标题
Structural determinants of 5-HT2B receptor activation and biased agonism
作者
关键词
-
出版物
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 25, Issue 9, Pages 787-796
出版商
Springer Nature America, Inc
发表日期
2018-08-13
DOI
10.1038/s41594-018-0116-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
- (2018) Tao Che et al. CELL
- 5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
- (2018) Yao Peng et al. CELL
- Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist
- (2018) Wanchao Yin et al. Cell Discovery
- Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
- (2017) John D McCorvy et al. Nature Chemical Biology
- Regulatory Forum Review*: Utility of in Vitro Secondary Pharmacology Data to Assess Risk of Drug-induced Valvular Heart Disease in Humans: Regulatory Considerations
- (2017) Thomas Papoian et al. TOXICOLOGIC PATHOLOGY
- GPCR Dynamics: Structures in Motion
- (2016) Naomi R. Latorraca et al. CHEMICAL REVIEWS
- Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
- (2016) Dean P. Staus et al. NATURE
- PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
- (2015) Wesley K Kroeze et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure and function of serotonin G protein-coupled receptors
- (2015) John D. McCorvy et al. PHARMACOLOGY & THERAPEUTICS
- PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
- (2015) Wesley K Kroeze et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Dynamic Process of β2-Adrenergic Receptor Activation
- (2013) Rie Nygaard et al. CELL
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
- (2013) Aaron M. Ring et al. NATURE
- Structural Basis for Molecular Recognition at Serotonin Receptors
- (2013) C. Wang et al. SCIENCE
- Structural Features for Functional Selectivity at Serotonin Receptors
- (2013) D. Wacker et al. SCIENCE
- The GPCR Network: a large-scale collaboration to determine human GPCR structure and function
- (2012) Raymond C. Stevens et al. NATURE REVIEWS DRUG DISCOVERY
- Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors
- (2012) Eugene Chun et al. STRUCTURE
- Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors
- (2011) John A. Allen et al. Annual Review of Pharmacology and Toxicology
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Diversity and modularity of G protein-coupled receptor structures
- (2011) Vsevolod Katritch et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Conserved Binding Mode of Human β2Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
- (2010) Daniel Wacker et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Expanded Biology of Serotonin
- (2009) Miles Berger et al. Annual Review of Medicine
- Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment
- (2009) X.-P. Huang et al. MOLECULAR PHARMACOLOGY
- Crystallizing membrane proteins using lipidic mesophases
- (2009) Martin Caffrey et al. Nature Protocols
- Multiple Switches in G Protein-Coupled Receptor Activation
- (2009) Shivani Ahuja et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Carcinoid heart disease
- (2008) B.I. Gustafsson et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure
- (2007) Christopher B. Roth et al. JOURNAL OF MOLECULAR BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started