Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

Proteodynamics in aging human T cells – The need for its comprehensive study to understand the fine regulation of T lymphocyte functions

(2018) Jacek M. Witkowski et al.   EXPERIMENTAL GERONTOLOGY

Role of the peripheral innate immune system in the development of Alzheimer's disease

(2018) Aurélie Le Page et al.   EXPERIMENTAL GERONTOLOGY

Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer’s Disease Development

(2018) Hugo Lövheim et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinical Trials for Disease-Modifying Therapies in Alzheimer’s Disease: A Primer, Lessons Learned, and a Blueprint for the Future

(2018) Jeffrey Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

The Past and the Future of Alzheimer’s Disease Fluid Biomarkers

(2018) Kaj Blennow et al.   JOURNAL OF ALZHEIMERS DISEASE

The Rationale Behind the New Alzheimer’s Disease Conceptualization: Lessons Learned During the Last Decades

(2018) José Luis Molinuevo et al.   JOURNAL OF ALZHEIMERS DISEASE

Interactions between Atrial Fibrillation, Cardiovascular Risk Factors, and ApoE Genotype in Promoting Cognitive Decline in Patients with Alzheimer’s Disease: A Prospective Cohort Study

(2018) Lorenzo Falsetti et al.   JOURNAL OF ALZHEIMERS DISEASE

Innovative Biomarkers for Alzheimer’s Disease: Focus on the Hidden Disease Biomarkers

(2018) Roberta Ghidoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease –Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase

(2018) Katja Kriebel et al.   Frontiers in Microbiology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

A Complex Proinflammatory Role for Peripheral Monocytes in Alzheimer's Disease

(2018) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Intracellular and Extracellular Roles for Tau in Neurodegenerative Disease

(2018) Diane P. Hanger et al.   JOURNAL OF ALZHEIMERS DISEASE

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Modulation of Immune Responses to Herpes Simplex Virus Type 1 by IFNL3 and IRF7 Polymorphisms: A Study in Alzheimer’s Disease

(2017) Andrea Saul Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Alterations in the Peripheral Immune System in Dementia

(2017) Mandy Busse et al.   JOURNAL OF ALZHEIMERS DISEASE

Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease Patients

(2017) Aurélie Le Page et al.   JOURNAL OF ALZHEIMERS DISEASE

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing

(2017) Ruth Alonso et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

The Failure of Solanezumab — How the FDA Saved Taxpayers Billions

(2017) Chana A. Sacks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences

(2017) Eric S. Wohleb et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Role of infiltrating monocytes/macrophages in acute and chronic neuroinflammation: Effects on cognition, learning and affective behaviour

(2017) Aedín M. Minogue   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Role of neuroinflammation in neurodegeneration: new insights

(2017) Róisín M. McManus et al.   Alzheimers Research & Therapy

The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

(2017) Gabriele Siegel et al.   Cell Reports

Periodontitis, Microbiomes and their Role in Alzheimer’s Disease

(2017) Anna B. Pritchard et al.   Frontiers in Aging Neuroscience

The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases

(2017) Chris J. Carter et al.   Frontiers in Aging Neuroscience

Exploring the Anti-quorum Sensing and Antibiofilm Efficacy of Phytol against Serratia marcescens Associated Acute Pyelonephritis Infection in Wistar Rats

(2017) Ramanathan Srinivasan et al.   Frontiers in Cellular and Infection Microbiology

Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort

(2017) Rebecca F. Gottesman et al.   JAMA Neurology

Chlamydophila Pneumoniae and the Etiology of Late-Onset Alzheimer's Disease

(2017) Brian J. Balin et al.   JOURNAL OF ALZHEIMERS DISEASE

Polymicrobial Infections In Brain Tissue From Alzheimer’s Disease Patients

(2017) Diana Pisa et al.   Scientific Reports

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

(2017) Yicong Liu et al.   Scientific Reports

Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation

(2016) Judith Miklossy et al.   Aging-US

Tau: From research to clinical development

(2016) David M. Holtzman et al.   Alzheimers & Dementia

Microglial toll-like receptors and Alzheimer’s disease

(2016) Fan Su et al.   BRAIN BEHAVIOR AND IMMUNITY

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Herpes and Alzheimer’s Disease: Subversion in the Central Nervous System and How It Might Be Halted

(2016) Ruth F. Itzhaki   JOURNAL OF ALZHEIMERS DISEASE

Anti-Viral Properties of Amyloid-β Peptides

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques

(2016) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Ion Channel Formation by Amyloid-β42Oligomers but Not Amyloid-β40in Cellular Membranes

(2016) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and treatment of the Staphylococcus aureus reservoir in vivo

(2016) Bas G.J. Surewaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amyloid formation: functional friend or fearful foe?

