Article
Pharmacology & Pharmacy
Mohammed H. Elkomy, Fatma I. Abo El-Ela, Randa Mohammed Zaki, Omar A. Alsaidan, Mohammed Elmowafy, Ameeduzzafar Zafar, Khaled Shalaby, Mohamed A. Abdelgawad, Hany A. Omar, Rania Salama, Hussein M. Eid
Summary: This study developed and optimized a drug-loaded thermosensitive gel for intranasal administration to combat depression. The results demonstrated that compared to other formulations, this thermosensitive gel significantly improved behavioral performance and alleviated neural tissue changes in depressed rats. Further research is needed to determine its effectiveness in humans.
Article
Behavioral Sciences
Susan E. Martelle, Evelin M. Cotella, Nawshaba Nawreen, Carrie Chen, Benjamin A. Packard, Maureen Fitzgerald, James P. Herman
Summary: PACAP is highly expressed in putative pyramidal neurons in the infralimbic cortex of rats, while PAC1 is enriched in interneurons. Infusion of PACAP into the IL alters stress responses, increases anxiety-like behavior, and enhances fear memory retention in rodents.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Neurosciences
Josh Allen, Raquel Romay-Tallon, Milann A. Mitchell, Kyle J. Brymer, Jenessa Johnston, Carla L. Sanchez-Lafuente, Graziano Pinna, Lisa E. Kalynchuk, Hector J. Caruncho
Summary: Chronic stress is a significant risk factor for depression. Reelin protein can rapidly restore depressive-like behavior and neurochemical abnormalities induced by chronic stress through intravenous injections.
Article
Biochemistry & Molecular Biology
Vittorio Canale, Magdalena Kotanska, Anna Dziubina, Matylda Stefaniak, Agata Siwek, Gabriela Starowicz, Krzysztof Marciniec, Patryk Kasza, Grzegorz Satala, Beata Duszynska, Xavier Bantreil, Frederic Lamaty, Marek Bednarski, Jacek Sapa, Pawel Zajdel
Summary: The study designed and synthesized a series of dual-acting ligands arylsulfonamide derivatives of dihydrobenzofuranoxy)ethyl piperidines, with compound 8 showing potential for treating depressive symptoms and high selectivity. By targeting both alpha(2)-adrenoceptors and 5-HT7 receptors, these compounds could be potential candidates for future antidepressants.
Article
Neurosciences
A. G. Sartim, J. Marques, K. M. Silveira, P. H. Gobira, F. S. Guimaraes, G. Wegener, S. R. Joca
Summary: The study found that CBD can exhibit antidepressant effects without causing hyperactivity, and it can also inhibit the psychostimulant effects induced by ketamine. The combined administration of CBD and ketamine may be a promising therapeutic strategy for achieving antidepressant effects while reducing unwanted side effects.
Article
Behavioral Sciences
Marcela Pereira, Isadora P. Siba, Alexandra Acco, Diego Correia, Fernanda R. Lapa, Adair R. S. Santos, Ana P. Ruani, Moacir G. Pizzolatti, Roberto Andreatini
Summary: The study found that myricitrin can reverse depressive behavior induced by chronic mild stress and reduce adrenal hypertrophy and levels of the inflammatory cytokine IL-6 in the hippocampus. This suggests that myricitrin has antidepressant and anti-inflammatory effects.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Plant Sciences
Taiwo G. Olubodun-Obadun, Ismail O. Ishola, Timisola P. Adesokan, Blessing O. Anih, Olufunmilayo O. Adeyemi
Summary: This study investigates the antidepressant and anxiolytic effects of ethanol seed extract of Cajanus cajan in mice. The extract shows potential in treating anxiety and other neurological disorders, possibly through the involvement of monoaminergic systems and GABA receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Yixue Qin, Haoxuan Li, Yuqi Zhang, Jun-Li Cao, Wenxin Zhang, Hongxing Zhang
Summary: The addition of retigabine as an adjunctive treatment enhances the antidepressant effect of ketamine, allowing for a lower dose of ketamine to be effective in the forced swim test. Simultaneous administration of retigabine with ketamine significantly improves the duration and effectiveness of ketamine's antidepressant effect.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Neurosciences
Elena Carazo-Arias, Phi T. Nguyen, Marley Kass, Hyun Jung Jee, Katherine M. Nautiyal, Valerie Magalong, Lilian Coie, Valentine Andreu, Mark M. Gergues, Huzefa Khalil, Huda Akil, Danusa Mar Arcego, Michael Meaney, Christoph Anacker, Benjamin A. Samuels, John E. Pintar, Irina Morozova, Sergey Kalachikov, Rene Hen
Summary: The opioid system is involved in the antidepressant effects of fluoxetine, potentially mediated through the upregulation of proenkephalin in a specific subgroup of mature granule cells.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat
Summary: This study aimed to synthesize benzodiazepine derivatives and evaluate their antidepressant potentials. The results showed that compounds 2 and 5 exhibited significant antidepressant effects and increased GABA levels in the brain's hippocampus of experimental animals, indicating the possible involvement of the GABAergic mechanism.
Article
Behavioral Sciences
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
Summary: Research indicates that acetylcholinesterase inhibitors exhibit an antidepressant-like effect in mice, showing a U-shaped dose-response curve. Three different AChEIs show therapeutic effects at low doses without causing hyperactivity or anxiolytic effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Paola Colucci, Alessia Santori, Luca Romanelli, Clemens Zwergel, Antonello Mai, Sergio Scaccianoce, Patrizia Campolongo
Summary: The study found that amphetamine enhances memory consolidation in rats under mild stress conditions, but impairs long-term memory performance in rats exposed to strong stress, depending on the stress-induced activation of the peripheral adrenergic response.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Elif Beyza Guven, Nicole Melisa Pranic, Gunes Unal
Summary: Environmental enrichment in rodents has various benefits on physiology, affect, and cognition. On the other hand, social isolation negatively affects neurobiological mechanisms and cognitive performance. This study showed that brief environmental enrichment following long-term social isolation had a significant anxiolytic effect but also increased behavioral despair in rats. Furthermore, the enriched rats exhibited better memory performance in the early stages of a water Y-maze test, indicating faster learning ability.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Scheila Daiane Schmidt, Carolina Garrido Zinn, Lorena Evelyn Cavalcante, Flavia Fagundes Ferreira, Cristiane Regina Guerino Furini, Ivan Izquierdo, Jociane De Carvalho Myskiw
Summary: Social recognition, crucial for social group establishment, reproduction, and species survival, relies on the consolidation of social stimuli in long-term memory. This study reveals the involvement of specific serotonin receptors in the consolidation of social recognition memory, shedding light on the molecular mechanisms underlying this process.
Article
Chemistry, Medicinal
Armen G. Mezhlumyan, Anna Tallerova, Polina Y. Povarnina, Aleksey Tarasiuk, Nellya M. Sazonova, Tatiana A. Gudasheva, Sergey B. Seredenin
Summary: This study compares the antidepressant effects of different neurotrophin mimetics and identifies GSB-106 as the most promising candidate for developing antidepressant drugs.
Article
Neurosciences
Cristina Luz Tosta, Gabriela Pandini Silote, Maria Paula Fracalossi, Ariandra Guerini Sartim, Roberto Andreatini, Samia Regiane Lourenco Joca, Vanessa Beijamini
Article
Chemistry, Medicinal
Palloma de A. S. Hocayen, Etiele Wendler, Debora D. Vecchia, Luiz K. S. Kanazawa, Ana Carolina Issy, Elaine Del Bel, Roberto Andreatini
PHYTOTHERAPY RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Pedro Felipe Pereira Chaves, Palloma de Almeida S. Hocayen, Jorge Luiz Dallazen, Maria Fernanda de Paula Werner, Marcello Iacomini, Roberto Andreatini, Lucimara M. C. Cordeiro
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Anesthesiology
Erika Ivanna Araya, Darciane Favero Baggio, Laura de Oliveira Koren, Roberto Andreatini, Rainer K. W. Schwarting, Gerald W. Zamponi, Juliana Geremias Chichorro
Article
Obstetrics & Gynecology
Irene Sterpu, Emma Fransson, Luisa W. Hugerth, Juan Du, Marcela Pereira, Liqin Cheng, Sebastian Alexandru Radu, Lorena Calderon-Perez, Yinghua Zha, Pia Angelidou, Alexandra Pennhag, Fredrik Boulund, Annika Scheynius, Lars Engstrand, Eva Wiberg-Itzel, Ina Schuppe-Koistinen
Summary: The study found no evidence supporting the existence of a placental microbiome in 76 term pregnancies. Incidental findings of bacterial species could be due to contamination or low-grade bacterial presence in some locations.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Chemistry, Analytical
Patrik Kallback, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Nicoletta Schintu, Marcela Pereira, Florian Barre, Henrik Wadensten, Per Svenningsson, Per E. Andren
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Vasco C. Sousa, Ioannis Mantas, Nikolas Stroth, Torben Hager, Marcela Pereira, Haitang Jiang, Sandra Jabre, Wojciech Paslawski, Oliver Stiedl, Per Svenningsson
Summary: Patients with mood disorders and anxiety often show hyperresponsiveness in the hypothalamic-pituitary-adrenocortical (HPA) axis and autonomic nervous system. It has been found that p11 deficiency is associated with depression-like phenotypes. In this study, p11-deficient mice were used to investigate the role of p11 in stress responsiveness, showing increased response to stress in p11KO mice, along with hyperactivity in the HPA and SAM axes. These findings suggest that p11 deficiency may lead to increased stress reactivity and behavioral changes related to depression and anxiety.
