Allosteric signaling through an mGlu2 and 5-HT2Aheteromeric receptor complex and its potential contribution to schizophrenia

Exploratory Analysis for a Targeted Patient Population Responsive to the Metabotropic Glutamate 2/3 Receptor Agonist Pomaglumetad Methionil in Schizophrenia

(2015) Bruce J. Kinon et al.   BIOLOGICAL PSYCHIATRY

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment

(2015) Amr Ellaithy et al.   TRENDS IN NEUROSCIENCES

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Computational Approaches for Modeling GPCR Dimerization

(2014) Xuan-Yu Meng et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

(2014) Li Xue et al.   Nature Chemical Biology

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia

(2013) David H Adams et al.   BMC Psychiatry

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Preclinical models of antipsychotic drug action

(2013) José L. Moreno et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Animal Models of Serotonergic Psychedelics

(2012) James B. Hanks et al.   ACS Chemical Neuroscience

Restructuring G-Protein- Coupled Receptor Activation

(2012) Martin Audet et al.   CELL

Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects

(2012) Carolina Muguruza et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

(2012) José L. Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

(2012) Mitsumasa Kurita et al.   NATURE NEUROSCIENCE

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades

(2012) Hannah K. Delille et al.   NEUROPHARMACOLOGY

Clinical development of pomaglumetad methionil: A non-dopaminergic treatment for schizophrenia

(2012) Bruce J. Kinon et al.   NEUROPHARMACOLOGY

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

(2012) D. El Moustaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Inter- and Intrasubunit Rearrangements During Activation of Dimeric Metabotropic Glutamate Receptor 1

(2012) V. Hlavackova et al.   Science Signaling

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

A Multicenter, Inpatient, Phase 2, Double-Blind, Placebo-Controlled Dose-Ranging Study of LY2140023 Monohydrate in Patients With DSM-IV Schizophrenia

(2011) Bruce J. Kinon et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

(2011) José L. Moreno et al.   NEUROSCIENCE LETTERS

GPCR oligomers in pharmacology and signaling

(2011) Javier González-Maeso   Molecular Brain

Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: Antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients

(2010) Jesús A. García-Sevilla et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Group II metabotropic glutamate receptors and schizophrenia

(2009) José L. Moreno et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration

(2009) Marie-Laure Rives et al.   EMBO JOURNAL

Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors

(2009) Adam J. Kuszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses

(2008) Sophie K. Billa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

G Protein Activation by the Leukotriene B4Receptor Dimer

(2008) Marjorie Damian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling dimerizations of transmembrane proteins using Brownian dynamics simulations

(2008) Meng Cui et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

(2008) Damien Maurel et al.   NATURE METHODS

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY