Disorders

(2016) Mara Perrone et al.   Scientific Reports

Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia

(2015) Zhen Fan et al.   Alzheimers & Dementia

The methodology of TSPO imaging with positron emission tomography

(2015) Federico E. Turkheimer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

(2015) Vijay K Ramanan et al.   BRAIN

Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer’s disease

(2015) Zhen Fan et al.   BRAIN

Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis

(2015) Paul M Matthews et al.   Expert Opinion on Drug Discovery

Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients

(2015) Sandeep SV Golla et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging

(2015) Jing Zhang   Journal of Neuroinflammation

Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?

(2015) L. Vivash et al.   JOURNAL OF NUCLEAR MEDICINE

Optimized Quantification of Translocator Protein Radioligand 18F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers

(2015) S. Lavisse et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein

(2015) C. H. Lyoo et al.   JOURNAL OF NUCLEAR MEDICINE

Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?

(2015) Z. Fan et al.   JOURNAL OF NUCLEAR MEDICINE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

In-vivo imaging of grey and white matter neuroinflammation in Alzheimer’s disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA

(2015) I Suridjan et al.   MOLECULAR PSYCHIATRY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease

(2015) Michael M. Zeineh et al.   NEUROBIOLOGY OF AGING

TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?

(2015) Rudolph E. Tanzi   NEW ENGLAND JOURNAL OF MEDICINE

Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

(2015) Michael Schöll et al.   Scientific Reports

The dynamics of monocytes and microglia in Alzheimer’s disease

(2015) Peter Thériault et al.   Alzheimers Research & Therapy

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

(2015) Leah D. Gershen et al.   JAMA Neurology

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

(2015) Nicole R. Zürcher et al.   NeuroImage-Clinical

Radiosynthesis and Preliminary Biological Evaluation of [ 18 F]VC701, a Radioligand for Translocator Protein

(2015) Giuseppe Di Grigoli et al.   Molecular Imaging

Imaging Striatal Microglial Activation in Patients with Parkinson’s Disease

(2015) Yuko Koshimori et al.   PLoS One

Neuroinflammation in bipolar disorder – A [11C]-(R)-PK11195 positron emission tomography study

(2014) Bartholomeus C.M. (Benno) Haarman et al.   BRAIN BEHAVIOR AND IMMUNITY

Imaging Neuroinflammation? A Perspective from MR Spectroscopy

(2014) Natalie M. Zahr et al.   BRAIN PATHOLOGY

The 18 kDa Translocator Protein, Microglia and Neuroinflammation

(2014) Guo-Jun Liu et al.   BRAIN PATHOLOGY

Neuroinflammation and � Amyloid Deposition in Alzheimer's Disease: In vivo Quantification with Molecular Imaging

(2014) C. Hommet et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Astrocytosis measured by 11C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer’s patients

(2014) IL Han Choo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects

(2014) Andrea Varrone et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Kinetic Modeling without Accounting for the Vascular Component Impairs the Quantification of [11C]PBR28 Brain PET Data

(2014) Gaia Rizzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation

(2014) Bieneke Janssen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging

(2014) Eduardo Zimmer et al.   Journal of Neuroinflammation

Human whole-body biodistribution and dosimetry of a new PET tracer, [11C]ketoprofen methyl ester, for imagings of neuroinflammation

(2014) Akihito Ohnishi et al.   NUCLEAR MEDICINE AND BIOLOGY

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

(2014) Kazushiro Takata et al.   PLoS One

Imaging Neuroinflammation in Gray and White Matter in Schizophrenia: An In-Vivo PET Study With [18F]-FEPPA

(2014) M. Kenk et al.   SCHIZOPHRENIA BULLETIN

Molecular magnetic resonance imaging of brain–immune interactions

(2014) Maxime Gauberti et al.   Frontiers in Cellular Neuroscience

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study

(2013) Jonas Hannestad et al.   BRAIN BEHAVIOR AND IMMUNITY

[11C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches

(2013) Zhangjie Su et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer’s disease patients