(2016) P. Bergman et al.   JOURNAL OF INTERNAL MEDICINE

Danger-associated molecular patterns in Alzheimer’s disease

(2016) Carmen Venegas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

(2016) Barry W. Festoff et al.   Journal of Neuroinflammation

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Human gut microbiota: the links with dementia development

(2016) Rashad Alkasir et al.   Protein & Cell

Fungal Enolase, β-Tubulin, and Chitin Are Detected in Brain Tissue from Alzheimer’s Disease Patients

(2016) Diana Pisa et al.   Frontiers in Microbiology

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line

(2016) Kah Yan How et al.   Frontiers in Microbiology

Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis, and Alzheimer’s disease

(2016) Ingar Olsen et al.   Journal of Oral Microbiology

Reactivated herpes simplex infection increases the risk of Alzheimer's disease

(2015) Hugo Lövheim et al.   Alzheimers & Dementia

The Innate Immunity in Alzheimer Disease- Relevance to Pathogenesis and Therapy

(2015) Zofia Blach-Olszewska et al.   CURRENT PHARMACEUTICAL DESIGN

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Porphyromonas gingivalisPeriodontal Infection and Its Putative Links with Alzheimer’s Disease

(2015) Sim K. Singhrao et al.   MEDIATORS OF INFLAMMATION

New insight into the molecular control of bacterial functional amyloids

(2015) Jonathan D. Taylor et al.   Frontiers in Cellular and Infection Microbiology

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease

(2015) Xiaojuan Sun et al.   Frontiers in Pharmacology

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Amyloid and Alzheimer's Disease: Inside and Out

(2014) Joshua H. K. Tam et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

A study on the association between infectious burden and Alzheimer's disease

(2014) X.-L. Bu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Pathogenic microbes, the microbiome, and Alzheimer’s disease (AD)

(2014)   Frontiers in Aging Neuroscience

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Microbial amyloids – functions and interactions within the host

(2013) Kelly Schwartz et al.   CURRENT OPINION IN MICROBIOLOGY

Alzheimer's disease and the microbiome

(2013) Surjyadipta Bhattacharjee et al.   Frontiers in Cellular Neuroscience

Microanatomy at Cellular Resolution and Spatial Order of Physiological Differentiation in a Bacterial Biofilm

(2013) D. O. Serra et al.   mBio

Disease to Dirt: The Biology of Microbial Amyloids

(2013) David A. Hufnagel et al.   PLoS Pathogens

Soluble amyloid precursor protein β as blood-based biomarker of Alzheimer’s disease

(2013) R Perneczky et al.   Translational Psychiatry

Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

(2012) Denise Galante et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro

(2012) Eva Sapi et al.   PLoS One

Exploring New Biological Functions of Amyloids: Bacteria Cell Agglutination Mediated by Host Protein Aggregation

(2012) Marc Torrent et al.   PLoS Pathogens

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Emerging roles of pathogens in Alzheimer disease

(2011) Judith Miklossy   EXPERT REVIEWS IN MOLECULAR MEDICINE

Alzheimer’s Disease: Implications of the Updated Diagnostic and Research Criteria

(2011) Eric M. Reiman et al.   JOURNAL OF CLINICAL PSYCHIATRY

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

(2011) Judith Miklossy   Journal of Neuroinflammation

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2010) Elena Biagi et al.   PLoS One

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Alzheimer disease versus mixed dementias: An EEG perspective

(2008) Ursula Schreiter Gasser et al.   CLINICAL NEUROPHYSIOLOGY

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY