Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Synthesis and Structure–Activity Relationship Studies of Conformationally Flexible Tetrahydroisoquinolinyl Triazole Carboxamide and Triazole Substituted Benzamide Analogues as σ2 Receptor Ligands

(2014) Suping Bai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic Modulation of Soluble A  Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

(2014) S. W. Fowler et al.   JOURNAL OF NEUROSCIENCE

An Antidepressant Decreases CSF A  Production in Healthy Individuals and in Transgenic AD Mice

(2014) Y. I. Sheline et al.   Science Translational Medicine

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

5-HT4 Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10

(2012) Maud Cochet et al.   ACS Chemical Neuroscience

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice

(2012) Thomas Freret et al.   BEHAVIOURAL BRAIN RESEARCH

Identification of Multiple 5-HT4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease

(2012) Michael A. Brodney et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Biphasic and Brain-Region Selective Down-Regulation of Cyclic Adenosine Monophosphate Concentrations Supports Object Recognition in the Rat

(2012) Maïte Hotte et al.   PLoS One

Effects of a putative antidepressant with a rapid onset of action in defeated mice with different coping strategies

(2012) Eneritz Gómez-Lázaro et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Serotonin signaling is associated with lower amyloid-  levels and plaques in transgenic mice and humans

(2011) J. R. Cirrito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library

(2010) Jana Sopkova-de Oliveira Santos et al.   Journal of Chemical Information and Modeling

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Effects of the 5-HT4 receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels

(2010) Cecilie Löe Licht et al.   NEUROSCIENCE LETTERS

Selective Serotonin Reuptake Inhibitors Potentiate the Rapid Antidepressant-Like Effects of Serotonin4 Receptor Agonists in the Rat

(2010) Guillaume Lucas et al.   PLoS One

Design, Synthesis, and Biological Evaluation of New 5-HT4Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease

(2009) Olivier Russo et al.   JOURNAL OF MEDICINAL CHEMISTRY

High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media

(2008) Bruno Bard et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased particulate phosphodiesterase 4 in the prefrontal cortex supports 5-HT4 receptor-induced improvement of object recognition memory in the rat

(2008) Guénaëlle Levallet et al.   PSYCHOPHARMACOLOGY