(2013) Andrea Varrone et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: A [11C]TMSX Brain PET Study

(2013) Eero Rissanen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Influence of TSPO Genotype on 11C-PBR28 Standardized Uptake Values

(2013) K. K. Yoder et al.   JOURNAL OF NUCLEAR MEDICINE

Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding

(2013) Q. Guo et al.   JOURNAL OF NUCLEAR MEDICINE

Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity — A Critical Update

(2013) Markus Laube et al.   MOLECULES

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

(2013) I. Suridjan et al.   NEUROIMAGE

Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia

(2013) Paul Edison et al.   NEUROPSYCHOPHARMACOLOGY

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

(2013) Philippe Corcia et al.   PLoS One

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

(2012) William C Kreisl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Optimization of Supervised Cluster Analysis for Extracting Reference Tissue Input Curves in (R)-[11C]PK11195 Brain PET Studies

(2012) Maqsood Yaqub et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

(2012) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain

(2012) Hui Zhang et al.   NEUROIMAGE

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

(2012) S. Iannaccone et al.   PARKINSONISM & RELATED DISORDERS

Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment–dementia converters measured by positron emission tomography with [11C]DAA1106

(2012) Fumihiko Yasuno et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

In vivo imaging of astrocytosis in Alzheimer’s disease: an 11C-L-deuteriodeprenyl and PIB PET study

(2011) Alexander Frizell Santillo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography

(2011) Pablo M Rusjan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28

(2011) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine

(2011) Balázs Gulyás et al.   NEUROIMAGE

Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients

(2011) Masahiro Mishina et al.   PLoS One

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease

(2010) Masamichi Yokokura et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation

(2010) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma

(2010) S. G. Temel et al.   JOURNAL OF MOLECULAR HISTOLOGY

Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

(2010) D. R. J. Owen et al.   JOURNAL OF NUCLEAR MEDICINE

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography

(2010) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL

Three-Dimensional Structure of TspO by Electron Cryomicroscopy of Helical Crystals

(2010) Vladimir M. Korkhov et al.   STRUCTURE

Carbon 11–Labeled Pittsburgh Compound B and Carbon 11–Labeled (R)-PK11195 Positron Emission Tomographic Imaging in Alzheimer Disease

(2009) Clayton A. Wiley et al.   ARCHIVES OF NEUROLOGY

Assessment of MAO-B Occupancy in the Brain With PET and [11C]-L-Deprenyl-D2: A Dose-Finding Study With a Novel MAO-B Inhibitor, EVT 301

(2009) J Hirvonen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans

(2009) C. J. Endres et al.   JOURNAL OF NUCLEAR MEDICINE

Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation

(2009) F. Chauveau et al.   JOURNAL OF NUCLEAR MEDICINE

Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study

(2009) J. Doorduin et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker

(2009) William C. Kreisl et al.   NEUROIMAGE

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Imaging Microglial Activation in Alzheimer's Disease: What Does It Mean?

(2008) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106

(2008) Fumihiko Yasuno et al.   BIOLOGICAL PSYCHIATRY

Imaging Microglial Activation During Neuroinflammation and Alzheimer’s Disease

(2008) Sriram Venneti et al.   Journal of Neuroimmune Pharmacology

The Positron Emission Tomography Ligand DAA1106 Binds With High Affinity to Activated Microglia in Human Neurological Disorders

(2008) Sriram Venneti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

(2008) G. Esposito et al.   JOURNAL OF NUCLEAR MEDICINE

Novel Reference Region Model Reveals Increased Microglial and Reduced Vascular Binding of 11C-(R)-PK11195 in Patients with Alzheimer's Disease

(2008) G. Tomasi et al.   JOURNAL OF NUCLEAR MEDICINE

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system

(2008) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY