Practical considerations for choosing a mouse model of Alzheimer’s disease
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Title
Practical considerations for choosing a mouse model of Alzheimer’s disease
Authors
Keywords
Transgenic mouse, Knockout, Knock-in, Amyloid precursor protein, APP, Aβ, Tau, MAPT, TREM2, Apolipoprotein E, ApoE
Journal
Molecular Neurodegeneration
Volume 12, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-12-22
DOI
10.1186/s13024-017-0231-7
References
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Note: Only part of the references are listed.- Reduction in open field activity in the absence of memory deficits in the App NL−G−F knock-in mouse model of Alzheimer’s disease
- (2018) Lauren S. Whyte et al. BEHAVIOURAL BRAIN RESEARCH
- Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease
- (2017) Alexandra J. Mably et al. HIPPOCAMPUS
- Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal
- (2017) Silvia S Kang et al. HUMAN MOLECULAR GENETICS
- Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy
- (2017) Lucia Buccarello et al. JOURNAL OF ALZHEIMERS DISEASE
- Challenges and opportunities in limiting abdominal aortic aneurysm growth
- (2017) Jonathan Golledge et al. JOURNAL OF VASCULAR SURGERY
- Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
- (2017) Anastasia G. Efthymiou et al. Molecular Neurodegeneration
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Not just amyloid: physiological functions of the amyloid precursor protein family
- (2017) Ulrike C. Müller et al. NATURE REVIEWS NEUROSCIENCE
- Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
- (2017) Na Zhao et al. NEURON
- Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways
- (2017) Aleksandra M. Wojtas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel
- (2017) Yunyao Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease
- (2017) Robert J. Andrew et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential Incorporation of Tau Isoforms in Alzheimer's Disease
- (2017) Marisol Espinoza et al. JOURNAL OF ALZHEIMERS DISEASE
- Apparent Behavioral Benefits of Tau Overexpression in P301L Tau Transgenic Mice
- (2017) Dave Morgan et al. JOURNAL OF ALZHEIMERS DISEASE
- Alzheimer’s disease: experimental models and reality
- (2016) Eleanor Drummond et al. ACTA NEUROPATHOLOGICA
- Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex
- (2016) Fani Koukouli et al. Aging-US
- Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice
- (2016) Sumihiro Maeda et al. EMBO REPORTS
- A TgCRND8 Mouse Model of Alzheimer’s Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve
- (2016) Matthew W. Granger et al. JOURNAL OF ALZHEIMERS DISEASE
- Soluble Conformers of A and Tau Alter Selective Proteins Governing Axonal Transport
- (2016) M. A. Sherman et al. JOURNAL OF NEUROSCIENCE
- Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression
- (2016) T. Saito et al. JOURNAL OF NEUROSCIENCE
- Gamma frequency entrainment attenuates amyloid load and modifies microglia
- (2016) Hannah F. Iaccarino et al. NATURE
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- Cognitive deficits in single App knock-in mouse models
- (2016) Akira Masuda et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo
- (2016) Sarah K. Kaufman et al. NEURON
- Impaired burrowing is the most prominent behavioral deficit of aging htau mice
- (2016) Philippine Camilla Geiszler et al. NEUROSCIENCE
- Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease
- (2016) T.L. Platt et al. NEUROSCIENCE
- IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline
- (2016) Amy K. Y. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction
- (2016) Michael J. Yetman et al. PLoS One
- Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
- (2015) Adam K. Walker et al. ACTA NEUROPATHOLOGICA
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
- (2015) Nicole Maphis et al. BRAIN
- Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
- (2015) Rik van der Kant et al. DEVELOPMENTAL CELL
- Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
- (2015) Sujeong Yang et al. EXPERIMENTAL NEUROLOGY
- Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model
- (2015) Casey Cook et al. HUMAN MOLECULAR GENETICS
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
