Article
Neurosciences
Stevenson Desmercieres, Virginie Lardeux, Jean-Emmanuel Longueville, Myriam Hanna, Leigh Panlilio, Nathalie Thiriet, Marcello Solinas
Summary: The newly developed PSS procedure provides a quantifiable breakpoint to measure animals' propensity to continue working for a reward despite progressively increasing electric shock intensity. The break point is sensitive to hunger and changes in the qualitative incentive value of the reward, and it shows differences compared to the traditional PR procedure.
Article
Behavioral Sciences
Anna U. Odland, Jesper L. Kristensen, Jesper T. Andreasen
Summary: This study confirmed that psychedelics acting as 5-HT2AR agonists can reduce compulsive-like digging behavior in mice, while also suggesting that both 5-HT2A and 5-HT(2C)Rs may work in parallel on this behavior. Results with psilocybin indicate that a 5-HT2R-independent mechanism may also contribute to its effect on repetitive digging behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
Jianping Chen, Erik J. Garcia, Christina R. Merritt, Joshua C. Zamora, Andrew A. Bolinger, Konrad Pazdrak, Susan J. Stafford, Randy C. Mifflin, Eric A. Wold, Christopher T. Wild, Haiying Chen, Noelle C. Anastasio, Kathryn A. Cunningham, Jia Zhou
Summary: In this study, novel oleamide analogues were designed and synthesized as selective 5-HT2CR agonists or dual 5-HT2CR/5-HT2AR positive allosteric modulators using a fragment-based discovery approach. Compound 13 (JPC0323) showed on-target properties, acceptable plasma exposure and brain penetration, and negligible displacement to orthosteric sites of over 50 GPCRs and transporters. Moreover, compound 13 suppressed novelty-induced locomotor activity in a 5-HT2CR-dependent manner, indicating 5-HT2CR agonist activity at the whole organism level at the employed doses of 13. This research discovered new selective 5-HT2CR agonists and first-in-class 5-HT2CR/5-HT2AR dual positive allosteric modulators, expanding the pharmacological toolbox for exploring the biology of these important receptors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Philip Jean-Richard-dit-Bressel, Jessica C. Lee, Shi Xian Liew, Gabrielle Weidemann, Peter F. Lovibond, Gavan P. McNally
Summary: Individuals differ in their sensitivity to the consequences of their actions. Three pathways, including motivational, behavioral, and cognitive pathways, contribute to this sensitivity. Punishment sensitivity is influenced by the individuals' beliefs about the causes of their actions. Incorrect causal beliefs can lead to maladaptive behaviors, especially when punishment is infrequent, causing resistance to updating behavior based on experience and information.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Orr Shahar, Alexander Botvinnik, Noam Esh-Zuntz, Michal Brownstien, Rachel Wolf, Amit Lotan, Gilly Wolf, Bernard Lerer, Tzuri Lifschytz
Summary: There is growing interest in the therapeutic potential of psilocybin. This study examined the role of different serotonergic receptors and TAAR1 in modulating the head twitch response induced by 5-HTP and psilocybin in mice. The findings suggest that compounds that modulate psychedelic-induced head twitch response may have important therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jelena Nikolic, Katarina Vukojevic, Violeta Soljic, Josip Miskovic, Martina Orlovic Vlaho, Mirna Saraga-Babic, Natalija Filipovic
Summary: We studied the expression of serotonin receptors 5-HT1A, 5-HT2A, and 5-HT3A at different stages of fetal lung development. The receptors were strongly expressed in the epithelium of the proximal airways and vascular walls during early and mid-fetal development. In the later stages, they were also expressed in type I and type II pneumocytes. The expression of 5-HT2A decreased while 5-HT3A expression increased toward the final stage of lung development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Joanna Jastrzebska, Malgorzata Frankowska, Irena Smaga, Magdalena Hubalewska-Mazgaj, Agata Suder, Renata Pieniazek, Edmund Przegalinski, Malgorzata Filip
Summary: The study revealed the key role of 5-HT2C receptors in treating CUD and comorbid depression and CUD, supporting further research into pharmacological strategies targeting these receptors.
