Article
Psychology, Multidisciplinary
Ruth Gallagher, Klaus Kessler, Jessica Bramham, Martin Dechant, Maximilian A. Friehs
Summary: This proof-of-concept study evaluates a remotely administered gamified Stop-Signal Task (gSST) for future use in child studies, showing its potential advantages and positive feedback from child participants.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychiatry
Wan-Sen Yan, Dan-Hui Zheng, Meng-Meng Liu
Summary: The study found that in undiagnosed young adults, BED may be associated with trait impulsivity such as attentional impulsiveness, motor impulsiveness, negative urgency, positive urgency, and lack of perseverance, while choice impulsivity was not significantly related to binge eating behavior in the BED sample.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Jolyon A. Jones, Katharina Zuhlsdorff, Jeffrey W. Dalley
Summary: Drug addiction is manifested in some individuals and involves multifaceted processes such as cognitive control failures. Impulsivity, which includes reckless behavior without foresight, underlies most drug-taking behavior. While the neural substrates of the relationship between trait impulsivity and drug compulsion are poorly understood, advances have been made in studying limbic cortico-striatal circuits and neuromodulatory influences.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Psychology, Multidisciplinary
Wi Hoon Jung, Euitae Kim
Summary: In this study, we examined the global and regional topological properties of gray matter volume-based structural covariance networks in high discounting group (HDG) and low discounting group (LDG). The results showed that HDG had lower clustering coefficient and characteristic path length compared to LDG, indicating lower network segregation and higher integration. Moreover, HDG exhibited more significant small-worldness. In terms of local properties, HDG had lower betweenness centrality in the parahippocampal gyrus and amygdala compared to LDG. These findings suggest the involvement of structural covariance network topology in impulsive choice measured by delay discounting, and enhance our understanding of the association between impulsive choice and brain morphological features.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Brian F. O'Donnell, Patrick D. Skosnik, William P. Hetrick, Daniel J. Fridberg
Summary: Chronic cannabis users showed impairments in decision making tasks compared to non-users, displaying a preference for immediate rewards, less advantageous decisions, and greater impulsivity. However, both groups had similar performance on the Probabilistic Reversal Learning Task.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
Guy A. Higgins, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel
Summary: In this study, the effects of AMP and ATX were compared in different tasks, with ATX showing a reducing effect on impulsive behavior but no significant impact on impulsive choice and risky decision making, while AMP affecting choice preference and discounting, but in a nuanced manner.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Shubham Pandey, Rashmi Gupta
Summary: Response inhibition is a crucial component of executive control. Studies have shown that emotion processing can divert attention away from tasks, and irrelevant angry facial expressions can impair inhibitory control when the go signal is non-emotional.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Chloe S. Chernoff, Tristan J. Hynes, Catharine A. Winstanley
Summary: The study suggests that NA plays an important role in cue-induced deficits in decision making observed in laboratory-based gambling paradigms, indicating that NAergic drugs like atomoxetine and guanfacine may be useful in treating GD.
PSYCHOPHARMACOLOGY
(2021)
Review
Behavioral Sciences
Chi C. Chan, Sharon Alter, Erin A. Hazlett, Keith M. Shafritz, Rachel Yehuda, Marianne Goodman, M. Mehmet Haznedar, Philip R. Szeszko
Summary: This PRISMA-guided systematic review integrates findings on the neurocircuitry associated with impulsivity in bipolar disorder (BD). Functional neuroimaging studies using the Go/No-Go Task, Stop-Signal Task, and Delay Discounting Task were analyzed. Results suggest trait-like brain activation abnormalities in impulsivity-related regions that persist across mood states. BD exhibit under-activation in key frontal, insular, parietal, cingulate, and thalamic regions during rapid-response inhibition, but over-activation when emotional stimuli are involved. The study highlights the need for more research on delay discounting tasks in BD and proposes a working model of neurocircuitry dysfunction underlying behavioral impulsivity.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Construction & Building Technology
Tianjun Sun, Zhenhai Gao, Fei Gao, Tianyao Zhang, Di Ji, Siyan Chen
Summary: A humanized learning control model is proposed to improve the automatic stop-and-go task of intelligent vehicles. By analyzing real drivers' experiments, automatic starting and braking functions are designed, with positive results shown in simulation and real vehicle tests.
ADVANCES IN CIVIL ENGINEERING
(2021)
Article
Psychology, Biological
Kate M. Witt, Anne C. Macaskill
Summary: This study examined the relationship between delay discounting and subjective time perception. The experiments found that participants displayed greater delay discounting in waiting tasks, but there was no significant difference in time perception. Additionally, discounting rates were not correlated with subjective time perception. Changes in delay discounting may be understood in terms of context or reference effects.
