International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
出版年份 2020 全文链接
标题
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
作者
关键词
-
出版物
PHARMACOLOGICAL REVIEWS
Volume 73, Issue 1, Pages 310-520
出版商
American Society for Pharmacology & Experimental Therapeutics (ASPET)
发表日期
2020-12-24
DOI
10.1124/pr.118.015552
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- Serotonin 2A and 2B receptor-induced phrenic motor facilitation: differential requirement for spinal NADPH oxidase activity
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- Role of Protein Transamidation in Serotonin-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells
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- Repinotan, a Selective 5-HT1A-R-Agonist, Antagonizes Morphine-Induced Ventilatory Depression in Anesthetized Rats
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- Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways
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- GPCR Interacting Proteins (GIPs) in the Nervous System: Roles in Physiology and Pathologies
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- Behavioral and neurochemical effects of chronic L-DOPA treatment on nonmotor sequelae in the hemiparkinsonian rat
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- Dopamine D2 and 5-hydroxytryptamine 5-HT2A receptors assemble into functionally interacting heteromers
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- Addiction: Decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit
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- Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
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- Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome
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- Agonists and Antagonists Bind to an A-A Interface in the Heteromeric 5-HT3AB Receptor
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- Distribution of 5-HT 1B , 5-HT 1D and 5-HT 1F receptor expression in rat trigeminal and dorsal root ganglia neurons: Relevance to the selective anti-migraine effect of triptans
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- The 5-HT2B receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment
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- Acute treatment of migraine with the selective 5-HT1F receptor agonist lasmiditan – A randomised proof-of-concept trial
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- Role of 5-HT2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats
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- Serotonin 2B receptor signaling is required for craniofacial morphogenesis and jaw joint formation in Xenopus
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- Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy
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- F15599, a preferential post-synaptic 5-HT1A receptor agonist: Activity in models of cognition in comparison with reference 5-HT1A receptor agonists
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- Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats
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- Controversies Involving the Role of 5-Hydroxytryptamine in Generating Colonic Migrating Motor Complexes: What Is Spontaneous?
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- Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice
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- The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing
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- Regulation of antigen-specific CTL and Th1 cell activation through 5-Hydroxytryptamine 2A receptor
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- 5-HT1A receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups
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- 5-HT6 antagonism attenuates cue-induced relapse to cocaine seeking without affecting cocaine reinforcement
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- The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT2C receptors
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- Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT1A receptors but not 5-HT2A receptors
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- Serotonergic 5-HT2BReceptor Controls Tissue-nonspecific Alkaline Phosphatase Activity in Osteoblasts via Eicosanoids and Phosphatidylinositol-specific Phospholipase C
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- Physical Interaction of Jab1 with Human Serotonin 6 G-protein-coupled Receptor and Their Possible Roles in Cell Survival
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- Can We Really Accelerate and Enhance the Selective Serotonin Reuptake Inhibitor Antidepressant Effect?
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- Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
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- Synthesis, Structure−Affinity Relationships, and Radiolabeling of Selective High-Affinity 5-HT4Receptor Ligands as Prospective Imaging Probes for Positron Emission Tomography
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- An Accurate, Clinically Feasible Multi-Gene Expression Assay for Predicting Metastasis in Uveal Melanoma
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- The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity
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- Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior
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- The identification of N-glycosylated residues of the human 5-HT3B receptor subunit: importance for cell membrane expression
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- Motoneuron Excitability and Muscle Spasms Are Regulated by 5-HT2B and 5-HT2C Receptor Activity
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- The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors
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- Serotonin Modulates Fast-Spiking Interneuron and Synchronous Activity in the Rat Prefrontal Cortex through 5-HT1A and 5-HT2A Receptors
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- Leptin Excites Proopiomelanocortin Neurons via Activation of TRPC Channels
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- Enhanced Function of Prefrontal Serotonin 5-HT2 Receptors in a Rat Model of Psychiatric Vulnerability
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- Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a -Arrestin2/Src/Akt Signaling Complex In Vivo
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- PRX-08066, a Novel 5-Hydroxytryptamine Receptor 2B Antagonist, Reduces Monocrotaline-Induced Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Rats
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- Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
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- G protein coupled receptors as allosteric proteins and the role of allosteric modulators
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- ORIGINAL RESEARCH—BASIC SCIENCE: Acute and Repeated Flibanserin Administration in Female Rats Modulates Monoamines Differentially Across Brain Areas: A Microdialysis Study
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- Role of N-Linked Glycosylation of the 5-HT2A Receptor in JC Virus Infection
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- Risperidone-Induced Inactivation and Clozapine-Induced Reactivation of Rat Cortical Astrocyte 5-Hydroxytryptamine7 Receptors: Evidence for In Situ G Protein-Coupled Receptor Homodimer Protomer Cross-Talk
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- Disrupting 5-HT2A Receptor/PDZ Protein Interactions Reduces Hyperalgesia and Enhances SSRI Efficacy in Neuropathic Pain
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- A population-specific HTR2B stop codon predisposes to severe impulsivity
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- Serotonin regulates pancreatic beta cell mass during pregnancy
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- Involvement of 5-Hydroxytryptamine in Canine Intestinal Motility Patterns
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- LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin
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- A 5-HT4-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult
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- Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter
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- Functional Genomics of Serotonin Receptor 2A (HTR2A): Interaction of Polymorphism, Methylation, Expression and Disease Association
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- 5-HT1A Autoreceptor Levels Determine Vulnerability to Stress and Response to Antidepressants
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- 5-HT2C receptor regulation of defensive responses in the rat dorsal periaqueductal gray
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- Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT2B Receptors for Dexfenfluramine Anorectic Effects
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- Stimulation of Medial Prefrontal Cortex Serotonin 2C (5-HT2C) Receptors Attenuates Cocaine-Seeking Behavior
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- No link of serotonin 2C receptor editing to serotonin transporter genotype
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- Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury
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- Effects of the 5-HT4 receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels
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- Serotonin receptor 5-HT5A in rat hippocampus decrease by leptin treatment
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- LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor
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- Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method
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- Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity
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- Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
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- Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin
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- The relevance of preclinical research models for the development of antimigraine drugs: Focus on 5-HT1B/1D and CGRP receptors
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- 5-HT3 receptors: Role in disease and target of drugs
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- Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels
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- Reversal of hippocampal neuronal maturation by serotonergic antidepressants
- (2010) K. Kobayashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Blocker drugs mediate calcium signaling in native central nervous system neurons by -arrestin-biased agonism
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- Correction of respiratory disorders in a mouse model of Rett syndrome
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- RGS inhibition at G i2 selectively potentiates 5-HT1A-mediated antidepressant effects
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- E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat
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- Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions
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- Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats
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- Reversal of sibutramine-induced anorexia with a selective 5-HT2C receptor antagonist
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- The structural basis of function in Cys-loop receptors
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- The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivo
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- MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants
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- Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention
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- Therapeutic potential of β-arrestin- and G protein-biased agonists
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- Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice
- (2010) Weber Frontiers in Neuroscience
- Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy
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- G Protein - Mediated Signaling: Same Receptor, Multiple Effectors
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- Efficacy of 5-HT3 Antagonists and 5-HT4 Agonists in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis
- (2009) Alexander C Ford et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- The spleen is required for 5-HT1A receptor agonist-mediated increases in mean circulatory filling pressure during hemorrhagic shock in the rat
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- Inhibition of the cardiovascular response to stress by systemic 5-HT1A activation: sympathoinhibition or anxiolysis?
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- RhoA and Rho Kinase Activation in Human Pulmonary Hypertension
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- Do Variations in the 5-HT3A and 5-HT3B Serotonin Receptor Genes (HTR3A and HTR3B) Influence the Occurrence of Postoperative Vomiting?
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- Wnt2 acts as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibits expression of stanniocalcin-1
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- Mirtazapine Use in Human Immunodeficiency Virus–Infected Patients With Progressive Multifocal Leukoencephalopathy
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- Serotonin release and uptake in the gastrointestinal tract
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- Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion.
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- The 5-HT7 receptor is involved in allocentric spatial memory information processing
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- Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity
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- Constitutive Gs-mediated, but not G12-mediated, activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain
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- The Serotonin-1A Receptor in Anxiety Disorders
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- 5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress
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- Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors
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- Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5-HT1B receptor
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- Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1Areceptor agonist
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- Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2Breceptor in rodent large bowel physiology
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- A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure
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- Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptorsviaERK1/2 signalling pathways
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- Serotonin 4 receptor (5-HT4R) internalization is isoform-specific: Effects of 5-HT and RS67333 on isoforms A and B
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- BODY DISTRIBUTION OF INFUSED SEROTONIN IN RATS
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- Vilazodone: A 5-HT1AReceptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders
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- Serotonin Receptors, Type 4: A New Hope?
- (2009) Guillaume Lucas CURRENT DRUG TARGETS
- The 5-HT1B Receptor: A Novel Target for the Pathophysiology of Depression (Supplementary Tables)
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- Nicotinic acetylcholine receptors at atomic resolution
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- The role of dimerisation in the cellular trafficking of G-protein-coupled receptors
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- Species Differences in the Formation of Vabicaserin Carbamoyl Glucuronide
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- Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene
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- β-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling
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- Effect of piboserod, a 5-HT4serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
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- Serotonin excites fast-spiking interneurons in the striatum
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- [18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging
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- Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery
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- In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT4 receptor
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- Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors
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- D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia
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- Evaluation of the effect of selective serotonin-reuptake inhibitors on lymphocyte subsets in patients with a major depressive disorder
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- Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
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- Serotonin Has a Key Role in Pathogenesis of Experimental Colitis
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- Serotonin promotes tumor growth in human hepatocellular cancer
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- Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour
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- Agonist-dependent modulation of G-protein coupling and transduction of 5-HT1A receptors in rat dorsal raphe nucleus
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- Lurasidone in the Treatment of Acute Schizophrenia
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- Mechanism of interdigestive migrating motor complex in conscious dogs
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- A Multivalent Approach to the Design and Discovery of Orally Efficacious 5-HT4Receptor Agonists
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- Platelet derived serotonin drives the activation of rat cardiac fibroblasts by 5-HT2A receptors
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- 5-HT4 and 5-HT2 receptors antagonistically influence gap junctional coupling between rat auricular myocytes
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- Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT2Areceptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and β arrestin-2 interactions
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- Global Gene Expression Analysis of Rodent Motor Neurons Following Spinal Cord Injury Associates Molecular Mechanisms With Development of Postinjury Spasticity
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- Layer II/III of the Prefrontal Cortex: Inhibition by the Serotonin 5-HT1A Receptor in Development and Stress
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- PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors
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- 5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice
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- Role of p11 in Cellular and Behavioral Effects of 5-HT4 Receptor Stimulation
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- An innovative real-time PCR method to measure changes in RNA editing of the serotonin 2C receptor (5-HT2CR) in brain
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- Adaptations in 5-HT receptor expression and function: Implications for treatment of cognitive impairment in aging
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- Kinetic Modeling of 11C-SB207145 Binding to 5-HT4 Receptors in the Human Brain In Vivo
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- Expression of mRNA for 5-HT2 Receptors and Proteins Related to Inactivation of 5-HT in Mouse Osteoblasts
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- Direct Subunit-Dependent Multimodal 5-Hydroxytryptamine3 Receptor Antagonism by Methadone