- (2015) A. Caccamo et al. JOURNAL OF NEUROSCIENCE
- Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease
- (2015) H. Zhang et al. JOURNAL OF NEUROSCIENCE
- Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
- (2015) Elena Zenaro et al. NATURE MEDICINE
- Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
- (2015) Sang-Won Min et al. NATURE MEDICINE
- Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance
- (2015) Linda Madisen et al. NEURON
- Sex Dimorphism Profile of Alzheimer’s Disease-Type Pathologies in an APP/PS1 Mouse Model
- (2015) Shu-Sheng Jiao et al. NEUROTOXICITY RESEARCH
- Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile
- (2015) Peng Liu et al. PLoS One
- Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
- (2015) Carlo Condello et al. Nature Communications
- Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
- (2015) Guilian Xu et al. Acta Neuropathologica Communications
- DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease
- (2015) Harriet M. Jackson et al. PLoS One
- Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains
- (2014) Susana Boluda et al. ACTA NEUROPATHOLOGICA
- Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
- (2014) V. A. Polito et al. EMBO Molecular Medicine
- Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
- (2014) Edgar Dawkins et al. JOURNAL OF NEUROCHEMISTRY
- Genetic Modulation of Soluble A Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease
- (2014) S. W. Fowler et al. JOURNAL OF NEUROSCIENCE
- Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease
- (2014) H. A. Born et al. JOURNAL OF NEUROSCIENCE
- Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
- (2014) Hongmei Li et al. Molecular Neurodegeneration
- Single App knock-in mouse models of Alzheimer's disease
- (2014) Takashi Saito et al. NATURE NEUROSCIENCE
- Protective Effects of Minocycline against Short-Term Ischemia-Reperfusion Injury in Rat Brain
- (2014) Mustafa Aras et al. PEDIATRIC NEUROSURGERY
- Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid- accumulation modifier
- (2014) T. Morihara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteopathic tau seeding predicts tauopathy in vivo
- (2014) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
- (2014) Scott J. Webster et al. Frontiers in Genetics
- Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model
- (2013) Marcio Lazzarini et al. GLIA
- A Rapid Gene Delivery-Based Mouse Model for Early-Stage Alzheimer Disease-Type Tauopathy
- (2013) Robert Siman et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Repetitive Mild Traumatic Brain Injury Augments Tau Pathology and Glial Activation in Aged hTau Mice
- (2013) Joseph-Olubunmi Ojo et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis
- (2013) T. Melnikova et al. JOURNAL OF NEUROSCIENCE
- Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
- (2013) M. Iba et al. JOURNAL OF NEUROSCIENCE
- Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
- (2013) William A Eimer et al. Molecular Neurodegeneration
- Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain
- (2013) Raphaëlle Caillierez et al. MOLECULAR THERAPY
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- Modeling Alzheimer’s Disease in Mouse without Mutant Protein Overexpression: Cooperative and Independent Effects of Aβ and Tau
- (2013) Qinxi Guo et al. PLoS One
- Effective combination of human bone marrow mesenchymal stem cells and minocycline in experimental autoimmune encephalomyelitis mice
- (2013) Yun Hou et al. Stem Cell Research & Therapy
- Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
- (2013) Scott J Webster et al. Alzheimers Research & Therapy
- Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
- (2013) E.-M. Mandelkow et al. Cold Spring Harbor Perspectives in Medicine
- Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model
- (2013) Jingheng Cheng et al. eLife
- Strain Background Influences Neurotoxicity and Behavioral Abnormalities in Mice Expressing the Tetracycline Transactivator
- (2012) H. J. Han et al. JOURNAL OF NEUROSCIENCE
- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
- (2012) B. Zhang et al. JOURNAL OF NEUROSCIENCE
- Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
- (2012) Shaefali P Rodgers et al. Molecular Neurodegeneration