PHARMACOLOGICAL REPORTS
(2023)
Article
Neurosciences
Brooke N. Bender, Mary M. Torregrossa
Summary: Intermittent access (IntA) models have been developed to mimic human cocaine use and have been shown to enhance pharmacological and behavioral effects of cocaine. This study examined sex differences and cue extinction in the IntA model. Results showed that IntA increased motivation for cocaine in females and facilitated punished cocaine self-administration in males. Additionally, after 10 days of IntA training, drug-seeking was dependent on DLS dopamine in males. These findings suggest that IntA is valuable for studying sex differences and early stages of drug use.
Article
Neurosciences
Alexandra J. Ng, Lindsay K. Vincelette, Jiayi Li, Bridget H. Brady, John P. Christianson
Summary: Behaviors associated with distress can influence the anxiety-like states in observers and shape social interactions among stressed individuals. Serotonin and its receptors, particularly the 5-HT2C receptor, play a crucial role in modulating social affective decision-making and are involved in the social reactions to stressed individuals. Furthermore, these effects are not influenced by gender.
Review
Biochemistry & Molecular Biology
Joachim Neumann, Britt Hofmann, Stefan Dhein, Ulrich Gergs
Summary: Serotonin controls human cardiac contractile function solely through 5-HT4-receptors, leading to positive inotropic and chronotropic effects, as well as arrhythmias. This review focuses on the potential effects of 5-HT4-receptors in sepsis, ischemia, and reperfusion. The formation and inactivation of serotonin in the heart, as well as its role in cardiovascular diseases, are discussed. Mechanisms of cardiac signal transduction through 5-HT4-receptors and potential roles in cardiac diseases are addressed, along with future research directions and potential animal models. The potential clinical utility of 5-HT4-receptor agonists or antagonists is also discussed, considering the extensive studies on serotonin over the years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Tsen Vei Lim, Rudolf N. Cardinal, Edward T. Bullmore, Trevor W. Robbins, Karen D. Ersche
Summary: The study revealed that SUD patients have significantly reduced learning rates from punishment compared to healthy controls, while reward learning rates were not measurably impaired. Furthermore, the dopaminergic receptor agents modulated RL parameters differently in SUD patients and healthy participants.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kinga Gawlinska, Dawid Gawlinski, Malgorzata Filip, Edmund Przegalinski
Summary: Recent studies have shown a relationship between maternal diet composition and the risk of mental illnesses in offspring by affecting serotonin receptors in the brain. Different maternal diets, such as high-fat, high-carbohydrate, and mixed diets, induce specific changes in 5-HT2C and 5-HT2A receptor levels in different brain regions of the offspring. Specifically, high-fat maternal diet reduces 5-HT2C receptor expression in male rats at PND 28 but increases it at PND 63 in certain brain regions.
PHARMACOLOGICAL REPORTS
(2021)
Article
Neurosciences
Jason Yuen, Abhinav Goyal, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Yoonbae Oh, Hojin Shin
Summary: Although dopamine is the most implicated neurotransmitter in addiction, serotonin also plays a vital role. This study used N-shaped fast-scan cyclic voltammetry to investigate the acute effects of cocaine on phasic serotonin release in the nucleus accumbens core. The findings contribute to our understanding of the mechanism of action of cocaine and provide a baseline for further research in cocaine addiction.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Romain Gerbier, Delphine Ndiaye-Lobry, Pablo B. Martinez de Morentin, Erika Cecon, Lora K. Heisler, Philippe Delagrange, Florence Gbahou, Ralf Jockers
Summary: Functional fingerprint of heteromers composed of G(i)-coupled melatonin MT2 receptors and G(q)-coupled serotonin 5-HT2C receptors was identified in mouse brain, with melatonin activating G(q) proteins and PLC in a concentration-dependent manner in the hypothalamus and cerebellum. These effects were absent in cortex, inhibited by the 5-HT2C receptor-specific inverse agonist SB-243213, and were fully recapitulated in MT2 and 5-HT2C knockout mice. Furthermore, antidepressant agomelatine had similar effects to melatonin but blocked melatonin-promoted G(q) activation due to its 5-HT2C antagonistic component, providing strong functional evidence for the existence of MT2/5-HT2C heteromeric complexes.