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- Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment
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- Genome-wide association study identifies five loci associated with lung function
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- Enhanced tonic GABAA inhibition in typical absence epilepsy
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- Fibrosis and carcinoid syndrome: from causation to future therapy
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- A placebo-controlled trial of the 5-HT1Aagonist R-137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia
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- 5-hydroxyindalpine, an agonist at the putative 5-HT1Preceptor, has no activity on human recombinant monoamine receptors but accelerates distension-induced peristalsis in mouse isolated colon
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- Translating 5-HT4receptor pharmacology
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- A selective, high affinity 5-HT2Breceptor antagonist inhibits visceral hypersensitivity in rats
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- Lack of serotonin 5-HT2Breceptor alters proliferation and network volume of interstitial cells of Cajalin vivo
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- Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients
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- Editing of Serotonin 2C Receptor mRNA in the Prefrontal Cortex Characterizes High-Novelty Locomotor Response Behavioral Trait
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- Neurocircuitry of Addiction
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- The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats
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- Colocalization of 5-HT1F receptor and calcitonin gene-related peptide in rat vestibular nuclei
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- 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice
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- Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders
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- Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT4 receptor
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- The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs
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- Serotonylation of Vascular Proteins Important to Contraction
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- 5-Hydroxytryptamine Modulates Migration, Cytokine and Chemokine Release and T-Cell Priming Capacity of Dendritic Cells In Vitro and In Vivo
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- Role of Serotonin via 5-HT2B Receptors in the Reinforcing Effects of MDMA in Mice
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- Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
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- Activation of 5-HT6 receptors facilitates attentional set shifting
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- Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors
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- A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients With Acute Ischemic Stroke
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- The role of the dorsal raphe nucleus in the development, expression, and treatment of L-dopa-induced dyskinesia in hemiparkinsonian rats
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- ‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins
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- The role of serotonin in intestinal luminal sensing and secretion
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- Balancing Drug Risk and Benefit: Toward Refining the Process of FDA Decisions Affecting Patient Care
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- Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum
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- Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice
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- Identification of Biomarkers of Adrenocortical Carcinoma Using Genomewide Gene Expression Profiling
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- Improvement of phencyclidine-induced social behaviour deficits in rats: Involvement of 5-HT1A receptors
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- A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats
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- Molecular biology of 5-HT receptors
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- The role of 5-HT1A receptors in learning and memory
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- The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat
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- Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice
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- Pharmacology of 5HT2C receptor-mediated ERK1/2 phosphorylation: Agonist-specific activation pathways and the impact of RNA editing
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- S100B's double life: Intracellular regulator and extracellular signal
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- Organic Background of Restrictive-Type Anorexia Nervosa Suggested by Increased Serotonin1A Receptor Binding in Right Frontotemporal Cortex of Both Lean and Recovered Patients: [18F]MPPF PET Scan Study
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- Novel antagonists of serotonin-4 receptors: Synthesis and biological evaluation of pyrrolothienopyrazines
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- The existence of a local 5-hydroxytryptaminergic system in peripheral arteries
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- 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
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- Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts
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- Phospholipase A2 Biochemistry
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- Serotonin and Angiotensin Receptors in Cardiac Fibroblasts Coregulate Adrenergic-Dependent Cardiac Hypertrophy
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- BOTH 5-HYDROXYTRYPTAMINE 5-HT2AAND 5-HT1BRECEPTORS ARE INVOLVED IN THE VASOCONSTRICTOR RESPONSE TO 5-HT IN THE HUMAN ISOLATED INTERNAL THORACIC ARTERY
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- Effects of 5-Hydroxytryptamine (Serotonin) Type 3 Antagonists on Symptom Relief and Constipation in Nonconstipated Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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- Serotonergic agents and the irritable bowel syndrome: what goes wrong?
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- Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat
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- Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells
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- Fenfluramine: riddle or Rosetta stone?