- Impaired Performance of Female APP/PS1 Mice in the Morris Water Maze Is Coupled with Increased A� Accumulation and Microglial Activation
- (2012) J.J. Gallagher et al. Neurodegenerative Diseases
- Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
- (2012) Alix de Calignon et al. NEURON
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trans-Synaptic Spread of Tau Pathology In Vivo
- (2012) Li Liu et al. PLoS One
- PGC-1 Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
- (2012) T. Tsunemi et al. Science Translational Medicine
- Cognitive phenotyping of amyloid precursor protein transgenic J20 mice
- (2011) Tim Karl et al. BEHAVIOURAL BRAIN RESEARCH
- A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
- (2011) Prem K. Premsrirut et al. CELL
- ApoE is required for maintenance of the dentate gyrus neural progenitor pool
- (2011) C.-P. Yang et al. DEVELOPMENT
- Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons
- (2011) Hung-Kai Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- Biology and pathophysiology of the amyloid precursor protein
- (2011) Hui Zheng et al. Molecular Neurodegeneration
- Neuronal activity regulates the regional vulnerability to amyloid-β deposition
- (2011) Adam W Bero et al. NATURE NEUROSCIENCE
- Combination therapy prevents amyloid-dependent and -independent structural changes
- (2011) Gauri Malthankar-Phatak et al. NEUROBIOLOGY OF AGING
- Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction
- (2011) Melissa J. Alldred et al. NEUROBIOLOGY OF DISEASE
- Multiple Forms of Activity-Dependent Competition Refine Hippocampal Circuits In Vivo
- (2011) Masahiro Yasuda et al. NEURON
- P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating
- (2011) Hiroki Takeuchi et al. PLoS One
- Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau
- (2010) Dara L. Dickstein et al. Brain Structure & Function
- Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity
- (2010) Izumi Maezawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
- (2010) K. R. Brunden et al. JOURNAL OF NEUROSCIENCE
- Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease
- (2010) Sadim Jawhar et al. NEUROBIOLOGY OF AGING
- Regulation of Tau Pathology by the Microglial Fractalkine Receptor
- (2010) Kiran Bhaskar et al. NEURON
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
- (2010) Brian R. Hoover et al. NEURON
- Visualizing the Distribution of Synapses from Individual Neurons in the Mouse Brain
- (2010) Ling Li et al. PLoS One
- Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease
- (2010) Latha Devi et al. Molecular Brain
- Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
- (2010) Claire J. Garwood et al. Frontiers in Psychiatry
- Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin
- (2009) Kiren Ubhi et al. ACTA NEUROPATHOLOGICA
- Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology
- (2009) M. Polydoro et al. JOURNAL OF NEUROSCIENCE
- The role of tau in neurodegeneration
- (2009) Tania F Gendron et al. Molecular Neurodegeneration
- Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy
- (2009) Mei Yue et al. NEUROBIOLOGY OF AGING
- Doxycycline is Neuroprotective Against Nigral Dopaminergic Degeneration by a Dual Mechanism Involving MMP-3
- (2009) Yuri Cho et al. NEUROTOXICITY RESEARCH
- AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice
- (2009) Tomasz Jaworski et al. PLoS One
- Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model
- (2008) Chiho Hirata-Fukae et al. BRAIN RESEARCH
- rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse
- (2008) Mitsuru Morimoto et al. DEVELOPMENTAL BIOLOGY
- Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP
- (2008) Rita Joao Guerreiro et al. NEUROBIOLOGY OF AGING
- Gender-Specific Neuroimmunoendocrine Aging in a Triple-Transgenic 3×Tg-AD Mouse Model for Alzheimer’s Disease and Its Relation with Longevity
- (2008) Lydia Giménez-Llort et al. NEUROIMMUNOMODULATION
- Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation
- (2008) M. Osinde et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease
- (2007) Davis Ryman et al. NEUROBIOLOGY OF AGING
- Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology
- (2007) Lijun Wang et al. NEUROBIOLOGY OF DISEASE
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