Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

Oxidative and Nitrosative Modifications of Biliverdin Reductase-A in the Brain of Subjects with Alzheimer's Disease and Amnestic Mild Cognitive Impairment

(2018) Eugenio Barone et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated from Lymphocytes from Patients with Alzheimer's Disease: Insights into the Role of Oxidative Stress in Alzheimer's Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder

(2018) Rukhsana Sultana et al.   JOURNAL OF ALZHEIMERS DISEASE

HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology

(2017) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders

(2017) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

(2017) Mark A. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration

(2017) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage

(2016) Fabio Di Domenico et al.   Current Alzheimer Research

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype

(2016) Antonella Tramutola et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53

(2015) Eugenio Barone et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Vitamin D deficiency and Alzheimer disease: Common links

(2015) Jeriel T. Keeney et al.   NEUROBIOLOGY OF DISEASE

Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

(2015) Chun-Hau Chen et al.   NEUROBIOLOGY OF DISEASE

Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?

(2015) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach

(2014) Giovanna Cenini et al.   FREE RADICAL BIOLOGY AND MEDICINE

The 2013 SFRBM discovery award: Selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment

(2014) D. Allan Butterfield   FREE RADICAL BIOLOGY AND MEDICINE

Tracking the earliest pathologic changes in Alzheimer disease

(2014) S. M. Landau et al.   NEUROLOGY

Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies

(2013) Aaron M. Swomley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease

(2013) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

(2013) Jeriel T.R. Keeney et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mass spectrometry and redox proteomics: Applications in disease

(2013) D. Allan Butterfield et al.   MASS SPECTROMETRY REVIEWS

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

(2013) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B

(2012) Eugenio Barone et al.   ANTIOXIDANTS & REDOX SIGNALING

Do Proteomics Analyses Provide Insights into Reduced Oxidative Stress in the Brain of an Alzheimer Disease Transgenic Mouse Model with an M631L Amyloid Precursor Protein Substitution and Thereby the Importance of Amyloid-Beta-Resident Methionine 35 in Alzheimer Disease Pathogenesis?

(2012) Rukhsana Sultana et al.   ANTIOXIDANTS & REDOX SIGNALING

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

(2012) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain

(2012) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer’s disease versus controls

(2012) Jason A. Bailey et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation

(2012) Gilyana G. Borlikova et al.   NEUROBIOLOGY OF AGING

Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights from Proteomics into Important Pathways Regulated by p53

(2012) Ada Fiorini et al.   PLoS One

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

(2011) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

(2011) Giovanna Cenini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

(2011) Rukhsana Sultana et al.   Journal of Proteomics

Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects

(2011) Fabio Di Domenico et al.   Journal of Proteomics

Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor proteinΞ

(2011) R.A.S. Robinson et al.   NEUROSCIENCE

Cell Cycle Proteins in Brain in Mild Cognitive Impairment: Insights into Progression to Alzheimer Disease

(2011) Jeriel T. R. Keeney et al.   NEUROTOXICITY RESEARCH

Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: Insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive

(2011) Renã A. S. Robinson et al.   PROTEOMICS

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

(2011) Marzia Perluigi et al.   Proteomics Clinical Applications

Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: An investigation on the role of cellular stress response in the progression of Alzheimer disease

(2010) Fabio Di Domenico et al.   BRAIN RESEARCH

Identification of the oxidative stress proteome in the brain

(2010) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

The wheat germ agglutinin-fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression

(2010) Fabio Di Domenico et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Age-related loss of phospholipid asymmetry in APPNLh/APPNLh x PS-1P264L/PS-1P264L human double mutant knock-in mice: Relevance to Alzheimer disease

(2010) Miranda L. Bader Lange et al.   NEUROBIOLOGY OF DISEASE

Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

(2009) Rukhsana Sultana et al.   ACTA NEUROPATHOLOGICA

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism

(2009) D. Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Glutathionylation of the Pro-apoptotic Protein p53 in Alzheimer’s Disease Brain: Implications for AD Pathogenesis

(2009) Fabio Di Domenico et al.   NEUROCHEMICAL RESEARCH

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

(2009) Marzia Perluigi et al.   Proteomics Clinical Applications

Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age

(2008) Hafiz Mohmmad Abdul et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease

(2008) Giovanna Cenini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

(2008) Tanea T. Reed et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

(2008) Giovanna Cenini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

(2008) Mubeen Ahmad Ansari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

(2008) Hyoung-gon Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease

(2007) Miranda L. Bader Lange et al.   NEUROBIOLOGY OF DISEASE

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease

(2006) Wycliffe O. Opii et al.   NEUROBIOLOGY OF AGING