Transglutaminase 2-mediated serotonylation in pulmonary hypertension

Bone morphogenetic protein 2 decreases TRPC expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells

(2013) Yi Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension

(2013) Yang Xia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice

(2013) Sung Mee Jung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation

(2013) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An in Vivo Tagging Method Reveals that Ras Undergoes Sustained Activation upon Transglutaminase-Mediated Protein Serotonylation

(2013) Jason Ching-Yao Lin et al.   CHEMBIOCHEM

Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice

(2012) Shariq Abid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Serotonylated fibronectin is elevated in pulmonary hypertension

(2012) Lin Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA–Rho kinase and Akt signalling pathways in rats

(2012) Han-Ming Wang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Enhanced Ca 2+ -Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension

(2012) Aya Yamamura et al.   CIRCULATION RESEARCH

Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling

(2012) Jakob Vowinckel et al.   FEBS LETTERS

Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: Evidence for a general mechanism of monoaminylation

(2012) René Hummerich et al.   FEBS LETTERS

Gene Therapy by Targeted Adenovirus-mediated Knockdown of Pulmonary Endothelial Tph1 Attenuates Hypoxia-induced Pulmonary Hypertension

(2012) Ian Morecroft et al.   MOLECULAR THERAPY

Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases

(2011) Diego J. Walther et al.   FEBS Journal

New insights into the functions and localization of nuclear transglutaminase 2

(2011) Ting-Fang Kuo et al.   FEBS Journal

Extracellular TG2: emerging functions and regulation

(2011) Alexey M. Belkin   FEBS Journal

Reactivity of the N-terminal Region of Fibronectin Protein to Transglutaminase 2 and Factor XIIIA

(2011) Brian R. Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Extracellular Transglutaminase 2 by Thioredoxin

(2011) Xi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells

(2011) Evgeny A. Zemskov et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice

(2011) Keunhee Oh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered Gene Expression in Pulmonary Tissue of Tryptophan Hydroxylase-1 Knockout Mice: Implications for Pulmonary Arterial Hypertension

(2011) Richard B. Rothman et al.   PLoS One

Unconventional Secretion of Tissue Transglutaminase Involves Phospholipid-Dependent Delivery into Recycling Endosomes

(2011) Evgeny A. Zemskov et al.   PLoS One

Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells

(2010) Wenying Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Protein Transamidation in Serotonin-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

(2010) Yinglin Liu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transglutaminase 2: a multi-functional protein in multiple subcellular compartments

(2010) Donghyun Park et al.   AMINO ACIDS

Anti-inflammatory effects of the R2 peptide, an inhibitor of transglutaminase 2, in a mouse model of allergic asthma, induced by ovalbumin

(2010) Dae Yong Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Extracellular transglutaminase 2 has a role in cell adhesion, whereas intracellular transglutaminase 2 is involved in regulation of endothelial cell proliferation and apoptosis

(2010) C. Nadalutti et al.   CELL PROLIFERATION

Serotonin—more than a neurotransmitter: transglutaminase-mediated serotonylation of C6 glioma cells and fibronectin

(2010) René Hummerich et al.   NEUROCHEMISTRY INTERNATIONAL

RhoA and Rho Kinase Activation in Human Pulmonary Hypertension

(2009) Christophe Guilluy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis

(2009) W Malorni et al.   CELL DEATH AND DIFFERENTIATION

Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-κB activity in hypoxic tumor cells

(2009) G -Y Jang et al.   ONCOGENE

Serotonylation of Vascular Proteins Important to Contraction

(2009) Stephanie W. Watts et al.   PLoS One

Pulmonary vasodilator testing and use of calcium channel blockers in pulmonary arterial hypertension

(2009) Adriano R. Tonelli et al.   RESPIRATORY MEDICINE

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

(2009) Nils Paulmann et al.   PLOS BIOLOGY

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

(2008) R. J. Collighan et al.   AMINO ACIDS

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS

Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

(2008) Matthew Siegel et al.   PLoS One