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Yann Pelloux, Christelle Baunez
PSYCHOPHARMACOLOGY
(2017)
Article
Neurosciences
Emiliano Merlo, Amy L. Milton, Barry J. Everitt
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Yann Pelloux, Mickael Degoulet, Alix Tiran-Cappello, Candie Cohen, Sylvie Lardeux, Olivier George, George F. Koob, Serge H. Ahmed, Christelle Baunez
MOLECULAR PSYCHIATRY
(2018)
Review
Biology
Barry J. Everitt, Chiara Giuliano, David Belin
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Review
Neurosciences
Nathan J. Marchant, Erin J. Campbell, Yann Pelloux, Jennifer M. Bossert, Yavin Shaham
PSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
Karen L. Smith, Rahul R. Rao, Clara Velazquez-Sanchez, Marta Valenza, Chiara Giuliano, Barry J. Everitt, Valentina Sabino, Pietro Cottone
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Yann Pelloux, Jennifer E. Murray, Barry J. Everitt
PSYCHOPHARMACOLOGY
(2015)
Review
Neurosciences
Christian Luscher, Trevor W. Robbins, Barry J. Everitt
NATURE REVIEWS NEUROSCIENCE
(2020)
Article
Neurosciences
Emmanuel Breysse, Julie Meffre, Yann Pelloux, Catharine A. Winstanley, Christelle Baunez
Summary: Bilateral STN lesions in rats were found to reduce risk-taking behavior in both the PDT and loss-chasing task, suggesting that STN inactivation could decrease risky decision-making. However, opposite results were observed in a small number of animals with lesions extending to the zona incerta, indicating the specificity of STN involvement in these processes.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chiara Giuliano, Mickael Puaud, Rudolf N. Cardinal, David Belin, Barry J. Everitt
Summary: Excessive drinking is a key characteristic of alcohol addiction, but individuals addicted to alcohol also crave and seek alcohol despite negative consequences, eventually leading to intoxication. Habitual alcohol seeking behavior is associated with compulsive alcohol drinking, indicating the involvement of the habit system in the development of alcohol addiction.
Article
Multidisciplinary Sciences
Alexander C. W. Smith, Sietse Jonkman, Alexandra G. Difeliceantonio, Richard M. O'Connor, Soham Ghoshal, Michael F. Romano, Barry J. Everitt, Paul J. Kenny
Summary: The study showed that neural activity increases in the anterior dorsolateral striatum when mice successfully learn a new lever-press response, indicating that D1-MSNs encode new instrumental actions while D2-MSNs promote the expression of habitual actions. Disruption of D1-MSNs inhibits the consolidation process, whereas inhibition of D2-MSNs strengthens consolidation but blocks the expression of previously learned habit-like responses.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yann Pelloux, Jennifer K. Hoots, Carlo Cifani, Sweta Adhikary, Jennifer Martin, Angelica Minier-Toribio, Jennifer M. Bossert, Yavin Shaham
Article
Neurosciences
Yann Pelloux, Angelica Minier-Toribio, Jennifer K. Hoots, Jennifer M. Bossert, Yavin Shaham
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Emiliano Merlo, Patrizia Ratano, Elena C. Ilioi, Miranda A. L. S. Robbins, Barry J. Everitt, Amy L. Milton