MOLECULAR PSYCHIATRY
(2021)
Article
Microbiology
Luisa W. Hugerth, Marcela Pereira, Yinghua Zha, Maike Seifert, Vilde Kaldhusdal, Fredrik Boulund, Maria C. Krog, Zahra Bashir, Marica Hamsten, Emma Fransson, Henriette Svarre Nielsen, Ina Schuppe-Koistinen, Lars Engstrand
Article
Neurosciences
Debora Dalla Vecchia, Luiz Kae Sales Kanazawa, Etieli Wendler, Palloma de Almeida Soares Hocayen, Maria Aparecida Barbato Frazao Vital, Reinaldo Naoto Takahashi, Claudio Da Cunha, Edmar Miyoshi, Roberto Andreatini
Summary: Ketamine has shown promising results in improving depressive-like behaviors and short-term memory impairment in an animal model of PD, indicating its potential for treating PD patients.
BRAIN RESEARCH BULLETIN
(2021)
Article
Behavioral Sciences
Inara Fernanda Misiuta Raupp-Barcaro, Isabella Caroline da Silva Dias, Erika Meyer, Jeane Cristina Fonseca Vieira, Giovana da Silva Pereira, Arthur Ribeiro Petkowicz, Rubia Maria Weffort de Oliveira, Roberto Andreatini
Summary: The antidepressant-like effects of amantadine in mice may be mediated by its actions on D2 and NMDA receptors, likely involving hippocampal neurogenesis.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Luiz K. S. Kanazawa, Debora R. Radulski, Gabriela S. Pereira, Jos Prickaerts, Rainer K. W. Schwarting, Alexandra Acco, Roberto Andreatini
Summary: The study showed that andrographolide has antimanic-like effects on LDX-induced manic behaviors, which may be mediated through its antioxidant properties.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Shokouh Arjmand, Anne M. Landau, Bardia Varastehmoradi, Roberto Andreatini, Samia Joca, Gregers Wegener
Summary: Despite advances in managing depressive disorders, difficulties remain. Recent research has shown that the brain's anti-reward system, the lateral habenula (LHb), is disrupted in depression. Astrocytes and the endocannabinoid system may play crucial roles in these abnormalities. Modulating astrocyte receptors could potentially regulate mood and improve depressive symptoms.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Marcela Pereira, Isadora P. Siba, Alexandra Acco, Diego Correia, Fernanda R. Lapa, Adair R. S. Santos, Ana P. Ruani, Moacir G. Pizzolatti, Roberto Andreatini
Summary: The study found that myricitrin can reverse depressive behavior induced by chronic mild stress and reduce adrenal hypertrophy and levels of the inflammatory cytokine IL-6 in the hippocampus. This suggests that myricitrin has antidepressant and anti-inflammatory effects.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Marcela Pereira, Ju Kyoung Oh, Dae-Kyung Kang, Lars Engstrand, Valerie Diane Valeriano
Summary: Infectious diseases caused by mucosal pathogens can be targeted at their primary entry points to consolidate protective immunity. Research on SARS-CoV-2 infection shows that the upper respiratory mucosa is highly affected and dysregulation of gut-lung axis microbiota plays a crucial role in symptom severity. Understanding mucosal and adaptive immune responses allows for effective design of bacterial mucosal vaccine vectors.
Article
Neurosciences
Thiago Rodrigues da Silva, Jeferson Machado Batista Sohn, Roberto Andreatini, Cristina Aparecida Stern