BEHAVIOURAL PROCESSES
(2022)
Article
Psychiatry
James M. Bjork, Lori Keyser-Marcus, Jasmin Vassileva, Tatiana Ramey, David C. Houghton, F. Gerard Moeller
Summary: Positive social connections are crucial for recovery from Substance Use Disorder (SUD). Different groups of individuals with SUD may show idiosyncratic biases towards social signals, with variations in response patterns to emotional faces as targets. Understanding these differences can help develop tailored interventions for recovery.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Business, Finance
Anum Khan, Muhammad Shujat Mubarak
Summary: The purpose of this study is to develop a reliable and valid measurement scale for neurotransmitters and investigate their role in financial decision making. A threefold approach was used for scale development and validation. The study identified an eight-dimensional second-order model of neurotransmitters and highlighted the importance of considering neurotransmitter effects on financial decisions and investment behavior. This research contributes to the existing knowledge by defining and verifying dimensions of neurotransmitters and suggests the use of the developed scale as a research tool in cross-cultural studies of financial decision making.
INTERNATIONAL JOURNAL OF FINANCE & ECONOMICS
(2022)
Article
Behavioral Sciences
Irina Trofimova
Summary: This paper suggests examining existing and potential theoretical paradigms and formalisms and shifting from implicit behaviorism to Functional Constructivism (FC) approach. It highlights the variability and transient nature of behavior and proposes behavior as a generative process. The paper also proposes a model for diagnosing consistent behavioral patterns and classifying contexts.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2022)
Article
Behavioral Sciences
Sandra Sanchez-Roige, Samuel A. Barnes, Jazlene Mallari, Rebecca Wood, Oksana Polesskaya, Abraham A. Palmer
Summary: The membrane glycoprotein M6B (Gpm6b) is involved in neuronal differentiation, myelination, and inactivation of the serotonin transporter. Recent studies have shown its association with psychiatric disorders. A mutant allele of Gpm6b was created in mice, leading to deficits in delay discounting but enhanced reward sensitivity and behavioral flexibility.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Emmanuel Breysse, Julie Meffre, Yann Pelloux, Catharine A. Winstanley, Christelle Baunez
Summary: Bilateral STN lesions in rats were found to reduce risk-taking behavior in both the PDT and loss-chasing task, suggesting that STN inactivation could decrease risky decision-making. However, opposite results were observed in a small number of animals with lesions extending to the zona incerta, indicating the specificity of STN involvement in these processes.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Melanie Tremblay, Wendy K. Adams, Catharine A. Winstanley
Summary: Impairments in decision-making under uncertainty are observed in individuals with temporal lobe epilepsy and rats with amygdala damage, impacting their ability to avoid risky options. Stimulation of the basolateral amygdala in rats led to an increase in risk-averse choices and impulsivity among certain individuals. These findings suggest that amygdala activity can influence decision-making processes and promote impulsive behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Mason M. Silveira, Sebastian N. Wittekindt, Sophie Ebsary, Catharine A. Winstanley
Summary: Although temporary bilateral inactivation of the ventrolateral OFC (vlOFC) in female Long-Evans rats led to increased omissions and motor impulsivity during cognitive tasks, it did not affect their willingness or ability to exert cognitive effort for larger rewards. This suggests that the vlOFC plays a minimal role in cognitive effort allocation and valuations of effort.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tristan J. Hynes, Kelly M. Hrelja, Brett A. Hathaway, Celine D. Hounjet, Chloe S. Chernoff, Sophie A. Ebsary, Graeme D. Betts, Brittney Russell, Lawrence Ma, Sukhbir Kaur, Catharine A. Winstanley
Summary: Gambling and substance use disorders show high comorbidity, with the dopamine system potentially playing a role in both disorders. Inhibiting VTA dopamine neurons can affect decision-making and addiction behaviors, but the effects vary depending on biological sex.
Article
Clinical Neurology
Graeme D. Betts, Tristan J. Hynes, Catharine A. Winstanley
Summary: The study found that adding reward-concurrent cues to the rat gambling task altered decision-making and impulse control, suggesting the important role of the cholinergic system in these processes.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Chloe S. Chernoff, Tristan J. Hynes, Catharine A. Winstanley
Summary: The study suggests that NA plays an important role in cue-induced deficits in decision making observed in laboratory-based gambling paradigms, indicating that NAergic drugs like atomoxetine and guanfacine may be useful in treating GD.