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- Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice
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- 5-Hydroxytryptamine (5HT)-induced valvulopathy: Compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats
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- Localized Release of Serotonin (5-Hydroxytryptamine) by a Fecal Pellet Regulates Migrating Motor Complexes in Murine Colon
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- Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain
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- The Discovery and Development of the Triptans, a Major Therapeutic Breakthrough
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- Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model
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- First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome
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- Serotonin 5-HT 2B Receptor Blockade Prevents Reactive Oxygen Species–Induced Cardiac Hypertrophy in Mice
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- Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice
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- Structural Determinants of Ca2+Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor
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- Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2ASignaling
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- Evaluation of the Novel 5-HT4 Receptor PET Ligand [11C]SB207145 in the Göttingen Minipig
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- Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3and GABA ρ1 Receptors Lacking the Large Cytoplasmic M3M4 Loop
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- Phospholipase A2structure/function, mechanism, and signaling
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- Structural Modifications ofN-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT7Receptor Activity. Part III
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- Characterisation of 5-HT3C, 5-HT3Dand 5-HT3Ereceptor subunits: evolution, distribution and function
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- Dysregulated Editing of Serotonin 2C Receptor mRNAs Results in Energy Dissipation and Loss of Fat Mass
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- Targeting of the 5-HT1A Serotonin Receptor to Neuronal Dendrites Is Mediated by Yif1B
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- Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro
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- A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
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- Effects of a Cannabinoid1 Receptor Antagonist and Serotonin2C Receptor Agonist Alone and in Combination on Motivation for Palatable Food: A Dose-Addition Analysis Study in Mice
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- Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization
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- Strain-specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice
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- Asenapine: a novel psychopharmacologic agent with a unique human receptor signature
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- Antiangiogenic Effect of a Selective 5-HT4 Receptor Agonist
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- Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels
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- Physical Interaction of Calmodulin with the 5-Hydroxytryptamine2C Receptor C-Terminus Is Essential for G Protein-independent, Arrestin-dependent Receptor Signaling
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- Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors
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- Sumatriptan Inhibits Synaptic Transmission in the Rat Midbrain Periaqueductal Grey
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- Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6
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- Apneusis responding to buspirone in multiple sclerosis
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- Identification of a serotonin/glutamate receptor complex implicated in psychosis
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- Hormones of the gut–brain axis as targets for the treatment of upper gastrointestinal disorders
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- Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
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- Activation of G proteins and extracellular signal-regulated kinase 1/2 phosphorylation via human dopamine D4.4 receptors: differential pathway-dependent potencies of receptor agonists
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- The in vivo gastrointestinal activity of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity
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- Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium
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- Serotonin pharmacology in the gastrointestinal tract: a review
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- Serotonergic signalling in the stomach and duodenum of patients with gastroparesis
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- Distribution of serotonin receptors and interacting proteins in the human sigmoid colon
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- 5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis
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- 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus
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- Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases
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- Fine-tuning serotonin2c receptor function in the brain: Molecular and functional implications
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- An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function
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- 5-HT4 receptors: History, molecular pharmacology and brain functions
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- Effects of serotonin in failing cardiac ventricle: Signalling mechanisms and potential therapeutic implications
- (2008) Finn Olav Levy et al. NEUROPHARMACOLOGY
- Serotonin and GI clinical disorders
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- Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens
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- Allosteric modulation of 5-HT1A receptors by zinc: Binding studies
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- 5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor
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- Region-specific changes in 5-HT1A agonist-induced Extracellular signal-Regulated Kinases 1/2 phosphorylation in rat brain: A quantitative ELISA study
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- The 5-HT3 receptor – the relationship between structure and function
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- Role of ventral medial prefrontal cortex in incubation of cocaine craving
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- Stress Impairs 5-HT2A Receptor-Mediated Serotonergic Facilitation of GABA Release in Juvenile Rat Basolateral Amygdala
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- 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus
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- Central 5-HT receptors in cardiovascular control during stress
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- 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer’s disease
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- Serotonin type 3 receptor genes:HTR3A, B, C, D, E
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- Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors
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- Alternative splicing and exon duplication generates 10 unique porcine 5-HT4 receptor splice variants including a functional homofusion variant
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