期刊
BEHAVIOURAL BRAIN RESEARCH
卷 249, 期 -, 页码 65-74出版社
ELSEVIER
DOI: 10.1016/j.bbr.2013.04.024
关键词
Wakefulness; REM sleep; Serotonin; 5-HT6 receptor agonist; WAY-208466; Rat
资金
- Programa de Desarrollo de las Ciencias Basicas (PEDECIBA), Uruguay
The effects of WAY-208466, a selective 5-HT6 receptor agonist on spontaneous sleep were studied in adult rats implanted for chronic sleep recordings. Systemic administration of WAY-208466 during the light phase of the light-dark cycle significantly increased wakefulness (W) and reduced slow wave sleep (SWS), REM sleep (REMS) and the number of REMS periods. Pretreatment with the selective 5-HT6 receptor antagonist RO-399885 prevented the effects of the 5-HT6 receptor agonist on W, SWS and REMS. Direct infusion of WAY-208466 into the dorsal raphe nucleus, locus coeruleus, basal forebrain (horizontal limb of the diagonal band of Broca) or laterodorsal tegmental nucleus specifically decreased REMS without significantly altering War SWS. In all instances the REMS suppression was dependent upon the reduction of REMS periods. The finding that WAY-208466 increases extracellular gamma-aminobutyric acid (GABA) levels in the rat frontal cortex tends to suggest that the neurotransmitter could be involved in the 5-HT6 receptor agonist-induced disruption of the sleep-wake cycle. However, further studies are needed to resolve this issue. (C) 2013 Elsevier B.V. All rights reserved.
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