PSYCHOPHARMACOLOGY
(2021)
Review
Neurosciences
Andrea Augustine, Catharine A. Winstanley, Vaishnav Krishnan
Summary: Parkinson's disease patients are not only affected by motor impairments, but also at risk for impulse control disorders. There is currently a lack of consensus on the best approach to addressing these symptoms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Brittney Russell, Wendy K. Adams, Kelly M. Hrelja, Fiona D. Zeeb, Matthew D. Taves, Sukhbir Kaur, Kiran K. Soma, Catharine A. Winstanley
Summary: Social isolation is a known risk factor for mental illness and impaired immune function. Research shows that neuroinflammatory processes may contribute to mental illness through cytokine-induced neural activity modulation. The study examined the effects of LPS administration and social home cage environment on cognitive performance and corticosterone and cytokine levels in rats. The results suggest that social isolation and LPS administration can both affect cognitive performance and hormone levels in rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Hannah G. Brodie, Brett A. Hathaway, Andrew Li, Samantha L. Baglot, Sukhbir Kaur, Matthew N. Hill, Catharine A. Winstanley
Summary: The study investigated the cognitive effects of acute oral administration of two different commercially available cannabis extracts in rats. It found that C. indica extract at the highest dose decreased the rats' willingness to exert cognitive effort, while repeated dosing with a medium dose did not influence choice. These findings suggest that different cannabis cultivars may have dissociable cognitive effects.
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Caitlin A. Orsini, Travis E. Brown, Travis E. Hodges, Yanaira Alonso-Caraballo, Catharine A. Winstanley, Jill B. Becker
Summary: Sex differences in motivation for food rewards, gambling, and drugs of abuse are influenced by sensory stimuli, gonadal hormones, and cognitive bias. Neural systems regulating executive functions respond differently to cues, drugs of abuse, and a high-fat diet in males and females. Gonadal hormones mediate sex differences in risky decision-making, cognitive bias, and motivation for food and drugs of abuse in both sexes.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Leili Mortazavi, Tristan J. Hynes, Chloe S. Chernoff, Shrishti Ramaiah, Hannah G. Brodie, Brittney Russell, Brett A. Hathaway, Sukhbir Kaur, Catharine A. Winstanley
Summary: Dopamine agonist therapies used to treat Parkinson's disease can exacerbate impulse control and gambling disorders, but the underlying mechanisms are unclear. Recent studies have found that adding win-paired cues to the rat gambling task increases risky decision-making and impulsivity via the dopamine system. Ropinirole treatment in male rats transiently increased motor impulsivity and choice of high-risk/high-reward options, especially during acquisition of the cued gambling task. The drug enhanced model-free learning and suppressed the activity of dopaminergic midbrain neurons, leading to perpetuated risky choice.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Jacqueline-Marie N. Ferland, Randall J. Ellis, Graeme Betts, Mason M. Silveira, Joao Bronze de Firmino, Catharine A. Winstanley, Yasmin L. Hurd
Summary: Adolescent cannabis use increases the risk of developing cannabis use disorder in adulthood, especially for high-potency cannabis. It remains unclear whether adolescent cannabis exposure and THC potency specifically predict risky decision-making or influence cognitive response to the drug later in life. This study leveraged a human data set and a rat model to evaluate the long-term outcomes of adolescent THC exposure on adult decision-making and impulse control.
Article
Behavioral Sciences
C. A. Hales, L. Clark, C. A. Winstanley
Summary: Computational modeling has become a crucial tool in neuroscience and psychiatry research for understanding cognitive processes in normal and pathological behavior. Reinforcement learning and drift diffusion modeling have shown potential in investigating gambling and Gambling Disorder, but they oversimplify real-world decision making. This review discusses studies that have used these modeling frameworks and highlights the potential of Bayesian models for tailored approaches.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Meeting Abstract
Neurosciences
Catharine Winstanley
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Brittney Russell, Michael M. Barrus, Melanie Tremblay, Lawrence Ma, Kelly Hrelja, Christina Wong, Tristan J. Hynes, Scott Hobson, Andrew J. Grottick, Catharine A. Winstanley
Summary: Research suggests that GPR52 agonists may be beneficial in treating iatrogenic gambling disorder or other conditions characterized by hyperdopaminergic states, as they can prevent an increase in preference for uncertain outcomes without altering baseline decision-making patterns.
BEHAVIORAL NEUROSCIENCE
(2021)